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FYR Diagnostics

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Missoula, Montana, US

About FYR Diagnostics

FYR Diagnostics is a privately-held company headquartered in Missoula, MT. Our ability to quickly adapt and utilize novel technologies gives us a competitive advantage over other research groups.

Services:
RNA Sequencing, qPCR, RT-PCR, Histology and Pathology, clinical research and consulting, DNA analysis, gene expression analysis, extensive biochemistry and molecular biology services, neurological research consulting, grant writing, experimental design, and patentability/commercialization assessments

Proven research expertise in:
miRNA, smiRNA, lncRNA, DNA/RNA expression analysis, molecular biology, biomarker development, epilepsy, TBI, CTE, neurodegenerative disorders, neurobiology, diagnostic tool risk analysis

Lead Scientists:

  • Sarjubhai Patel PhD
  • Braxton Norwood PhD
  • Thomas Rau PhD

Select publications by our researchers
Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction. PLoS One. 2012;7(9):e40881. Epub 2012 Sep 11. Rau TF, Lu Q, Sharma S, Sun X, Leary G, Beckman ML, Hou Y, Wainwright MS, Kavanaugh M, Poulsen DJ, Black SM.

Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures. Eur J Neurosci. 2011 Sep 21 Lu Q, Rau TF, Harris V, Johnson M, Poulsen DJ, Black SM.

Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia. Neuroscience. 2008 Sep 9;155(4):1204-11. Weller ML, Stone IM, Goss A, Rau T, Rova C, Poulsen DJ.

Norwood BA, Bauer S, Wegner S, Hamer HM, Oertel WH, Sloviter RS, Rosenow F. Electrical stimulationinduced
seizures in rats: a "dose-response" study on resultant neurodegeneration. Epilepsia. 2011
Sep;52(9):e109-12.

Will JL, Eckart MT, Rosenow F, Bauer S, Oertel WH, Schwarting RK, Norwood BA. Enhanced sequential
reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal
sclerosis. Behav Brain Res. 2013 Mar 16;247C:65-72.

Meyer M, Kienzler-Norwood F, Bauer S, Rosenow F, Norwood BA. Removing entorhinal cortex input to the
dentate gyrus does not impede low frequency oscillations, which are a biomarker of hippocampal
epileptogenesis. Nature Sci Rep. 2016 May 10;6:25660.

Kienzler-Norwood F, Neubert V, Costard L, Müller P, Sadangi C, Bauer S, Rosenow F, Norwood BA. A novel
animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic
acid and lorazepam. Epilepsia. 2017 Feb;58(2):222-230.

Sadangi C, Rosenow F, Norwood BA. Validation of Reference Genes for Quantitative Gene Expression
Analysis in Experimental Epilepsy. J Neurosci Res.

Patel, S.A., Warren, B.A., Rhoderick, J.F. & Bridges, R.J. (2004). Differentiation of
substrate and non-substrate inhibitors of transport system xc-: an obligate exchanger of Lglutamate
and L-cystine. Neuropharm. Feb; 46(2):273-84. PMID: 14680765

Patel, S.A., Rajale, T., O'Brien, E., Burkhart, D.J., Nelson, J.K., Twamley, B.,
Blumenfeld, A., Szabon-Watola, M.I., Gerdes, J.M., Bridges, R.J. & Natale, N.R. (2010).

Isoxazole analogues bind the system xc- transporter: structure-activity relationship and
pharmacophore model. Bioorg Med Chem. Jan 1;18(1):202-13. PMID: 19932968.

Ahmed, S.K., Etoga, J.G., Patel, S.A., Bridges, R.J. & Thompson, C.M. (2011). Use of
the hydantoin isostere to produce inhibitors showing selectivity toward the vesicular
19 glutamate transporter versus the obligate exchange transporter System xc Bioorg MedChem Lett. Jul; 21(14):4358-62. PMID 21669531.

Newell, J.L., Keyari, C.M., McDaniel, S.W., Diaz, P.J., Natale, N.R., Patel, S.A., Bridges,
R.J. (2013) Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the
system xc cystine/glutamate exchanger. Neurochem Int. Dec 11. pii: S0197-
0186(13)00309-4. doi: 10.1016/j.neuint.2013.11.012. [Epub ahead of print] PMID:
24333322.

Our Services (10)


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MicroRNA (miRNA) Quantification

Quantitative PCR microRNA quantitation
Price on request

FYR Diagnostics offers qPCR services for miRNA studies that include,

● RNA Isolation for samples
● SYBR-based qPCR assays
● High resolution Melt studies
● Perform data analysis using relative expression (△△ Cq) or standard curve method

Bio-Rad CFX Qiagen Qiacube qPCR RT-qPCR SYBR Green Quantitative RT-qPCR Kit Plasma Serum Biofluids Biopsy tissue CFX Manager™ Software Human Rat Mouse miRNA Show 14 more tags Show less

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Assay Development

Price on request

Expert assistance with designing experiments involving, for example, expression analysis. Includes preclinical and clinical studies.


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qPCR Arrays

quantitative PCR array
Price on request

FYR Diagnostics offers qPCR array services that include,

● RNA Isolation for samples
● SYBR and Probe-based qPCR assays for reliable gene expression analysis of biological pathways
● Primer and Probe Design for unique gene expression analysis
● High resolution Melt studies
● Perform data analysis using relative expression (△△ Cq) or standard curve method
● Provide suitable endogenous controls


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Biomarker Analysis

Price on request

Quantification of nucleic acid biomarkers in biosamples, e.g. tissue and biofluids (serum, CSF).

Bio-Rad CFX Qiagen Qiacube qPCR RT-qPCR SYBR Green Quantitative RT-qPCR Kit Plasma Serum Biofluids CFX Manager™ Software Human Rat Mouse miRNA Show 13 more tags Show less

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Biomarker Assay Development

Price on request

Design and development of assays to detect/quantify biomarkers expressed in tissue/biofluids. For example, miRNA.


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Biomarker Study Design

Price on request

Design of preclinical and clinical studies intended to discover biomarkers expressed in tissue/biofluids. For example, miRNA.


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Histology and Pathology Services

Price on request

Histological analysis of brain tissue samples to evaluate neuroanatomy and pathology. Includes staining (e.g. Nissl, TUNEL) and immunohistochemistry methods.


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Genotyping and Gene Expression Assays

Price on request

Genotype establishment for preclinical (e.g. transgenic mice) and clinical samples.


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Grant Writing

Price on request

Expert assistance designing experiments and writing grant applications. Our scientists have secured numerous competitive awards from both public and private sources.


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Patent Application Support

Price on request

Designing experiments around patentability assessments.
Assisting in the patent design and submissions process.


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