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EpiCypher

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Research Triangle Park, North Carolina, US

About EpiCypher

EpiCypher offers cutting edge tools and service for epigenetics and chromatin biology research. We pioneered the manufacture of designer recombinant nucleosomes that contain defined post-translational modifications. Our latest product, SNAP-ChIP, is the gold standard for antibody validation for chromatin IP,... Show more »

EpiCypher offers cutting edge tools and service for epigenetics and chromatin biology research. We pioneered the manufacture of designer recombinant nucleosomes that contain defined post-translational modifications. Our latest product, SNAP-ChIP, is the gold standard for antibody validation for chromatin IP, and also serves as the most reproducible spike-in for normalizing ChIP and ChIP-seq assays. EpiCypher also develops assays for chromatin-modifying enzymes and PTM-binding proteins using a variety of readouts, such as Alpha, FRET and radioactivity, employing nucleosome or peptide-based substrates.

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Our Services (13)


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Antibody Validation

Starting at $1,000.00 per sample

Histone PTM-specific Antibody Validation

EpiCypher provides application-specific validation services for histone PTM-specific antibodies. Antibodies can be validated in either histone or nucleosomal context, depending on end-users needs. SNAP-ChIP pioneers the use of DNA barcoded recombinant designer nucleosomes (dNucs) as... Show more »

Histone PTM-specific Antibody Validation

EpiCypher provides application-specific validation services for histone PTM-specific antibodies. Antibodies can be validated in either histone or nucleosomal context, depending on end-users needs. SNAP-ChIP pioneers the use of DNA barcoded recombinant designer nucleosomes (dNucs) as next-generation spike-ins for chromatin immunoprecipitation (ChIP).

Multiple platforms available

  • SNAP-ChIP: First-in-class specificity testing for ChIP assays
  • AlphaLISA / AlphaScreen: For high-throughput biochemical and cell-based assays
  • ELISA: For biochemical or cell-based assays
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Luminex FLEXMAP 3D Histone modification SNAP-ChIP Nucleosome Histone Drug Discovery Genomics Epigenetics Histone modification antibodies Luminex® AlphaScreen AlphaLISA Show 12 more tags Show less

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High Throughput Chromatin Remodeling Assays

Price on request

Chromatin Remodeling HTS assays

EpiCypher has developed EpiDyne, a family of recombinant nucleosome substrates to monitor chromatin remodeling activity in vitro.

Services capabilities

- Assay development / optimization
- Inhibitor profiling / specificity testing
- HTS assay optimization /... <a class="nowrap js-toggle-description" href="#">Show more »</a>

Chromatin Remodeling HTS assays

EpiCypher has developed EpiDyne, a family of recombinant nucleosome substrates to monitor chromatin remodeling activity in vitro.

Services capabilities

- Assay development / optimization
- Inhibitor profiling / specificity testing
- HTS assay optimization / miniaturization

Multiple assay formats

- FRET
- Restriction Enzyme Accessibility
- DAM methyltransferase
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TR-FRET Restriction Enzyme Accessibility DAM methyltransferase Epigenetics

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Recombinant Nucleosomes

Price on request

Custom Modified Nucleosome Development

Nucleosomes are the in vivo targets of chromatin regulating proteins (i.e. readers, writers, and erasers), making them ideal biochemical substrates for drug development over peptides, providing access to historically challenging targets. EpiCypher offers a custom nucleosome development... Show more »

Custom Modified Nucleosome Development

Nucleosomes are the in vivo targets of chromatin regulating proteins (i.e. readers, writers, and erasers), making them ideal biochemical substrates for drug development over peptides, providing access to historically challenging targets. EpiCypher offers a custom nucleosome development service of fully defined and homogeneous recombinant nucleosomes incorporating different DNA and histone modifications, site mutations, or histone variants.

Services capabilities

  • Assay development / optimization
  • HTS assay optimization / miniaturization
  • Any DNA and histone modifications, site mutations and histone variants
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Epigenetics

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Chromatin Binding Interaction Discovery

Price on request

EpiCypher has developed a new epigenetics discovery service, dCypher, combining the diversity of peptide array with the high sensitivity of Alpha Technology to discover chromatin interactions.
Applications

  • Reader binding interactions discovery
  • Drug target identification and validation

EpiCypher has developed a new epigenetics discovery service, dCypher, combining the diversity of peptide array with the high sensitivity of Alpha Technology to discover chromatin interactions.
Applications

  • Reader binding interactions discovery
  • Drug target identification and validation
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Epigenetics Drug Development Reader binding interactions AlphaScreen dCypher

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Antibody Screening

Price on request

EpiCypher provides application-specific validation services for histone PTM-specific antibodies. Antibodies can be validated in either histone or nucleosomal context, depending on end-users needs. SNAP-ChIP pioneers the use of DNA barcoded recombinant designer nucleosomes (dNucs) as next-generation spike-ins for chromatin... Show more »

EpiCypher provides application-specific validation services for histone PTM-specific antibodies. Antibodies can be validated in either histone or nucleosomal context, depending on end-users needs. SNAP-ChIP pioneers the use of DNA barcoded recombinant designer nucleosomes (dNucs) as next-generation spike-ins for chromatin immunoprecipitation (ChIP).

Multiple platforms available

  • SNAP-ChIP: First-in-class specificity testing for ChIP assays
  • AlphaLISA / AlphaScreen: For high-throughput biochemical and cell-based assays
  • ELISA: For biochemical or cell-based assays
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Oncology Antibodies Epigenetics Luminex®

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Assay Development

Price on request
Request a quote for more information about this service.

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Epigenetic Studies

Price on request
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Drug Target Validation

Price on request
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Drug Target Identification

Price on request
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High Throughput Screening (HTS)

Price on request
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Chromatin Immunoprecipitation (ChIP) Assays

Price on request
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Hit Identification

Price on request

Hit Identification Services

Hit Identification Services

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Chromatin Accessibility Assay

Price on request
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AA

Ana Aza, PhD

Marketing Manager
JB

James Bone

President
MK

Mark Kaderli

Key Account Manager

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