Cytomem Biosciences is consulting and assay development company with a mission to create unique solutions for quantitative imaging and molecular characterization in life sciences. We provide services in advanced microscopy, surface bio-functionalization, and assay development aimed at characterizing membrane proteins.
Supported membranes are functionalized with ligands or antibodies whose surface density will be quantified. Cells expressing the appropriate receptor and/or drug of interest (small molecules or biologics) are then introduced at different concentrations and time points. Receptor engagement and activity of drug can be quantified through live cell imaging. Besides drug efficacy, this method also provide information about binding parameters between the drug-target pair.
Newer analysis methods have been developed that allows us to measure a several molecular characteristics of an analyte including translational diffusion rates, specific brightness, fluorescence anisotropy, fluorescence lifetime, spectral characteristics, and photochemical properties. All of this translates into a powerful set of applications for monitoring an enormous variety of molecular processes. The advantages of FFS techniques are:
Experts at Cytomem have many years of experience developing advanced FFS methods using time-correlated single photon counting (TCSPC) setup in quantifying molecular interactions.
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