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HarkerBIO, LLC

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Buffalo, New York, US

About HarkerBIO, LLC

Founded: 2014 Type: Privately Held Size: 1-10 employees

HarkerBIO is a provider of Structural Biology services to anyone who wishes to utilize macromolecular structure in order to advance their projects (drug discovery and development, protein optimization, protein design, formulation, stability, regulatory compliance, etc.).

Our mission is to become the premier... Show more »

HarkerBIO is a provider of Structural Biology services to anyone who wishes to utilize macromolecular structure in order to advance their projects (drug discovery and development, protein optimization, protein design, formulation, stability, regulatory compliance, etc.).

Our mission is to become the premier structural biology services provider by consistently exceeding customer expectations. We are focused, continually improving, and utterly dedicated to your projects and your needs from start to finish.

Our core capabilities include the entire gene - to - structure pipeline (construct design, multiparallel cloning, protein expression in bacteria, yeast, insect cells or HEK-293, protein purification and crystallization, data collection and structure solution) as well as protein engineering and design, microbiology, small angle X-ray scattering, protein characterization and antibody crystallization.

Our current customer list includes over twenty large- and medium- sized Pharma/Biotech companies as well as a score of academics. We pride ourselves on executing your projects with speed, precision, and integrity - we are an integrated services provider, meaning that we do not often rely on other companies to do our work; almost everything we do is completely internal. This approach affords us exceptional control over all the processes involved in the complex and intricate structural projects.

Among our services, we would like to highlight our exceptional ability to crystallize difficult targets by means of rational protein design that enhances crystal-forming propensity of the target.

We offer a fair and objectively priced line of services that can be purchased either as a flat fee-for-service, milestone payment plan, success fee plan, or FTE billing -- depending on our needs and budget.

We are a commercial spin-off from the world-renowned Hauptman-Woodward Institute located in Buffalo, NY. Our major commercial partner is Albany Molecular Research, Inc (AMRI).

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Our Services (28)


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SHG Conformational Analysis

Second Harmonic Generation
Starting at $20.00 per sample

HarkerBIO's Biophysics team is now offering full assay development and screening using SPR, NMR, and SHG expertise and instruments. Understanding your Protein- Protein interactions via binding affinity, kinetic, (SPR) , conformational changes, (second-harmonic generation), or in solution by STD-NMR including DEEP NMR now, one... Show more »

HarkerBIO's Biophysics team is now offering full assay development and screening using SPR, NMR, and SHG expertise and instruments. Understanding your Protein- Protein interactions via binding affinity, kinetic, (SPR) , conformational changes, (second-harmonic generation), or in solution by STD-NMR including DEEP NMR now, one can monitor structural changes at any site within a protein, in real time. Since protein function is determined by its structure, and changes in structure cause changes in function, characterizing these changes will provide significant insights into how our bodies function and respond to treatments.

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Surface Plasmon Resonance (SPR)

Price on request

HarkerBIO's newest Biacore S200 and newest team members Dr. Delphine Collin and Dr. Elizabeth Anderson now offer complex assay development and screening for difficult and challenging proteins.

HarkerBIO's newest Biacore S200 and newest team members Dr. Delphine Collin and Dr. Elizabeth Anderson now offer complex assay development and screening for difficult and challenging proteins.

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Biacore

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Protein Crystallization Screening and Optimization

Price on request
  • Exclusive license to a patented high-throughput crystallization technology

  • Affiliation with established expertise and crystallization infrastructure
    - $2M crystallization laboratory
    - State-of-the-art SONICC imaging system
    - Highly experienced: 21.5 million unique protein crystallization... Show more »

  • Exclusive license to a patented high-throughput crystallization technology

  • Affiliation with established expertise and crystallization infrastructure
    - $2M crystallization laboratory
    - State-of-the-art SONICC imaging system
    - Highly experienced: 21.5 million unique protein crystallization experiments conducted
    - > 2X success rate for producing verified protein crystals

  • Proprietary Antibody Crystallization Screen, GRAS (Generally Recognized As Safe) Screening for formulation and delivery, etc.

  • Established protocols for sample anonymity and client confidentiality

Please request a quote for more accurate pricing information.

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Fragment Screening

Price on request

Harker's expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling.

Through our collaboration with AMRI we offer a number of compound libraries for... Show more »

Harker's expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling.

Through our collaboration with AMRI we offer a number of compound libraries for screening and selection.

We can also use client-supplied libraries (fragments or full-sized molecular scaffolds) for parallel co-crystallization or soaking.

Please contact us for details.

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Membrane Protein Crystallization

Price on request

Structural characterization of membrane proteins is a vital component in efforts to understand the processes behind many disease states. Crystallization of a membrane protein is hampered by the requirement of detergent, which is used to extract the protein from the lipid bilayer to form a protein-detergent complex (PDC). Hartmut... Show more »

Structural characterization of membrane proteins is a vital component in efforts to understand the processes behind many disease states. Crystallization of a membrane protein is hampered by the requirement of detergent, which is used to extract the protein from the lipid bilayer to form a protein-detergent complex (PDC). Hartmut Michel and other early pioneers of membrane protein crystallization research observed the formation of crystals near the phase boundary of the detergent used to form the PDC. Understanding the variables associated with detergent phase behavior and crystallogenesis enables their rational modulation.

We have generated chemically diverse phase boundary data utilizing dye-based phase partitioning and eleven detergents commonly used to crystallize membrane proteins. The resulting data have been used to guide the formulation of a 1536-cocktail crystallization screen for membrane proteins. The experimentally derived phase boundary data and the 1536-well membrane screen are now available through the high-throughput crystallization facility at HarkerBIO.

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Structure Determination

Price on request

Three-Dimensional Crystallographic Structure Determination

HarkerBIO research team provides a full suite of services to help you solve difficult structures with speed and accuracy. We utilize state of the art software, augmented by decades of solution and refinement experience, to rapidly solve crystal structures of... Show more »

Three-Dimensional Crystallographic Structure Determination

HarkerBIO research team provides a full suite of services to help you solve difficult structures with speed and accuracy. We utilize state of the art software, augmented by decades of solution and refinement experience, to rapidly solve crystal structures of macromolecules and complexes.

We have access to several high-brilliance synchrotron beam lines at APS and CLS - as well as access to SSRL via a partner company.

Our secure data server uses advanced encryption to safeguard the privacy of your proprietary data.

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Gene-to-Protein Services

Price on request

Cloning, Expression and Purification

Please request a quote for more accurate pricing information.

Cloning, Expression and Purification

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Recombinant Protein Expression

Price on request

Bacterial, Yeast, Insect Cell and Mammalian expression platforms.

Please request a quote for accurate pricing information

Bacterial, Yeast, Insect Cell and Mammalian expression platforms.

Please request a quote for accurate pricing information

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E. coli Bacillus Pichia pastoris Mammals Insects

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X-ray Crystallography

Price on request
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X-ray Diffraction Data Collection

Price on request
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X-ray Diffraction Data Analysis

Price on request
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Cell-Based Compound Screening

Price on request
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Adaptive Surface Alphabet Protein Re-Engineering for Crystallization

Price on request

Adaptive Surface Alphabet Method- Used to re-engineer the protein to crystallize and diffract.

Please contact request a quote to hear more about this exciting technique.

Adaptive Surface Alphabet Method- Used to re-engineer the protein to crystallize and diffract.

Please contact request a quote to hear more about this exciting technique.

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Drug Discovery & Development

Price on request
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Structural Biology

Price on request
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Hit Identification

Price on request
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Analytical Chemistry Services

Price on request
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Data Services

Price on request
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Protein Services

Price on request
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Image Analysis

Price on request
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Protein Production

Price on request
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Protein Purification

Price on request
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Biomolecular Interaction Analysis

Price on request
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Computational Modeling

Price on request
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Biochemistry & Molecular Biology

Price on request
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Drug Discovery

Price on request
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Sequencing data in FASTQ

Price on request
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Chemistry and Materials

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HarkerBIO_PSDI2015_presentation.pdf

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