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Expesicor

Kalispell, MT, US

We offer an array of preclinical GLP-compliant services. Our core competence is neuroscience R&D. Our primary techniques are used for in vitro and in vivo efficacy and toxicology. For example, induced hippocampal neurodegeneration (neuroprotection), rodent epilepsy/seizure models, transgenic models, video-EEG monitoring, behavioral assays, and histology. Our focus disease areas include neurodegenerative disorders, e.g. Alzheimer's, epilepsy, and neurological injury, e.g. traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE).

Selected publications

  • Kienzler-Norwood F, et al. "A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam." Epilepsia. 2017.
  • Meyer M, et al. "Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of... Show more »

We offer an array of preclinical GLP-compliant services. Our core competence is neuroscience R&D. Our primary techniques are used for in vitro and in vivo efficacy and toxicology. For example, induced hippocampal neurodegeneration (neuroprotection), rodent epilepsy/seizure models, transgenic models, video-EEG monitoring, behavioral assays, and histology. Our focus disease areas include neurodegenerative disorders, e.g. Alzheimer's, epilepsy, and neurological injury, e.g. traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE).

Selected publications

  • Kienzler-Norwood F, et al. "A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam." Epilepsia. 2017.
  • Meyer M, et al. "Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis." Nature Scientific Reports. 2016
  • Will J, et al. "Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis." Behavioral Brain Research. 2013.
  • Norwood BA, et al. "Electrical stimulation-induced seizures in rats: a dose-response study on resultant neurodegeneration." Epilepsia. 2011.
  • Norwood BA, et al. “Classic hippocampal sclerosis and hippocampal-onset epilepsy produced by a single "cryptic" episode of focal hippocampal excitation in awake rats.“ Journal of Comparative Neurology. 2010.
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Expesicor has not listed any services.

Microbiome Studies
Price on request

Services to analyze and quantify microbial populations within samples, e.g. stool or cecal.

Services to analyze and quantify microbial populations within samples, e.g. stool or cecal.

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Microbiome Sequencing
Price on request

Methods including 16s/18s RNA, DNA sequencing, and Bioinformatics to determine alpha- and beta-diversity of populations within a sample.

Methods including 16s/18s RNA, DNA sequencing, and Bioinformatics to determine alpha- and beta-diversity of populations within a sample.

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Preclinical Histology
Price on request

Various histological methods including Nissl staining and immunocytochemistry/immunohistochemistry, and analyses such as stereology (i.e. neuron counting). Also stains for neurodegeneration, such as Fluorojade.

Various histological methods including Nissl staining and immunocytochemistry/immunohistochemistry, and analyses such as stereology (i.e. neuron counting). Also stains for neurodegeneration, such as Fluorojade.

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neurodegenerative diseases
Epilepsy
TBI
Animal Behavior Studies
Price on request

We offer an array of behavioral assays that includes, but is not limited to: Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test.

We offer an array of behavioral assays that includes, but is not limited to: Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test.

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neurodegenerative diseases
Epilepsy
TBI
Neurodegeneration Animal Models
Price on request

Various in vivo rodent models of neurodegeneration, based on chemical (e.g. kainic acid) and electrical (e.g. perforant pathway) stimulation.

Various in vivo rodent models of neurodegeneration, based on chemical (e.g. kainic acid) and electrical (e.g. perforant pathway) stimulation.

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neuroscience
neurodegenerative diseases
Alzheimer
Parkinson
Epilepsy & Seizure Animal Models
Price on request

Includes evoked and spontaneous seizure models. With and without video-EEG monitoring.

Includes evoked and spontaneous seizure models. With and without video-EEG monitoring.

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CNS/Neurology
Epilepsy
Seizure
PTE
Animal Electroencephalography (EEG)
Price on request

Video-EEG monitoring (mice and rats) utilizing telemeters (for free movement) and infrared cameras.

Video-EEG monitoring (mice and rats) utilizing telemeters (for free movement) and infrared cameras.

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DNA Sequencing
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Animal Models and Studies
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Animal Model in vivo Analyses
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Animal Models of Disease
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Biology
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Cells and Tissues
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Next Generation Sequencing (NGS)
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Microbiology, Virology, and Parasitology
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Animal Learning, Memory, and Behavior Tests
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CNS/Neurology Animal Models
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DNA
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Animal Cognition & Behavior Tests
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Biochemistry & Molecular Biology
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Animal Imaging
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Nucleic Acid Services
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Microbiology Assays
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