With a longstanding tradition of quality and service, ExonBIO expands the capabilities of academic laboratories, biotechnology companies and pharmaceutical companies involved in generating new leads and developing therapeutics. We work in partnership with our clients to ensure the most efficient and cost effective way to generate superior recombinant proteins for structural based drug discovery, HTS, and functional validation for drug discovery.
Our novel proprietary Single Plasma Cell Interrogation (SPIN®) technology capable of developing monoclonal antibodies from any animals (rabbit, Llama, chicken, cow, sheep or human), the broad epitope coverage and high affinity made the technology perfect for therapeutics and diagnostic antibody development. Our mammalian transient expression platforms are revolutionary in recombinant protein and antibody production. Our know-how and experience enable us to provide premium quality molecular biology and protein expression services to academia, biotech and pharmaceutical companies.
ExonBIO offers fast and professional antibody cloning and sequencing services for your valuable monoclonal antibodies. We can sequence from any antibody producing cell line with a service that can be tailored to your requirements.
Why sequence your McAb:
What we offer:
Antibody engineering holds the potential for creating antibodies with multiple specificities, greater affinity for their targets, and fewer side effects. Among these approaches, more-or-less traditional protein engineering remains a topic of intense interest.
Stable Cell Pool: With stable promoter and antibiotic selection, the stale cell pool can produce grams of antibody within short timeline.
Stable Cell Line: Either for research or for manufacture, we can generate stable cell line at the yield of 1 gram/liter industrial production level.
Developing monoclonal antibody from common species, such as rabbit, llama or chicken; or not so common species, such as shark, cow, sheep or vaccinated/pathogen infected human.
SPIN® technology started with plasma cells, the most mature B cell population and screening antigen-specific antibody clones one by one avoid the bias of epitope selection. Antibody generate by SPIN® shows high affinity and broad diversity.
Our proprietary Single Plasma Cell Interrogation (SPIN® ) platform uses microfluidic technology to combine the identification and isolation of antigen-specific matured plasma cells. Automation-facilitated high-throughput screening has made the interrogation of the natural antibody repertoire possible.
As part of our additional services, exonbio provides SPIN® Grade peptide synthesis services.
SPIN® Grade: purity > 95%, LC-MS verified.
Applications: Immunization, Antigen specific cell selection and Antibody screening
Mammalian transient expression with proprietary transfection reagent (TransPERfect®), 5-fold cheaper than the MAX reagent from Invitrogen, 2-fold higher yield than MAX reagent.
High yield and efficient purification (protein A, Nickel, Ion exchange, Heparin, SEC), QC with SDS-PAGE, analytic SEC, Endotoxin-free.
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