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General Biosystems, Inc.

Morrisville, North Carolina, US

General Biosystems, Inc. is a US-based biotech company. It has a passion to understand how genetic information is stored and programmed in DNA and how it is used to direct various biological processes. With this knowledge, it develops innovative technologies and instruments to program and physically write or print new genetic codes. The new codes will form the blueprints for novel or improved biological functions and biological systems. These new biosystems will have broad applications and benefit human life and society in major ways.

Scientists at General Biosystems are pioneers in genomics, proteomics, systems biology, synthetic biology and bioengineering. In genomics area, they have been involved in decoding the human genome and the genomes of various other organisms. They have contributed to major cancer genome projects for understanding the genetic cause of cancer and other genetic diseases. In synthetic... Show more »

General Biosystems, Inc. is a US-based biotech company. It has a passion to understand how genetic information is stored and programmed in DNA and how it is used to direct various biological processes. With this knowledge, it develops innovative technologies and instruments to program and physically write or print new genetic codes. The new codes will form the blueprints for novel or improved biological functions and biological systems. These new biosystems will have broad applications and benefit human life and society in major ways.

Scientists at General Biosystems are pioneers in genomics, proteomics, systems biology, synthetic biology and bioengineering. In genomics area, they have been involved in decoding the human genome and the genomes of various other organisms. They have contributed to major cancer genome projects for understanding the genetic cause of cancer and other genetic diseases. In synthetic biology area, they have pioneered the technology of using microchip to economically synthesize oligonucleotide pools and gene libraries, and built the world's first parallel on-chip gene synthesizer. They have also developed sophisticated software programs to design and optimize complex gene libraries and genetic systems. In biotechnology front, they have developed technology platforms for empirically optimizing protein expression to achieve specified expression levels and maximum solubility. These new technologies are ushering synthetic biology and biological research into a new era.

Selected Publications

  • Quan J, Tian J. Circular polymerase extension cloning. Methods Mol Biol.
    2014;1116:103-17.
  • Ma S, Tang N, Tian J. DNA synthesis, assembly and applications in synthetic
    biology. Curr Opin Chem Biol. 2012 Aug;16(3-4):260-7.
  • Ma S, Saaem I, Tian J. Error correction in gene synthesis technology. Trends
    Biotechnol
    . 2012 Mar;30(3):147-54.
  • Saaem I, Ma S, Quan J, Tian J. Error correction of microchip synthesized genes
    using Surveyor nuclease. Nucleic Acids Res. 2012 Feb;40(3):e23.
  • Quan J, Saaem I, Tang N, Ma S, Negre N, Gong H, White KP, Tian J. Parallel
    on-chip gene synthesis and application to optimization of protein expression. Nat
    Biotechnol
    . 2011 May;29(5):449-52.
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General Biosystems, Inc. has not listed any services.

Gene Synthesis
Starting at $0.16 per base

Gene synthesis at General Biosystems saves you time and money for your research! With world's top-level expert team, most advanced equipment, and sophisticated gene design and optimization software, General Biosystems can synthesize genes of any length and complexity to suit your needs. We can synthesize and clone any DNA... Show more »

Gene synthesis at General Biosystems saves you time and money for your research! With world's top-level expert team, most advanced equipment, and sophisticated gene design and optimization software, General Biosystems can synthesize genes of any length and complexity to suit your needs. We can synthesize and clone any DNA sequences (even complex, GC-rich, repeated, or long genes) into prokaryotic, eukaryotic or viral vectors. Genes up to 3,000 bp are normally synthesized in 1-2 weeks!

Features & Benefits

  • Free codon optimization upon request.
  • Accept genes over 40-kb in length.
  • Flexible cloning choices: standard cloning, custom cloning and GB Seamless Cloning.
  • Free subcloning into one of our standard vectors.
  • As low as $49 for subcloning into any vector of our choice.
  • As fast as 5 Business Days, on average 2 weeks turn around time.
  • 100% sequence-guaranteed synthetic genes of the highest quality.
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Molecular Cloning
Starting at $49.00 per clone

DNA cloning technology is a set of experimental methods in molecular biology that are used to assemble and amplify recombinant DNA molecules in host organisms. DNA cloning methods are central to many contemporary areas of modern biology and medicine. General Biosystems cloning services are customized by highly experienced... Show more »

DNA cloning technology is a set of experimental methods in molecular biology that are used to assemble and amplify recombinant DNA molecules in host organisms. DNA cloning methods are central to many contemporary areas of modern biology and medicine. General Biosystems cloning services are customized by highly experienced molecular biologists to meet your specific needs. Your gene of interest can be obtained by PCR, RT-PCR or restriction digestion and cloned into any vector of your choice.

Service Features

  • Broad range of services (sequencing, DNA preparation and site-directed mutagenesis).
  • Project design by highly experienced molecular biologists.
  • Progress report from dedicated technical staff to keep you informed.
  • Delivery of target construct in several working days.
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Plasmid DNA Preparation
Starting at $39.00 per unit

General Biosystems provides plasmid DNA preparation services to meet the demands of research labs as well as biotech and pharmaceutical companies. General Biosystems offers a full spectrum of plasmid DNA preparation services to help researchers achieve highly efficient cell transfection for DNA vaccine development, antibody... Show more »

General Biosystems provides plasmid DNA preparation services to meet the demands of research labs as well as biotech and pharmaceutical companies. General Biosystems offers a full spectrum of plasmid DNA preparation services to help researchers achieve highly efficient cell transfection for DNA vaccine development, antibody production, and other preclinical research projects.

Service Descriptions

What we need

  • Starting material can be DNA (at least 100 ng in water or TE); Bacterial Colony: Fresh Colonies (<3 days old).
  • Glycerol Stock: 200 µl frozen stock
  • If your DNA requires special hosts, please provide the bacterial colony or glycerol stock as starting material.
  • Please contact us with any questions or for additional shipping instructions.

Quality assurance

  • A260/280 Analysis
  • Supercoil Percentage Analysis
  • RNA Residue Analysis
  • Genomic DNA Analysis
  • Restriction Enzyme Analysis (optional)
  • Endotoxin Analysis (optional)
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Site-Directed Mutagenesis
Starting at $89.00 per unit

Site-directed mutagenesis introduces changes to DNA fragments by PCR method, including deletion, insertion and point mutation, which is the most useful means of gene modification and optimization and also is the important tool to study the complicated relation between the protein structure and functions. General Biosystems can... Show more »

Site-directed mutagenesis introduces changes to DNA fragments by PCR method, including deletion, insertion and point mutation, which is the most useful means of gene modification and optimization and also is the important tool to study the complicated relation between the protein structure and functions. General Biosystems can customize site-directed mutagenesis protocol according to different research purposes. Our specialized services enable you to obtain mutant constructs quickly.

Service Descriptions

  • General Biosystems will design and optimize the experimental program to get the accurate experimental results;
  • Please provide the required plasmid with related information;
  • Please provide the original gene sequence with sequencing chromatograms and mutant target sequence. If you can't provide the sequencing chromatogram, we will charge the sequencing cost;
  • Please provide a sufficient amount of high purity plasmid, concentration ≥100ng/μl, total volume ≥40μl. Electrophoresis and plasmid map are clear, no degradation.
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Protein Expression
Price on request

General Biosystems offers professional protein expression and purification service in most host systems. Combined with our maximum or soluble expression service, we can meet most of your protein production needs.

Service Descriptions

  • Service available for most commonly used hosts, including Escherichia coli, yeast and... Show more »

General Biosystems offers professional protein expression and purification service in most host systems. Combined with our maximum or soluble expression service, we can meet most of your protein production needs.

Service Descriptions

  • Service available for most commonly used hosts, including Escherichia coli, yeast and mammalian cells. If you want to use other host cells or cell-free expression system, please contact us.
  • A variety of expression labels are available based on customer needs, including His, Sumo, GST, MBP, etc.
  • Expression optimization is specific to the expression vector that customer uses.
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Metabolic engineering
Price on request

It is challenging to design an optimal and efficient metabolic pathway for valuable substrate production. The expression of functional enzymes, proteins and sometimes RNAs need to be precisely controlled and regulated. Using a combination of proven sequence design, synthesis and expression optimization platforms, General... Show more »

It is challenging to design an optimal and efficient metabolic pathway for valuable substrate production. The expression of functional enzymes, proteins and sometimes RNAs need to be precisely controlled and regulated. Using a combination of proven sequence design, synthesis and expression optimization platforms, General Biosystems provides metabolic engineering service to assist our client in design and optimization of metabolic pathways.

Features & Benefits

  • Advanced and reliable gene synthesis technology.
  • Guaranteed maximum soluble protein expression.
  • Comprehensive project management.
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Directed Enzyme & Protein Evolution
Price on request

General Biosystems provide advanced protein evolution service to generate and shuffle large related gene libraries and select the best target candidate for our customer.

Features & Benefits

  • Advanced and reliable gene synthesis technology.
  • Guaranteed maximum soluble protein expression.
  • Comprehensive project management.

General Biosystems provide advanced protein evolution service to generate and shuffle large related gene libraries and select the best target candidate for our customer.

Features & Benefits

  • Advanced and reliable gene synthesis technology.
  • Guaranteed maximum soluble protein expression.
  • Comprehensive project management.
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Protein Services
Price on request
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Biology
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Microbiology, Virology, and Parasitology
Price on request
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Microbial Fermentation and Bioprocessing
Price on request
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DNA Synthesis
Price on request
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DNA
Price on request
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Plasmids and Vectors
Price on request
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Biochemistry & Molecular Biology
Price on request
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Nucleic Acid Services
Price on request
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Mutagenesis
Price on request
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