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EXCILONE

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Elancourt, FR

About EXCILONE

Since its creation Excilone has developed an unique expertise in sample’s analysis through the image or the molecular content.
We use what we sell and we sell what we use
Our dual approach of service provider as well as vendor of our solutions brings us an unequaled expertise on the performance and the use... Show more »

Since its creation Excilone has developed an unique expertise in sample’s analysis through the image or the molecular content.
We use what we sell and we sell what we use
Our dual approach of service provider as well as vendor of our solutions brings us an unequaled expertise on the performance and the use of our products that benefit our customers.
Pharmaceutical and cosmetic companies, academic research labs and other CROs are all users of our services.
Our R&D department allows us to regularly supplement our offer as recently with the isolation, characterization and analysis of extracellular vesicles from any type of sampling (blood, urine, milk, tissues, …).
Our services are aimed at all private and academic labs that need to use operational analysis techniques without having to invest in expensive devices which also are time consuming to set protocols and to validate them.
To reply to the needs of the scientific community about the analysis of samples through images or molecular content Excilone offers a wide range of services in Microgenomics, Nanogenomics, and Cellular Imaging. As the understanding of biological phenomena is now done at the scale of the cell,
Excilone presents you the excellence in epsilon quantity.

Our vision
To give you access to the most innovative technologies with experts recognized in their application field. To improve research methods to understand the birth of molecular mechanisms before they are detectable by current techniques.
With Excilone services the Future is now.

Our values
Expertise • Well-known specialists in their application field to perform your projects.
Quality • Qualified teams that follow a strict quality management process.
Innovation • Experts who develop new approaches and push current limits.
Confidentiality • Works done in complete confidentiality with signatures of protocols (NDA, …) if necessary.
Listening • Technical referents to understand your projects and reply to your needs.

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Our Services (97)


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RNAscope Assay

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Zeta Potential Measurement Training

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Zeta Potential Measurements

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Whole Section Image Analysis

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Trichrome Staining

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Tissue Slide Preparation

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Tissue Sectioning

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Tissue Section Imaging

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Tissue Processing

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Tissue Preparation

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Tissue Fixation

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Tissue Embedding

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Tissue Decalcification

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Special Slide Staining

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Single Cell Isolation

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DEPArray cell isolation

DEPArray cell isolation

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Single Cell Gene Expression Analysis

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RNA Quantification

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RNA Extraction and Purification

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Quantitative Image Analysis

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Quantitative Histology

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Proteomics

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Protein Quantification

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Protein Purification

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Protein Expression Visualization

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Protein Characterization

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Preclinical Histology

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Particle Size Distribution

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Particle Analysis and Characterization

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Paraffin Sectioning

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Paraffin Embedding

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Orcein Staining

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Microscopy Image Analysis

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Microarray Experimental Design

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Microarray Data Analysis

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Microarray Spotting

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Microarray Scanning

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Masson's Trichrome Staining

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Laser Capture Microdissection Training

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In situ Hybridization (ISH)

In Situ Hybridization
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RNA Scope Chromogenic

RNA Scope Chromogenic

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Immunostaining Experimental Design

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Immunostaining

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Multiplex Immunohistochemistry (mIHC)

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Immunohistochemistry (IHC)

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Immunofluorescence

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Immunocytochemistry

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Imaging Training

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Imaging Technology Platforms

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ImageJ Image Analysis

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Image Processing and Analysis Training

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Histopathology Consulting

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Histopathologic Scoring

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Histomorphometric Analysis

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Histomorphological Analysis

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Histology Control Slides

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Histological Staining

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HALO Image Analysis

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H&E Staining

Hematoxylin and eosin staining
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Genomic DNA Extraction

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Fluorescence-Based Microscopy

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Fluorescence in situ Hybridization (FISH)

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RNA Scope Fluorescence

RNA Scope Fluorescence

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Fixed Human Tissue

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Feasibility Studies

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Extracellular Vesicle Analysis

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Exosome Isolation and Characterization

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Exosomal RNA Sequencing

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Equipment

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Equipment Maintenance and Support

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DNA/RNA Analysis and Quality Control

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DNA Services

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DNA Hybridization

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DNA Extraction

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DNA Extraction and Purification

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Digital Pathology Software

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Digital Pathology Image Analysis

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Digital Microscopy

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Custom Proteomics

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Cryosectioning

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Coverslipping

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Common Histochemical Stains

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Bright-Field Microscopy

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Biochemistry & Molecular Biology

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Automated Image Analysis

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Anatomic Pathology

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Antibody Validation

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Antibody Optimization

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Antibody Characterization

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Image Acquisition and Slide Digitization

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Brightfield, Fluorescence and FISH, Mega Slide:

  • Histology slides (H&E, HES, special stains)
  • IHC and ISH slides
  • A choice of different resolutions for final images according to your applications
  • Any size of slides from the standard one (75 x 25 mm) to 150 x 200 mm
  • Ability to scan slides by using oil immersion objective for... Show more »

Brightfield, Fluorescence and FISH, Mega Slide:

  • Histology slides (H&E, HES, special stains)
  • IHC and ISH slides
  • A choice of different resolutions for final images according to your applications
  • Any size of slides from the standard one (75 x 25 mm) to 150 x 200 mm
  • Ability to scan slides by using oil immersion objective for higher resolution and quality
  • High throughput scanning up to 400 slides per day
  • Virtual slides files sent on external hard disk or through remote access (please refer to Sharing Platform part)
  • Up to 5 colors + DAPI (Fluorescence and FISH)
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Histology and Pathology Services

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Excilone services cover the whole histology process:

  • Chemical fixation and tissue processing or tissue freezing (SnapFrost®)
  • Sectioning : paraffin sections, frozen sections, floating sections, fresh or fixed tissue sections
  • Histology staining (H&E and special stains), IHC, HIS
  • Tissue Micro-Arrays paraffin TMA(Minicore®)... Show more »

Excilone services cover the whole histology process:

  • Chemical fixation and tissue processing or tissue freezing (SnapFrost®)
  • Sectioning : paraffin sections, frozen sections, floating sections, fresh or fixed tissue sections
  • Histology staining (H&E and special stains), IHC, HIS
  • Tissue Micro-Arrays paraffin TMA(Minicore®) and frozen TMA
  • Slides scanning
  • Bright field, fluorescence (up to 5 colors + DAPI), FISH on tissue
  • Any size of slide from the standard one to a 150x200 mm size
  • A fleet of 3 different devices
  • Image analysis in bright field or in fluorescence
  • Slides reading
  • Virtual slides sharing platform
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Lab Equipment Rental

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Tissue Microarrays

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Excilone offers a complete Service around TMA technique :

  • Paraffin and frozen TMA
  • TMA sections and staining protocols
  • Slide scanning
  • Image analysis (Spot Browser® 4)
  • Statistical studies (Tisalys®)
  • Data traceability from donor blocks

Excilone offers a complete Service around TMA technique :

  • Paraffin and frozen TMA
  • TMA sections and staining protocols
  • Slide scanning
  • Image analysis (Spot Browser® 4)
  • Statistical studies (Tisalys®)
  • Data traceability from donor blocks
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Whole Slide Imaging/Digital Slide Scanning

Price on request

Brightfield, Fluorescence and FISH, Mega Slide:

  • Histology slides (H&E, HES, special stains)
  • IHC and ISH slides
  • A choice of different resolutions for final images according to your applications
  • Any size of slides from the standard one (75 x 25 mm) to 150 x 200 mm
  • Ability to scan slides by using oil immersion objective for... Show more »

Brightfield, Fluorescence and FISH, Mega Slide:

  • Histology slides (H&E, HES, special stains)
  • IHC and ISH slides
  • A choice of different resolutions for final images according to your applications
  • Any size of slides from the standard one (75 x 25 mm) to 150 x 200 mm
  • Ability to scan slides by using oil immersion objective for higher resolution and quality
  • High throughput scanning up to 400 slides per day
  • Virtual slides files sent on external hard disk or through remote access (please refer to Sharing Platform part)
  • Up to 5 colors + DAPI (Fluorescence and FISH)
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Image Analysis

Price on request

Image Analysis in bright field and fluorescence

  • Area quantification
  • IHC quantification (nuclear staining, cytoplasm staining, membrane staining)
  • Object counting
  • Signal Co-localization
  • Image Analysis for amplification, break-apart probes, spot counting

Image analysis protocol may require a pre-study step (feasibility... Show more »

Image Analysis in bright field and fluorescence

  • Area quantification
  • IHC quantification (nuclear staining, cytoplasm staining, membrane staining)
  • Object counting
  • Signal Co-localization
  • Image Analysis for amplification, break-apart probes, spot counting

Image analysis protocol may require a pre-study step (feasibility testing).

  • Whole slide or ROI Image analysis
  • TMA Image Analysis
  • Analyze of ROI on FISH slides. Matching from a bright field image
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Digital Pathology Services

Price on request

Excilone solutions for Digital Histo-Pathology (Virtual Pathology) allow with a high resolution the scanning, the management and the sharing of virtual slides (non-treated, immunofluorescence and FISH).
Access and management of slides are now very simple to handle allowing an easy request for a second opinion when needed:... Show more »

Excilone solutions for Digital Histo-Pathology (Virtual Pathology) allow with a high resolution the scanning, the management and the sharing of virtual slides (non-treated, immunofluorescence and FISH).
Access and management of slides are now very simple to handle allowing an easy request for a second opinion when needed: tele-pathology, collaborative research projects or educative program.
Quantification of biomarkers by image analysis for prognosis and research purpose is also possible with our software solutions for analysis with customizable image selection.
To meet your needs Excilone also offers investment solutions, rental solution and services for e-pathology and image analysis.
Nothing like the canvas to create links between pathologists and researchers!

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Laser Capture Microdissection

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LCM: Laser Capture Microdissection takes on your challenges

  • Collect a pure cells population from an heterogeneous sample
  • Visualize, identify, isolate and control with the unique technology of Arcturus'instruments
  • Obtain enough materials for your downstream analysis
  • Maintain perfect integrity of your biomolecules
  • Obtain... Show more »

LCM: Laser Capture Microdissection takes on your challenges

  • Collect a pure cells population from an heterogeneous sample
  • Visualize, identify, isolate and control with the unique technology of Arcturus'instruments
  • Obtain enough materials for your downstream analysis
  • Maintain perfect integrity of your biomolecules
  • Obtain reproductible analysis
  • Laser capture microdissection services are under quality management procedures and are ISO9001 certified

Arcturus instruments, a unique technology

  • Capture using IR laser and cut using UV laser
  • The unique IR laser technology from Arcturus does not impact your biomolecules
  • Arcturus intruments are the only ones coupling IR and UV lasers
  • Targeted cells or aeras are "fixed" on a support, allowing visual control after isolation from an heterogeneous tissue

For all tissues types

  • Fresh
  • Frozen
  • Fixed (FFPE)

Obtain your biomolecules of interest from pure populations

  • DNA
  • RNA
  • Proteins
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Nanoparticle Tracking Analysis

Price on request

Excilone offers an expertise in isolation of extracellular vesicles (EVs) and Exosomes, their characterization, and analysis of their nucleic acid (mRNA, miRNA, DNA), protein and lipid content

Proposed procedure in Exosome studies:

  • Isolation of the extracellular vesicles and their subpopulations (exosomes, microvesicles,... Show more »

Excilone offers an expertise in isolation of extracellular vesicles (EVs) and Exosomes, their characterization, and analysis of their nucleic acid (mRNA, miRNA, DNA), protein and lipid content

Proposed procedure in Exosome studies:

  • Isolation of the extracellular vesicles and their subpopulations (exosomes, microvesicles, etc.)
  • Morphological and morphometric validation of the EV sub-populations by Transmission Electron Microscopy (TEM) with negative staining
  • Measurement of size distribution and particle concentration by DLS, NTA or TRPS
  • Determination of the EV/Exosome protein concentration
  • Detection of the specific EV/Exosome protein markers by Western blotting and ELISA
  • Analysis of exosome protein content by LC-MS/MS approach and nucleic acid composition (mRNA, miRNA) by NGS and RT-PCR
  • Feasibility study
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Scanning Probe Microscopy

Price on request
  • A choice of different resolutions for final images according to your applications: - 0.25 μm/pxl (40X) / 0.5 μm/pxl (20X) / 1 μm/pxl (10X)
  • Scanning by using 60x oil immersion objective with a resolution of 0,107 µm/pixel for FISH on tissue slides
  • Up to 5 colors + DAPI
  • Virtual slides files sent on external hard disk or... Show more »
  • A choice of different resolutions for final images according to your applications: - 0.25 μm/pxl (40X) / 0.5 μm/pxl (20X) / 1 μm/pxl (10X)
  • Scanning by using 60x oil immersion objective with a resolution of 0,107 µm/pixel for FISH on tissue slides
  • Up to 5 colors + DAPI
  • Virtual slides files sent on external hard disk or through remote access (please refer to Sharing platform part)

Virtual slides allows to visualize the stained sections on a computer.

It also gives access to many measurement tools (length, area, …), annotation tools, sharing tools through the web and Image analysis algorithms.

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Omics

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Bertrand Damart

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Stéphanie Fage

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Nicolas Virely

Sales Manager

FileType/PDF Created with Sketch. Excilone - Amplification ARN GB.pdf

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FileType/PDF Created with Sketch. Excilone - Exosome GB.pdf

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FileType/PDF Created with Sketch. Excilone - FFPE GB.pdf

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