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Genesis Drug Discovery & Development (GD3)

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Hamilton, New Jersey, US

About Genesis Drug Discovery & Development (GD3)

Genesis Drug Discovery and Development (GD3), a member of the Genesis Biotechnology Group is a contract research organization focused on providing services to support preclinical drug discovery programs from early discovery through preclinical development. The Company’s diversified portfolio of services covers all areas of preclinical drug discovery/development including “Discovery Biology”, “Synthetic Organic and Medicinal Chemistry”, DMPK/in-vivo pharmacology and Toxicology. GD3’s capabilities includes platforms for therapeutic areas such as oncology, ophthalmology, inflammation/autoimmunity, metabolic diseases and microbiome.

Our Services (43)


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Clinical Chemistry

Price on request

Metabolism

  • Thyroxine
  • Triglycerides
  • Lactate
  • Creatine kinase
  • Amylase
  • Hemaglobin A1c

Liver Function

Alanine aminotransferase

  • Aspartate aminotransferase
  • gamma-Glutamyl transferase
  • Albumin
  • Globulin
  • Albumin/Globulin Ratio
  • Total Proteins
  • Total Bilirubin
  • Alkaline phosphatase
  • Lactate dehydrogenase

Renal Function

  • Sodium
  • Potassium
  • Chloride
  • Creatinine
  • Blood Urea Nitrogen
  • Uric Acid
  • Calcium
  • Phosphorus

Urine Chemistry

  • Volume
  • Sodium
  • Potassium
  • Chloride
  • Calcium
  • pH*
  • Total Protein+
  • Nitrates/Nitrites+
  • Creatinine





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CNS/Neurology Animal Models

Price on request

Behavior

  • Elevated Plus Maze for Anxiety
  • Open Field for Locomotion and Anxiety

Neurological

  • Rotarod Assay for Motor Coordination
  • Irwin Observational Battery
  • Inverted grip test
  • Long Term Monitoring for Activity (CCMS)

Addiction

  • Naloxone precipitated opiate withdrawal



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Pain/Neuropathy Animal Models

Price on request

Thermal Pain

  • Hot Plate
  • Tail Flick
  • Hargreave’s

Mechanical Pain

  • Manual von Frey Tests

Induced Inflammatory Pain

  • Acetic Acid-induced Writhing Test
  • Carrageenan-induced Inflammation
  • Complete Freund's Adjuvant (CFA) Challenge

Neuropathic Pain

  • Perineural inflammation by CFA (Rat)



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Cardiovascular Animal Models

Price on request

Cardiovascular Function

  • Heart Failure
    • Treadmill with calorimetry
  • Atherosclerosis
    • Serum TGs, FAs, Cholesterol VLDL,LDL, HDL
    • Animal models
    • LDLr-/- mice
    • ApoB-CETP Tg mice
  • Hypertension
  • Non-invasive BP and Heart Rate
  • L-NMA Induced Hypertension


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Obesity Animal Models

Price on request

Energy Homeostasis 

  • Food Intake
  • Indirect Calorimetry & Activity in CCMS
  • Hormone/Adipokine measurments:
  • Longitudinal Body Weight
  • Body Composition by DEXA



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Diabetes Animal Models

Price on request

Animal models:

  • Diet-induced Obese-early Type II
  • Db/db-later Type II
  • Non-obese diabetic-Type I
  • STZ-induced diabetic-Type I or II
  • GK rat-Type II

Glucose Homeostasis

  • Glucose and Insulin Levels in OGT Test
  • HbA1c Levels
  • Gastric Emptying
  • Insulin Tolerance Test
  • Tissue Glycogen Levels
  • Pancreatic Insulin Content
  • Hormone/Adipokine measurments: Glucagon, GLP-1, adiponectin, leptin, insulin

Diabetes related complications:

  • Hind-limb ischemia



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NAFLD/NASH Mouse Model

Price on request

Animal Models

  • High Fat choline deficient diet in C57BL/6
  • STAM Model
  • High saturated fat and fructose diet
  • Fast food diet

Measurements

  • Hepatic lipid content
  • Serum clinical chemistries for liver enzymes
  • Histopathological analysis with H&E, Masson’s Trichrome, Oil Red O
  • NAS Score by pathologist
  • Computer scanned histology quantification
  • OH-Pro Liver

Lipid Homeostasis

  • Oral Lipid Tolerance Test
  • Serum TGs, FAs, Cholesterol VLDL,LDL, HDL



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Flow Cytometry

Price on request
  • 5 lasers allows for multichannel evaluation of up to 20 markers in a single tube
  • Basic to comprehensive immuno-profiling available including lymphoid and myeloid panels for mouse and humans
  • Full service analytical team available for on-demand data analysis



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Hit to Lead and Lead Optimization

Price on request

Assay Development

  • Expertise in multiple target classes & therapeutic areas 
  • In Vitro, Functional, & Cell Based Assays
  • Fluorescent & Luminescent Detection Technologies

High-Throughput Screening

  • Proprietary ECLiPS (ECLiPS = Encoded Combinatorial Libraries on Polymeric Support) Technology 
  • Collection of ~5.5 million compounds
  • uHTS in 1536-well format
  • Proven technology with over 20 years of success
  • Diverse, drug-like, and innovative chemistries with 85% of the compound collection has 0 or 1 Lipinski violation
  • Screening usually identifies multiple hit chemotypes
  • Each chemotype has SAR around it that jump starts Hit to Lead

Medicinal Chemistry

  • Design and synthesis of new analogs based on SAR 
  • Integrated approach in lead optimization improving compound potency, selectivity, ADME and pharmacokinetic profiles
  • Scale-up synthesis to multi-gram quantity for in vivo studies

Analytical Chemistry

  • In vitro assays using LCMS 
  • Solubility, microsomal stability, protein binding
  • Cold metabolite ID
  • Bioanalysis for PK and PK/PD studies

Structural Biology & Computational Chemistry

  • X-ray crystallography of target proteins with drug candidates 
  • Computational analysis of function-related conformational changes and structural basis of molecular recognition

Pharmacology (in vitro / in vivo)

  • Drug testing services and phenotypic characterization of genetically modified rodents
  • In vivo animal models across multiple therapeutic areas to support pharmacology and safety/toxicology studies;
    • Oncology
    • Metabolic
    • Inflammation and immunology
    • Ocular
    • Microbiome 

Biomarker Development

  • Biomarker identification
  • Immunoassay Technologies (Traditional ELISA and MSD ECL)
  • In Vitro cell-based assays
  • Protein Assays

Exploratory Toxicology




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Structure-Based Drug Design

Price on request

X-ray crystallography of target proteins with drug candidates



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Drug Target Identification

Price on request

Molecular Biology and Biochemistry Services

  • In vitro and in vivo assay development
  • Cell line generation and characterization
  • Protein purification and characterization
  • Antibody purification and labelling
  • Immunoassay development (single and multi-plex)
  • Cell based assay development
  • Anti-drug antibody immunogenicity assay development

Discovery Biology

  • Assay Development to uHTS to Compound Profiling
  • Cloning Capabilities & Cell Line Development (single-clone or pool)



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Autoimmune Disease Animal Models

Price on request

Experimental Autoimmune Encephalitis (EAE)

  •  MOG induced EAE in C57BL/6 and
  • GFAP-Luc Light Producing Tg Mice

Rheumatoid Arthritis Models

  • Collagen-Induced Arthritis (CIA) in DBA1 mice and in C57BL/6 mice
  • Antigen-induced Arthritis (AIA) in C57BL/6 mice
  • Antigen and Collagen-Induced Arthritis (ACIA) in Balb/C
  • Spontaneous Arthritis in hTNFα Tg mice
  • Monoclonal Antibody Induced Arthritis – DBA1
  • KRN-serum Induced Arthritis

Inflammatory Bowel Disease Models

  •  DSS induced colitis
  •  TNBS induced colitis

Pulmonary Inflammation Models

  • LPS induced acute lung injury (ALI)
  • Allergen-induced Pulmonary Inflammation
  • LPS-induced Airway Inflammation

IFNα Accelerated Lupus Model

Psoriasis Model induced by Imiquimod



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Animal Immunology Assays

Price on request

Ex vivo Bioassays

  • Serum and Tissue Cytokine Profiling in animal disease models 
  • FACS Analysis of Lymphoid Organs and Tissue Infiltrates in Naïve and Disease Induced Animals
  • Hematology Five Parts Differential Cell Count
  • In vitro B cell proliferation Induced by LPS
  • In vitro T cell Proliferative Responses Induced by Anti-CD3/CD28
  • Cytokine Production by T cells after stimulation with anti-CD3/CD28
  • Cytokine Production by Monocytes after stimulation with LPS 
  • Cytotoxic T-cell Activity (CTL)
  • LAK- Lymphokine-Activated Killer Cell Cytotoxicity
  • NK- Natural Killer Cell Activity
  • Th17 Polarizing Conditions from CD4+ T cells (ELISA for Il-17 and IL-22)
  • Treg Polarization from CD4+ T cells (ELISA for IL-10)
  • Th1 Differentiation from CD4+ T cells (ELISA for INF-gamma)
  • Th2 Differentiation from CD4+ T cells (ELISA for IL-4)


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Cytokine Analysis

Price on request
  • Serum and Tissue Cytokine Profiling in animal disease models



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Psoriasis Animal Models

Price on request

induced by Imiquimod


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Fluorescence Polarization

Price on request
Request a quote for more information about this service.

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Luminescence Imaging

Price on request

Advanced Xenograft Tumor Models Using IVIS Bioluminescent Imaging Technology

  • Othortopic tumor models with spontaneous metastases
  • Spontaneous metastatic models by surgical removal of primary tumor
  • Experimental metastatic models (i.v., i.t, i.c. direct seeding to metastatic sites)


IVIS

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In vitro Protein Binding Assays

Price on request
Request a quote for more information about this service.

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Cell Line Generation

Price on request

Mammalian Cell Transfection and Clonal Cell Line Development



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Custom Immunoassay Development

Price on request
  • Colorimetric ELISA
  • Meso Scale Discovery MSD Electrochemiluminescence


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Custom Cell-Based Assay Development

Price on request
Request a quote for more information about this service.

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Bioanalytical Analysis LC/MS/MS

Price on request

Complex mass spectrum 

  • Protein Extraction
  •  Protein Fractionalization
  •  MS/MS or MS/TOF Quantification


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High Throughput Screening (HTS)

Price on request
  • Collection of ~5.5 million compounds
  • 1536-well assay exclusively (4-8 µL volume)
  • All assays are off-bead – compound is already added into the wells
  • Survey primary assay against full collection
  • Primary Multi-cmpd/well survey looks for a active area of chemistry
  • Counter-screen assay on an active subset collection


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Animal Image-Guided Radiation Therapy

Price on request
  • CT imaging with precise radiation delivery to pinpoint an exact anatomical target
  • Bilateral tumor studies can be run to evaluate potential abscopal effects
  • Focal radiation can be combined with immune modulating agents, chemotherapies, and many other therapeutic test agents 



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Pancreas Patient Derived Xenograft (PDX)

Price on request
Request a quote for more information about this service.

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Bladder Patient Derived Xenograft (PDX)

Price on request
Request a quote for more information about this service.
Bladder cancer

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Patient-Derived Xenograft (PDX)

Price on request

Molecular Characterization

  • IHC,
  • Targeted gene expression profiling

Validation with SOC (for selected model)

Patient data



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Assay Development

Price on request

Immunoassay Technologies (Traditional ELISA

  and MSD ECL)

In Vitro cell-based assays

  • LH/hCG receptor
  • GHRH receptor

Protein Assays and Biomarkers 

  • VEGF
  • PDGF receptor / PDGF-AA / PDGF-BB
  • Galectin-3
  • LH
  • hCG
  • PAX-6: paired box protein transcription factor
  • Anti-drug antibody (ADA) bridging immunoassays
  • SMN protein
  • TGF-beta
  • Cadherin


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Ultra-High-Throughput Sequencing

Price on request
Request a quote for more information about this service.

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Compound Profiling

Price on request
  • Can be in 384-well or 1536-well assay
  • Generally in low-volume 384-well format (10-20 µL volume)
  • Each compound gets a full 12-point concentration-dependence curve
  • Each compound will be tested multiple times on different days
  • Typically profile compounds in multiple assays
  • Selectivity vs. related proteins
  • Ortholog in relevant species


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Medicinal Chemistry

Price on request

Asymmetric synthesis

  • Classical resolutions 
  • Derivatization methods
  • Chiral HPLC method development
  • Asymmetric hydrogenations

High speed optimization

  • Parallel synthesis 
  • Directed chemical libraries
  • Automated purification systems

Metabolite synthesis (Phase I and II)

  • Glucuronides 
  • Sulfates

Process development and scale-up

  • Large scale rotary evaporator (20 L capacity)  
  • Large scale chromatography system (> 10 kg silica gel)

Stable isotopically labeled compounds (2H, 13C, 15N)

Molecular probes (fluorophores and biotinylated targets) 

Structure identification and characterization 

Natural product synthesis 

Specific chemistry expertise 

  • Amino acids 
  • Heterocycles
  • Peptides
  • Boronic acids
  • Natural product synthesis
  • Transition metal catalyzed coupling reactions
  • Phospholipids
  • Nucleosides and nucleotides


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Computational Chemistry

Price on request

Computational analysis of function-related conformational changes and structural basis of molecular recognition



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Process and Scale-Up Chemistry

Price on request
  • 20-30 L reactors
  • Large scale rotary evaporator (20 L capacity)
  • Large scale chromatography system (> 10 kg silica gel)


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Analytical Chemistry Services

Price on request
  • Mass spectrometry, Thermo Ultra and Sciex 4000
  • Method development for compounds including peptides, amino acids, macrolides, and routine small molecules
  • Biomarker Development



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Antibody-Drug Conjugate (ADC) Development

Antibody Drug Conjugate Development
Price on request
Request a quote for more information about this service.

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Protein Production

Price on request

Protein Production

  • Geared for Drug Discovery Operations
  • mg scale - enough for HTS campaigns & Compound Profiling
  • High level purity for X-ray Crystallography
  • E. coli, insect, yeast, and mammalian expression experience
  • BacMam System for Assay Development and Protein Production

Instrumentation 

  • Acta Explorer
  • Acta Purifier
  • Sarorius Biostat Wave Reactor
  • Capable of 2-5 L cultures
  • O2 sensing capabilities



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Oncology Animal Models

Price on request

PDX, Synegeneic and CDX models

  • Orthotopic
  • Disseminated
  • Subcutaneous
  • Metastatic

Humanized mice

Breast cancer Pancreatic cancer Esophageal cancer Gastric Cancer Liver cancer Ovarian Cancer Head and neck cancer Non-small cell lung cancer (NSCLC) Small-cell lung cancer (SCLC) Mesothelioma Lymphoma Renal Cancer Bladder cancer Skin Cancer Human Humanized Mouse Mice Immuno-Oncology Oncology Show 19 more tags Show less

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
  • Mass spectrometry, Thermo Ultra and Sciex 4000
  • Method development for compounds including peptides, amino acids, macrolides, and routine small molecules
  • High throughput sample analysis with rapid turnaround
  • Method validation following Crystal City and OECD guidelines
  • Development of sensitive, reproducible assays for ocular and other target tissues
  • Multiple extraction techniques – SPE, SLE, and PPT


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Experimental Autoimmune Encephalomyelitis (EAE) Animal Models

Price on request
  •  MOG induced EAE in C57BL/6 and
  • GFAP-Luc Light Producing Tg Mice



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Rheumatoid Arthritis Animal Models

Price on request
  • Collagen-Induced Arthritis (CIA) in DBA1 mice and in C57BL/6 mice
  • Antigen-induced Arthritis (AIA) in C57BL/6 mice
  • Antigen and Collagen-Induced Arthritis (ACIA) in Balb/C
  • Spontaneous Arthritis in hTNFα Tg mice
  • Monoclonal Antibody Induced Arthritis – DBA1
  • KRN-serum Induced Arthritis


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IBS/IBD Animal Models

Irritable Bowel Syndrome/Disease Animal Models
Price on request
  •  DSS induced colitis
  •  TNBS induced colitis



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Pulmonary Inflammation Animal Models

Price on request
  • LPS induced acute lung injury (ALI)
  • Allergen-induced Pulmonary Inflammation
  • LPS-induced Airway Inflammation



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Lupus Animal Models

Price on request
Request a quote for more information about this service.

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PB

Prabal Banerjee

Director of Business Development
CG

Caroline Giordano

Senior Manager of Operations
KG

Kris Grembowiec

IT Manager/Systems Administrator
DL

Doug Lee

Business Development Manager

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