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Hamamatsu Pharma Research, Inc.

Hamamatsu, JP

Hamamatsu Pharma Research is a Japan-based preclinical CRO specializing in pharmacological efficacy studies using nonhuman primate (NHP) disease models. As nonhuman primates are phylogenetically and physiologically more similar to human than rodents, our NHP efficacy models will help you to obtain preclinical proof of concept (POC) relevant to clinical efficacy.
Hamamatsu Pharma Research is an AAALAC International accredited facility in JAPAN and creates exquisite NHP models, leveraging extensive experience in translational research and animal care. Develop your novel therapeutics with Hamamatsu Pharma research’s nonhuman primate efficacy models with higher efficacy.

Publications
Pain
- Nagasaka K, Yamanaka K, Ogawa S, Takamatsu H, Higo N. Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity. Scientific reports. 2017; 7: Article number:... Show more »

Hamamatsu Pharma Research is a Japan-based preclinical CRO specializing in pharmacological efficacy studies using nonhuman primate (NHP) disease models. As nonhuman primates are phylogenetically and physiologically more similar to human than rodents, our NHP efficacy models will help you to obtain preclinical proof of concept (POC) relevant to clinical efficacy.
Hamamatsu Pharma Research is an AAALAC International accredited facility in JAPAN and creates exquisite NHP models, leveraging extensive experience in translational research and animal care. Develop your novel therapeutics with Hamamatsu Pharma research’s nonhuman primate efficacy models with higher efficacy.

Publications
Pain
- Nagasaka K, Yamanaka K, Ogawa S, Takamatsu H, Higo N. Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity. Scientific reports. 2017; 7: Article number: 4305.
- Shidahara Y, Ogawa S, Nakamura M, Nemoto S, Awaga Y, Takashima M, Hama A, Matsuda A, Takamatsu H. Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity. Pharmacology Research & Perspectives. 2016; 4(1): e00216.
- Hama A, Takamatsu H. Chemotherapy-Induced Peripheral Neuropathic Pain and Rodent Models. CNS & neurological disorders drug targets. 2016; 15(1): 7-19.
- Hama A, Toide K, Takamatsu H. Beyond Rodent Models of Pain: Non-Human Primate Models for Evaluating Novel Analgesic Therapeutics and Elaborating Pain Mechanisms. CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders). 2013, Dec; 12(8): 1257-1270.

Parkinson’s Disease
- Saito Y, Akazawa-Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, Kobayashi M, Mita Y, Shichiri M, Hisahara S, Hara Y, Fujimura H, Takamatsu H, Hagihara Y, Yoshida Y, Hamakubo T, Kusunoki S, Shimohama S, Noguchi N. Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients. Scientific Reports. 2016; 6: Article number: 30793.

Osteoarthritis
- Ogawa S, Awaga Y, Takashima M, Hama A, Matsuda A, Takamatsu H. Antinociceptive effect of clinical analgesics in a nonhuman primate model of knee osteoarthritis. European Journal of Pharmacology. 2016; 786: 179-185.
- Ogawa S, Awaga Y, Takashima M, Hama A, Matsuda A, Takamatsu H. Knee osteoarthritis pain following medial meniscectomy in the nonhuman primate. Osteoarthritis and Cartilage. 2016; 24(7): 1190-1199.

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Non-Human Primate Models
Price on request

Nonhuman primate (NHP) models deliver great value to your preclinical findings because of their genetic closeness to humans. NHPs, especially the macaque, are ideal for providing higher predictability of clinical efficacy of potential therapeutics than small animals such as rodents.

Pharmacological Studies
- Pain:... Show more »

Nonhuman primate (NHP) models deliver great value to your preclinical findings because of their genetic closeness to humans. NHPs, especially the macaque, are ideal for providing higher predictability of clinical efficacy of potential therapeutics than small animals such as rodents.

Pharmacological Studies
- Pain: Osteoarthritis (OA), Chemotherapy-induced neuropathic pain (CINP)
- Cerebral ischemia: Stroke
- Neurological disorders: Parkinson's disease
- Ophthalmology: Dry & wet Age-related macular degeneration (AMD), glaucoma
- Gastroenterology: Inflammatory bowel disease (IBD)
- Reproductive diseases: Spontaneous endometriosis

Other therapeutic areas available on request

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Non-human primates
Stroke Animal Models
Price on request

Non-Human Primate Stroke Models

  • Photochemically-induced thrombosis (PIT) model
  • Permanent occlusion
  • Transient occlusion
  • Embolism

Non-Human Primate Stroke Models

  • Photochemically-induced thrombosis (PIT) model
  • Permanent occlusion
  • Transient occlusion
  • Embolism
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cardiovascular
Stroke
Non-human primates
Pain/Neuropathy Animal Models
Price on request

Non-Human Primate Pain-Related Models

  • Capsaicin-induced heat hypersensitivity
  • Medial meniscectomy (MMX)-induced osteoarthritis
  • Oxaliplatin-induced peripheral neuropathy
  • Postoperative pain

Non-Human Primate Pain-Related Models

  • Capsaicin-induced heat hypersensitivity
  • Medial meniscectomy (MMX)-induced osteoarthritis
  • Oxaliplatin-induced peripheral neuropathy
  • Postoperative pain
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Pain
Neuropathic Pain
Non-human primates
Osteoarthritis
Ophthalmology Animal Models
Price on request

Non-Human Primate Opthalmology Models

  • Wet age-related macular degeneration (AMD)
  • Dry age-related macular degeneration
  • Glaucoma

Non-Human Primate Opthalmology Models

  • Wet age-related macular degeneration (AMD)
  • Dry age-related macular degeneration
  • Glaucoma
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Non-human primates
Glaucoma
Wet AMD
dry AMD
Thrombosis Animal Models
Price on request

Non-Human Primate Thrombosis Model

  • AV shunt

Non-Human Primate Thrombosis Model

  • AV shunt
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Thrombotic disease
Non-human primates
Reproductive System Animal Models
Price on request

Non-Human Primates Reproductive Disease Model

  • Spontaneous endometriosis

Non-Human Primates Reproductive Disease Model

  • Spontaneous endometriosis
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Non-human primates
Gastroenterology Animal Models
Price on request

Non-Human Primate Model

  • Inflammatory bowel disease (IBD)

Non-Human Primate Model

  • Inflammatory bowel disease (IBD)
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IBD
Parkinsons Disease Animal Models
Price on request

Non-Human Primate Parkinson's Disease Model

  • Systemic MPTP
  • Hemi-parkinsonism

Non-Human Primate Parkinson's Disease Model

  • Systemic MPTP
  • Hemi-parkinsonism
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Non-human primates
Parkinson's Disease
Animal Tissue Procurement
Price on request

NHP material for in vitro translational research
- Control tissues
- Disease tissues / Endometriosis tissues

NHP material for in vitro translational research
- Control tissues
- Disease tissues / Endometriosis tissues

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Non-human primates
Non-Human Primate Biospecimens
Price on request
Request a quote for more information about this service.
On-Site Rodent Model Establishment
Price on request

Technical establishment of mouse / rat models on your site
- Stroke models (PIT model, Tamura model, Koizumi model)

Technical establishment of mouse / rat models on your site
- Stroke models (PIT model, Tamura model, Koizumi model)

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Mouse
Rat
Rodents
Stroke
Animal Model Housing and Maintenance
Price on request

Nonhuman primates (cynomolgus macaque). The facility is located in Japan

Nonhuman primates (cynomolgus macaque). The facility is located in Japan

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Animal Imaging
Price on request

Non-invasive in vivo imaging

Non-invasive imaging of NHPs reduces the number of animals required for a study and translates preclinical results to clinical outcomes.

Imaging Equipment:
- MRI (Signa HDxt 3.0T, GE Healthcare)
- X-ray CT scanner (Bright Speed Elite SD, GE Healthcare)
- C-arm fluoroscope (Siremobil compact... Show more »

Non-invasive in vivo imaging

Non-invasive imaging of NHPs reduces the number of animals required for a study and translates preclinical results to clinical outcomes.

Imaging Equipment:
- MRI (Signa HDxt 3.0T, GE Healthcare)
- X-ray CT scanner (Bright Speed Elite SD, GE Healthcare)
- C-arm fluoroscope (Siremobil compact L, Siemens)

Examples:
- Bone imaging
- Evaluating cartilage damage
- Pain-associated brain activity
- Brain infarction / perfusion
- Measuring cyst volume
- Funduscopy & OCT for evaluating retinal damage
- Diffusion Tensor Imaging for visualizing optic nerve damage

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MRI
Osteoarthritis (OA)
Neuropathic Pain
stroke
Pain
Stroke
Non-human primates
Osteoarthritis
endometriosis
glaucoma
X-ray CT scanner
C-arm fluroscope
Funduscopy
OCT
Diffusion Tensor Imaging
Opthalmology
Endometriosis
Animal Model in vivo Analyses
Price on request

Animal Model in vivo Analyses Services, using nonhuman primates (cynomolgus macaque)

Animal Model in vivo Analyses Services, using nonhuman primates (cynomolgus macaque)

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