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Darts Sciences, Inc.

Los Angeles, California, US

DARTS Sciences utilizes the patented Drug Affinity Responsive Target Stability (DARTS) technology to identify the binding targets of small molecule drugs and compounds. DARTS represents a paradigm change because it does not require modification, immobilization, or purification of the small molecule nor does it depend on the compound’s biological activity. Instead, DARTS takes advantage of the thermodynamic stabilization that occurs in the target protein upon drug binding, which results in a pronounced and specific protection from protease digestion. This specificity can be exploited to identify the binding target(s) of a small molecule with any cell lysate or protein mixture.

Darts Sciences, Inc. has not listed any services.

Drug Target Identification
Starting at $48,500.00 per study

Our premium drug target identification service utilizes DARTS and mass spectrometry-based proteomics to perform proteome-wide binding analysis. Simply send us your compound, let us know what kind of cell or tissue you would like to perform the analysis in, and we do the rest. You will receive a ranked list of candidate binding... Show more »

Our premium drug target identification service utilizes DARTS and mass spectrometry-based proteomics to perform proteome-wide binding analysis. Simply send us your compound, let us know what kind of cell or tissue you would like to perform the analysis in, and we do the rest. You will receive a ranked list of candidate binding proteins in as little as 2-3 months. Depending on sample type and other study characteristics, we can perform label-free quantitation, SILAC, or TMT labeling for quantitation. All proteomics analyses are performed by nanoLC-MS/MS on our Fusion Lumos mass spectrometer, the fastest and most sensitive instrument currently available.

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Drug Target Validation
Starting at $4,950.00 per study

Drug target validation (target engagement) assays are performed with your compound and lysate of choice to detect binding to specific protein targets with DARTS and immunoblotting. Simply send us your compound and we will assay binding to your target protein(s) of interest in a relevant cell line or tissue extract. Target... Show more »

Drug target validation (target engagement) assays are performed with your compound and lysate of choice to detect binding to specific protein targets with DARTS and immunoblotting. Simply send us your compound and we will assay binding to your target protein(s) of interest in a relevant cell line or tissue extract. Target detection and quantitation is performed by immunoblotting with a validated antibody against the endogenous target protein, if available, or by expressing the Flag-tagged version of the target protein in a relevant cell line and assayed with anti-Flag antibody.

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Protein Identification
Starting at $475.00 per sample

We perform protein identification for your samples of interest using trypsin digestion and LC-MS/MS analysis. All you need to do is send your sample(s) (either liquid or gel band/spot), and we will do the rest. You will get your protein identification in as little as 1-2 weeks depending on the number of samples. Our Fusion... Show more »

We perform protein identification for your samples of interest using trypsin digestion and LC-MS/MS analysis. All you need to do is send your sample(s) (either liquid or gel band/spot), and we will do the rest. You will get your protein identification in as little as 1-2 weeks depending on the number of samples. Our Fusion Lumos mass spectrometer is the fastest and most sensitive instrument available. We can identify up to hundreds of proteins from a single gel band or thousands of proteins from a whole cell or tissue lysate.

Our prices are tiered, starting at $500 per sample for 1 sample. Contact us for a quote today.

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Protein Sequencing
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Protein Services
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Biology
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Lead Identification and Validation
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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