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Enantia, S.L.

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Barcelona, ES

About Enantia, S.L.

We are a growing company specialised in R&D Process Chemistry, Solid Form Development, and Medicinal Chemistry. Our strengths are Asymmetric Chemistry and cocrystallisation technologies.

We can handle almost any kind of project related to organic chemistry, both from a technical and project management point of view. The most challenging projects are part of our day-to-day routine.

In addition to offering services to industry as a Contract Research Organisation (CRO), we also develop various internal research programs which are later commercialised through a variety of agreements and licensing options.

Our mission is to provide fully integrated chemistry services for the worldwide fine chemical, pharmaceutical and biotechnology industry with the aim to contribute all the way from initial research to a scalable route for manufacturing.

What makes us stand out from the crowd

  • Cutting-edge solid form technologies: cocrystal screening
  • Strong know-how of asymmetric synthesis
  • State-of-the-art facilities fostering high quality productivity

Our Services (21)


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Solid-State Chemistry

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The suitability of a compound or of a solid formulation depends on its physical characteristics, such as its crystalline or amorphous nature, its polymorphic identity and the presence of impurities or patented solid forms.

At Enantia we are experts in the analysis and characterisation of the solid state phase of a compound. We can help you not only in the design of the right analyses but also the interpretation of the results to get the maximum information as fast and comprehensively as possible.

To establish the quality of drug products and substances, our services include:

  • Full characterisation of a given solid form
  • Quantification of one crystalline form in another crystalline form
  • Determination of an amorphous content in a crystalline matrix or vice-versa
  • Evaluation of the presence or absence of different crystalline forms in given samples
  • Evaluation of sample thickness
  • Particle size and shape characterisation
  • Stability monitoring

Our crystallographic and analytic team plan the most relevant analyses, execute them and interpret the results for you. Selecting the right techniques and experimental conditions will be sure to obtain the required information at any stage of a project.

Available techniques

  • X-ray powder diffraction (transmission and reflection)
  • Single crystal X-ray diffraction
  • Synchrotron X-ray diffraction (powder and single crystal)
  • FTIR spectroscopy
  • Raman spectroscopy
  • Differential scanning calorimetry (DSC)
  • Thermogravimetric analysis (TGA)
  • Dynamic vapour sorption (DVS)
  • Scanning electron microscopy
  • Transmission electron microscopy (TEM)
  • Optical microscopy
  • Particle size distribution (PSD)
  • Specific surface area analysis (BET) and porosimetry
  • Karl Fischer titration

XRPD Synchrotron Differential Scanning Calorimetry (DSC) Raman Spectroscopy TGA NMR Show 6 more tags Show less

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Solid Form Screening

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One of the aims of a solid form screen is to find the optimal solid form with the ideal characteristics for development of a given substance. The choice of the form for development is usually a fine balance between physical, chemical, pharmaceutical and biopharmaceutical properties. Different screens can be performed at different points in the development process, depending on the information needed and the goal of the screen.

Enantia has its roots deep in solid forms screening. Techniques such as grinding, slurring, evaporation and crystallisation among others combined with our analytical capabilities allow us to identify new solid forms in an effective and exhaustive way. Enantia uses XRPD as a routine analytical technique during the screening stage. A complete solid form screening includes polymorph, amorphous, salt and cocrystal screening. Any of these studies can be undertaken separately or combined depending on our client interests.

Amorphous forms: The use of a variety of techniques allowing the formation of amorphous solids such as solvent evaporation, freeze drying, desolvation, melt quenching, grinding and fast precipitation.

Polymorph screening: identification of new polymorphs, solvates or hydrates is possible applying the adequate techniques to favour the appearance of stable and metastable forms.

Salt and cocrystal screening: Both our salt and cocrystal programs are based around two key factors: Strategically planned experiments, and the application of internal knowhow. These factors allow us to tackle the more ambitious projects with speed and confidence. During a cocrystal screen, special attention is paid to the solid state. The presence of a conformer or the use specific procedures of a cocrystal screen can favour the formation of new polymorphs even for compounds which have previously been studies in depth by the rest of the scientific community.

In all of the aforementioned options, preliminary characterisation of the newly found forms is usually performed to allow us to select the most promising one for the development phase. The properties measured at this stage might are project-dependent and rely on the final objective of the screen. Some of the most usual measured properties are solubility, chemical and crystalline stability under accelerated ICH conditions and hydroscopicity.

XRPD Synchrotron NMR Analytical HPLC

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Co-Crystallization

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The big advantage of cocrystals compared to salts is that cocrystallisation is also applicable to non- ionisable molecules where salt formation is not possible. Compared to amorphous solid forms, cocrystals tend to be more stable and have a more predictable behaviour. Cocrystals are also less prone to polymorphic transformations due to the higher complexity of their crystal structure when compared to single component systems, thus avoiding undesirable downstream processing surprises.

As a result of the increasing relevance of these solid forms, both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have issued guideline documents related to their regulatory classification.

We have been a pioneer in the cocrystal field, working in the area since 2006 and gaining significant expertise. Cocrystals offer great potential:

  • Improvement of solid state properties: several important characteristics of pharmaceutical substances like solubility, bioavailability, stability, hygroscopicity, morphology, filtration and flowability can be modified by means of cocrystal formation. In the case of APIs, it is noteworthy that the number of pharmaceutically-acceptable coformers is larger than the number of counterions for salt formation.
  • Chiral resolution: selective diastereomeric cocrystallisation can be achieved using an enantiomerically-pure coformer.
  • Separation and purification: cocrystals can be a good purification option, especially with non-ionisable products, consequently avoiding expensive chromatographic techniques.
  • Crystallisation of non-solid products: liquids, pastes and oily products can become a solid form by means of cocrystallisation, leading to more robust and efficient manufacturing processes.

During a cocrystal screen, special attention is paid to the solid state. The presence of a coformer or the use specific procedures of a cocrystal screen can favour the formation of new polymorphs even for compounds which have previously been studies in depth by the rest of the scientific community.

Over the last years, the number of pharmaceutical cocrystals has been increasing dramatically. Their novelty, utility and not obvious preparation make cocrystals an interesting approach from the point of view of intellectual property. In the case of commercial APIs, a patent of a cocrystal with better drug properties than previously known forms could be of high commercial value.

Cocrystals do not involve structural modification of the parent molecules, therefore, in the case of designing cocrystals of marketed drugs, their development programs (including clinical trials) will be significantly shorter and less risky than those of New Chemical Entities (NCEs).

Synchrotron XRPD TGA Differential Scanning Calorimetry (DSC) NMR co-crystallisation Analytical HPLC Show 7 more tags Show less

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Salt Screening

Price on request

Both our salt and cocrystal programs are based around two key factors: Strategically planned experiments, and the application of internal knowhow. These factors allow us to tackle the more ambitious projects with speed and confidence.


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Synchrotron Services

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When extra sensitivity is needed in either single crystal (scXRD) or powder x-ray diffraction (PXRD), synchrotron diffraction is the preferred method of choice for modern API producers and pharmaceutical companies.

At Enantia we use the ALBA synchrotron on nearly a weekly basis in order to resolve our clients more challenging projects


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Polymorphism Screening

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Identification of new polymorphs, solvates or hydrates is possible applying the adequate techniques to favour the appearance of stable and metastable forms.


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Process and Scale-Up Chemistry

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Enantia's holistic approach starts from an extensive bibliographic and IP search, which is then combined with brainstorming creative synthetic routes to target. A dynamic academic and industrial scientific board contributes to the design of new routes of synthesis, which are scouted in our laboratories.

The best identified route is then scaled-up and critical parameters are developed to ensure a quality and robust process for the production of the target molecule.

Fluent communication and transparency are always maintained with periodic meetings, conference calls and reports, all tailored to our clients needs, which facilitate a rapid and accurate technology transfer process. Learn more about our working principles.

Our strengths:

  • Chiral chemistry expertise: from its foundation, Enantia has specialised in preparing enantiomerically pure compounds.
  • Broad chemical expertise: exposure to diverse projects gives us experience with a full spectrum of chemical targets and transformations.
  • Specific purification know-how
  • Analytical method development
  • Impurity profiling: isolation, identification and synthesis.

We can tackle almost every kind of organic chemistry project although we are known as experts in the field of asymmetric synthesis.

Moreover, we are able to rapidly satisfy custom synthesis requests up to kilo-lab scale in-house, such as the synthesis of:

  • APIs and intermediates
  • Samples and reference compounds
  • Metabolites
  • Repeat samples
  • Reagents, scaffolds and building blocks
  • Cold labelled compounds (13C, D, 15N..)

Our manufacturing partners can tackle projects which need special technologies like high pressure hydrogenations and low temperature reactions. If you additionally need any chemical development we can offer you an integrated service taking care of your project at any stage and moving it forward selecting the most suitable manufacture partner for your process. In any case the quality of the service and confidentiality will follow the highest standards.


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Medicinal Chemistry

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Enantia's medicinal chemistry platform has a solid background in the design and synthesis of small molecules as ligands for a broad range of therapeutic targets, including GPCRs, enzymes, kinases, ion channels, and nuclear receptors among others. Combining our MedChem team with state-of-the-art facilities, we can contribute to different stages of a drug discovery program.

Our expertise:

  • We love chirality: the introduction of chiral centres is a successful strategy for improving properties such as selectivity and solubility by escaping from planarity. At Enantia, we are not afraid of chiral compounds. Our expertise in chiral synthesis, purification and analysis is key in delivering compounds bearing chiral centres in their enantiomerically pure form.
  • We love chemistry: we have broad experience in handling any type of chemistry including MedChem essentials such as heterocyclic chemistry, cross-coupling reactions, functional group derivatisation, and protecting groups as well as specialised chemistry such as organometallics or photochemistry.

Our team:

  • Balanced group of highly skilled synthetic organic chemists from academia combined with experienced medicinal chemists coming from the pharmaceutical industry.
  • Dynamic and adaptative to the always changing scenarios of a MedChem program.
  • Creative, pragmatic and rigorous to solve any chemistry challenge.
  • Motivated, tenacious and highly productive to comply with your project demands.


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X-Ray Powder Diffraction

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Chemical Synthesis

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Analytical Chemistry Services

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Analytical Chemistry Services


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Synthetic Chemistry

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Synthetic Chemistry Services


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Physical Analysis Methods

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Physical Analysis Methods Services


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Chemistry and Materials

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Chemistry and Materials Services


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Drug Discovery

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Drug Discovery Services


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Drug Discovery & Development

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Drug Discovery & Development Services


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X-ray Crystallography

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Chemical Stability Testing

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Quantification of Amorphous Content

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More and more the regulatory agencies are asking for our customers to demonstrate the amount of amorphous content of a product. At Enantia we have the know-how to quantify this to a high level of sensitivity. We have sucessfully completed this for our clients, transferring the developed methods so they can control the amount of amorphous with accuracy in every batch.

Do not hesitate to contact us to learn more


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Porosity/Porosimetry Analysis

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Particle Size Distribution

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