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Dualsystems Biotech AG

3 Orders Completed

About Dualsystems Biotech AG

Dualsystems Biotech is a provider of proteomics services for industry and academia. The technology platforms are directed to identify intracellular as well as extracellular drug targets. Our specialities LRC-TriCEPS™, ligand-receptor capture (CaptiRec) and CaptiVate make use of mass spectrometry analysis of... Show more »

Dualsystems Biotech is a provider of proteomics services for industry and academia. The technology platforms are directed to identify intracellular as well as extracellular drug targets. Our specialities LRC-TriCEPS™, ligand-receptor capture (CaptiRec) and CaptiVate make use of mass spectrometry analysis of protein complexes.

  • Established in 2000
  • Facilities in Zurich, Switzerland
  • Provider of target screening technologies
  • Swiss Quality

Recent Publications

  • Jonathan M Peterson, April 2016, The FASEB Journal, vol. 30 no. 1 Supplement 1249.2 Identification of cell surface receptors for the novel adipokine CTRP3
  • Alisson M. Gontijo, 29 October 2015 Nature Communications 6, Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing
  • Damaris Bausch-Fluck et al. (April 2015) A Mass Spectrometric-Derived Cell Surface Protein Atlas
  • Frei et al. (2012) Nature Biotechnology 30:997-1001
  • Frei et al. (2013) Nature Protocols 8:1321-1336
  • Slavoff and Sagathelian (2012) Nature Biotechnology 30:959-961
  • De Souza (2012) Nature Methods 9, 1044–1045
  • Donner (2012) Nature Chemical Biology 8:950
  • Protter data base: Omasits U, Ahrens CH, Müller S, Wollscheid B. Bioinformatics. 2013 Nov21.
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Our Services (24)


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Receptor Deorphanization

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Biomarker Analysis

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Ligand-Based Receptor Capture

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LRC-TriCEPS™ Service

Now available: The next generation of LCR-TriCEPS

TriCEPSTM V.3.0 enables receptor identification for your orphan ligands at the surface of living cells without genetic manipulation. Key features of the new TriCEPSTM V.3.0 and LRC- TriCEPSTM technology are:

LRC-TriCEPS™ Service

Now available: The next generation of LCR-TriCEPS

TriCEPSTM V.3.0 enables receptor identification for your orphan ligands at the surface of living cells without genetic manipulation. Key features of the new TriCEPSTM V.3.0 and LRC- TriCEPSTM technology are:

  • Reduction of the number of cells needed:
  • TRICEPS V3.0 LRC experiments require 5-10 fold less starting material for successful receptor identification compared to TRICEPS V2.0.
  • High coverage of the surfaceome.
    • A modified LRC workflow enabled by TriCEPSTM V.3.0 allows for the theoretical identification of up to 85% of all putative cell surface proteins.
  • Identification of N-, C-, O- glycosylated targets
  • More sensitive identification of low copy number cell surface receptors through all tryptic

Decoding the extracellular interactome using LRC-TriCEPS™

A novel approach to analyse extracellular cell signaling by discovering cell surface receptors and off-targets for a ligand of interest on the living cell: label ligand with the LRC-TriCEPS™crosslinker, incubate with living cells or tissue expressing target receptor(s), purify receptor crosslinked peptides, analyse by LC-MS/MS. This new technology was invented by Andreas Frei and Bernd Wollscheid from the ETH Zurich who published the technology in Nature Biotechnology (Frei et al.(2012) Nature Biotechnology 30:997-1001).

Orphan ligands:

  • Extracellular proteins
  • Peptide ligands
  • Antibodies
  • Viruses
  • Engineered affinity binders

Dualsystems Biotech AG, is a biotech company that provides services to analyse protein-protein interactions.

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CaptiVate Shotgun Proteomics Services

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Identification of protein complexes and protein interactions in mammalian cells using a tagged bait

CaptiVate Shotgun Proteomics Services using LC-MS/MS

  • Identification of protein complexes and protein interactions in mammalian cells
  • Profiling of signaling pathways
  • analysis of post-translational... Show more »

Identification of protein complexes and protein interactions in mammalian cells using a tagged bait

CaptiVate Shotgun Proteomics Services using LC-MS/MS

  • Identification of protein complexes and protein interactions in mammalian cells
  • Profiling of signaling pathways
  • analysis of post-translational modifications

Applications

  1. Identify protein interactions and protein complexes
  • Approach
    • Select protein of interest (bait)
    • Generation of stable cell line expressing tagged bait
    • Purification of protein complex, analysis by affinity purification and LC-MS/MS
  • Results
    • Identify proteins interacting with your protein of interest
    • Characterize protein complexes around your protein of interest
  • Study protein complex dynamics
    • Approach
      • Select protein of interest (bait)
      • Generation of stable cell line expressing tagged bait
      • Treatment with drug, ligand, growth factor, etc.
      • Purification of treated and non-treated protein complexes, analysis by affinity purification and LC-MS/MS
    • Results
      • Identify changes in protein complexes upon drug treatment or stimulation with growth factors
      • Quantitative analysis of treatment-induced changes in protein complexes

Your benefits

  • Full service – from project design to delivery of data
  • Quality – extensive optimization and integrated workflow ensure top quality data
  • Sensitivity – membrane proteins and post-translational modifications accessible
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Assay Development

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Cell Line Generation

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Custom Proteomics

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Drug Target Identification

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Quantitative Shotgun Proteomics

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Biomarkers

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Lead Identification and Validation

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Proteomics

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Cells and Tissues

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Bioanalysis

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Drug Discovery & Development

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Biology

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Drug Discovery

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Receptor Assays

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Pharmacology & Toxicology

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Biochemistry & Molecular Biology

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Biochemical Assays

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Omics

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Mammalian Cell Culture

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Project Management

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