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DKMS Life Science Lab GmbH

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Dresden, DE

About DKMS Life Science Lab GmbH

Founded in 1997, DKMS Life Science Lab in Dresden (Germany) is part of the worldwide DKMS family. The lab is accredited by the EFI (European Federation of Immunogenetics) and the ASHI (American Society for Histocompatibility and Immunogenetics).

 

DKMS Life Science Lab provides genotyping services, currently focusing...

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Founded in 1997, DKMS Life Science Lab in Dresden (Germany) is part of the worldwide DKMS family. The lab is accredited by the EFI (European Federation of Immunogenetics) and the ASHI (American Society for Histocompatibility and Immunogenetics).

 

DKMS Life Science Lab provides genotyping services, currently focusing on a process called HLA typing. Here DNA extracted from blood or buccal swab (cheek smear) samples is analysed to determine the exact genetic profiles of the human compatibility genes. These profiles are essential for matching potential donors to patients needing stem cell transplantation. Only highly similar compatibility gene variants in both donor and patient can minimise the risk of complications following transplantation.

 

DKMS Life Science Lab employs the most advanced biotechnological methods to perform high resolution, high capacity HLA typing. In 2013, as the world’s first HLA typing lab, we started using novel sequencing technology, NGS, for HLA typing in a truly high throughput and highly parallelised fashion. Using this process, over 1 million potential stem cell donors are typed each year.

 

A clinical lab and a clinical search unit accredited by the German National Registry of Blood Stem Cell Donors (ZKRD) are affiliated with DKMS Life Science Lab. The clinical lab performs all patient-associated typings (patient, relatives and confirmatory typing of unrelated donors), while the search unit carries out donor searches for individual patients both among relatives and unrelated potential donors.

 

We are proud of our highly skilled and motivated employees. Our staff includes internationally recognised specialists in genotyping and related technologies.

 
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Our Services (3)


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HLA Typing

Price on request

HLA Typing 

Service Description

  • Advanced HLA high resolution typing
  • Exon 2,... Show more »

HLA Typing 

Service Description

  • Advanced HLA high resolution typing
  • Exon 2, 3

 

Profile:

  • HLA-A
  • HLA-B,
  • HLA-C
  • HLA-DPA1
  • HLA-DPB1
  • HLA-DRB1
  • HLA-DRB3/4/5
  • HLA-DQA1
  • HLA-DQB1

 

Extended profile:

  • blood groups (ABO, RhD – molecular)
  • KIR genotypes at an absence/presence of genes level or allelic level
  • CMV (immune status cytomegalovirus, NEW determined from buccal swabs)
  • CCR5Δ32 (mutation of the CCR5 receptor)
  • HLA-E
  • MICA, MICB

 

Areas of application:

  • Registry / Recruitment / Initial Typing
  • Research
  • Population Studies
  • Personalised Healthcare & Lifestyle

Clinical HLA Typing

 

ervice Description

Advanced HLA high resolution typing using buccal swabs
Whole gene or long range
Short turnaround times
With clinical report
 

Profile

HLA-A (exon 1 to exon 8)
HLA-B (exon 1 to exon 7)
HLA-C (exon 1 to exon 8)
HLA-DRB1 (exon 2 to exon 5)
HLA-DQB1 (exon 1 to exon 6)
HLA-DPB1 (exon 2 to exon 5) 
 

Areas of application:

Confirmatory Typing before Hematopoietic Stem Cell Transplantation
Clinical studies on pharmacogenomics/cancer
HLA typing in context of personalized medicine
Whenever high resolution or an allelic level resolution is required 

 
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Leukemia Buccal swab Blood DNA Hematology Immunology Human Show 7 more tags Show less

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KIR Genotyping

Killer Cell Immunoglobulin-Like Receptor Genotyping
Price on request

 Service Description:

  • Advanced Killer Cell Immunoglobulin-like Receptor typing
  • High resolution typing using buccal swabs
  • Presence/absence level and/or Allelic group level
  • Exon 3, 4, 5, 7,8 and 9

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 Service Description:

  • Advanced Killer Cell Immunoglobulin-like Receptor typing
  • High resolution typing using buccal swabs
  • Presence/absence level and/or Allelic group level
  • Exon 3, 4, 5, 7,8 and 9


Profile:

  • KIR2DL1
  • KIR2DL2/L3
  • KIR2DL4
  • KIR2DL5A
  • KIR2DL5B
  • KIR2DS1
  • KIR2DS2
  • KIR2DS3
  • KIR2DS4
  • KIR2DS5 
  • KIR3DL1/S1
  • KIR3DL2
  • KIR3DL3
  • Pseudogenes
  • KIR2DP1
  • KIR3DP1  

 

Areas of application

  • Genotyping for KIR as a means to predict NK cell alloreactivity
  • Improved donor selection
  • Individualised patient treatment based on predictive risk scoring
  • Economical KIR typing for studies and clinical research
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Leukemia Buccal swab Blood DNA Immunology Hematology Show 6 more tags Show less

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DNA Extraction and Purification

Price on request

Service description

  • High throughput DNA isolation 
  • handle very high sample amounts in parallel
  • Buccal Swab based ease of sample taking as well as easy logistics at low price 

 

Additional benefits

  • normalisation workflow available
  • customised... Show more »

Service description

  • High throughput DNA isolation 
  • handle very high sample amounts in parallel
  • Buccal Swab based ease of sample taking as well as easy logistics at low price 

 

Additional benefits

  • normalisation workflow available
  • customised follow up workflows possible
  • DNA Storage possible
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Buccal swab Blood

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Kati Schuffenhauer

Sales & Business Development

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