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Gateway Pharmacology Laboratories

US

Gateway Pharmacology Laboratories is a preclinical Cardio-Renal pharmacology contract research laboratory that provides confidence in disease relevance and compound safety enabling seamless project advancement into clinical evaluation.

We Specialize in characterizing drug candidates in a rapid and impactful fashion by customizing study designs and delivering quality data. We operate in state-of-the-art research facilities, located in the heart of St. Louis, including an AAALAC accredited vivarium.

Our Staff consists of highly qualified and experienced pharmaceutical industry research professionals who have demonstrated success in advancing projects from preclinical to Phase III clinical trials.

Our Mission is to support the advancement of your project to product launch.

Gateway Pharmacology Laboratories has not listed any services.

Animal Cardiac Test Panel
Price on request

Species: Rat, Mouse and Guinea Pig

Disease Models: Myocardial Infarction, Ischemia/Reperfusion, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)

  • Echocardiography: Systolic and diastolic function and geometry (M-Mode, B-Mode & Doppler)
  • Radio-Telemetry: Blood pressure, ECG, temperature and... Show more »

Species: Rat, Mouse and Guinea Pig

Disease Models: Myocardial Infarction, Ischemia/Reperfusion, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)

  • Echocardiography: Systolic and diastolic function and geometry (M-Mode, B-Mode & Doppler)
  • Radio-Telemetry: Blood pressure, ECG, temperature and activity
  • Left Ventricular Hemodynamics: +/-dP/dt, Tau, LVEDP and LVESP
  • Ex Vivo Left Ventricular Pressure/Volume Compliance
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Guinea pig
Mouse
Rat
ultrasound
Cardiovascular
Echocardiography
Telemetry
Echocardiography
Telemetry
Heart Failure
Chronic Kidney Disease Models
Price on request

Disease Models: Uninephrectomized, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), ischemia/reperfusion (IR), Puromycin Aminonucleoside (PAN) (additional models available)

  • Proteinuria, albuminuria, GFR, Creatinine Clearance, histological evaluation
  • Plasma/Urine Biomarkers of damage
  • Chronic blood pressure monitoring using radio telemetry

Disease Models: Uninephrectomized, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), ischemia/reperfusion (IR), Puromycin Aminonucleoside (PAN) (additional models available)

  • Proteinuria, albuminuria, GFR, Creatinine Clearance, histological evaluation
  • Plasma/Urine Biomarkers of damage
  • Chronic blood pressure monitoring using radio telemetry
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Mouse
Rat
Telemetry
Radiotelemtry
Hypertension Animal Models
Price on request
  • Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months

  • Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up... Show more »

  • Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months

  • Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up to 10 days

Disease Models: SHR, Dahl Salt Sensitive (DSS), ZSF1, ANGII-induced (additional models available)

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Guinea pig
Mouse
Rat
Rodents
Telemetry
Tethered BP
Hypertension
Animal Imaging
Price on request

Rodent Echocardiography, ultrasound

Rodent Echocardiography, ultrasound

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IVIS
Animal Telemetry
Price on request
  • Blood Pressure
  • ECG
  • Activity
  • Temperature

Capacity of up to 136 radio-telemeterized rodents

Rat, Mouse and Guinea Pig models available

  • Blood Pressure
  • ECG
  • Activity
  • Temperature

Capacity of up to 136 radio-telemeterized rodents

Rat, Mouse and Guinea Pig models available

« Show less
Guinea pig
Mouse
Rat
Rodents
Telemetry
Telemetry
Hypertension
Hypertension
Radiotelemetry
ECG
Temperature
Activity
Renal Disease Animal Models
Price on request

Model: Unilateral Ureteral Obstruction (UUO), Renal Ischemia/Reperfusion (IR)

  • Collagen/Hydroxyproline Content
  • Creatinine, BUN
  • GFR
  • Histological Evaluation

Model: Unilateral Ureteral Obstruction (UUO), Renal Ischemia/Reperfusion (IR)

  • Collagen/Hydroxyproline Content
  • Creatinine, BUN
  • GFR
  • Histological Evaluation
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Heart Failure Animal Models
Price on request

Left Ventricular Function, Cardiac remodeling and Histological evaluation

Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)

Disease Models: Myocardial Infarction (MI), Ischemia/reperfusion (IR), ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)

Left Ventricular Function, Cardiac remodeling and Histological evaluation

Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)

Disease Models: Myocardial Infarction (MI), Ischemia/reperfusion (IR), ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)

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Mouse
Rat
cardiovascular
Cardiac Function
cardiomyopathy
Liver Fibrosis Animal Models
Price on request

Model: Bile Duct Ligation (BDL)

  • Collagen/Hydroxyproline Content
  • Liver enzymes and Bilirubin
  • Histological Evaluation

Model: Bile Duct Ligation (BDL)

  • Collagen/Hydroxyproline Content
  • Liver enzymes and Bilirubin
  • Histological Evaluation
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Pulmonary Hypertension Animal Models
Price on request

Model: Monocrotaline Rat

  • Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
  • Heart and Lung Weight
  • Myocardial, Pulmonary Artery and Lung Histology

Model: Monocrotaline Rat

  • Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
  • Heart and Lung Weight
  • Myocardial, Pulmonary Artery and Lung Histology
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Infusion Toxicology
Price on request

Infusion Pharmacology Platform in unrestrained rodents

  • Continuous infusion of test article for up to 14 days
  • Simultaneous blood pressure & heart rate analysis
  • Clinical chemistry and hematology
  • Clinical observations
  • Histopathology

Infusion Pharmacology Platform in unrestrained rodents

  • Continuous infusion of test article for up to 14 days
  • Simultaneous blood pressure & heart rate analysis
  • Clinical chemistry and hematology
  • Clinical observations
  • Histopathology
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Guinea pig
Mouse
Rat
Rodents
Custom Hematology Animal Models
Price on request
Request a quote for more information about this service.
Safety Pharmacology
Price on request

Cardiovascular Safety

  • Cardiovascular Telemetry Platform – Continuous measurement of blood pressure, heart rate, ECG, respiration, temperature & activity in conscious, unrestrained animals for up to 6 months. Blood, urine, fecal and tissue sampling available.
  • Infusion Pharmacology Platform – Continuous infusion of... Show more »

Cardiovascular Safety

  • Cardiovascular Telemetry Platform – Continuous measurement of blood pressure, heart rate, ECG, respiration, temperature & activity in conscious, unrestrained animals for up to 6 months. Blood, urine, fecal and tissue sampling available.
  • Infusion Pharmacology Platform – Continuous infusion of test compound and simultaneous blood pressure & heart rate analysis for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
  • Cardiac, Lipid and Metabolic Biomarkers – Markers of tissue and biochemical damage (e.g. CK, CRP, chol, trigs, glucose, HbA1c, etc.)
  • Echocardiography – Left Ventricular Function & Dimensions
  • Left Ventricular Function – +/-dP/dt, Tau, LVEDP and LVESP

Renal Safety

  • Renal Function – Creatinine Clearance, GFR, proteinuria and electrolytes
  • Kidney Histology – Glomerulosclerosis, tubular damage, fibrosis, etc.
  • Renal Biomarker Panel – Analysis of FDA/EMA approved urinary biomarkers that are predictive of drug-induced renal toxicity and translatable to human nephrotoxicity

General Safety and Toxicology

  • Chronic Infusion Studies – Continuous infusion of test agent for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
  • Hematology – 23-parameter complete blood count plus 5-point WBC differential analysis on blood samples from in-life studies
  • Clinical Chemistry – 180 analytes available including markers of liver, kidney, cardiac, pancreas and bone damage; as well as lipids, metabolic and inflammation
  • Histopathology – Standard or tailored to your target tissue of interest

Gastrointestinal Safety and Function

  • Intestinal Motility – Charcoal meal test
  • Intestinal Secretion – Closed and Open loop models of fluid and electrolyte secretion as well as compound absorption

Microscopy & Histology

  • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy
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Guinea pig
Mouse
Rat
ultrasound
Echocardiography
Telemetry
Echocardiography
Telemetry
Radiotelemetry
In vivo Pharmacology Studies
Price on request

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic... Show more »

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic pump

Sample Collection:

  • Simultaneous blood, bile, urine and fecal sampling in conscious, unrestrained rats
  • Repeated, small volume blood sampling and fluid replenishment using the Automated Blood Sampler allows for reduction in animal use and minimizes test compound quantity requirement

Species: Rat, Mouse and Guinea Pig

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In vivo PK/PD Studies
Price on request

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic... Show more »

Pharmacokinetic and ADME Studies

  • Standard PK
  • 1st Pass Metabolism
  • Enterohepatic Re-circulation
  • Biliary/Renal/Fecal Clearance

Cassette dosing and analysis is available and economical!

Routes of Dosing:

  • Oral, Intravenous (bolus and continuous), Intraperitoneal, Subcutaneous, Intramuscular, Mini-osmotic pump

Sample Collection:

  • Simultaneous blood, bile, urine and fecal sampling in conscious, unrestrained rats
  • Repeated, small volume blood sampling and fluid replenishment using the Automated Blood Sampler allows for reduction in animal use and minimizes test compound quantity requirement

Species: Rat, Mouse and Guinea Pig

« Show less
Mouse
Rat
Rodents
Gastrointestinal Disease Animal Models
Price on request
  • Infectious Diarrhea – Rotavirus-induced diarrhea
  • Intestinal Secretion – Open and closed loop models of secretion induced by cholera toxin or ETEC (LT/ST)
  • Stool Output – Castor oil-induced diarrhea model
  • Intestinal Motility – Charcoal meal test
  • Infectious Diarrhea – Rotavirus-induced diarrhea
  • Intestinal Secretion – Open and closed loop models of secretion induced by cholera toxin or ETEC (LT/ST)
  • Stool Output – Castor oil-induced diarrhea model
  • Intestinal Motility – Charcoal meal test
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Drug Development
Price on request

With years experience in drug discovery and development and proven track records of advancing projects from lead development to clinical trial and product launch, our professional consultants have multi-disciplinary skills including pharmacology, PK/PD, medicinal chemistry, toxicology, project management and regulatory strategy... Show more »

With years experience in drug discovery and development and proven track records of advancing projects from lead development to clinical trial and product launch, our professional consultants have multi-disciplinary skills including pharmacology, PK/PD, medicinal chemistry, toxicology, project management and regulatory strategy and submission.

Senior Consultants

  • Brian R. Bond, PhD – Pharmacology
    Dr. Bond has 15 years of experience in pharmaceutical drug development advancing numerous compounds from preclinical to clinical development.
  • Sandy Curtiss, PhD – Safety/Toxicology
    Dr. Curtiss has 15 years of experience in investigative toxicology advancing numerous compounds through development in the pharmaceutical industry.
  • John Walker, PhD – Medicinal Chemistry
    Dr. Walker has 12 years of pharmaceutical research experience with Searle, Pharmacia and Pfizer where he co-invented seven clinical candidates in multiple therapeutic areas.
  • Jon Jacobsen, PhD – Medicinal Chemistry
    Dr. Jacobsen had a distinguished, 25 year career with Upjohn, Pharmacia, and Pfizer where he led teams that advanced eight compounds from Lead Development through Phase I/II clinical studies.
  • John Long, DVM, DACLAM – Veterinarian
    Dr. Long is chairman of the Comparative Medicine Department at Saint Louis University and also has experience supporting drug development in the pharmaceutical industry.
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Microscopy
Price on request
  • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques... Show more »
  • We offer a wide range of microscopy and histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy
« Show less
Histological Staining
Price on request
  • We offer a wide range of histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy
  • We offer a wide range of histology services to enable detailed quantitative organ/tissue analysis and morphometry
  • Fixation and processing of samples into paraffin, OCT and plastic
  • Sectioning and staining of tissue blocks for LM histology and EM ultrastructure
  • Range of quantitative microscopy techniques including; Epi-fluorescence, Laser scanning & capture, Electron microscopy
« Show less
Cardiovascular Animal Models
Price on request
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Hepatic Animal Models
Price on request
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Veterinary Research & Diagnostic Services
Price on request
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Respiratory Disease Animal Models
Price on request
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Hematology Animal Models
Price on request
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Gastroenterology Animal Models
Price on request
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Drug Discovery & Development
Price on request
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Animal Models of Disease
Price on request
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Animal Models and Studies
Price on request
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Imaging & Spectroscopy
Price on request
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Pharmacology & Toxicology
Price on request
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Animal Physiology Analyses
Price on request
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In vivo Toxicity Testing
Price on request
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Safety Pharmacology & Efficacy Testing
Price on request
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Animal Model in vivo Analyses
Price on request
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Veterinary Laboratory Services
Price on request
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2016-12-20 13:49:35 -0800

Net Promoter Score of 10 received for Cardiac Risk Panel.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.
December 1, 2016

Positive review received for Cardiac Risk Panel:

"Excellent and experienced CRO. They were prompt and accommodating. I would highly recommend them."

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