1399675051144 1fcac5fb7c358414f7ec1957e0ace79c

Empire Genomics

Buffalo, New York, US

Empire Genomics was created in 2006 from research started at the prestigious Roswell Park Cancer Institute in Buffalo, New York. The laboratory has a strong track record in the development of high throughput technologies to enable genome-wide analyses aimed at determining the underlying mechanisms for diseases. Having played a fundamental role in the Human Genome Project and created the foundational Bacterial Artificial Chromosomes which served as the basis for sequencing the genome, Empire Genomics developed significant expertise in genomic research. It is from this strong experiential base that we bring our capabilities, tools and techniques to support the research, clinical and drug discovery global community.

Realizing the possibility of where genomics tools will take medicine is not difficult to see, however for this potential to become reality will take genomic solutions which are robust and permit the high... Show more »

Empire Genomics was created in 2006 from research started at the prestigious Roswell Park Cancer Institute in Buffalo, New York. The laboratory has a strong track record in the development of high throughput technologies to enable genome-wide analyses aimed at determining the underlying mechanisms for diseases. Having played a fundamental role in the Human Genome Project and created the foundational Bacterial Artificial Chromosomes which served as the basis for sequencing the genome, Empire Genomics developed significant expertise in genomic research. It is from this strong experiential base that we bring our capabilities, tools and techniques to support the research, clinical and drug discovery global community.

Realizing the possibility of where genomics tools will take medicine is not difficult to see, however for this potential to become reality will take genomic solutions which are robust and permit the high resolution detection of genomic aberrations and their corresponding correlations to underlying phenotypes. Traditionally the field has been plagued with immature technological tools with too much inconsistency, no customization and uncontrollable variability. Empire Genomics is excited to bring its expertise to bear on these challenges.

Empire Genomics is committed to working with the scientific community to bring the best in genomic technologies to bear on the complex systems biology questions that we collectively seek to answer. We will continually work to remove costly variation, inconsistency and the lack of reproducibility that has prevented the field from rapidly moving forward with discoveries.

Certifications:
- New York State Department of Health - PFI 8680
- Clinical Laboratory Improvement Amendments (CLIA) - 33D2043745
- California State – COS 800496

Scientific citations samples:
- Mesenchymal Stem Cells Induce Epithelial Proliferation Within the Inflamed Stomach
- Intragenic CAMTA1 deletions are associated with a spectrum of neurobehavioral phenotypes
- Xq28 duplication overlapping the int22h-1/int22h-2 region and including RAB39B and CLIC2 in a family with intellectual and developmental disability

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Fluorescence in situ Hybridization (FISH)
Price on request

Since we were born out of Roswell Park Cancer Institute, FISH has always been a specialty for us. We have since moved beyond simply manufacturing fully customized FISH probes, and now are fully certified to analyze samples in our clinical lab. Our FISH services are certified by New York State and California, as well as being both... Show more »

Since we were born out of Roswell Park Cancer Institute, FISH has always been a specialty for us. We have since moved beyond simply manufacturing fully customized FISH probes, and now are fully certified to analyze samples in our clinical lab. Our FISH services are certified by New York State and California, as well as being both CLIA and CAP certified.

Our FISH service processes require and include the following details:
+ # Of Samples and/or Sample ID
+ Cell Type
+ Growth/Storage Media Conditions
+ Volume of Samples (mL)
+ Concentration Cells/Volume [Blood >1 mL | Concentration >25 ng/μl]
+ Positive or Negative Controls

Sample Requirements/Minimum Starting Material:
+ Bone Marrow Aspirate 1-3mL
+ Leukemic Blood 5-10mL
+ Fresh Tissue 1cm3
+ FFPE Tissues 4-5µM section
At least 2 or more replicates required per sample. If non-diagnostic result occurs the client will only be charged for analysis once, but hybridization and processing charges still apply.

TAT: 5-28 days

FISH Probe Qualification and Optimization includes:
+ Slide Preparation
+ Hybridization
+ Localization
+ Determining Signal Strength and Intensity

Client Specimen Analysis Includes:
+ Hybridization
+ Analysis of minimum of 100 interphase nuclei
+ Comprehensive Report

Sample Storage:
All client samples are destroyed 30 days after results reported to client. Unless otherwise instructed, DNA and blood are stored at 4º centigrade, tissue and cell suspensions are stored at -20º centigrade. Please specify if other storage options needed.

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COPOX
FECH
EVI1
ROS1
ADCY
AKAP9-BRAF
EGFR
CEP7
cMYC
RET
HER2
P53
CEP17
ATRX
ALK
PDL1
PD-L1
CD274
KRAS
EML4
1p1q
ABL1
ABL2
ATM
BCL3
BCL6
BRAF
RELA
C11orf95
CCND1
CIC
CRLF2
CSF1R
EPOR
ERBB2
FGFR1
FGFR2
FGFR3
Control
JAK2
HMGA2
MAML2
TP53
MDM2
MDM4
MYC
MYB
P16
RB1
LAMP1
5p5q
6q21
7q31.2
BCR/ABL
BCR ABL
CHEK1
PAX5
PDGFRB
PDGFB
PDGFRA
Fusion
ZNF217
Break Apart
NTRK
NFKB
PRKACA
DUX4
Karyotyping
Price on request

Empire Genomics is clinically certified by New York and California to run Karyotypes to be used as a tool for diagnosis and prognosis. Our lab is both CLIA and CAP approved, and our team of experts has over 80 years of combined experience in Karyotype analyses.

Our Karyotyping service processes require and include the... Show more »

Empire Genomics is clinically certified by New York and California to run Karyotypes to be used as a tool for diagnosis and prognosis. Our lab is both CLIA and CAP approved, and our team of experts has over 80 years of combined experience in Karyotype analyses.

Our Karyotyping service processes require and include the following details:
+ Number of Samples and/or Sample ID
+ Cell Type
+ Growth/Storage Media Conditions
+ Volume of Samples (mL)
+ Concentration Cells/Volume [Blood >1 mL | Concentration >25 ng/μl]
+ Positive or Negative Controls

Karyotyping Services includes:
+ 20 metaphases analyzed
+ Representative karyotypes

Sample Requirements/Minimum Starting Material:
+ Bone Marrow Aspirate 1-3mL
+ Leukemic Blood 5-10mL
+ Fresh Tissue 1cm3

TAT: 5-14 days

Sample Storage:
All client samples are destroyed 30 days after results reported to client. Unless otherwise instructed, DNA and blood are stored at 4º centigrade, tissue and cell suspensions are stored at -20º centigrade. Please specify if other storage options needed.

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Cell biology
Oncology
Biology
CLIA
Genomics
Cancer
Karyotype analysis
Chromosomal Abnormalities
Clinical Trials
Clinical Research
Karyotype
Karyotyping
G Banding
Custom FISH Probes
Price on request

Empire Genomics specializes in custom development of FISH probes based on customer specifications. We can design both single and multi-colored probes using our RP11 library of over 550,000 clones.

Empire Genomics will work with you to design custom FISH probes for coverage of larger regions of interest, which may require the... Show more »

Empire Genomics specializes in custom development of FISH probes based on customer specifications. We can design both single and multi-colored probes using our RP11 library of over 550,000 clones.

Empire Genomics will work with you to design custom FISH probes for coverage of larger regions of interest, which may require the design of a probe panel for full coverage of specific diseases.

Product Specifications:
+ Test Kits: 20 Reactions (40uL)
+ ISH Buffer: 20 (200uL)
+ TAT: 24 hours (in-stock) | 7-10 business days (custom)
+ Dye Colors: Aqua, Gold, Green, Orange, Red

Sample offering: 1p1q, 5p5q, 6q21, 7q31.2, ALK, ATM, BCR-ABL1, BRAF, BRD4, c-MET, CCND1, CHEK1, CREB1, D13S319, EGFR, ERBB2, ERG, ESR1, ETV1, ETV5, EYV6, EWSR1, FGFR1, FGFR2, FGFR3, IGH, KIT, KRAS, MAF, MLL, MYB, MYC, NPM1, NTRK3, P16, P53, PAX5, PDGFB, PDGFRA, PDGFRB, PIK3CA, PML, PREX2, PTEN, RARA, RB1, REL, RET, ROS1, RREB1, TERT, TFE3, TFEB, TMPRSS2, USP6, VEGFR2, VHL, WT1, WWTR1, YWHAE, ZNF217, etc., and thousands more!

Please contact us for volume discounts.

Fluorescence in situ hybridization (FISH) is a molecular diagnostic technique utilizing labeled DNA probes to detect or confirm gene or chromosome abnormalities. It is often used in cancer diagnosis.

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Immunotherapy
Oncology
FISH
CLIA
Immunooncology
Cancer
bone marrow
TERT
ROS1
EGFR
MET
RET
HER2
P53
Fluorescence in situ Hybridization
Clinical Trials
Clinical Research
ALK
PDL1
PD-L1
CD274
1p1q
ATM
BRAF
RELA
C11orf95
CCND1
ERBB2
JAK2
TP53
MYC
RB1
5p5q
6q21
7q31.2
BCR/ABL
BCR-ABL
BCR ABL
BRD4
CCND
CHEK1
CREB
PML-RARA
RARA
PML
PML/RARA
TMPRSS2
PAX5
USP6
PDGFRB
PDGFB
PDGFRA
Fusion
VEGFR2
ZNF217
DDIT
DDIT3
GNAS
Peripheral Blood
FFPE
Solid tumor
Solid Tissue
Genotyping by PCR
Price on request

qPCR is technology that is becoming more widely used due to its precision, flexibility, and its rapid reporting of results. Turnaround time for a custom qPCR project is about 7 days upon receiving a sample.

Our Genotyping (qPCR) service processes require and include the following details:
+ # Of Samples and/or Sample ID
+... Show more »

qPCR is technology that is becoming more widely used due to its precision, flexibility, and its rapid reporting of results. Turnaround time for a custom qPCR project is about 7 days upon receiving a sample.

Our Genotyping (qPCR) service processes require and include the following details:
+ # Of Samples and/or Sample ID
+ Sample Type [BM, PB, FFPE etc.]
+ Growth/Storage Media Conditions [TE buffer or comparable buffering solution preferred]
+ Volume of Samples (mL)
+ Concentration Cells/Volume [Blood >1 mL | Concentration >25 ng/μl]
+ Positive or Negative Controls [Acrometrix (+) control | NIST hapmap (-) control | Please specify if other customer needs apply]

Minimum Starting Material:
+ >500ng total DNA at 25ng/µL

TAT: 7 days

Quality Control:
Genomic DNA is assayed for concentration and purity using a high sensitivity DNA assay kit and spectrophotometer. Concentrations are used to quantitate the samples. Amount of RNA contamination and purity of the sample is measured by assessing 260/280 and 260/230 ratios. The client is contacted to determine whether to proceed if the deviations of the read value to the preferred range are below our cutoff, (Concentration < 1 ng/ul, 260/280 ratio < 1.5 and 260/230 < 1.5).

Genotyping Report:
Genotyping results in raw and analyzed tabular format

Sample Storage:
All client samples are destroyed 30 days after results reported to client. Unless otherwise instructed, DNA and blood are stored at 4º centigrade, tissue and cell suspensions are stored at -20º centigrade. Please specify if other storage options needed.

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Immunotherapy
Oncology
PCR
qPCR
biomarker
Immunooncology
real-time PCR
qPCR Assay
Gene Therapy
Experimental Design
Price on request

We will apply our expertise in both cytogenetics and molecular biology to help you determine the right testing for your project. Whether you are looking for SNPs and INDELs or larger aberrations, we will make sure that you are supplied with the right technology for the job.

We will apply our expertise in both cytogenetics and molecular biology to help you determine the right testing for your project. Whether you are looking for SNPs and INDELs or larger aberrations, we will make sure that you are supplied with the right technology for the job.

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Clinical Biomarkers
Price on request

Biomarker identification in research projects requires precision tools. In order to support that a gene is in fact causative of a phenotype, a level of consistency in testing is required. Our laboratory is held to some of the highest standards by New York State, California, CAP, and CLIA. You can be sure that our lab will deliver consistent results because of this.

Biomarker identification in research projects requires precision tools. In order to support that a gene is in fact causative of a phenotype, a level of consistency in testing is required. Our laboratory is held to some of the highest standards by New York State, California, CAP, and CLIA. You can be sure that our lab will deliver consistent results because of this.

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Cytogenetics
Price on request

Our cytogenetics services include both karyotyping and FISH. We utilize our own high-quality FISH probes in our CLIA laboratory. We can tailor the right mix of testing for clinical or research applications.

Our cytogenetics services include both karyotyping and FISH. We utilize our own high-quality FISH probes in our CLIA laboratory. We can tailor the right mix of testing for clinical or research applications.

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FISH
Karyotype analysis
Assay Development
Price on request

Taking an assay through the regulatory process of the FDA requires all facets of the assay to be well supported. Whether you are working towards an LDT, ASR, or IVD, we can provide both products and custom services to help support approval.

Taking an assay through the regulatory process of the FDA requires all facets of the assay to be well supported. Whether you are working towards an LDT, ASR, or IVD, we can provide both products and custom services to help support approval.

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Molecular Profiling
Price on request

We can combine a mix of molecular technologies to profile based on desired specifications. Analysis can be performed using target panels on our Ion Torrent, qPCR, and short read whole genome sequencing on an Illumina platform.

We can combine a mix of molecular technologies to profile based on desired specifications. Analysis can be performed using target panels on our Ion Torrent, qPCR, and short read whole genome sequencing on an Illumina platform.

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Gene Copy Number Analysis
Price on request

Amplifications of a gene or its promoter can cause problems with gene dosage and thus deleterious phenotypes. FISH is an excellent technology to visualize copy number variations. We can either provide you with the custom probes to do the testing yourself, or take your samples into our CLIA laboratory and provide you with a detailed report of our results.

Amplifications of a gene or its promoter can cause problems with gene dosage and thus deleterious phenotypes. FISH is an excellent technology to visualize copy number variations. We can either provide you with the custom probes to do the testing yourself, or take your samples into our CLIA laboratory and provide you with a detailed report of our results.

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Targeted Sequencing
Price on request

The Ion Torrent platform allows us to analyze targeted gene panels. This is useful when an entire overview of the genome is not necessary. Panels can be customized by gene and allele, and we will only evaluate targets that are important to your project.

Our NGS service processes require and include the following details:
+ #... Show more »

The Ion Torrent platform allows us to analyze targeted gene panels. This is useful when an entire overview of the genome is not necessary. Panels can be customized by gene and allele, and we will only evaluate targets that are important to your project.

Our NGS service processes require and include the following details:
+ # Of Samples and/or Sample ID
+ Sample Type [BM, PB, FFPE etc.]
+ Growth/Storage Media Conditions [TE buffer or comparable buffering solution preferred]
+ Volume of Samples (mL)
+ Concentration Cells/Volume [Blood >1 mL | Concentration >25 ng/μl]
+ Positive or Negative Controls [Acrometrix (+) control | NIST hapmap (-) control | (Please specify if other customer needs apply]

Minimum Starting Material:
+ Minimum of 10 ng of high quality DNA,
+ Preferably 1 µg of high quality DNA
At least 2 or more replicates required per sample. If non-diagnostic result occurs the client will only be charged for analysis once, but our processing charges still apply.

Turn Around Time (TAT): 5-14 days

NGS Services Include:
+ Total of 207 amplicons and 2800 variants
+ Data Analysis and Interpretation based on client needs

NGS Data Analysis can be provided in the following formats:
> FastQ Raw Data
+ 70 – 250 bp of fragments averages on amplicon size
> BAM
+ Takes FastQ files and aligns it to targeted sequencing bed file of clients choice
+ Detection of 1500 – 2500 variants
> VCF
+ Filtering parameters applied to sequences
+ Detection of 15 – 30 variants
> Data Interpretation & Analysis
+ Provided with final report
+ Sample NGS Report (available upon request)

Sample Storage:
All client samples are destroyed 30 days after results reported to client. Unless otherwise instructed, DNA and blood are stored at 4º centigrade, tissue and cell suspensions are stored at -20º centigrade. Please specify if other storage options needed.

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Single Nucleotide Polymorphism (SNP) Genotyping
Price on request

SNP genotyping can be performed either in targeted panels on our Ion Torrent, or in a whole exome sequence on the Illumina platform. qPCR can also read down to about 4 base pairs to help deliver a complete profile.

SNP genotyping can be performed either in targeted panels on our Ion Torrent, or in a whole exome sequence on the Illumina platform. qPCR can also read down to about 4 base pairs to help deliver a complete profile.

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PCR
Price on request

We can either run a standard PCR assay followed by gel electrophoresis or qPCR for more detailed analysis.

We can either run a standard PCR assay followed by gel electrophoresis or qPCR for more detailed analysis.

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Biology
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Clinical Molecular Diagnostics
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Clinical Chemistry
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Nucleic Acid Services
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DNA Services
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DNA Hybridization
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Project and Process Management
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Targeted Gene Sequencing
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Biochemistry & Molecular Biology
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Next Generation Sequencing (NGS)
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Chromosome Analysis
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Antibody/Antigen Detection Based Testing
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Regulatory Affairs Services
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Clinical Research
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Clinical Laboratory Services
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DNA Sequencing
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Genetic Marker Screening Services
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Genetic Marker Screening Services

Genetic Marker Screening Services

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Pharmacology & Toxicology
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