Yo4bp8rb6elxjc2mlvrq search

E-Phys

No Reviews Yet
1 Order Completed
Clermont-Ferrand, FR

About E-Phys

E-phys’ expertise is based on many years of experience of the founder and collaborators within drug discovery research in CROs and large pharmaceutical companies.
E-phys’ activity started in summer 2012, with the installation of its own dedicated in vivo electrophysiology platform within the medical and... Show more »

E-phys’ expertise is based on many years of experience of the founder and collaborators within drug discovery research in CROs and large pharmaceutical companies.
E-phys’ activity started in summer 2012, with the installation of its own dedicated in vivo electrophysiology platform within the medical and pharmaceutical school in the Université d’Auvergne, Clermont-Ferrand, France.

Animal Welfare

The use of animals is at the very heart of our work. Accordingly, E-Phys is committed to maximising the well-being of the animals we use, adhering to all legal requirements of in vivo preclinical research and respecting the core philosophy of the 3Rs. Specifically:

  • E-phys complies with the French and European legislation on animal experiments.
  • Our animal facility is accredited by the government agency and all animal technicians are fully trained and licensed.
  • All protocols are designed in alignment with the 3 Rs and in compliance with the International Association for the Study of Pain recommendations.
  • All protocols are approved by the local ethics committee, a board of 25 independent scientists, 7 of whom are experts in the field of pain.

Reliability

Selecting the next drug candidate or validating a new target share a common requirement: data you can rely on.

  • We only commercialize assays in which we have sufficient experience and confidence.
  • Experiments follow a fully validated Standard Operating Procedure (SOP).
  • Inclusion and exclusion criteria are clearly defined a priori.
  • All experiments include a positive control.

Quality

The fate of a project eventually depends on the quality of the data included in the preclinical package.

  • With more than 10 years’ experience in physiology in anesthetized rodent models, we provide the most accurate and meaningful data.
  • Our quality control measures start with the ordering of the animals from a regulated breeding facility and ends with a comprehensive report.
  • Data are provided in a transparent, traceable format, allowing complete step by step verification by third parties from the dosing of the animal to results quantification.
Show less

Our Services (11)


ic

Custom Pain Animal Models

Price on request
Request a quote for more information about this service.

ic

Electrophysiology Animal Models

Price on request
Request a quote for more information about this service.

ic

Wide Dynamic Range Neuron Evoked Pain Studies

Price on request

Description

  • Deep anaesthesia, monitoring of cardiovascular parameters, laminectomy
  • Electrode inserted in the dorsal horn of the spinal cord for recording the activity of WDR neurons
  • Excitation of WDR neurons is driven by sensory input from the receptive field on the plantar region of the foot

Interest

Description

  • Deep anaesthesia, monitoring of cardiovascular parameters, laminectomy
  • Electrode inserted in the dorsal horn of the spinal cord for recording the activity of WDR neurons
  • Excitation of WDR neurons is driven by sensory input from the receptive field on the plantar region of the foot

Interest

  • Any type of stimulus can be used
  • Activity of the spinal WDR is “proportional” to the intensity of pain elicited by the stimulus
  • Possibility to quantify responses to non-noxious “subthreshold” as well as noxious “suprathreshold” nociceptive stimulus

Endpoints

  • Number of spikes before and after drug treatment
  • Blood pressure and heart rate
Show less
Mouse Rat

ic

Microneurography

Price on request

Description

  • Deep anaesthesia, monitoring of cardiovascular parameters, laminectomy
  • Electrode inserted in the dorsal horn of the spinal cord for recording the activity of WDR neurons
  • Excitation of WDR neurons is driven by sensory input from the receptive field on the plantar region of the foot

Interest

Description

  • Deep anaesthesia, monitoring of cardiovascular parameters, laminectomy
  • Electrode inserted in the dorsal horn of the spinal cord for recording the activity of WDR neurons
  • Excitation of WDR neurons is driven by sensory input from the receptive field on the plantar region of the foot

Interest

  • Action potentials induced by electrical stimulation and/or ectopic activity are tracked within single fibres
  • Conduction velocity profile allows fibre subtype identification
  • Variation in conduction velocity reflects the ectopic activity induced by neuropathic state

Endpoints

  • Action potential latency
  • Blood pressure and heart rate

Pathophysiology

  • Neuropathy (Sciatic nerve crush, Chronic Constriction Injury)
Show less
Rat

ic

Animal Models of Disease

Price on request
Request a quote for more information about this service.

ic

Pain/Neuropathy Animal Models

Price on request
Request a quote for more information about this service.

ic

Animal Models and Studies

Price on request
Request a quote for more information about this service.

ic

In vivo Electrophysiology

Price on request
Request a quote for more information about this service.

ic

Electrophysiology

Price on request

Electrophysiology Services

Electrophysiology Services

Show less

ic

CNS/Neurology Animal Models

Price on request
Request a quote for more information about this service.

ic

Biology

Price on request
Request a quote for more information about this service.

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.

E-Phys has not received any reviews.

E-Phys has not received any endorsements.