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HD Biosciences

Shanghai, CN

HD Biosciences (HDB) is a leading biology focused preclinical drug discovery contract research organization. The company offers comprehensive technology platforms and expertise around target discovery, hit-to-lead, lead generation and optimization and candidate selection in preclinical drug discovery and development for both small molecules and biologics. Our services include biology assay development, compound profiling, high throughput screening, DMPK, toxicology, in vivo pharmacology, drug efficacy and safety assessment, natural product based lead compound discovery, as well as medicinal chemistry to support SAR focused research capability.

HDB has provided extensive and high quality services to multinational large pharmaceutical companies, including Pfizer, Janssen, Lilly, Merck, GSK, as well to many other pharmaceutical and biotech companies around the world. The outstanding track records of services and the... Show more »

HD Biosciences (HDB) is a leading biology focused preclinical drug discovery contract research organization. The company offers comprehensive technology platforms and expertise around target discovery, hit-to-lead, lead generation and optimization and candidate selection in preclinical drug discovery and development for both small molecules and biologics. Our services include biology assay development, compound profiling, high throughput screening, DMPK, toxicology, in vivo pharmacology, drug efficacy and safety assessment, natural product based lead compound discovery, as well as medicinal chemistry to support SAR focused research capability.

HDB has provided extensive and high quality services to multinational large pharmaceutical companies, including Pfizer, Janssen, Lilly, Merck, GSK, as well to many other pharmaceutical and biotech companies around the world. The outstanding track records of services and the capability to provide inputs and expertise in the projects have helped the company earn great reputation in the industry.

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Epigenetic Assay Development
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Single Nucleotide Polymorphism (SNP) Genotyping
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HDB provides SNP genotyping services with high-confidence results using TaqMan genotyping technology to researchers around the world. With the largest collection of ready-to use human SNP assays available, TaqMan technology enables us to do almost all sorts of SNP genotyping using either pre-designed or custom human & mouse... Show more »

HDB provides SNP genotyping services with high-confidence results using TaqMan genotyping technology to researchers around the world. With the largest collection of ready-to use human SNP assays available, TaqMan technology enables us to do almost all sorts of SNP genotyping using either pre-designed or custom human & mouse SNP assays. Upon receipt of the SNP assays and your DNA, the standard TaqMan SNP assay will be run following the protocol as recommended by the manufacturer.

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In vivo Genotoxicity Testing
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MicroRNA (miRNA) Expression Profiling
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HDB also provides fast, easy and accurate microRNA profiling services using Evagreen and TaqMan based real-time qPCR run on the Applied Biosystems 7900HT Fast Real-Time PCR System. Profiling of hundreds of miRNAs can be completed in wihtin 5 hours. It's ideal for human, mouse, and rat profiling and requires only minimal sample... Show more »

HDB also provides fast, easy and accurate microRNA profiling services using Evagreen and TaqMan based real-time qPCR run on the Applied Biosystems 7900HT Fast Real-Time PCR System. Profiling of hundreds of miRNAs can be completed in wihtin 5 hours. It's ideal for human, mouse, and rat profiling and requires only minimal sample amounts — as little as 1 ng of total RNA input — making it suitable for FFPE, FACS, biopsy, and other very small samples.

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Flow Cytometry
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HDB provides direct expression and comparison analysis of biomarkers using multi-color fluorescence flow cytometry. Our BD FACSCalibur is equipped with dual lasers which allow exploring cell type markers and activation markers in one assay on the single cell level with high sensitivity, minimal compensation and maximum flexibility... Show more »

HDB provides direct expression and comparison analysis of biomarkers using multi-color fluorescence flow cytometry. Our BD FACSCalibur is equipped with dual lasers which allow exploring cell type markers and activation markers in one assay on the single cell level with high sensitivity, minimal compensation and maximum flexibility in fluorochrome selection. Up to four different biomarkers, intracellular markers or cell surface markers can be analyzed in parallel. It's also equipped with HTS sampler compatible for 96- and 384-well assay format with dramatically increased throughput.

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ELISA
Enzyme-linked immunosorbent assay
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Phage Display Library Construction and Screening
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scFv/Fab phage display vector construction and optimization

scFv/Fab human antibody phage display library construction and characterization

  • Start from PBMC, B cells, or commercial RNA
  • 10E5 or above diversity for light chain
  • 10E7 or above diversity for heavy chain
  • 10E9 to 10E11 diversity for scFv/Fab... Show more »

scFv/Fab phage display vector construction and optimization

scFv/Fab human antibody phage display library construction and characterization

  • Start from PBMC, B cells, or commercial RNA
  • 10E5 or above diversity for light chain
  • 10E7 or above diversity for heavy chain
  • 10E9 to 10E11 diversity for scFv/Fab library
  • >80% functionality for library clones
  • Duplication less than 1%

Library panning

  • Plate based
  • Magnetic beads based
  • Successful hits for over 20 targets in the past years
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Monoclonal Antibody (mAb) Production
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Peptide Synthesis
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HDB applies its extensive experience and uses state-of-the-art equipment for peptide synthesis. We offer high-quality custom peptides synthesis service with a wide variety of purity levels, scales and modifications to best fit your research needs. We choose standard stepwise solid phase peptide synthesis (SPPS) procedures,... Show more »

HDB applies its extensive experience and uses state-of-the-art equipment for peptide synthesis. We offer high-quality custom peptides synthesis service with a wide variety of purity levels, scales and modifications to best fit your research needs. We choose standard stepwise solid phase peptide synthesis (SPPS) procedures, including both Boc and Fmoc chemical synthesis technique, the current and the best method of peptide synthesis. Our process includes both automatic and manual peptide synthesizers, purification and
analytical HPLC systems, and state of the art technology.

Every peptide from HDB is tested by Mass spectrum and/or HPLC chromatogram, and the quality analysis data sheet is provided to our customers.

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Demyelination Animal Models
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Liver Disease Animal Models
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Cuprizone Animal Models
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Myelination Animal Models
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Autoimmune Disease Animal Models
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Chain Shuffling
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Calcium Channel Assays
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Cytometric Bead Array (CBA) FACS Analysis
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Constant Fragment (Fc) Engineering
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Complementary Determining Region (CDR) Walking Mutagenesis
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Antibody Resurfacing
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Complementary Determining Region (CDR) Grafting
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Organic Ion Transporter Assays
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Amino Acid Transporter Assays
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Microinjection Transfection
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Stroke Animal Models
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Pulmonary Fibrosis Animal Models
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Anxiety Animal Models
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Depression Animal Models
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Hepatitis Animal Models
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Hepatitis B
Hepatitis C
Polymerase Assays
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Neuroscience Animal Models
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Parkinsons Disease Animal Models
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Site-Directed Mutagenesis
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Viral Infection Animal Models
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HT ADME
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Lupus Animal Models
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Natural Product Isolation and Purification
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Natural Product Libraries
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Histopathological Examination
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Cognition and Behavior Animal Models
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Carcinogenicity/Tumorigenicity Testing
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In silico Drug-Drug Interaction Modeling
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Liver Fibrosis Animal Models
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Tobacco Smoke-Induced Disease Animal Models
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Patent Searching and Analysis
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Compound Sourcing
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Custom Pain Animal Models
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Multidrug Resistance (MDR) Testing
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Schizophrenia Animal Models
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Diabetes Animal Models
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Non-human primates
Drug Target Identification
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Huntington's Disease Animal Models
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Animal Model in vivo Analyses
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Obesity Animal Models
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Histology and Pathology Services
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hERG Channel Inhibition Assay
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Bacterial Infection Animal Models
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In vitro Diabetes Models
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Natural Product Screening
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Compound Profiling
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In vivo Protein Binding Assays
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Knock-In Mouse Development
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HDB Functional Genetic Center (HDB-FTC) is a custom request-based platform providing full-scale service from gene cloning, making gene expression vector/targeting construct, pronuclear/blastocyst microinjection, genotyping, to characterizations of phenotypes at both in vitro and in vivo levels in the mouse, among which the last... Show more »

HDB Functional Genetic Center (HDB-FTC) is a custom request-based platform providing full-scale service from gene cloning, making gene expression vector/targeting construct, pronuclear/blastocyst microinjection, genotyping, to characterizations of phenotypes at both in vitro and in vivo levels in the mouse, among which the last capacity/feasibility differentiates HDB-FTC from other transgenic resources.

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DNA Methylation Analysis
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Antibody Amplification
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Alzheimer's Disease Animal Models
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Electrophysiology Animal Models
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In vitro Genotoxicity Testing
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Mutagenicity Testing
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Custom Cell-Based Assays
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Cell Culture Consulting
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Assay Development Consulting
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Drug Target Validation
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Assay Development
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HD Biosciences offers comprehensive assays and assay development/validation services that cover all major therapeutic target classes including GPCRs, nuclear receptors & other receptors, kinases, epigenetics enzymes, PDEs & other enzymes, ion channels and transporters, etc. Our teams are familiar and experienced with... Show more »

HD Biosciences offers comprehensive assays and assay development/validation services that cover all major therapeutic target classes including GPCRs, nuclear receptors & other receptors, kinases, epigenetics enzymes, PDEs & other enzymes, ion channels and transporters, etc. Our teams are familiar and experienced with various formats and technologies. All assays are well developed and optimized with robust and reproducible outcomes and validated with reference compounds. Most assays can be available in high-throughput screening (HTS) format after HTS adaptation and validation.

HD Biosciences specializes in both biochemical assays and cell-based assays. Our assay
technologies include but not limited to:

  • Biochemical assays
  • Radiometric assays
  • Cell-based target assays
  • High content and multiplexing assays
  • Phenotypic functional assays
  • Biophysical assays
  • Mass spectrometry

Instrument and Technology

Multimode plate readers

  • Caliper (EZreaderII); Biacore (3000)
  • FACS (CaliperBA), FACSJazz Flow Cytometer (BD),
  • MSD (SI6000)
  • Topcount; MicroBeta
  • Viewlux; FLIPR; Envision; SpetraMax
  • UPLC/MS/MS; RapidFire/MS/MS
  • Cellomics ArrayScan, Acumen X3
  • ABI 7300, ABI ViiA7
  • INCUCYTE™ Kinetic Imaging
  • EPC 10 manual patch clamping device (HEKA)
  • xCELLigence System RTCA Cardio Instrument

Liquid handling systems

  • Echo550 (Labcyte)

  • Mosquito (TTP), Platemate Plus (Thermo)

  • Bravo (Agilent), Hamilton StarLet (Hamilton)

  • JANUS Workstation (PE)

  • Multidrop Combi w/ stackers (Thermo)

  • Apricot (Apricot Designs)

  • Precision 2000 (Biotek)

  • REMP Piercer

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Induced Pluripotent Stem Cell (iPSC) Generation
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  1. iPSC generation service
    Our strong iPS cell experienced scientists can also generate human iPS cell from human peripheral blood, fibroblast or adipose-derived stem cells (ADSCs) using episomal DNA vectors containing the reprogramming factors
    1) For fibroblast, need > 1 x 106 cells from normal or patients (we also provide... Show more »
  1. iPSC generation service
    Our strong iPS cell experienced scientists can also generate human iPS cell from human peripheral blood, fibroblast or adipose-derived stem cells (ADSCs) using episomal DNA vectors containing the reprogramming factors
    1) For fibroblast, need > 1 x 106 cells from normal or patients (we also provide fibroblast isolation service)
    2) For PBMC, need 2 vials of 5 x 106 cell/vial from normal or patients (we also provide PBMC isolation service)
    3) iPSC clones formation, expansion and characterization using pluripotency markers

  2. iPSC genome editing service
    Service includes:
     iPSC gene KO or KI service by CRISPR/Cas9 + gene specific sgRNA + DNA template (KI only)
     iPSC single clones formation and sequence identification
     iPSC positive clones expansion
     iPSC characterization using pluripotency marker staining

  3. iPSC differentiation service
    Service includes:
     iPSC neural stem cell (NSC) differentiation, neural stem cell characterization by NSC marker staining
     iPSC cardiomyocyte differentiation, cardiomyocyte characterization by TNNT2 and a-SMA staining

  4. iPSC characterization service
    Service includes:
     iPSC characterization by pluripotency marker staining
     Embryoid body formation
     Teratoma formation
     iPSC karyotyping service

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Virus Production
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Custom viral production service

  1. Lentivirus production service
    Service includes: Lentiviral vector construction—cloning gene of interest (GOI), shRNA or sgRNA into the viral vector; Low-titer virus production (10E6~10E7 TU/ml); virus concentration by ultracentrifugation (>10E8 or 10E9 TU/ml) and virus titration... Show more »

Custom viral production service

  1. Lentivirus production service
    Service includes: Lentiviral vector construction—cloning gene of interest (GOI), shRNA or sgRNA into the viral vector; Low-titer virus production (10E6~10E7 TU/ml); virus concentration by ultracentrifugation (>10E8 or 10E9 TU/ml) and virus titration determined by qPCR (measuring the viral genome/host cell)
  2. Adenovirus production service
    Service includes: Adenovirus vector construction—cloning gene of interest (GOI), shRNA or sgRNA into the viral vector; Primary, low-titer virus stock production; Large scale of virus production using primary low-titer virus stock; Virus purification by gradient ultracentrifugation and dialysis and Virus titration by measuring PFU.
  3. Adeno-Associated Virus production service
    Service includes: Adeno-associated virus vector construction—cloning gene of interest (GOI), shRNA or sgRNA into the viral vector; Large scale of virus production by transfection (viral vector + helper vectors); Virus purification by gradient ultracentrifugation and dialysis and Virus titration determined by qPCR (measuring the viral genome/host cell).
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In vitro Monoclonal Antibody (mAb) Production
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  1. Antibody Expression
    • Gene synthesis light chain and heavy chain
    • Express and purify recombinant antibody
    • Validate monoclonal antibody by ELISA
    • Expand and purify antibody
  2. Antibody validation assays by ELISA, WB and Flow Cytometry
  3. Antibody Sequencing Service
  4. Other Services including antigen affinity... Show more »
  1. Antibody Expression
    • Gene synthesis light chain and heavy chain
    • Express and purify recombinant antibody
    • Validate monoclonal antibody by ELISA
    • Expand and purify antibody
  2. Antibody validation assays by ELISA, WB and Flow Cytometry
  3. Antibody Sequencing Service
  4. Other Services including antigen affinity purification, protein A/G/L purification; ELISA/Western blot/Dot blot/IHC/IF/IP/Co-IP/ChIP-seq and antibody labeling with Biotin, FITC, 5-FAM, rhodamine, HRP,etc.
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Specialized Cell-Based Assays
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Cell and Tissue Culture
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Cells and Tissues
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Chemistry and Materials
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Virology Services
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Natural Products
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Metabolic Animal Models
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Cytometry
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Lead Identification and Validation
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Clinical Research
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Clinical Laboratory Services
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Biochemistry & Molecular Biology
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Compound Libraries
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Synthetic Chemistry
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Protein Quantification
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Transgenic Mouse Services
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Mammalian Cell Culture
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Safety Pharmacology & Efficacy Testing
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Drug Discovery & Development
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Epigenetic Studies
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Clinical and Anatomic Pathology
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Biomolecular Interaction Analysis
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Cellular Ion Channel Assays
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Protein Services
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Biology
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Infectious Disease Animal Models
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Cardiovascular Toxicology
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Biochemical Assays
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Formulation Services
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Transfection
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Animal Models of Disease
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Hepatic Animal Models
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Respiratory Disease Animal Models
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Business Development Consulting
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Experimental Design
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Computational Chemistry
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Transgenic Animal Model Development
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Project and Process Management
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Protein Conjugation
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Transporter & Cell Uptake Assays
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Clinical Microbiology, Virology and Parasitology
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CNS/Neurology Animal Models
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Cell-Based Assays
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In vitro Disease Models
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Mutagenesis
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Genotyping Services
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Transferase Assays
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Process Consulting
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Pain/Neuropathy Animal Models
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Animal Models and Studies
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Cognitive, Behavioral, and Psychiatric Animal Models
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Toxicology
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Antibody Services
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Nucleic Acid Services
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RNA Services
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Genetic Engineering
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DNA Services
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Drug Discovery
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Microbiology Services
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Enzyme Assays
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Pharmacology & Toxicology
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Immunology Animal Models
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In vivo Toxicity Testing
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In vivo Toxicity Testing Services

In vivo Toxicity Testing Services

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In vitro Toxicity Testing
Price on request

In vitro Toxicity Testing Services

In vitro Toxicity Testing Services

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2018-08-07 11:49:40 -0500

Net Promoter Score of 9 received for Safety Pharmacology & Efficacy Testing.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-05-09 11:10:21 -0500

Net Promoter Score of 10 received for Assay Development.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-01-09 11:30:11 -0600

Net Promoter Score of 9 received for Assay Development.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-01-09 11:29:33 -0600

Net Promoter Score of 9 received for Assay Development.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.

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