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GeneNarus LLC

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Highland Park, New Jersey, US

About GeneNarus LLC

GeneNarus offers a full range of analytical packages and stand-alone services that are capable of supporting biopharmaceutical and biotechnology development. We provide analytical development work of large molecule analytical teams including method development, method validation, technology transfer, stability... Show more »

GeneNarus offers a full range of analytical packages and stand-alone services that are capable of supporting biopharmaceutical and biotechnology development. We provide analytical development work of large molecule analytical teams including method development, method validation, technology transfer, stability studies, and problem-solving. Known as a trusted source for high quality, high sensitivity ELISAs, cell-based assay and other super analytical service, including recombinant protein expression, compounds screening and mechanism-driven biomarkers to provide a wide range of essential services. We are dedicated to providing not only the best, but also the most reliable in analytical testing services. We are well-equipped to handle almost any project regardless of scope or complexity.

GeneNarus also provides strategic advice and consulting services to the biotechnology and pharmaceutical industry. Our goal is to help our clients to strategize their preclinical development work on protein-based therapeutics (biologics) and provide troubleshooting in Molecular Cell Biology, Biochemistry, Microbiology and Immunology.

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Our Services (36)


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Cell-Based Assays

Price on request

More than 25+ years experience in cell biology and cell culture enables our staff at GeneNarus to employ both the scientific approach and the “art” of cell culture to your projects. We can recommend strategies and provide contract services for cell-based assays, cell culture optimization, bioassays allowing your custom assay... Show more »

More than 25+ years experience in cell biology and cell culture enables our staff at GeneNarus to employ both the scientific approach and the “art” of cell culture to your projects. We can recommend strategies and provide contract services for cell-based assays, cell culture optimization, bioassays allowing your custom assay development to be brought through pre-clinical assay validation to clinical drug development.

Cell-based assays can be used to evaluate a variety of functional and biochemical effects, including cell proliferation, apoptosis and cell death, signal transduction, enzyme activity, and reporter gene activity. Because live cells are used, cell-based assays provide a functional read-out of compound activity, or produce results that are more biologically relevant or have physiological relevance.

Cell-based assay or bioassay development can range from cytotoxic assays including apoptosis to cell proliferation and metabolic assays. Cell-based assay development can also include high throughput screening assays and other custom bioassays. Mechanisms of action, such as receptor binding, receptor activation, cell signaling, drug internalization and subcellular localization can be delineated in cell-based assays following treatment with your pharmaceuticals. Bioassay development can encompass testing of conditioned medium, cell lysates or whole cells in a variety of formats including ELISA and immunohistochemical methods.

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ELISA

Enzyme-linked immunosorbent assay
Price on request

GeneNarus offers ELISA services to quantify and analyze protein of your interest in any biological samples by direct and sandwich ELISA. Service includes protein extraction, antibody characterization, immunoassay, and quantitative analysis.

Capabilities:

  • Kit-based, custom designed ELISA
  • Sandwich, competitive, in-Cell... Show more »

GeneNarus offers ELISA services to quantify and analyze protein of your interest in any biological samples by direct and sandwich ELISA. Service includes protein extraction, antibody characterization, immunoassay, and quantitative analysis.

Capabilities:

  • Kit-based, custom designed ELISA
  • Sandwich, competitive, in-Cell ELISA (ICE)
  • Homogenization of cell/tissue lysates
  • Transfection/Transduction of mammalian/non-mammalian cells
  • Optimization of protocols for commercial kits
  • Analyze serum, plasma, cells, tissues
  • Analyze fluorescent/chemiluminescent/chromogenic substrates

• Number of samples processed in a single experiment: 96-well plate format
• Typical turn-around time: 5 days
• ELISA with TMB substrate. Primary Antibody, standards or ELISA kit needs to be provided

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Endotoxin Testing

Price on request

We test water or samples of media to determine the level of endotoxin using Kinetic-QCL™ Kinetic Chromogenic LAL Assays, provides the benefit of less product interference for proteins, vaccines and other biologicals as well as greater sensitivity, detecting as low as 0.005 EU/ml. Three dilutions per sample are tested routinely, along with a set of blanks and positive controls.

We test water or samples of media to determine the level of endotoxin using Kinetic-QCL™ Kinetic Chromogenic LAL Assays, provides the benefit of less product interference for proteins, vaccines and other biologicals as well as greater sensitivity, detecting as low as 0.005 EU/ml. Three dilutions per sample are tested routinely, along with a set of blanks and positive controls.

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Assay Development

Price on request

Our scientists will help to design and qualify study-specific biomarker assays and readouts for small and large research animal models. We can transfer and qualify assays, or develop them for you. Fast and accurate testing services are available once the assay is developed.

  • Therapeutic area-specific bioassays
  • Bioanalytical... Show more »

Our scientists will help to design and qualify study-specific biomarker assays and readouts for small and large research animal models. We can transfer and qualify assays, or develop them for you. Fast and accurate testing services are available once the assay is developed.

  • Therapeutic area-specific bioassays
  • Bioanalytical immunoassays
  • Infectious disease
  • Genetic biomarkers
  • Gene expression testing
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Biomarkers

Price on request

GeneNarus provides a comprehensive range of biomarker services in key therapeutic areas. From early discovery stages to clinical support, the experienced scientists in the Biomarker Services group have the expertise to relate our biomarker service offerings to your drug development program, every step of the way.

Scientists... Show more »

GeneNarus provides a comprehensive range of biomarker services in key therapeutic areas. From early discovery stages to clinical support, the experienced scientists in the Biomarker Services group have the expertise to relate our biomarker service offerings to your drug development program, every step of the way.

Scientists identify and analyze molecular biomarkers in their pathways of interest to get a clearer understanding of these pathways and the resulting physiology or pathology.

Drug developers incorporate biomarker discovery into their R&D, pre-clinical, and clinical workflows to develop targeted therapies which will result in better efficacy. Some biomarkers that have resulted in effective targeted drugs include BRAF, HER2, EGFR, and KRAS to name a few. Biomarkers have recently taken on added significance in cancer diagnosis and treatment but also play an important role in various other therapeutic areas.

In medicine, healthcare practitioners rely on pharmacogenomics testing to analyze a patient’s genomic profile in order to accurately prescribe the most effective medications with as few side-effects as possible.

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Biochemical Compound Screening

Price on request

Screen compounds in cell-based or biochemical assays to quickly identify new hits and direct optimization efforts. Services are available for libraries of virtually any size. GeneNarus has resources in molecular biology to develop, transfer, optimize and validate assays. Services include generation of stable assays for a wide... Show more »

Screen compounds in cell-based or biochemical assays to quickly identify new hits and direct optimization efforts. Services are available for libraries of virtually any size. GeneNarus has resources in molecular biology to develop, transfer, optimize and validate assays. Services include generation of stable assays for a wide variety of genes including GPCRs, proteases and kinases as well as various others enzymes, transmembrane proteins and adhesion molecules with a variety of readouts, fluorescence, absorbance, and luminiscence.

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Cell-Based Compound Screening

Price on request

Screen compounds in cell-based or biochemical assays to quickly identify new hits and direct optimization efforts. Services are available for libraries of virtually any size. GeneNarus has resources in molecular biology to develop, transfer, optimize and validate assays. Services include generation of stable assays for a wide... Show more »

Screen compounds in cell-based or biochemical assays to quickly identify new hits and direct optimization efforts. Services are available for libraries of virtually any size. GeneNarus has resources in molecular biology to develop, transfer, optimize and validate assays. Services include generation of stable assays for a wide variety of genes including GPCRs, proteases and kinases as well as various others enzymes, transmembrane proteins and adhesion molecules with a variety of readouts, fluorescence, absorbance, and luminiscence.

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Transient Protein Expression

Price on request

Recombinant protein production in eukaryotic cells has been essential in advancing our understanding of the functional significance of genes. Transient expression in mammalian cells is especially crucial when post-translational modifications and appropriate protein folding is desired for downstream applications. GeneNarus... Show more »

Recombinant protein production in eukaryotic cells has been essential in advancing our understanding of the functional significance of genes. Transient expression in mammalian cells is especially crucial when post-translational modifications and appropriate protein folding is desired for downstream applications. GeneNarus transient expression services offer rapid production and delivery of high quality proteins and recombinant antibodies (rAbs) from microgram to gram quantities.

We use Chinese Hamster Ovary (CHO) and Human Embryonic Kidney 293 (HEK) as our primary cell lines for transient expression owing to the ease of handling, robust growth rates, excellent transfectability and high yield recombinant protein-generation capacity.
*QC data: SDS-PAGE and/or HPLC will be performed to determine protein and rAb purity. BCA or Bradford assay will be used to measure protein concentration and A280 will be used to measure rAb concentration.

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Cell Line Generation

Price on request

Stable cell lines are used in a variety of research applications such as recombinant protein and antibody production, assay development, gene editing, functional studies and more. At GeneNarus, we offer comprehensive stable cell line development capabilities that either begins with DNA provided by our clients or that are powered... Show more »

Stable cell lines are used in a variety of research applications such as recombinant protein and antibody production, assay development, gene editing, functional studies and more. At GeneNarus, we offer comprehensive stable cell line development capabilities that either begins with DNA provided by our clients or that are powered by our fast, high efficiency gene synthesis service that seamlessly integrates all steps of stable cell line generation, delivering high quality stable clones of your choice. Boost your productivity and improve your results by leveraging GeneNarus’s top quality stable cell line services.

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qPCR

Quantitative PCR
Price on request

Quantitative Real Time PCR (qPCR) is an important research tool for quantifying gene expression or DNA copy number. GeneNarus offers rapid, high quality qPCR analysis using our state of the art equipment. Our full service qPCR offering includes RNA and cDNA preparation, primer design, experimental design, qPCR experiment execution... Show more »

Quantitative Real Time PCR (qPCR) is an important research tool for quantifying gene expression or DNA copy number. GeneNarus offers rapid, high quality qPCR analysis using our state of the art equipment. Our full service qPCR offering includes RNA and cDNA preparation, primer design, experimental design, qPCR experiment execution and data analysis, including normalization to internal controls. GeneNarus utilizes both general fluorescent dyes (ex. SYBR Green) and gene specific probes.

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RT-PCR

Reverse transcription polymerase chain reaction
Price on request

Reverse Transcriptase PCR (RT-PCR) is a technique where mRNAs are reverse transcribed into cDNA using the enzyme reverse transcriptase. The resulting cDNA can be used for a variety of applications including qPCR, sequence validation or expression. cDNA can be amplified using standard PCR and cloned directly into cloning or... Show more »

Reverse Transcriptase PCR (RT-PCR) is a technique where mRNAs are reverse transcribed into cDNA using the enzyme reverse transcriptase. The resulting cDNA can be used for a variety of applications including qPCR, sequence validation or expression. cDNA can be amplified using standard PCR and cloned directly into cloning or expression vectors.
GeneNarus offers comprehensive qPCR and RT-PCR services tailored to the needs of our clients. GeneNarus can save you time by managing the entire process all the way through qPCR experiments and data analysis or from cell line expansion, RNA preparation and cDNA synthesis to downstream applications.

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Western Blot

Price on request

GeneNarus offers Northern blot and Southern blot analysis services to extract total RNA, microRNA, purification of mRNA, isolation of genomic DNA and construct ready-to-hybridize Northern blots and southern blots. RNA/mRNA, DNA samples are extracted from tissues provided by GeneNarus or customers. To ensure high quality blots,... Show more »

GeneNarus offers Northern blot and Southern blot analysis services to extract total RNA, microRNA, purification of mRNA, isolation of genomic DNA and construct ready-to-hybridize Northern blots and southern blots. RNA/mRNA, DNA samples are extracted from tissues provided by GeneNarus or customers. To ensure high quality blots, each sample whether provided by the customers or GeneNarus is subjected to rigorous quality control test before use.

GeneNarus also offers complete Western blot custom services including extraction of total proteins from tissues or cells provided by GeneNarus or customers, construction of premade Western blots, immunostaining blots with any antibody, quantitative analysis of immunostaining, and sending high quality digital images.

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Northern Blot

Price on request

GeneNarus offers Northern blot and Southern blot analysis services to extract total RNA, microRNA, purification of mRNA, isolation of genomic DNA and construct ready-to-hybridize Northern blots and southern blots. RNA/mRNA, DNA samples are extracted from tissues provided by GeneNarus or customers. To ensure high quality blots,... Show more »

GeneNarus offers Northern blot and Southern blot analysis services to extract total RNA, microRNA, purification of mRNA, isolation of genomic DNA and construct ready-to-hybridize Northern blots and southern blots. RNA/mRNA, DNA samples are extracted from tissues provided by GeneNarus or customers. To ensure high quality blots, each sample whether provided by the customers or GeneNarus is subjected to rigorous quality control test before use.

GeneNarus also offers complete Western blot custom services including extraction of total proteins from tissues or cells provided by GeneNarus or customers, construction of premade Western blots, immunostaining blots with any antibody, quantitative analysis of immunostaining, and sending high quality digital images.

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Southern Blot

Price on request

GeneNarus offers Northern blot and Southern blot analysis services to extract total RNA, microRNA, purification of mRNA, isolation of genomic DNA and construct ready-to-hybridize Northern blots and southern blots. RNA/mRNA, DNA samples are extracted from tissues provided by GeneNarus or customers. To ensure high quality blots,... Show more »

GeneNarus offers Northern blot and Southern blot analysis services to extract total RNA, microRNA, purification of mRNA, isolation of genomic DNA and construct ready-to-hybridize Northern blots and southern blots. RNA/mRNA, DNA samples are extracted from tissues provided by GeneNarus or customers. To ensure high quality blots, each sample whether provided by the customers or GeneNarus is subjected to rigorous quality control test before use.

GeneNarus also offers complete Western blot custom services including extraction of total proteins from tissues or cells provided by GeneNarus or customers, construction of premade Western blots, immunostaining blots with any antibody, quantitative analysis of immunostaining, and sending high quality digital images.

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Site-Directed Mutagenesis

Price on request

Site-Directed Mutagenesis is an important research tool for protein engineering and structure/function studies. GeneNarus can be conducted using PCR Nucleotide Substitution mediated mutagenesis and allows rational design of protein variants using variety methodologies. GeneNarus’s site-directed mutagenesis services provide a fast,... Show more »

Site-Directed Mutagenesis is an important research tool for protein engineering and structure/function studies. GeneNarus can be conducted using PCR Nucleotide Substitution mediated mutagenesis and allows rational design of protein variants using variety methodologies. GeneNarus’s site-directed mutagenesis services provide a fast, cost-saving, way to get 100% accurate mutant DNA clones, without having to spend your time and money on mutagenesis kits to do PCR mutagenesis, cloning, and sequencing in your own lab.

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Protein Quantification

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Mammalian Cell Culture

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Protein Production

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Drug Discovery & Development

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Bioanalysis

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Biology

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Biochemistry & Molecular Biology

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Testing of Cell Lines

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Drug Discovery

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DNA Fragment Analysis

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Protein Expression Visualization

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Mutagenesis

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Pharmacology & Toxicology

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Protein Services

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Project Management

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Cells and Tissues

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PCR

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DNA Services

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Nucleic Acid Services

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RNA Services

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Hit Identification

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Aiguo Xu

Founder & CEO

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