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Gateway Pharmacology Laboratories

20 Orders Completed
St. Louis, Missouri, US

About Gateway Pharmacology Laboratories

Gateway Pharmacology Laboratories is a preclinical in vivo pharmacology laboratory specializing in cardiovascular, renal and hepatic models and endpoints. Our studies support proof of concept, drug candidate characterization and safety assessment enabling a seamless advancement into clinical evaluation. We offer standard and customized study designs, expert consultation and high quality data with rapid timelines. We operate in state-of-the-art research facilities including an AAALAC accredited vivarium. Our staff consists of highly qualified and experienced pharmaceutical industry research professionals.

Certifications & Qualifications

AAALAC

Diversity Certificates

Small business

Our Services (37)


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Animal Echocardiography

Price on request

VisualSonics Vevo 3100 Ultrasound System


Echocardiography Modes:

M-Mode

B-Mode

Pulse-Wave Doppler

Tissue Doppler

Color Doppler


Parameters:

Chamber Geometry and Thickness

Systolic and Diastolic Function


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Animal Cardiac Test Panel

Price on request

Gateway offers numerous cardiac models including:  

Myocardial Infarction (MI) - permanent and ischemia/reperfusion

Trans-Aortic Constriction (TAC) - myocardial hypertrophy

Dahl Salt Sensitive Rat (DSS) - systolic heart failure

ZSF1 Rat

Spontaneous Hypertensive Heart Failure Rat (SHHF)


ENDPOINTS:

Echocardiography: Systolic and diastolic function and geometry (M-Mode, B-Mode & Doppler)

Radio-Telemetry: Blood pressure, ECG, temperature and activity

Left Ventricular Hemodynamics: +/-dP/dt, Tau, LVEDP and LVESP

Rat Ultrasound Telemeters Echocardiography Telemetry Mouse Guinea pig Cardiovascular Myocardial infarction (MI) Heart failure hemodynamics Show 11 more tags Show less

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Chronic Kidney Disease Models

Price on request

Disease Models:

5/6 Nephrectomy

Uninephrectomized

Dahl Salt Sensitive (DSS)

ZSF1 Rat

Streptozotocin (STZ)

Unilateral Urethral Obstruction (UUO)

Renal Ischemia/reperfusion (IR)

Puromycin Aminonucleoside (PAN)


Endpoints:

Proteinuria, Glomerular Filtration Rate (GFR), Creatinine Clearance (eGFR), Blood Pressure, Plasma/Urine Biomarkers, Histology/IHC 

Telemetry Rat Radiotelemetry Mouse

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Hypertension Animal Models

Price on request

Models:

SHR

Dahl Salt Sensitive (DSS)

ZSF1

5/6 Nephrectomy

ANGII-induced


Endpoints:

Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months.


Anesthetized measurement via cannulation of carotid artery

Rat Mouse Guinea pig Telemeters Tethered BP Cardiovascular Rodents Show 7 more tags Show less

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Animal in vivo Imaging

Price on request

VisualSonics Vevo 3100 Ultrasound System


Echocardiography Modes:

M-Mode

B-Mode

Pulse-Wave Doppler

Tissue Doppler

Color Doppler


Parameters:

Chamber Geometry and Thickness

Systolic and Diastolic Function

IVIS vevo 3100 Echocardiography Cardiovascular

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Animal Telemetry

Price on request

Data Sciences International (DSI) System  (120 units)


Species:

Rat, Mouse Guinea Pig


Parameters:

MAP, SBP, DBP, HR, ECG, Body Temperature and Activity

Rat Guinea pig Hypertension Telemeters Radiotelemetry Telemetry ECG Temperature Cardiovascular Mouse Rodents Show 11 more tags Show less

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Renal Disease Animal Models

Price on request

Models:

Unilateral Ureteral Obstruction (UUO)

Renal Ischemia/Reperfusion Injury (IRI)

5/6 Nephrectomy

Dahl Salt Sensitive Rat (DSS)


Endpoints:

Glomerular Filtration Rate (GFR), Proteinuria, Creatinine, BUN, Collagen/Hydroxyproline Content, Histological Evaluation

Nephrology and Urology Nephrology and Urology

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Heart Failure Animal Models

Price on request

Models:

Myocardial Infarction (MI)

Myocardial Ischemia/reperfusion (IR)

Trans-Aortic Constriction (TAC)

Dahl Salt Sensitive (DSS)

Spontaneous Hypertensive Heart Failure (SHHF)


Endpoints:

Echocardiography (M-Mode, B-Mode & Doppler)

Invasive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)

Histological evaluation

Rat Mouse Cardiovascular

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Liver Fibrosis Animal Models

Price on request

Models:

Bile Duct Ligation (BDL)

Carbon Tetrachloride (CCl4)


Endpoints:

Portal Vein Pressure

Liver enzymes and Bilirubin

Collagen/Hydroxyproline Content

Histological Evaluation


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Pulmonary Hypertension Animal Models

Price on request

Model: Monocrotaline Rat

  • Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
  • Heart and Lung Weight
  • Myocardial, Pulmonary Artery and Lung Histology


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Infusion Toxicology

Price on request

Infusion Pharmacology Platform in unrestrained rodents

  • Continuous infusion of test article for up to 14 days
  • Simultaneous blood pressure & heart rate analysis
  • Clinical chemistry and hematology
  • Clinical observations
  • Histopathology

Rat Mouse Guinea pig Rodents

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Custom Hematology Animal Models

Price on request
Request a quote for more information about this service.

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Safety Pharmacology

Price on request

Cardiovascular Safety

  • Cardiovascular Telemetry Platform – Continuous measurement of blood pressure, heart rate, ECG, respiration, temperature & activity in conscious, unrestrained animals for up to 6 months. Blood, urine, fecal and tissue sampling available.
  • Infusion Pharmacology Platform – Continuous infusion of test compound and simultaneous blood pressure & heart rate analysis for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
  • Cardiac, Lipid and Metabolic Biomarkers – Markers of tissue and biochemical damage (e.g. CK, CRP, chol, trigs, glucose, HbA1c, etc.)
  • Echocardiography – Left Ventricular Function & Dimensions
  • Left Ventricular Function – +/-dP/dt, Tau, LVEDP and LVESP

Renal Safety

  • Renal Function – Creatinine Clearance, GFR, proteinuria and electrolytes
  • Kidney Histology – Glomerulosclerosis, tubular damage, fibrosis, etc.
  • Renal Biomarker Panel – Analysis of FDA/EMA approved urinary biomarkers that are predictive of drug-induced renal toxicity and translatable to human nephrotoxicity

General Safety and Toxicology

  • Chronic Infusion Studies – Continuous infusion of test agent for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
  • Hematology – 23-parameter complete blood count plus 5-point WBC differential analysis on blood samples from in-life studies
  • Clinical Chemistry – 180 analytes available including markers of liver, kidney, cardiac, pancreas and bone damage; as well as lipids, metabolic and inflammation
  • Histopathology – Standard or tailored to your target tissue of interest

Gastrointestinal Safety and Function

  • Intestinal Motility – Charcoal meal test
  • Intestinal Secretion – Closed and Open loop models of fluid and electrolyte secretion as well as compound absorption

Microscopy & Histology

  • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy

Rat Mouse Guinea pig Telemeters Radiotelemetry Telemetry Ultrasound Echocardiography Show 8 more tags Show less

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In vivo Pharmacology Studies

Price on request

Gateway Pharmacology Laboratories is an in vivo pharmacology laboratory that specializes in cardiovascular, renal and hepatic models and methods with unique expertise in surgical models. Contact us for more information.


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In vivo PK/PD Studies

Price on request

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic pump

Sample Collection:

  • Simultaneous blood, bile, urine and fecal sampling in conscious, unrestrained rats
  • Repeated, small volume blood sampling and fluid replenishment using the Automated Blood Sampler allows for reduction in animal use and minimizes test compound quantity requirement

Species: Rat, Mouse and Guinea Pig

Rat Mouse Rodents

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Cardiovascular Animal Models

Price on request

Gateway Pharmacology Laboratories specializes in in vivo Cardiovascular models and methods. Contact us for more information.


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Hepatic Animal Models

Price on request

Models:

Bile Duct Ligation (BDL)

Carbon Tetrachloride (CCl4)


Endpoints:

Portal Vein Pressure

Liver enzymes and Bilirubin

Collagen/Hydroxyproline Content

Histological Evaluation


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Respiratory Disease Animal Models

Price on request
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Hematology Animal Models

Price on request
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Animal Models of Disease

Price on request
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Animal Models and Studies

Price on request
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Pharmacology & Toxicology

Price on request
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Animal Physiology Analyses

Price on request
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Animal Model in vivo Analyses

Price on request
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Veterinary Laboratory Services

Price on request
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Animal Electrolyte Analysis

Price on request
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Animal Complete Blood Count

Price on request
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Animal Blood Chemistry

Price on request
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Clinical Chemistry

Price on request
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Pharmacology

Price on request

Pharmacology Services


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In vivo Drug Efficacy Testing

Price on request
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Custom Cardiovascular Animal Models

Price on request

Gateway Pharmacology Laboratories specializes in Cardiovascular models and methods with a core competency in surgical models. We are able to support customized models and studies within our field of expertise. Contact us for more information.


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Animal Hemodynamics

Price on request

Data Sciences International (DSI) Telemetry System (120 units)


Species:

Rat, Mouse Guinea Pig


Parameters:

MAP, SBP, DBP, HR, ECG, Body Temperature and Activity


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Animal Ultrasound

Price on request

VisualSonics Vevo 3100 Ultrasound System


Echocardiography Modes:

M-Mode

B-Mode

Pulse-Wave Doppler

Tissue Doppler

Color Doppler


Parameters:

Chamber Geometry and Thickness

Systolic and Diastolic Function


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Animal Surgery

Price on request

Our laboratory specializes in standard and customized rodent surgical models and methods. Contact us for more information.


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Infusion Pump Implantation in Animals

Price on request
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Pulmonary Fibrosis Animal Models

Price on request
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Brian R. Bond, PhD

President and CEO
  • Positive review for Animal Telemetry:

    January 2019

    "We had a wonderful experience working with Brian & Dr. Yu. They were very accommodating for our last-minute requests, and study design changes as our project priority changes. Their expertise in cardiovascular physiology is superb too and were able to deliver the results in a relatively short timeline. I would highly recommend them and look forward to working with them again!"

  • Positive review for Histological Staining:

    August 2018

    "Gateway was outstanding to work with. They really gave a lot of thought to study design and making sure we got what we needed from the study. Study was executed well and on time. I would definitely recommend working with Gateway."

  • Positive review for Cardiac Risk Panel:

    December 2016

    "Excellent and experienced CRO. They were prompt and accommodating. I would highly recommend them."

Gateway Pharmacology Laboratories has not received any endorsements.