E-Phys

E-phys’ expertise is based on many years of experience of the founder and collaborators within drug discovery research in CROs and large pharmaceutical companies.
E-phys’ activity started in summer 2012, with the installation of its own dedicated in vivo electrophysiology platform within the medical and pharmaceutical school in the Université d’Auvergne, Clermont-Ferrand, France.

Animal Welfare

The use of animals is at the very heart of our work. Accordingly, E-Phys is committed to maximising the well-being of the animals we use, adhering to all legal requirements of in vivo preclinical research and respecting the core philosophy of the 3Rs. Specifically:

• E-phys complies with the French and European legislation on animal experiments.
• Our animal facility is accredited by the government agency and all animal technicians are fully trained and licensed.
• All protocols are designed in alignment with the 3 Rs and in compliance with the International Association for the Study of Pain recommendations.
• All protocols are approved by the local ethics committee, a board of 25 independent scientists, 7 of whom are experts in the field of pain.

Reliability

Selecting the next drug candidate or validating a new target share a common requirement: data you can rely on.

• We only commercialize assays in which we have sufficient experience and confidence.
• Experiments follow a fully validated Standard Operating Procedure (SOP).
• Inclusion and exclusion criteria are clearly defined a priori.
• All experiments include a positive control.

Quality

The fate of a project eventually depends on the quality of the data included in the preclinical package.

• With more than 10 years’ experience in physiology in anesthetized rodent models, we provide the most accurate and meaningful data.
• Our quality control measures start with the ordering of the animals from a regulated breeding facility and ends with a comprehensive report.
• Data are provided in a transparent, traceable format, allowing complete step by step verification by third parties from the dosing of the animal to results quantification.