EGC provides ICH-guidelines-
compliant glycosylation analysis services.
EGC is the analytical services branch of Procognia Ltd, a
leader in glycobiology research for over a decade.
EGC's experienced customer services team consists of
dedicated, highly qualified biochemists and
glycobiologists. We continuously expand our technics and
methods to provide our customers with top notch, up-todate,
high quality analyses.
Our services include:
N-link glycan Analysis by HPLC and Mass spectrometry
O-link glycan Analysis by HPLC and Mass spectrometry
Profiling and quantitative
analysis of sialic acid
High Throughput Analysis Using GlycoScope
Expert Consultancy regarding various factors in the development stages of biopharmaceuticals that may affect the glycosylation profile of the product, including cell line clone, fermentation conditions and purification methods.
Quantitative Monosaccharide Analysis. Monosaccharide analysis is used to identify and quantify the different monosaccharide residues of N-link and O-link glycans bound to a glycoprotein. In addition, it can be applied to quantify the number of glycans bound to a glycoprotein, and for detection of carbohydrate impurities in the purified biopharmaceutical sample.
Profiling and quantitative analysis of sialic acid: NeuAc and NeuGc (NANA NGNA).
N-Linked Glycosylation Analysis
Analysis of the N-linked glycan structures of a glycoprotein determines their glycan type and abundance.
This analysis provides quantitative information for:
• Glycan antennary: 1-antennary, 2-antennary,
3-antennary and 4-antennary.
• Fucose residues, antennary fucose or core fucose.
• Sialic acids distribution.
• Glycan termini residues: N-acetyl-galactoseamine
(GalNAc), bisecting N-acetyl-glucosamine
(GlcNAc), and the antigenic structure � 1-3 galactose.
• High mannose and hybrid structures.
$475 per sample
GlycoScope™ is a rapid, quantitative, multiple-sample glyco-analytical tool for monoclonal antibodies (mAbs). This analysis provides quantitative information for: • G0/G1/G2 precentage • Core fucose abundance • Sialic acid quantitation • The antigenic structure � 1-3 galactose • High mannose GlycoScope™ is applicable for screening mAb glycosylation profiles during the entire process of biopharmaceutical development and manufacturing, including cell line and clone selection, upstream and downstream process development and manufacturing in-process control.
O-link Glycosylation Analysis
Analysis of the O-linked glycan structures of a glycoprotein determines their glycan type and abundance.
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