Excelling in both science and service, GENEWIZ is the leading trusted partner for DNA services. Since 1999, our commitment is to advance research productivity through our distinctive combination of fast, reliable results, specialized expertise, competitive pricing, excellent project management and easy access to award-winning, friendly technical support. With state-of-the-art facilities at the local, national, and international levels, we value our loyal customers who have made GENEWIZ an industry leader. Together, we can make a difference in the pursuit of scientific discoveries, better medicines, a greener environment, and abundant healthy food supplies.
Next Generation Sequencing (NGS) involves massively parallel sequencing of millions of DNA fragments, providing vast amounts of data quickly and at an affordable cost. This enables in-depth analysis of entire genomes at unprecedented levels, allowing researchers to explore questions/hypotheses that previously would have required years to answer.
RNA-Seq is a powerful method for analyzing global gene expression levels and providing in-depth analysis of the transcriptome. RNA-Seq can be used to accurately analyze low expression genes and transcripts often not detected by other methods, discover novel genes and isoforms, and assemble transcriptomes not previously studied. GENEWIZ offers complete RNA-Seq solutions to customers via custom experimental design actions and advanced bioinformatics analysis designed to address different biological questions.
Backed by our 99.9% completion rate, GENEWIZ can synthesize naturally occurring sequences, codon-optimized genes, gene libraries, complex sequences, large sequences, or any other sequence you need for your research--no matter the difficulty level.
With industry-leading Ph.D.-level technical support to proactively communicate and troubleshoot technical difficulties, it's no wonder top research labs and pharma/biotech companies around the world rely on GENEWIZ's proprietary protocols to synthesize their long and difficult DNA sequences.
Our streamlined process offers timely and dependable results, giving you the flexibility to focus on other research priorities. Simply submit your nucleotide or amino acid sequence, and GENEWIZ will deliver it exactly as ordered.
At GENEWIZ, we are using next generation sequencing platforms like the powerful Illumina® HiSeq™ X Ten to support researchers all over the world with their genome sequencing needs at the research and CLIA-compliant levels.
GENEWIZ provides complete NGS solutions to our customers beginning with a free consultation regarding project scope, design and initiation. GENEWIZ offers both standard and custom solutions for NGS library preparation, sequencing, and/or bioinformatics analysis support. Our Ph.D.-level Project Management team is available to consult with you at every step of your project, including free post-delivery support.
CLIA-compliant whole genome sequencing offers analysis of the entire genome to uncover mutations in coding and non-coding regions, including structural and copy number variants. Our assay offers a precise detection of genetic variants enabling researchers to use genome-wide information for biomarker discovery and precision medicine.
While the greatest interest for whole genome sequencing tends to be related to human genomes, GENEWIZ supports whole genome analysis of any species including plants, animals, bacteria, and viruses.
Our Single-Cell RNA-Seq utilizes the latest technology on the market: the 10x Genomics Chromium™ system and Illumina® NovaSeq™ 6000. As an early adopter of these platforms, we have optimized our workflows—including pre-submission cryopreservation and post-submission dead cell removal—to maximize project flexibility, speed and data accuracy.
Features & Benefits:
The Illumina NovaSeq 6000 provides the most cost-effective sequencing and fastest turnaround times for your NGS experiments.
GENEWIZ’s expertise in the latest technologies and bioinformatics, including long-read sequencing on the PacBio® Sequel®, enable us to deliver high-quality data and analysis for the genomes of all organisms including humans, animals, plants, bacteria, and viruses.
GENEWIZ accepts pre-made amplicons or DNA fragments for next generation sequencing. GENEWIZ commonly adds sequencing adapters directly to your amplicons for contiguous sequencing. Alternatively, if your amplicons are large, we can fragment then perform standard DNA library preparation and sequencing. Applications for this service include antibody library screening, natural antibody repertoire profiling, disease genotyping, CRISPR mutation analysis, screening of molecular clones, and analysis of plasmid stocks.
ChIP-Seq (chromatin immunoprecipitation sequencing) combines the highly effective chromatin immunoprecipitation (ChIP) methodology and next generation sequencing (NGS) to analyze protein-DNA interactions. These interactions are important for a vast quantity of biological processes involved in normal development and disease progression, such as gene regulation, checkpoint regulation, DNA repair, and DNA synthesis. ChIP-Seq is a valuable tool for discerning and quantifying the specific DNA sequences where proteins bind or epigenetic modifications exist.
GENEWIZ provides complete solutions for exome sequencing projects at both the research and CLIA-compliant levels from experimental design through advanced bioinformatics analysis.
The exome and untranslated regulatory regions (UTRs) comprise only 1-2% of the human genome, yet house as many as 85% of disease-related mutations. As a research tool, exome sequencing is a powerful way to investigate common and rare genetic variations that play an important role in complex human diseases.
Targeted resequencing is an effective method for analyzing your selected gene(s) of interest by next generation sequencing. Whether you are interested in a few genes, or a few hundred genes, targeted resequencing panels offer high sensitivity and specificity, providing in-depth coverage, resulting in high-quality data.
With targeted resequencing gene panels, you can discover point mutations, insertions/deletions (INDELS), copy number variations (CNVs), and gene rearrangements.
16S-EZ Metagenomics Sequencing
Metagenomic sequencing is an important tool that often uses next generation amplicon sequencing to target specific hypervariable regions of the microbial 16S rRNA gene. This is used to identify any relative abundance calculation of bacteria and archaea present in heterogeneous samples, such as soil, marine, or gut microbiome.
16S-EZ sequences the V3 and V4 regions of the 16S rRNA gene and has enhanced sensitivity compared to traditional V4-only assays.
GENEWIZ bioinformatics solutions provide researchers with the tools required to effectively analyze and manage vast quantities of data. Bioinformatics solutions are available as standalone services for bioinformatics projects, as well as in conjunction with our Next Generation Sequencing Services. With flexible and customizable service options, GENEWIZ offers complete and effective solutions for your projects.
GENEWIZ can increase your research productivity by performing your time-consuming site-directed mutagenesis projects efficiently and cost-effectively. Our customized mutagenesis services provide a fail-safe approach to obtain mutant constructs quickly, with 100% accuracy, thus eliminating the possibility of undesired mutations in your gene
SYNTHETIC DNA LIBRARIES including Trimer-Controlled Library
Researchers working in fields such as protein engineering, discovery biology, structural biology, synthetic biology, antibody engineering, and enzyme engineering choose GENEWIZ’s Synthetic DNA Libraries because of our wide range of library types, reliable service, and best-in-class consultation from our Ph.D.-level customer support scientists. With competitive pricing and project completion in as little as 11 days, discover why hundreds of scientists from leading research facilities choose GENEWIZ for their partially (NNK) or completely randomized (NNN) nucleotide libraries.
GENEWIZ now offers a unique Trimer-Controlled library approach to create a highly accurate, combinatorial library with a precise amino acid distribution with fewer out-of-frame mutations.
TurboGENE™ Gene Synthesis
For fast gene synthesis delivery - scientists at the top pharmaceutical and biotech companies and thousands of published research scientists rely on GENEWIZ. We can deliver your gene sequences in as few as 5 business days using our 5-day TurboGENE™ service with 100% accuracy guaranteed. For a more cost effective but still fast delivery – use our 7-day TurboGENE™ service.
GENEWIZ Single-Stranded DNA (ssDNA) synthesis service provides fast and affordable, sequence-verified long ssDNA fragments between 151 and 5,000 nt. ssDNA fragments are derived from clonally purified double-stranded DNA, resulting in the highest possible quality. This increases the likelihood of homology directed repair (HDR) with reduced cellular toxicity. As the leader in working with complex gene sequences, you can trust GENEWIZ to deliver sequence-verified fragments for CRISPR-mediated gene knock-in, in vitro transcription and many more applications.
FragmentGENEs are double-stranded, linear DNA fragments of 100-3,000 bp, which are a convenient option due to their faster delivery time, lower cost, and greater flexibility. These fragments are synthesized with the same industry-leading proprietary technology that GENEWIZ has developed for standard gene synthesis products. We provide FragmentGENEs in a lyophilized form that can be easily re-suspended, cloned, and screened to identify the correct clone for downstream applications.
STANDARD PLASMID DNA PREPARATION-- Our standard plasmid DNA preparation service is a flexible and fast choice for a range of plasmid templates. Runs are available in the classic mini to giga scales, yielding micrograms to milligrams of purified plasmid DNA. Additional add-on service and analysis options are available, enabling project customization to meet budgetary and technical specifications.
TARGETED YIELD PLASMID DNA PREPARATION-- Our premium Plasmid DNA Preparation bundle service delivers specific quantities of high quality, transfection-grade DNA that you can count on. The Targeted Yield service is intended for stable, high-copy plasmids, and includes a free upgrade to an endo-free process with sequence confirmation, restriction digest, and sterility testing. Yield options range from 250ug to 20mg, with 100mg or larger preps available upon request.
GENEWIZ CLIA Sanger sequencing provides a CLIA-compliant workflow in our state-of-the-art CLIA-certified and CAP-accredited laboratory to support your clinical diagnostic assays.
CLIA Sanger sequencing is best utilized as the initial readout from a PCR assay or in conjunction with next generation sequencing, specifically to elucidate complex regions not approachable by other methodologies or to confirm variants uncovered by genome-wide techniques.
CLIA variant confirmation via PCR + Sanger sequencing is used to detect or confirm mutations within genomic DNA. This technique is a reliable method for initial analysis or orthogonal confirmation of next generation sequencing, microarrays, or qPCR results in clinical samples.
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