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Diagenode

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DENVILLE, New Jersey, US

About Diagenode

Diagenode is a leading global provider of complete solutions for epigenetics research, biological sample preparation, and diagnostics assays based in Liege, Belgium and NJ, USA. The company has developed a comprehensive approach to gain new insights into epigenetics studies. The company offers innovative... Show more »

Diagenode is a leading global provider of complete solutions for epigenetics research, biological sample preparation, and diagnostics assays based in Liege, Belgium and NJ, USA. The company has developed a comprehensive approach to gain new insights into epigenetics studies. The company offers innovative Bioruptor® shearing and IP-Star® automation instruments, reagent kits, and high quality antibodies to streamline DNA methylation, ChIP, and ChIP-seq workflows. The company's latest innovations include a unique, full automation system, the industry's most validated antibodies, the Megaruptor shearing system for long fragment generation in sequencing, and epigenetics assay services.

At Diagenode, our goal is to build products with pride and the highest level of performance. Our team of epigenetics experts develop products by getting feedback from our customers as well as the scientific and medical communities around us. We strive to develop superior and easy-to-use products to bring epigenetics research and diagnostics to new frontiers.

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Our Services (49)


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Epigenomic Sequencing

Price on request

Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer... Show more »

Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.

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ATAC-Seq

Assay for Transposase-Accessible Chromatin with High Throughput Sequencing
Price on request

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of... Show more »

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.

Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to understand the regulation of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.

ATAC-seq: closed/open chromatin regions

Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.

  • Nucleosome positioning
  • TF footprinting inference
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ChIP-Seq

Chromatin Immunoprecipitation Sequencing
Price on request

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of... Show more »

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.

Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to understand the regulation of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.

ChIP-seq/ChIP-qPCR histone modifications on 10,000 cells

Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation

  • Active promoter profiling: H3K4me3 enrichment
  • Inactive promoter profiling: H3K27me3 enrichment
  • Enhancer profiling: H3K4me1 and H3K27ac enrichment in regulatory regions
  • Active gene body: H3K36me3

ChIP-seq/ChIP-qPCR Transcription Factors

Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:

  • CTCF: transcriptional repressor and insulator activity
  • p300/CBP: histone acetyltransferase
  • Pol II, p53, and more
  • Epigenetic writers, readers, erasers
  • Nuclear receptors
  • Tumor suppressor genes

Custom NGS services

  • Low input libraries from picograms
  • Specific analyses
  • Complete customized project

ATAC-seq: closed/open chromatin regions

Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.

  • Nucleosome positioning
  • TF footprinting inference
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DNA Methylation Analysis

Price on request

The pattern of DNA methylation and histone modification(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation – hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide... Show more »

The pattern of DNA methylation and histone modification(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation – hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.

Reduced representation bisulfite sequencing (RRBS)

RRBS provides a powerful method to efficiently analyze DNA methylation at the single nucleotide level without the higher costs associated with whole genome bisulfite sequencing. By cutting the genome using the restriction MspI enzyme (CCGG target sites) followed by size selection, DNA is enriched to represent CpG-rich regions (including CpG islands), in which DNA methylation marks are typically found. Thus, RRBS provides a cost-effective method for analyzing DNA methylation by reducing the part of the genome that actually needs to be sequenced and focusing on relevant CpG islands.

  • CpG rich region (5-mC): single nucleotide resolution
  • Epigenetic biomarker discovery
  • Methylation patterns of CpG rich regions across the genome
  • Covers up to 4M CpG sites in Human

Whole genome bisulfite sequencing (WGBS)

WGBS is designed to prepare single and paired-end bisulfite converted DNA libraries for sequencing using Illumina® platforms. It has also been validated for bisulfite-converted library preparation from ChIP-derived samples in order to perform ChIP-Bis-Sequencing. Genome-wide bisulfite sequencing is suitable for studying DNA methylation sites and their role in gene regulation

  • Genome-wide 5-mC: single nucleotide resolution
  • Epigenetic biomarker discovery
  • Methylation patterns of CpG, CHG, and CHH regions across the genome
  • Epigenome-wide association studies (EWAS)
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RNA Sequencing

Price on request

RNA sequencing uses next-generation sequencing (NGS) to uncover the presence and quantity of RNA for gene expression profiling across the transcriptome. Diagenode utilizes the unique capture and amplification by tailing and switching (CATS) methodology for generating RNAseq libraries which is optimal for low or degraded inputs... Show more »

RNA sequencing uses next-generation sequencing (NGS) to uncover the presence and quantity of RNA for gene expression profiling across the transcriptome. Diagenode utilizes the unique capture and amplification by tailing and switching (CATS) methodology for generating RNAseq libraries which is optimal for low or degraded inputs including those from liquid biopsies, FFPE, exosomes, serum, or plasma.

  • Ideal for low input samples including patient samples
  • Proven to detect more transcripts than any other commercial method
  • Full range of RNA-seq services and RNA-seq analysis including the quantification of known transcripts

Small non-coding RNA including miRNA

  • Post-transcriptional regulation of gene expression
  • Novel transcripts and differentially-expressed small RNAs
  • miRNAs involved in regulation of onco- and tumor-suppressor gene expression
  • Differential miRNA expression

mRNA analysis

  • Protein-coding RNA with specific poly A selection
  • Cancer-related mRNA signatures
  • Aberrant mRNA translation in cancer pathogenesis
  • Gene expression profiling and identification of differentially expressed genes (DEG)
  • Epigenetic mechanism of gene expression (transcriptome plus H3K36me3 and H3K4me3 marks)
  • Functional annotation of coding genes

Long non-coding RNA and whole transcriptome

Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:

  • Analysis of whole transcriptome and RNAs larger than 200nt with optional rRNA depletion
  • Non-protein coding RNAs involved in chromatin remodeling & transcriptional/post-transcriptional regulation
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Antibody Products

Price on request

Since 2004 Diagenode has been the most trusted supplier for epigenetics-focused antibodies. We understand that high quality is crucial for the success of your ChIP and ChIP-seq experiments, so we emphasize strict quality standards and actual validation for all of our antibodies. Our partnerships with leading epigenetics experts... Show more »

Since 2004 Diagenode has been the most trusted supplier for epigenetics-focused antibodies. We understand that high quality is crucial for the success of your ChIP and ChIP-seq experiments, so we emphasize strict quality standards and actual validation for all of our antibodies. Our partnerships with leading epigenetics experts and epigenetics consortiums such as BLUEPRINT have allowed us to validate our antibodies to the highest degree, guaranteeing specificity, reproducibility, and success for each and every ChIP assay. In addition, unlike competing suppliers, we are fully transparent with our validation and provide all batch-specific validation data for tested applications on every data sheet right here on our website.

Diagenode has epigenetics antibodies of choice:

  • Unmatched expertise - We have been exclusively dedicated to epigenetics research with more than 10 years of epigenetics-focused antibody expertise
  • Strict quality standards with rigorous QC and validation using standardized protocols
  • Comprehensive selection of histone and non-histone antibodies
  • Numerous validation steps to guarantee your results, including peptide array confirmation and siRNA validation to assure antibody specificity
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Equipment

Price on request

Exceptional shearing and sonication of biological samples for any field of study

Diagenode focuses on state-of-the-art preparation of high quality biological and chemical samples by developing the industry’s most advanced water bath sonicators and hydrodynamic devices. Our instruments are ideal for a number of applications in... Show more »

Exceptional shearing and sonication of biological samples for any field of study

Diagenode focuses on state-of-the-art preparation of high quality biological and chemical samples by developing the industry’s most advanced water bath sonicators and hydrodynamic devices. Our instruments are ideal for a number of applications in various fields of studies including environmental research, toxicology, genomics and epigenomics, cancer research, stem cells and development, neuroscience, clinical applications, agriculture, and many more.

We offer three types of sonication/shearing devices to match your exact needs for your application:

  • The Bioruptor® uses a highly-controlled ultrasonic energy with ACT (Adaptive Cavitation Technology), a non-contact, parallel-processing and isothermal technology, to achieve optimal fragment sizes between 150bp-2kb which is ideal for chromatin shearing for chromatin immunoprecipitation (ChIP), genomic DNA shearing for next generation sequencing, and RNA shearing. In addition, the Bioruptor is perfect for cell and tissue disruption, protein processing for mass spectrometry, and much more. The Bioruptor is available in two models: the Bioruptor Plus, specifically designed for protein processing for mass spectrometry, high volume cell and tissue shearing, ChIP-qPCR, and other applications and the Bioruptor Pico for ChIP-seq and NGS.
  • The One® is a unique desktop sonication device perfect for optimal small volume DNA shearing for Next-Generation-Sequencing in the 150bp - 1kb range.
  • The Megaruptor® is a hydrodynamic shearing instrument for DNA shearing between 3kb - 75kb and represents the best shearing device for the tightest distribution of long DNA fragments for applications such as long fragment sequencing.
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Antibody Services

Price on request

Antibody Services

Antibody Services

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Protein-DNA Interaction Analysis

Price on request

Protein-DNA Interaction Analysis Services

Protein-DNA Interaction Analysis Services

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Chromatin Immunoprecipitation (ChIP) Assays

Price on request

Chromatin Immunoprecipitation qPCR

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene... Show more »

Chromatin Immunoprecipitation qPCR

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.

Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to understand the regulation of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.

ChIP-seq/ChIP-qPCR histone modifications on 10,000 cells

Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation

Active promoter profiling: H3K4me3 enrichment
Inactive promoter profiling: H3K27me3 enrichment
Enhancer profiling: H3K4me1 and H3K27ac enrichment in regulatory regions
Active gene body: H3K36me3

ChIP-seq/ChIP-qPCR Transcription Factors

Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:

CTCF: transcriptional repressor and insulator activity
p300/CBP: histone acetyltransferase
Pol II, p53, and more
Epigenetic writers, readers, erasers
Nuclear receptors
Tumor suppressor genes

Custom NGS services

Low input libraries from picograms
Specific analyses
Complete customized project

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Epigenetic Studies

Price on request

Epigenetic Analysis Services

Epigenetic Analysis Services

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DNA Services

Price on request

DNA Services

DNA Services

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RNA Services

Price on request

RNA Services

RNA Services

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Nucleic Acid Services

Price on request

Nucleic Acid Services

Nucleic Acid Services

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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Biology

Price on request

Biology Services

Biology Services

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ChIP-qPCR

Price on request

Chromatin Immunoprecipitation qPCR

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene... Show more »

Chromatin Immunoprecipitation qPCR

Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.

Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to understand the regulation of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.

ChIP-seq/ChIP-qPCR histone modifications on 10,000 cells

Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation

Active promoter profiling: H3K4me3 enrichment
Inactive promoter profiling: H3K27me3 enrichment
Enhancer profiling: H3K4me1 and H3K27ac enrichment in regulatory regions
Active gene body: H3K36me3

ChIP-seq/ChIP-qPCR Transcription Factors

Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:

CTCF: transcriptional repressor and insulator activity
p300/CBP: histone acetyltransferase
Pol II, p53, and more
Epigenetic writers, readers, erasers
Nuclear receptors
Tumor suppressor genes

Custom NGS services

Low input libraries from picograms
Specific analyses
Complete customized project

Show less

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Epigenomic Data Analysis

Price on request
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ChIP-Exo

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Hydroxymethylation Profiling

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Neuroscience

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RNA Expression Profiling

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mRNA Sequencing

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MeDIP-Sequencing (DNA Methylation)

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Chromosome Conformation Capture

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Methyl Binding Domain (MBD)-Enriched Genome Sequencing

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RNA Profiling

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Methylation-Sensitive Single-Strand Conformation Analysis

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Chromatin Interaction Analysis-Paired End Tag Sequencing

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Epigenetic Assay Development

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Methylation-Specific PCR

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DNase Footprinting Assay

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DNA Pull Down Assay

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MicroRNA (miRNA) Sequencing

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Reduced Representation Bisulfite Sequencing (RRBS)

Price on request

RRBS provides a powerful method to efficiently analyze DNA methylation at the single nucleotide level without the higher costs associated with whole genome bisulfite sequencing. By cutting the genome using the restriction MspI enzyme (CCGG target sites) followed by size selection, DNA is enriched to represent CpG-rich regions... Show more »

RRBS provides a powerful method to efficiently analyze DNA methylation at the single nucleotide level without the higher costs associated with whole genome bisulfite sequencing. By cutting the genome using the restriction MspI enzyme (CCGG target sites) followed by size selection, DNA is enriched to represent CpG-rich regions (including CpG islands), in which DNA methylation marks are typically found. Thus, RRBS provides a cost-effective method for analyzing DNA methylation by reducing the part of the genome that actually needs to be sequenced and focusing on relevant CpG islands.

CpG rich region (5-mC): single nucleotide resolution
Epigenetic biomarker discovery
Methylation patterns of CpG rich regions across the genome
Covers up to 4M CpG sites in Human

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Targeted Bisulfite Sequencing

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DNA Library Services

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Whole Genome Bisulfite Sequencing

Price on request

WGBS is designed to prepare single and paired-end bisulfite converted DNA libraries for sequencing using Illumina® platforms. It has also been validated for bisulfite-converted library preparation from ChIP-derived samples in order to perform ChIP-Bis-Sequencing. Genome-wide bisulfite sequencing is suitable for studying DNA... Show more »

WGBS is designed to prepare single and paired-end bisulfite converted DNA libraries for sequencing using Illumina® platforms. It has also been validated for bisulfite-converted library preparation from ChIP-derived samples in order to perform ChIP-Bis-Sequencing. Genome-wide bisulfite sequencing is suitable for studying DNA methylation sites and their role in gene regulation

Genome-wide 5-mC: single nucleotide resolution
Epigenetic biomarker discovery
Methylation patterns of CpG, CHG, and CHH regions across the genome
Epigenome-wide association studies (EWAS)

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Long Non-Coding RNA Profiling

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MicroRNA (miRNA) Quantification

Quantitative PCR microRNA quantitation
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ChIP Data Analysis

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Omics

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Immunoprecipitation

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DNA Sequencing

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Global Methylation Analysis

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Histone Modification Analysis

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Long Non-Coding RNA Sequencing

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Small RNA Sequencing

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Assay Development

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Geoffrey Berguet

Business Development Manager
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Chrystle Koster

Accountant and office manager

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