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Drug Discovery Core

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Salt Lake City, utah, US

About Drug Discovery Core

Divison of: University of Utah

Recognizing the importance of small molecules and the growing interest in screening them for basic and translational research, this University of Utah Shared Resource provides a low-cost alternative to the purchase of large, costly libraries for individual labs. The Drug Discovery Core serves to aid in the identification of novel compounds for a wide range of interests at the University of Utah.

The Drug Discovery Core at the University of Utah is an established Service/Recharge center that provides compound collections for screening, services for whole-genome CRISPR screening and virus production. Our mission is to provide customers low-cost and efficient access to chemical libraries for screening, to equipment for automation, and to drug discovery support for the characterization and validation of compounds for potential use as therapeutics, diagnostics and biological tools.

Our Services (18)


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CRISPR Screening

Price on request

The Drug Discovery Core at the University of Utah provides a service for whole-genome CRISPR screening in cells. Our screening service includes generation of cas9 expression cells, transduction of sgRNA lentiviral library, treatment with drug, and deep sequencing/data analysis. The customer only needs to provide the cell line and drug they are interested.


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Viral Packaging

Price on request

Small/large scale viral (lentivirus, adenovirus, adeno-associated virus) packaging, titrations, concentrations and transductions of cells of interest. Lentivirus delivery of Cas9 and sgRNA


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Compound Libraries

Price on request

The Drug Discovery Core at the University of Utah provides small molecule libraries (over 250K compounds) for HTS. Among the commercial libraries, there are diversity screening sets such as Chembridge Diverset, Enamine 3D Diversity Set and NCI Diversity Set IV. There are also specialized small libraries, such as FDA-approval drug collection, Epigenetics screening library, Natural Products Set, and University of Utah metabolite library. Our most valuable asset, however, are the private collections we offer. These consist of: a) 800 drug-like small molecules synthesized by the Chemistry Department at the University of Utah; b) 240 natural marine products from the Medicinal Chemistry Department; and c) the University of Utah Private Chemical Collection (UUPCC) consisting of 90,000 compounds. Many compounds in this collection are proprietary and not commercially available.


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High Throughput Screening (HTS)

Price on request
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High Content Screening

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Assay Development

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Hit Identification

Price on request

Hit Identification Services


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Cell-Based Screening Methods

Price on request

Cell-Based Screening Methods Services


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Drug Discovery

Price on request

Drug Discovery Services


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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Virus Production

Price on request

Small/large scale viral (lentivirus, adenovirus, adeno-associated virus) packaging, titrations, concentrations and transductions of cells of interest. Lentivirus delivery of Cas9 and sgRNA


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Cell-Based Assays

Price on request

Cell-Based Assays Services


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In vitro Genetic Screening

Price on request

In vitro Genetic Screening Services


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Genetic Engineering

Price on request

Genetic Engineering Services


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Virology Services

Price on request

Viral Production and Assays Services


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Microbiology

Price on request

Microbiology, Virology, and Parasitology Services


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Biology

Price on request

Biology Services


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Cell-Based Compound Screening

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Bai Luo

Director, Drug Discovery Core

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