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Gateway Pharmacology Laboratories

12 Orders Completed
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About Gateway Pharmacology Laboratories

**Gateway Pharmacology Laboratories** is a preclinical Cardio-Renal pharmacology contract research laboratory that provides confidence in disease relevance and compound safety enabling seamless project advancement into clinical evaluation. **We Specialize** in characterizing drug candidates in a rapid and impactful fashion by customizing study designs and delivering quality data. We operate in state-of-the-art research facilities, located in the heart of St. Louis, including an AAALAC accredited vivarium. **Our Staff** consists of highly qualified and experienced pharmaceutical industry research professionals who have demonstrated success in advancing projects from preclinical to clinical evaluation. **Our Mission** is to support the advancement of your project toward product launch.

Certifications & Qualifications

AAALAC

Diversity Certificates

Small business

Our Services (44)


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Animal Echocardiography

Price on request

Trans Aortic Contriction (TAC)

The  trans-aortic contriction (TAC) surgical model of cardiac hypertrophy. Progressive heart hypertrophy and function can be measured over time non-invasively using echocardiography (Vevo 3100 Ultrasound system) along with terminal measurement of heart weight and histopathology.


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Animal Cardiac Test Panel

Price on request

_Species:_ Rat, Mouse and Guinea Pig _Disease Models:_ Myocardial Infarction, Trans-Aortic Contriction (TAC), Ischemia/Reperfusion, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available) - Echocardiography: Systolic and diastolic function and geometry (M-Mode, B-Mode & Doppler) - Radio-Telemetry: Blood pressure, ECG, temperature and activity - Left Ventricular Hemodynamics: +/-dP/dt, Tau, LVEDP and LVESP - Ex Vivo Left Ventricular Pressure/Volume Compliance

Rat Ultrasound Telemeters Echocardiography Telemetry Mouse Guinea pig Cardiovascular Myocardial infarction (MI) Heart failure hemodynamics Show 11 more tags Show less

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Chronic Kidney Disease Models

Price on request

_Disease Models:_ 5/6 Nephrectomy, Uninephrectomized, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), ischemia/reperfusion (IR), Puromycin Aminonucleoside (PAN) (additional models available)

_Endpoints:_ Proteinuria, albuminuria, Glomerular Filtration Rate (GFR), Creatinine Clearance, histological evaluation - Plasma/Urine Biomarkers of damage - Chronic blood pressure monitoring using radio telemetry

Telemetry Rat Radiotelemetry Mouse

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Hypertension Animal Models

Price on request
  • Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months

  • Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up to 10 days

Disease Models: SHR, Dahl Salt Sensitive (DSS), ZSF1, ANGII-induced (additional models available)

Rat Mouse Guinea pig Telemeters Tethered BP Cardiovascular Rodents Show 7 more tags Show less

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Animal in vivo Imaging

Price on request

Rodent Echocardiography, ultrasound

IVIS vevo 3100 Echocardiography Cardiovascular

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Animal Telemetry

Price on request
  • Blood Pressure
  • ECG
  • Activity
  • Temperature

Capacity of up to 136 radio-telemeterized rodents

Rat, Mouse and Guinea Pig models available

Rat Guinea pig Hypertension Telemeters Radiotelemetry Telemetry ECG Temperature Cardiovascular Mouse Rodents Show 11 more tags Show less

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Renal Disease Animal Models

Price on request

_Models:_ Unilateral Ureteral Obstruction (UUO), Renal Ischemia/Reperfusion (IR), 5/6 Nephrectomy

_Endpoints:_ Glomerular Filtration Rate (GFR), Collagen/Hydroxyproline Content, Creatinine, BUN, Histological Evaluation

Nephrology and Urology Nephrology and Urology

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Heart Failure Animal Models

Price on request

Left Ventricular Function, Cardiac remodeling and Histological evaluation

Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)

Disease Models: Myocardial Infarction (MI), Ischemia/reperfusion (IR), ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)

Rat Mouse Cardiovascular

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Liver Fibrosis Animal Models

Price on request

_Models:_ Bile Duct Ligation (BDL), Carbon Tetrachloride (CCl4)

_Endpoints:_ Collagen/Hydroxyproline Content - Liver enzymes and Bilirubin - Histological Evaluation


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Pulmonary Hypertension Animal Models

Price on request

Model: Monocrotaline Rat

  • Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
  • Heart and Lung Weight
  • Myocardial, Pulmonary Artery and Lung Histology


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Infusion Toxicology

Price on request

Infusion Pharmacology Platform in unrestrained rodents

  • Continuous infusion of test article for up to 14 days
  • Simultaneous blood pressure & heart rate analysis
  • Clinical chemistry and hematology
  • Clinical observations
  • Histopathology

Rat Mouse Guinea pig Rodents

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Custom Hematology Animal Models

Price on request
Request a quote for more information about this service.

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Safety Pharmacology

Price on request

Cardiovascular Safety

  • Cardiovascular Telemetry Platform – Continuous measurement of blood pressure, heart rate, ECG, respiration, temperature & activity in conscious, unrestrained animals for up to 6 months. Blood, urine, fecal and tissue sampling available.
  • Infusion Pharmacology Platform – Continuous infusion of test compound and simultaneous blood pressure & heart rate analysis for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
  • Cardiac, Lipid and Metabolic Biomarkers – Markers of tissue and biochemical damage (e.g. CK, CRP, chol, trigs, glucose, HbA1c, etc.)
  • Echocardiography – Left Ventricular Function & Dimensions
  • Left Ventricular Function – +/-dP/dt, Tau, LVEDP and LVESP

Renal Safety

  • Renal Function – Creatinine Clearance, GFR, proteinuria and electrolytes
  • Kidney Histology – Glomerulosclerosis, tubular damage, fibrosis, etc.
  • Renal Biomarker Panel – Analysis of FDA/EMA approved urinary biomarkers that are predictive of drug-induced renal toxicity and translatable to human nephrotoxicity

General Safety and Toxicology

  • Chronic Infusion Studies – Continuous infusion of test agent for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
  • Hematology – 23-parameter complete blood count plus 5-point WBC differential analysis on blood samples from in-life studies
  • Clinical Chemistry – 180 analytes available including markers of liver, kidney, cardiac, pancreas and bone damage; as well as lipids, metabolic and inflammation
  • Histopathology – Standard or tailored to your target tissue of interest

Gastrointestinal Safety and Function

  • Intestinal Motility – Charcoal meal test
  • Intestinal Secretion – Closed and Open loop models of fluid and electrolyte secretion as well as compound absorption

Microscopy & Histology

  • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy

Rat Mouse Guinea pig Telemeters Radiotelemetry Telemetry Ultrasound Echocardiography Show 8 more tags Show less

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In vivo Pharmacology Studies

Price on request

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic pump

Sample Collection:

  • Simultaneous blood, bile, urine and fecal sampling in conscious, unrestrained rats
  • Repeated, small volume blood sampling and fluid replenishment using the Automated Blood Sampler allows for reduction in animal use and minimizes test compound quantity requirement

Species: Rat, Mouse and Guinea Pig


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In vivo PK/PD Studies

Price on request

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic pump

Sample Collection:

  • Simultaneous blood, bile, urine and fecal sampling in conscious, unrestrained rats
  • Repeated, small volume blood sampling and fluid replenishment using the Automated Blood Sampler allows for reduction in animal use and minimizes test compound quantity requirement

Species: Rat, Mouse and Guinea Pig

Rat Mouse Rodents

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Gastrointestinal Disease Animal Models

Price on request
  • Infectious Diarrhea – Rotavirus-induced diarrhea
  • Intestinal Secretion – Open and closed loop models of secretion induced by cholera toxin or ETEC (LT/ST)
  • Stool Output – Castor oil-induced diarrhea model
  • Intestinal Motility – Charcoal meal test


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Drug Development

Price on request

With years experience in drug discovery and development and proven track records of advancing projects from lead development to clinical trial and product launch, our professional consultants have multi-disciplinary skills including pharmacology, PK/PD, medicinal chemistry, toxicology, project management and regulatory strategy and submission.

Senior Consultants

  • Brian R. Bond, PhD – Pharmacology
    Dr. Bond has 15 years of experience in pharmaceutical drug development advancing numerous compounds from preclinical to clinical development.
  • Sandy Curtiss, PhD – Safety/Toxicology
    Dr. Curtiss has 15 years of experience in investigative toxicology advancing numerous compounds through development in the pharmaceutical industry.
  • John Walker, PhD – Medicinal Chemistry
    Dr. Walker has 12 years of pharmaceutical research experience with Searle, Pharmacia and Pfizer where he co-invented seven clinical candidates in multiple therapeutic areas.
  • Jon Jacobsen, PhD – Medicinal Chemistry
    Dr. Jacobsen had a distinguished, 25 year career with Upjohn, Pharmacia, and Pfizer where he led teams that advanced eight compounds from Lead Development through Phase I/II clinical studies.
  • John Long, DVM, DACLAM – Veterinarian
    Dr. Long is chairman of the Comparative Medicine Department at Saint Louis University and also has experience supporting drug development in the pharmaceutical industry.


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Microscopy

Price on request
  • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy


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Histological Staining

Price on request
  • We offer a wide range of histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy


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Cardiovascular Animal Models

Price on request
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Hepatic Animal Models

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Veterinary Research & Diagnostics

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Respiratory Disease Animal Models

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Hematology Animal Models

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Gastroenterology Animal Models

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Drug Discovery & Development

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Animal Models of Disease

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Animal Models and Studies

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Imaging & Spectroscopy

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Pharmacology & Toxicology

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Animal Physiology Analyses

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In vivo Toxicity Testing

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Animal Model in vivo Analyses

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Veterinary Laboratory Services

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Animal Electrolyte Analysis

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Animal Complete Blood Count

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Animal Blood Chemistry

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Clinical Chemistry

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Pharmacology

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Pharmacology Services


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In vivo Drug Efficacy Testing

Price on request
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Custom Cardiovascular Animal Models

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Animal Hemodynamics

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Animal Ultrasound

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Animal Surgery

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BB

Brian R. Bond, PhD

President and CEO
  • Positive review for Animal Telemetry:

    January 2019

    "We had a wonderful experience working with Brian & Dr. Yu. They were very accommodating for our last-minute requests, and study design changes as our project priority changes. Their expertise in cardiovascular physiology is superb too and were able to deliver the results in a relatively short timeline. I would highly recommend them and look forward to working with them again!"

  • Positive review for Histological Staining:

    August 2018

    "Gateway was outstanding to work with. They really gave a lot of thought to study design and making sure we got what we needed from the study. Study was executed well and on time. I would definitely recommend working with Gateway."

  • Positive review for Cardiac Risk Panel:

    December 2016

    "Excellent and experienced CRO. They were prompt and accommodating. I would highly recommend them."

Gateway Pharmacology Laboratories has not received any endorsements.