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Domain Therapeutics NA Inc.

Montreal, Quebec, CA

Domain Therapeutics NA (DTNA) Inc. specializes in G protein-coupled receptor (GPCR) signaling and function. Our BRET-based bioSensAllTM biosensor technology allows for detailed and broad spectrum signaling profiling of GPCRs and their ligands. This technology revolves primarily around the real-time monitoring of receptor proximal events immediately linked to GPCR activity, namely heterotrimeric G protein activation and β-arrestin coupling. Unique to this approach to ligand and receptor profiling is the ability to quantify the engagement of 14 distinct heterotrimeric G protein subtypes as well as both non-visual β-arrestin isoforms, thus providing a complete and detailed fingerprint of a GPCR’s and/or ligand’s signaling potential. Our bioSensAllTM platform is applicable to the study of agonists (including inverse agonists), antagonists and allosteric modulators and is ideally suited for the identification of biased... Show more »

Domain Therapeutics NA (DTNA) Inc. specializes in G protein-coupled receptor (GPCR) signaling and function. Our BRET-based bioSensAllTM biosensor technology allows for detailed and broad spectrum signaling profiling of GPCRs and their ligands. This technology revolves primarily around the real-time monitoring of receptor proximal events immediately linked to GPCR activity, namely heterotrimeric G protein activation and β-arrestin coupling. Unique to this approach to ligand and receptor profiling is the ability to quantify the engagement of 14 distinct heterotrimeric G protein subtypes as well as both non-visual β-arrestin isoforms, thus providing a complete and detailed fingerprint of a GPCR’s and/or ligand’s signaling potential. Our bioSensAllTM platform is applicable to the study of agonists (including inverse agonists), antagonists and allosteric modulators and is ideally suited for the identification of biased ligands. The assay is homogenous, does not require receptor modification and is performed in living cells, thus allowing for real-time analysis of signaling kinetics and dynamics.
We approach each project with an “agile” philosophy. After consultation with our staff scientists, a draft project proposal tailored to the client’s needs is rapidly (within 24h) generated and returned to the client for review. Upon mutual finalization of the service proposal, we are ready to begin the project. Our streamlined procedure ensures delivery of the highest quality data in the shortest possible timeframe, with an average project turnaround time of one month. We remain available for discussion during and after completion of the work.
As a company, DTNA strives to build close professional partnerships founded on confidence, transparency and confidentiality. We strongly believe in working collaboratively with, and not simply for, our partners and clients in addressing their needs and achieving their objectives. At DTNA, we are not simply service providers; rather, we consider ourselves as dedicated partners in your research and drug discovery endeavors.

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Tyrosine Kinase Assay
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GPCR Assays
G-Protein Coupled Receptor Assay
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GPCR Assay
Drug Target Validation
Price on request

Typical projects are aimed at assessing and/or comparing the global signaling profile of one or more target GPCRs, including receptor variants, subtypes, isoforms and orthologues. A restricted number of ligands (usually ≤ 5) are tested using a panel of 12 biosensors for the signaling events directly associated with GPCR activity... Show more »

Typical projects are aimed at assessing and/or comparing the global signaling profile of one or more target GPCRs, including receptor variants, subtypes, isoforms and orthologues. A restricted number of ligands (usually ≤ 5) are tested using a panel of 12 biosensors for the signaling events directly associated with GPCR activity (i.e., heterotrimeric G protein biosensors for the activation of Gαs, Gαq, Gα11, Gα14, Gα15, Gαi, GαoB, Gαz, Gα12 or Gα13; sensors for the engagement of β-arrestin 1 or β-arrestin 2). This panel of biosensors can be complemented with those measuring more receptor-distal signaling events (i.e., generation of second messengers including cAMP, DAG, PIP3; PKC and RhoA activation; Gßɣ activity). The latter distal biosensors can also serve to confirm data previously generated by clients using other technologies. These projects expose new users to the power of bioSensAllTM technology and allow them to evaluate our platform.

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GPCR Assay
HEK293
Drug discovery
Antibodies
Bioluminescence resonance energy transfer
BRET
Biased agonism
GRK
G-protein
Biosensors
Signal transduction
Beta-arrestins
G-protein subtype-specific sensors
Compound Profiling
Price on request

Ligand profiling services can be divided into small and large campaigns. Profiling can be performed on a minimum of 2 biosensors to analyze for signaling bias. Alternatively, a more global profiling with a broader set of biosensors can be conducted and the data ultimately used for classifying compounds into signaling clusters. We... Show more »

Ligand profiling services can be divided into small and large campaigns. Profiling can be performed on a minimum of 2 biosensors to analyze for signaling bias. Alternatively, a more global profiling with a broader set of biosensors can be conducted and the data ultimately used for classifying compounds into signaling clusters. We offer analysis of bias and compound clustering at an affordable cost.

As an extension of our ligand profiling services, compounds can also be counter-screened for selectivity against target GPCR subtypes, isoforms and/or orthologues. Counter-screens can be conducted using any number of biosensors.

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GPCR Assay
HEK293
Drug discovery
Antibodies
Bioluminescence resonance energy transfer
BRET
Biased agonism
GRK
G-protein
Biosensors
Signal transduction
Beta-arrestins
G-protein subtype-specific sensors
Assay Development
Price on request

The sky is truly the limit with bioSensAllTM technology. The extensive experience of our staff scientists in the development of BRET-based assays makes it possible to address numerous questions regarding the function, localization and/or activity of your target of interest. Following stringent validation, all newly developed... Show more »

The sky is truly the limit with bioSensAllTM technology. The extensive experience of our staff scientists in the development of BRET-based assays makes it possible to address numerous questions regarding the function, localization and/or activity of your target of interest. Following stringent validation, all newly developed assays can be performed at DTNA, or can be out-licensed exclusively to the client.

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Cell-Based Compound Screening
Price on request

Our bioSensAllTM assay is compatible with 96-well and 384-well formats, thus permitting for HTS campaigns. Please contact us to discuss your specific screening needs.

Our bioSensAllTM assay is compatible with 96-well and 384-well formats, thus permitting for HTS campaigns. Please contact us to discuss your specific screening needs.

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Experimental Design
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Project Management, Consulting, & Support Services
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Enzyme Assays
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Enzyme Assays Services

Enzyme Assays Services

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Biochemical Assays
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Biology
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Lead Identification and Validation
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Kinase Assays
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Kinase Assays Services

Kinase Assays Services

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Receptor Assays
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Hit Identification
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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2018-05-10 23:32:11 +0100

Net Promoter Score of 10 received for GPCR Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-05-10 23:31:44 +0100

Net Promoter Score of 10 received for GPCR Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-16 16:36:45 +0100

Net Promoter Score of 10 received for Biosensor Development.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 8.
2018-03-15 21:18:10 +0000

Net Promoter Score of 10 received for Assay Development.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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