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Forcyte Biotechnologies, Inc

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Los Angeles, California, US

About Forcyte Biotechnologies, Inc

Forcyte Biotechnologies, Inc. was formed to leverage FLECS Technology (originally developed in the Di Carlo Lab @ UCLA) to provide drug-makers and researchers direct access to cellular force generation at the single-cell level – a cellular behavior that was previously inaccessible in an automated way.

We provide a fundamentally new class of cell-based assays that functionally evaluate single-cell contractility, integrated into standard multi-wellplate vessels – available both as end-to-end services, and as consumables.

Our Services (3)


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Human Precision-Cut Lung Slice Assays

Price on request

Precision-Cut Lung Slice / ex vivo model for lung fibrosis

We induce fibrotic activation and phenotypes in human PCLS using fibrotic growth factors and evaluate fibrotic gene expression using RT-qPCR to evaluate effects of test compounds.


Inquire for more details.


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Cell-Based Assays

Price on request

Functional single-cell contractility / contraction / traction force assay -- use proprietary single-cell assay modality to quantify contractile cell force in 100s of primary cells simultaneously using automation. Ref: https://www.nature.com/articles/s41551-018-0193-2


Services:


- Screen compound libraries for effects on mechanical contraction of cells (384 format / >5K cmpds per day)


- Dose-response testing (20 steps / 2 fold serial dilution)


- Synergy testing of compound combinations




Relevant biology:


-Respiratory / airway smooth muscle contraction


-Reproductive / uterine smooth muscle contraction


- CV / arterial smooth muscle contraction


- bladder / bladder smooth muscle contraction




Other capabilities:


- precision cut lung slice model of pulmonary fibrosis






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High Throughput Screening (HTS)

Price on request

We can perform HTS for effects on contractility in numerous primary cell types using our 200K compound library, or using your compounds


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Ivan Pushkarsky

President

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