Hyo18pqsuz9xkc7ik4a0 expes

Expesicor

Kalispell, Montana, US

We offer an array of preclinical GLP-compliant services. Our core competence is neuroscience R&D. Our primary techniques are used for in vitro and in vivo efficacy and toxicology. For example, induced hippocampal neurodegeneration (neuroprotection), rodent models, transgenic models, video-EEG monitoring, behavioral assays, microbiome sequencing/analysis, and histology. Our focus disease areas include neurological disorders, e.g. Alzheimer's disease (AD), epilepsy, traumatic brain injury (TBI), mild cognitive impairment, and chronic traumatic encephalopathy (CTE).

Services
Hippocampal neurodegeneration (neuroprotection), rodent models, transgenic models, video-EEG monitoring, behavioral assays, microbiome sequencing/analysis, preclinical study design, best practice consulting for data and IP security, experimental design around patentability assessments, and histology

Our team has experience... Show more »

We offer an array of preclinical GLP-compliant services. Our core competence is neuroscience R&D. Our primary techniques are used for in vitro and in vivo efficacy and toxicology. For example, induced hippocampal neurodegeneration (neuroprotection), rodent models, transgenic models, video-EEG monitoring, behavioral assays, microbiome sequencing/analysis, and histology. Our focus disease areas include neurological disorders, e.g. Alzheimer's disease (AD), epilepsy, traumatic brain injury (TBI), mild cognitive impairment, and chronic traumatic encephalopathy (CTE).

Services
Hippocampal neurodegeneration (neuroprotection), rodent models, transgenic models, video-EEG monitoring, behavioral assays, microbiome sequencing/analysis, preclinical study design, best practice consulting for data and IP security, experimental design around patentability assessments, and histology

Our team has experience navigating and strategizing intellectual property filings. We are a patent holding company (drug and animal model patents) with vast experience designing experiments around legal patentability assessments.

Our team has experience applying to ~25 U.S state/federal, European, and foundation grants. Several grants received by our researchers.

Selected publications
- Kienzler-Norwood F, et al. "A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam." Epilepsia. 2017.
- Meyer M, et al. "Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis." Nature Scientific Reports. 2016
- Will J, et al. "Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis." Behavioral Brain Research. 2013.
- Norwood BA, et al. "Electrical stimulation-induced seizures in rats: a dose-response study on resultant neurodegeneration." Epilepsia. 2011.
- Norwood BA, et al. “Classic hippocampal sclerosis and hippocampal-onset epilepsy produced by a single "cryptic" episode of focal hippocampal excitation in awake rats.“ Journal of Comparative Neurology. 2010.

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Expesicor has not listed any services.

Neurodegeneration Animal Models
Price on request

Various in vivo rodent models of neurodegeneration, based on chemical (e.g. kainic acid) and electrical (e.g. perforant pathway) stimulation.

Various in vivo rodent models of neurodegeneration, based on chemical (e.g. kainic acid) and electrical (e.g. perforant pathway) stimulation.

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neuroscience
neurodegenerative diseases
Cognitive decline
Alzheimers Disease
AD
Parkinsons Disease
TBI
PTE
Mild cognitive impairment
Dementia
traumatic brain injury
Seizure Disorders
post traumatic epilepsy
Preclinical Histology
Price on request

Various histological methods including Nissl staining and immunocytochemistry/immunohistochemistry, and analyses such as stereology (i.e. neuron counting). Also stains for neurodegeneration, such as Fluorojade.

Various histological methods including Nissl staining and immunocytochemistry/immunohistochemistry, and analyses such as stereology (i.e. neuron counting). Also stains for neurodegeneration, such as Fluorojade.

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neurodegenerative diseases
Cognitive decline
Alzheimers Disease
AD
Epilepsy
TBI
PTE
Mild cognitive impairment
Dementia
traumatic brain injury
Seizure Disorders
post traumatic epilepsy
Digital Pathology Image Analysis
Price on request
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Preclinical Study Design
Price on request

We have substantial experience designing dozens of preclinical experiments.

We have substantial experience designing dozens of preclinical experiments.

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Epilepsy & Seizure Animal Models
Price on request

Includes evoked and spontaneous seizure models. With and without video-EEG monitoring.

Includes evoked and spontaneous seizure models. With and without video-EEG monitoring.

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Mouse
Rat
CNS/Neurology
Epilepsy
Seizure
PTE
Seizure Disorders
post traumatic epilepsy
Preclinical Population Studies
Price on request
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In vivo Drug Efficacy Testing
Price on request

Efficacy studies on neuroprotection, anti-seizure, and anticonvulsant effects. Relevant to various neurodegenerative disorders and brain injury.

Efficacy studies on neuroprotection, anti-seizure, and anticonvulsant effects. Relevant to various neurodegenerative disorders and brain injury.

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Histology and Pathology Services
Price on request
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Animal Electroencephalography (EEG)
Price on request

Video-EEG monitoring (mice and rats) utilizing telemeters (for free movement) and infrared cameras

Video-EEG monitoring (mice and rats) utilizing telemeters (for free movement) and infrared cameras

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neurodegenerative diseases
Alzheimers Disease
Epilepsy
EEG
TBI
PTE
Parkinson's disease
Mild cognitive impairment
Dementia
traumatic brain injury
Seizure Disorders
post traumatic epilepsy
video eeg
Infrared cameras
Telemeters
Video-EEG monitoring
Data Science International telemetry
Cybersecurity Consulting
Price on request

Consulting on data security best practices for VPNs, zero-knowledge cloud storage platforms, intellectual property data storage best practices, private 1:1 communication methods, enterprise-grade security communication platforms.

Consulting on data security best practices for VPNs, zero-knowledge cloud storage platforms, intellectual property data storage best practices, private 1:1 communication methods, enterprise-grade security communication platforms.

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Microbiome Sequencing
Price on request

Methods including 16s/18s RNA, DNA sequencing, and Bioinformatics to determine alpha- and beta-diversity of populations within a sample.

Methods including 16s/18s RNA, DNA sequencing, and Bioinformatics to determine alpha- and beta-diversity of populations within a sample.

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16S
16S rDNA sequencing
Bioinformatics
DNA sequencing
18s
18s RNA
Microbiome Studies
Price on request

Services to analyze and quantify microbial populations within samples, e.g. stool or cecal.

Services to analyze and quantify microbial populations within samples, e.g. stool or cecal.

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16S
feces
Cecum
16S rDNA sequencing
DNA sequencing
Animal Models of Disease
Price on request

Rodent models of neurological disorders/injuries.

Rodent models of neurological disorders/injuries.

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CNS/Neurology
Alzheimers Disease
AD
PD
Parkinsons Disease
Epilepsy
EEG
TBI
PTE
traumatic brain injury
Seizure Disorders
post traumatic epilepsy
Video-EEG monitoring
Animal Behavior Studies
Price on request

We offer an array of behavioral assays that includes, but is not limited to: Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test.

We offer an array of behavioral assays that includes, but is not limited to: Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test.

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neurodegenerative diseases
Barnes maze
Epilepsy
TBI
traumatic brain injury
post traumatic epilepsy
Morris water maze
Radial arm (water) maze
Rotorod
Novel object recognition
Object-place recognition task
Open-field test
Animal Learning, Memory, and Behavior Tests
Price on request

Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test

Barnes maze, Morris water maze, radial arm (water) maze, rotorod, novel object recognition, object-place recognition task, open-field test

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neurological
CNS/Neurology
Open field
neurodegenerative diseases
Barnes maze
Object recognition test
Alzheimers Disease
AD
PD
Epilepsy
TBI
PTE
Parkinson's disease
traumatic brain injury
post traumatic epilepsy
Morris water maze
Radial arm (water) maze
Rotorod
Novel object recognition
Object-place recognition task
Open-field test
Next Generation Sequencing (NGS)
Price on request
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DNA Sequencing
Price on request
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Animal Model in vivo Analyses
Price on request
Request a quote for more information about this service.
CNS/Neurology
histology
neurodegenerative diseases
Alzheimers Disease
AD
PD
Parkinsons Disease
Epilepsy
EEG
TBI
Seizure
PTE
traumatic brain injury
Seizure Disorders
post traumatic epilepsy
Video-EEG monitoring
Animal Cognition & Behavior Tests
Price on request
Request a quote for more information about this service.
Open field
Barnes maze
Object recognition test
Morris water maze
Radial arm (water) maze
Rotorod
Novel object recognition
Object-place recognition task
Open-field test
CNS/Neurology Animal Models
Price on request
Request a quote for more information about this service.
CNS/Neurology
neurodegenerative diseases
Alzheimers Disease
AD
PD
Epilepsy
TBI
PTE
Parkinson's disease
traumatic brain injury
Seizure Disorders
post traumatic epilepsy
David Kopf
Data Sciences International DSI
infrared video cameras
Nucleic Acid Services
Price on request
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Microbiology
Price on request
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Animal Models and Studies
Price on request
Request a quote for more information about this service.
neurodegenerative diseases
Cognitive decline
Alzheimers Disease
AD
PD
TBI
PTE
Parkinson's disease
Mild cognitive impairment
Dementia
traumatic brain injury
post traumatic epilepsy
Clinical and Anatomic Pathology
Price on request

Clinical and Anatomic Pathology Services

Clinical and Anatomic Pathology Services

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Clinical Laboratory Services
Price on request

Clinical Laboratory Services

Clinical Laboratory Services

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Clinical Research
Price on request

Clinical Research Services

Clinical Research Services

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Image Analysis
Price on request

Image Analysis Services

Image Analysis Services

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Data Services
Price on request

Data Analysis and Management Services. Consulting on data security best practices for VPNs, zero-knowledge cloud storage platforms, private 1:1 communication methods, enterprise-grade security communication platforms.

Data Analysis and Management Services. Consulting on data security best practices for VPNs, zero-knowledge cloud storage platforms, private 1:1 communication methods, enterprise-grade security communication platforms.

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Project and Process Management
Price on request

Project Management & Consulting Services

Project Management & Consulting Services

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Histopathological Examination
Price on request
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Experimental Design
Price on request
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