We offer an array of preclinical GLP-compliant services. Our core competence is neuroscience R&D with a focus in epilepsy and epilepsy-like disease modeling and treatment. Our goal is to provide the infrastructure necessary for Investigational New Drug (IND) development for the prevention and cure of neurologic disease. Our primary techniques are used for in vitro and in vivo drug development, addressing efficacy and toxicology. Techniques and models include: induced hippocampal neurodegeneration and subsequent neuroprotection against, rodent models, transgenic models, video-EEG monitoring, behavioral assays, microbiome sequencing/analysis, and histology. Disease areas include neurological disorders, e.g. Alzheimer's disease (AD), epilepsy, traumatic brain injury (TBI), mild cognitive impairment, and chronic traumatic encephalopathy (CTE).Services Hippocampal neurodegeneration (neuroprotection), rodent models, transgenic models, video-EEG monitoring, behavioral assays, microbiome sequencing/analysis, histology, preclinical study design, best practice consulting for data and IP security, and experimental design around patentability assessments. Our team has experience navigating and strategizing intellectual property filings. We are a patent holding company (drug and animal model patents) with vast experience designing experiments around legal patentability assessments. Our team has experience applying to ~25 U.S state/federal, European, and foundation grants. Several grants have been received by our researchers. **Selected publications** - Kienzler-Norwood F, et al. "A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam." *Epilepsia*. 2017. - Meyer M, et al. "Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis." *Nature Scientific Reports*. 2016 - Will J, et al. "Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis." *Behavioral Brain Research*. 2013. - Norwood BA, et al. "Electrical stimulation-induced seizures in rats: a dose-response study on resultant neurodegeneration." *Epilepsia*. 2011. - Norwood BA, et al. “Classic hippocampal sclerosis and hippocampal-onset epilepsy produced by a single "cryptic" episode of focal hippocampal excitation in awake rats.“ *Journal of Comparative Neurology*. 2010.
Various in vivo rodent models of neurodegeneration, based on chemical (e.g. kainic acid) and electrical (e.g. perforant pathway) stimulation.
Various histological methods including Nissl staining and immunocytochemistry/immunohistochemistry, and analyses such as stereology (i.e. neuron counting). Also stains for neurodegeneration, such as Fluorojade.
We have substantial experience designing dozens of preclinical experiments.
Includes evoked and spontaneous seizure models. With and without video-EEG monitoring.
Efficacy studies on neuroprotection, anti-seizure, and anticonvulsant effects. Relevant to various neurodegenerative disorders and brain injury.
Video-EEG monitoring (mice and rats) utilizing telemeters (for free movement) and infrared cameras
Consulting on data security best practices for VPNs, zero-knowledge cloud storage platforms, intellectual property data storage best practices, private 1:1 communication methods, enterprise-grade security communication platforms.
Services to analyze and quantify microbial populations within samples, e.g. stool or cecal.
Rodent models of neurological disorders/injuries.
We offer an array of behavioral assays that includes, but is not limited to: Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test.
Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test
Clinical and Anatomic Pathology Services
Data Analysis and Management Services. Consulting on data security best practices for VPNs, zero-knowledge cloud storage platforms, private 1:1 communication methods, enterprise-grade security communication platforms.
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Expesicor has not received any endorsements.