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Genome International Corporation

Madison, Wisconsin, US

Genome International Corporation (GIC) is a research-driven firm providing innovative bioinformatics products and custom research solutions for corporate, government, and academic laboratories in biomedical and plant sciences. Our scientists and engineers are passionate about delivering high quality yet cost effective products and services by innovating advances in bioinformatics and information technologies to optimize the management, analysis and mining of high-throughput molecular biology data.

Certifications: - 8(a) Small Disadvantaged Business (SDB) - Economically Disadvantaged Woman-Owned Small Business (EDWOSB) - CIO-SP3 – GIC holds the NIH Chief Information Officer – Solutions and Partners (CIO-SP3) GWAC as part of a JV

Standard shipping requests: DNA samples can be shipped overnight at room temperature in a sterile container. RNA samples degrade easily and they are usually shipped frozen on dry ice. ... Show more »

Genome International Corporation (GIC) is a research-driven firm providing innovative bioinformatics products and custom research solutions for corporate, government, and academic laboratories in biomedical and plant sciences. Our scientists and engineers are passionate about delivering high quality yet cost effective products and services by innovating advances in bioinformatics and information technologies to optimize the management, analysis and mining of high-throughput molecular biology data.

Certifications: - 8(a) Small Disadvantaged Business (SDB) - Economically Disadvantaged Woman-Owned Small Business (EDWOSB) - CIO-SP3 – GIC holds the NIH Chief Information Officer – Solutions and Partners (CIO-SP3) GWAC as part of a JV

Standard shipping requests: DNA samples can be shipped overnight at room temperature in a sterile container. RNA samples degrade easily and they are usually shipped frozen on dry ice. Other standard shipping procedures apply.

Select Publications:

  1. RoBuST: an integrated genomics resource for the root and bulb crop families Apiaceae and Alliaceae. A Bhasi, D Senalik, PW Simon, B Kumar, V Manikandan, P Philip, and P Senapathy, BMC Plant Biology (2010), 10:161, http://www.biomedcentral.com/1471-2229/10/161

  2. Targeted Genome-wide Enrichment of Functional Regions. Senapathy P, Bhasi A, Mattox J, Dhandapany PS, Sadayappan S., PLoS ONE (2010) Jun 16;5(6);e11138

  3. ExDom: an integrated database for comparative analysis of the exon-intron structures of protein domains in eukaryotes. Ashwini Bhasi et al. Nucleic Acids Research (2009) Database Issue 37:D703-D711

  4. AspAlt: A tool for inter-database, inter-genomic and customized comparative analysis of alternative transcription and alternative splicing in eukaryotes. Ashwini Bhasi et al. Genomics (2009) 94(1):48-54

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Genome International Corporation has not listed any services.

Whole Genome Assembly
Price on request

De novo genome assembly is typically carried out when a reference genome sequence of a particular organism is unavailable. The process involves putting together overlapping pieces of DNA obtained from sequencing of unknown template DNA (from an organism). It is a computationally intensive process and requires a number of parameter... Show more »

De novo genome assembly is typically carried out when a reference genome sequence of a particular organism is unavailable. The process involves putting together overlapping pieces of DNA obtained from sequencing of unknown template DNA (from an organism). It is a computationally intensive process and requires a number of parameter adjustments based on the nature of the organism. GIC's services include draft genome assembly plus detailed genome annotation, which can be visualized in a powerful genome browser environment.

  • De novo assembly at different K-mer lengths
  • Statistical information of assembled contigs (total number of assembled contigs, size distribution of assembled contigs, average contig size, N50 and N90 contig sizes).
  • Scaffolding of contigs
  • Gap closing and ordering contigs
  • Assembly validation
  • Genome annotation (structural and functional)
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Small RNA Sequencing
Price on request

Micro RNAs are a class of small non-coding RNAs of length 18-22bp. Recent discoveries about the functions and roles of miRNAs have sparked great interest in the study of a new level of gene regulation involved in development and disease.

  • Known and novel miRNA tagcounts.
  • Identification of differentially expressed miRNAs.
    -... Show more »

Micro RNAs are a class of small non-coding RNAs of length 18-22bp. Recent discoveries about the functions and roles of miRNAs have sparked great interest in the study of a new level of gene regulation involved in development and disease.

  • Known and novel miRNA tagcounts.
  • Identification of differentially expressed miRNAs.
  • Identification of target genes.
  • Pathway and GO analysis.
  • Data visualization.
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ChIP-Seq
Chromatin Immunoprecipitation Sequencing
Price on request

Chromatin immunoprecipitation (ChIP) followed by sequencing is a powerful method to determine the locations of DNA binding sites for a protein (transcription factor) of interest. Determining protein-DNA interactions involved in gene regulation is essential to fully understand biological processes and diseases.

Chromatin immunoprecipitation (ChIP) followed by sequencing is a powerful method to determine the locations of DNA binding sites for a protein (transcription factor) of interest. Determining protein-DNA interactions involved in gene regulation is essential to fully understand biological processes and diseases.

  • Alignment and fragment length distribution analysis.
  • Transcription factor binding site detection / motif discovery.
  • Target gene identification.
  • Pathway and GO analysis.
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Epigenomic Sequencing
Price on request

Analyze genome-wide DNA methylation patterns by immunoprecipitation of methylated cytosines or based on bisulfite conversion of methylated cytosines to uracil.

  • Alignment of bisulfite converted reads to the reference genome.
  • Detailed mapping of methylcytosine positions.
  • Discovery of differentially methylated regions.
  • Pathway and GO analysis.
  • Data Visualization.

Analyze genome-wide DNA methylation patterns by immunoprecipitation of methylated cytosines or based on bisulfite conversion of methylated cytosines to uracil.

  • Alignment of bisulfite converted reads to the reference genome.
  • Detailed mapping of methylcytosine positions.
  • Discovery of differentially methylated regions.
  • Pathway and GO analysis.
  • Data Visualization.
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Whole Exome Sequencing (WES)
Price on request

A quick and effective strategy to identify disease-causing genes for rare Mendelian disorders. The strategy is also being applied to profile all variants in complex diseases such as Cancer, Diabetes and AMD.

  • Alignment of exome data to the reference genome.
  • Coverage estimation.
  • Variant discovery.
  • Variant annotation.
  • Variant association testing.
  • Data Visualization.

A quick and effective strategy to identify disease-causing genes for rare Mendelian disorders. The strategy is also being applied to profile all variants in complex diseases such as Cancer, Diabetes and AMD.

  • Alignment of exome data to the reference genome.
  • Coverage estimation.
  • Variant discovery.
  • Variant annotation.
  • Variant association testing.
  • Data Visualization.
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RNA Sequencing
Price on request

Comprehensive method to understand gene expression and regulation in development and disease. Time-series data, data from genetic variants, and data from microarray platforms, are all supported.

  • Alignment of transcriptome data to the reference genome
  • Transcript assembly
  • Detection of novel Genes and isoforms
  • ... Show more »

Comprehensive method to understand gene expression and regulation in development and disease. Time-series data, data from genetic variants, and data from microarray platforms, are all supported.

  • Alignment of transcriptome data to the reference genome
  • Transcript assembly
  • Detection of novel Genes and isoforms
  • Expression analysis
  • Differential Expression analysis (if Case-Control experiment/time-series)
  • Pathway and GO Analysis
  • Gene Fusion Analysis
  • Data Visualization
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Biology
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Biochemistry & Molecular Biology
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Biomolecular Interaction Analysis
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Protein-DNA Interaction Analysis
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Chromatin Immunoprecipitation (ChIP) Assays
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Nucleic Acid Services
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Nucleic Acid Analysis
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Nucleic Acid Data Analysis
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Sequencing Data Analysis
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DNA Services
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DNA Sequencing
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Next Generation Sequencing (NGS)
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Targeted Gene Sequencing
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Exome Sequencing Services
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Epigenetic Studies
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RNA Services
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