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Cytoskeleton, Inc.

Denver, Colorado, US

Cytoskeleton, Inc. has been a reliable source of compound screening services in the areas of pre-clinical drug development programs and compound screening for rapid target validation projects, as well as secondary screening and assays for SAR drug development programs. We also have extensive experience in gene design and expression with an eye for producing highly purified, biological active proteins. Our expertise in protein purification is the basis for the complementary skill of assay design.
Whatever your requirement for protein or assays or screening services, we are confident that your project will proceed rapidly with regular communication and accurate reports, As examples of projects performed at Cytoskeleton, we have developed many functional assays for kinesins (e.g., Eg5, CenPE, MKLP2), myosins (e.g. cardiac, smooth, skeletal, and non-muscle isoforms), small G-proteins (e.g., Rho, Ras, Arf, Ral families),... Show more »

Cytoskeleton, Inc. has been a reliable source of compound screening services in the areas of pre-clinical drug development programs and compound screening for rapid target validation projects, as well as secondary screening and assays for SAR drug development programs. We also have extensive experience in gene design and expression with an eye for producing highly purified, biological active proteins. Our expertise in protein purification is the basis for the complementary skill of assay design.
Whatever your requirement for protein or assays or screening services, we are confident that your project will proceed rapidly with regular communication and accurate reports, As examples of projects performed at Cytoskeleton, we have developed many functional assays for kinesins (e.g., Eg5, CenPE, MKLP2), myosins (e.g. cardiac, smooth, skeletal, and non-muscle isoforms), small G-proteins (e.g., Rho, Ras, Arf, Ral families), tubulins (e.g., tumor, plant, and fungal origins) and actin binding proteins; many of them are multi-protein assays that might have protein complexes of 3 or more subunits, e.g., a soluble sarcomere format and the Arp2/3 complex based assay.
We can also provide stable formulations of proteins for standardizing your project. A particular speciality is the ability to rapidly create lyophilized formulations in appropriate daily use or weekly use amounts. This enables HTS use and reproducible daily performance. Our experiences in antibody and ELISA technology complement the cytoskeletal and signal transduction focus. We support all of our services with a dedicated technical services department and years of laboratory experience in the fields of cell biology, cancer biology, cardio-vascular research, and neuroscience.

For more details on these four main areas click on the Services section of our profile.

Compound Screening and Drug Development
Protein Purification
Assay Design and Development
ELISA and antibody development

We have exceptional and dedicated scientific staff and technical support:
40+ years of combined experience in: Assay development, compound screening, protein biochemistry, cell biology, cancer biology, cardio-vascular research and neuroscience

Product and Service Performance:
Modules with clearly defined deliverables
Activity tested to specification
Shipped in desiccated chambers & guaranteed for one year
Proven results with citations
Satisfied clients (See examples below)

Current Clients Include:
Merck & Co., Inc.
Eli Lilly & Co.
Amgen, Inc.
Abbott Laboratories
Pfizer, Inc.
Astra-Zeneca plc
GlaxoSmithKline plc
Genentech, Inc.
Johnson & Johnson
Bristol-Myers Squibb

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Cytoskeleton, Inc. has not listed any services.

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Tubulin Polymerization Assays
Starting at $85.00 per sample

Anti-Microtubule Compound Screening

Since 1993 Cytoskeleton has provided purified tubulin proteins to the scientific community. We continually strive to provide the purest, most biological active and relevant tubulin proteins, kits and reagents for today's researchers. Our screening services assisted the development of... Show more »

Anti-Microtubule Compound Screening

Since 1993 Cytoskeleton has provided purified tubulin proteins to the scientific community. We continually strive to provide the purest, most biological active and relevant tubulin proteins, kits and reagents for today's researchers. Our screening services assisted the development of multiple pre-clinical and clinical stage drugs. Compound screening is performed with the highest quality proteins available and we offer multiple tubulin assay formats such as polymerization assays in absorbance or fluorescence format, spin-down and binding assays. There are multiple tubulin targets to chose from such as; neuronal tubulin and microtubules, as well as specialized tubulins such as cancer cell line or tumor tubulin, plant tubulin and fungal tubulin. The report includes an executive summary, introduction, methods, results and interpretation if required. We look forward to providing you with the best service possible which includes regular communication and accurate reports.

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Biochemical Compound Screening
Starting at $85.00 per sample

Anti-Microtubule Compound Screening

Since 1993 Cytoskeleton has provided purified tubulin proteins to the scientific community. We continually strive to provide the purest, most biological active and relevant tubulin proteins, kits and reagents for today's researchers. Our screening services assisted the development of... Show more »

Anti-Microtubule Compound Screening

Since 1993 Cytoskeleton has provided purified tubulin proteins to the scientific community. We continually strive to provide the purest, most biological active and relevant tubulin proteins, kits and reagents for today's researchers. Our screening services assisted the development of multiple pre-clinical and clinical stage drugs. Compound screening is performed with the highest quality proteins available and we offer multiple tubulin assay formats such as polymerization assays in absorbance or fluorescence format, spin-down and binding assays. There are multiple tubulin targets to chose from such as; neuronal tubulin and microtubules, as well as specialized tubulins such as cancer cell line or tumor tubulin, plant tubulin and fungal tubulin. The report includes an executive summary, introduction, methods, results and interpretation if required. We look forward to providing you with the best service possible which includes regular communication and accurate reports.

Myosin Motor Protein Compound Screening

Cytoskeleton has set the standard for myosin motor protein screening service over the past ten years. Our experts can provide in depth knowledge and advice in the development of a new motor's assay or chose from one of the proteins here which are available as an established service: S1 and Heavy meromyosin fragments or full length of myosin I, myosin II (skeletal or cardiac), myosin V, myosin VI, myosin light chain kinase, soluble sarcomere, heavy meromyosin, thin filaments, myofibrils. We offer rapid turn around for small scale projects down to 1 week after receiving the compounds. Reports include an Executive summary, introduction, methods, results and interpretation if required.

Kinesin Motor Protein Compound Screening

Cytoskeleton has set the standard for kinesin motor protein screening service over the past ten years. Our experts can provide in depth knowledge and advice in the development of a new motor's assay or chose from one of the proteins here which are available as an established service: Eg5, KIF5, KIF1C, KIFC1, KIF, KIF3C, KIFC3, MKLP1, MKLP2, MCAK, CenPE, Chromokinesin. We offer rapid turn around for small scale projects down to 1 week after receiving the compounds. Reports include an Executive summary, introduction, methods, results and interpretation if required.

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Microtubules
Myosin motor proteins
Protein Purification
Starting at $90.00 per unit

Cytoskeleton, Inc. has been a reliable source of protein purification services in the areas of recombinant and native source proteins. We emphasize high purity and biological activity which enables the proteins to be used in many applications including diagnostic kits, pre-clinical drug development programs, early compound... Show more »

Cytoskeleton, Inc. has been a reliable source of protein purification services in the areas of recombinant and native source proteins. We emphasize high purity and biological activity which enables the proteins to be used in many applications including diagnostic kits, pre-clinical drug development programs, early compound screening in primary HTS projects, and in ELISA formats. We also have extensive experience in gene design and expression with an eye to produce the correct orientation and solubility for particular applications. Many purifications use the unique skills and expertise in cytoskeletal and signal transductions proteins. Using this combined knowledge we have produced many functional assays for kinesins (e.g. Eg5, CenPE, MKLP2), myosins (e.g. cardiac, smooth, skeletal and non-muscle isoforms, sarcomere assays), small G-proteins (e.g. Rho, Arf, Ral families), tubulins (e.g. tumor, plant and fungal origins), tubulin binding proteins (e.g. tau and MAPs) and actin binding proteins (e.g. cofilin, profiling, gelsolin), many of them are multi-protein assays that might have protein complexes of 3 or more subunits e.g. a soluble sarcomere format and the Arp2/3 complex based assay.

A particular speciality of Cytoskeleton's design formts is the ability to rapidly create lyophilized formulations in appropriate daily use or weekly use amounts. This enables HTS use and reproducible daily performance. Other experience in antibody and ELISA technology and protein synthesis complements the cytoskeletal and signal transduction focus.

We support all of our services with a dedicated technical services department and years of laboratory experience in the fields of protein biochemistry, cell biology, cancer biology, cardio-vascular research and neuroscience.

« Show less
Assay Development
Starting at $250.00 per unit

Cytoskeleton, Inc. has been a reliable source of assay design and development services for the past 20 years. We emphasize highly accurate and functional enzyme formats using highly purified and biologically activity proteins which enables the assays to reproduce the enzymatic parameters in the published literature, i.e. similar... Show more »

Cytoskeleton, Inc. has been a reliable source of assay design and development services for the past 20 years. We emphasize highly accurate and functional enzyme formats using highly purified and biologically activity proteins which enables the assays to reproduce the enzymatic parameters in the published literature, i.e. similar Kd's, Kcat's, Vmax or pKa's, IC50's and dose response.

A particular speciality of Cytoskeleton's design formts is the ability to rapidly formulate lyosphilized formulations in appropriate daily use or weekly use amounts. This enables HTS use and reproducible daily performance.

We also have extensive experience in gene design and expression with an eye to produce the correct orientation and solubility for particular applications.

Many assays use the unique skills and expertise in cytoskeletal and signal transductions proteins that no other company can match. Using this combined knowledge we have produced many functional assays for kinesins (e.g. Eg5, CenPE, MKLP2), myosins (e.g. cardiac, smooth, skeletal and non-muscle isoforms, sarcomere assays), small G-proteins (e.g. Rho, Arf, Ral families), tubulins (e.g. tumor, plant and fungal origins), tubulin binding proteins (e.g. tau and MAPs) and actin binding proteins (e.g. cofilin, profiling, gelsolin), many of them are multi-protein assays that might have protein complexes of 3 or more subunits e.g. a soluble sarcomere format and the Arp2/3 complex based assay.

« Show less
ELISA
Enzyme-linked immunosorbent assay
Starting at $80.00 per sample

We have recently developed a very high quality anti-phosphotyrosine antibody, clone 27G10.4. In some applications it is similar to 4G10 and in others it exceeds the 4G10 standards. We can provide a service for detecting phosphate on your Ip proteins or treated extracts. For the ELISA method the prices are given below. For other... Show more »

We have recently developed a very high quality anti-phosphotyrosine antibody, clone 27G10.4. In some applications it is similar to 4G10 and in others it exceeds the 4G10 standards. We can provide a service for detecting phosphate on your Ip proteins or treated extracts. For the ELISA method the prices are given below. For other methods such as probing an IP purified protein via western or whole cell protein by western please inquire.

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Western Blot
Price on request

We have recently developed a very high quality anti-phosphotyrosine antibody, clone 27G10.4. In some applications it is similar to 4G10 and in others it exceeds the 4G10 standards. We can provide a service for detecting phosphate on your Ip proteins or treated extracts.

We have recently developed a very high quality anti-phosphotyrosine antibody, clone 27G10.4. In some applications it is similar to 4G10 and in others it exceeds the 4G10 standards. We can provide a service for detecting phosphate on your Ip proteins or treated extracts.

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Elisa Kit Development
Starting at $250.00 per unit

Cytoskeleton Inc. developments tubulin elisas and tubulin monoclonal antibodies for use in basic research, drug discovery and compound development and pre-clinical drug development.

Cytoskeleton Inc. has also developed monoclonal antibodies for research and drug discovery. For more information click on the Documents tab above.

Cytoskeleton Inc. developments tubulin elisas and tubulin monoclonal antibodies for use in basic research, drug discovery and compound development and pre-clinical drug development.

Cytoskeleton Inc. has also developed monoclonal antibodies for research and drug discovery. For more information click on the Documents tab above.

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Project and Process Management
Price on request
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Experimental Design
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Biology
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Biochemistry & Molecular Biology
Price on request
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Protein Services
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Protein Expression Visualization
Price on request
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Protein Quantification
Price on request
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Protein Purification and Quantification
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Drug Discovery & Development
Price on request
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Drug Discovery
Price on request
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Hit Identification
Price on request
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Biochemical Assays
Price on request

Biochemical Assays Services

Biochemical Assays Services

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