Gateway Pharmacology Laboratories is a preclinical Cardio-Renal pharmacology contract research laboratory that provides confidence in disease relevance and compound safety enabling seamless project advancement into clinical evaluation.
We Specialize in characterizing drug candidates in a rapid and... Show more »
Gateway Pharmacology Laboratories is a preclinical Cardio-Renal pharmacology contract research laboratory that provides confidence in disease relevance and compound safety enabling seamless project advancement into clinical evaluation.
We Specialize in characterizing drug candidates in a rapid and impactful fashion by customizing study designs and delivering quality data. We operate in state-of-the-art research facilities, located in the heart of St. Louis, including an AAALAC accredited vivarium.
Our Staff consists of highly qualified and experienced pharmaceutical industry research professionals who have demonstrated success in advancing projects from preclinical to Phase III clinical trials.
Our Mission is to support the advancement of your project to product launch.
Species: Rat, Mouse and Guinea Pig
Disease Models: Myocardial Infarction, Ischemia/Reperfusion, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Species: Rat, Mouse and Guinea Pig
Disease Models: Myocardial Infarction, Ischemia/Reperfusion, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Disease Models: Uninephrectomized, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), ischemia/reperfusion (IR), Puromycin Aminonucleoside (PAN) (additional models available)
Disease Models: Uninephrectomized, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), ischemia/reperfusion (IR), Puromycin Aminonucleoside (PAN) (additional models available)
Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months
Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up... Show more »
Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months
Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up to 10 days
Disease Models: SHR, Dahl Salt Sensitive (DSS), ZSF1, ANGII-induced (additional models available)
Rodent Echocardiography, ultrasound
Rodent Echocardiography, ultrasound
Capacity of up to 136 radio-telemeterized rodents
Rat, Mouse and Guinea Pig models available
Capacity of up to 136 radio-telemeterized rodents
Rat, Mouse and Guinea Pig models available
Model: Unilateral Ureteral Obstruction (UUO), Renal Ischemia/Reperfusion (IR)
Model: Unilateral Ureteral Obstruction (UUO), Renal Ischemia/Reperfusion (IR)
Left Ventricular Function, Cardiac remodeling and Histological evaluation
Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)
Disease Models: Myocardial Infarction (MI), Ischemia/reperfusion (IR), ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Left Ventricular Function, Cardiac remodeling and Histological evaluation
Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)
Disease Models: Myocardial Infarction (MI), Ischemia/reperfusion (IR), ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Model: Bile Duct Ligation (BDL)
Model: Bile Duct Ligation (BDL)
Model: Monocrotaline Rat
Model: Monocrotaline Rat
Infusion Pharmacology Platform in unrestrained rodents
Infusion Pharmacology Platform in unrestrained rodents
Cardiovascular Safety
Cardiovascular Safety
Renal Safety
General Safety and Toxicology
Gastrointestinal Safety and Function
Microscopy & Histology
Pharmacokinetic and ADME Studies
Cassette dosing and analysis is available and economical!
Routes of Dosing:
Pharmacokinetic and ADME Studies
Cassette dosing and analysis is available and economical!
Routes of Dosing:
Sample Collection:
Species: Rat, Mouse and Guinea Pig
Pharmacokinetic and ADME Studies
Cassette dosing and analysis is available and economical!
Routes of Dosing:
Pharmacokinetic and ADME Studies
Cassette dosing and analysis is available and economical!
Routes of Dosing:
Sample Collection:
Species: Rat, Mouse and Guinea Pig
With years experience in drug discovery and development and proven track records of advancing projects from lead development to clinical trial and product launch, our professional consultants have multi-disciplinary skills including pharmacology, PK/PD, medicinal chemistry, toxicology, project management and regulatory strategy... Show more »
With years experience in drug discovery and development and proven track records of advancing projects from lead development to clinical trial and product launch, our professional consultants have multi-disciplinary skills including pharmacology, PK/PD, medicinal chemistry, toxicology, project management and regulatory strategy and submission.
Senior Consultants
Biology Services
Biology Services
Pharmacology Services
Pharmacology Services
"We had a wonderful experience working with Brian & Dr. Yu. They were very accommodating for our last-minute requests, and study design changes as our project priority changes. Their expertise in cardiovascular physiology is superb too and were able to deliver the results in a relatively short timeline. I would highly recommend them and look forward to working with them again!"
"Gateway was outstanding to work with. They really gave a lot of thought to study design and making sure we got what we needed from the study. Study was executed well and on time. I would definitely recommend working with Gateway."
"Excellent and experienced CRO. They were prompt and accommodating. I would highly recommend them."
Gateway Pharmacology Laboratories has not received any endorsements.