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Cyprotex Discovery Ltd

Macclesfield, GB

Cyprotex is the world's largest contract research organisation specialising in preclinical ADME Tox.

Cyprotex serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals Industries as well as academia and not-for-profit organisations. Over 1500 organisations trust Cyprotex for their ADME-Tox and Bioscience research needs.

We focus heavily on R&D and our goal is to continually develop and improve approaches to more accurately predict human clinical outcome following exposure to a drug or chemical using robust in vitro methods combined with in silico technology.

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Biomarker Analysis
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Physicochemical Testing
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RT-PCR
Reverse transcription polymerase chain reaction
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Cyprotex use the Applied Biosystems 7900HT system to monitor and quantify either up-regulation or down-regulation of genes. These effects may be a consequence of disease, drug- or chemical-induced effects or physiological effects.

Cyprotex use the Applied Biosystems 7900HT system to monitor and quantify either up-regulation or down-regulation of genes. These effects may be a consequence of disease, drug- or chemical-induced effects or physiological effects.

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Cellular Bioenergetics
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A shift between respiration and glycolysis is observed in several pathological states including cancer, obesity, diabetes, and mitochondrial, cardiovascular, and neurodegenerative diseases. Cellular bioenergetics also play a role in aging, immune response, hypoxia and drug toxicity. The Seahorse Flux Analyser measures the... Show more »

A shift between respiration and glycolysis is observed in several pathological states including cancer, obesity, diabetes, and mitochondrial, cardiovascular, and neurodegenerative diseases. Cellular bioenergetics also play a role in aging, immune response, hypoxia and drug toxicity. The Seahorse Flux Analyser measures the metabolic phenotype of cells by simultaneously quantifying respiration and glycolysis in real time. Cyprotex is able to develop methods using the Seahorse XFe Flux Analyser to investigate specific disease states and the mechanisms behind the cellular bioenergetics effects.

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Agilent Seahorse XF Analyzer
Microelectrode Array (MEA) Recordings
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Microelectrode Array Neurotoxicity and Cardiotoxicity Assays

Microelectrode array instruments monitor whole cell electrophysiology allowing multiple ion channels to be monitored simultaneously. Cyprotex has developed cardiac and neuronal models using iPSC-derived cardiomyocytes and cortical neurons respectively.

Microelectrode Array Neurotoxicity and Cardiotoxicity Assays

Microelectrode array instruments monitor whole cell electrophysiology allowing multiple ion channels to be monitored simultaneously. Cyprotex has developed cardiac and neuronal models using iPSC-derived cardiomyocytes and cortical neurons respectively.

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High Content Screening
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High content screening uses fluorescent dyes, fluorescently labelled antibodies or reporter based fluorescent protein systems to track processes or components within the cell. Cyprotex can offer both conventional and confocal high content screening techniques, the latter being beneficial for imaging 3D cell models. We have... Show more »

High content screening uses fluorescent dyes, fluorescently labelled antibodies or reporter based fluorescent protein systems to track processes or components within the cell. Cyprotex can offer both conventional and confocal high content screening techniques, the latter being beneficial for imaging 3D cell models. We have previous experience developing many phenotypic screening assays as well as novel protein-protein interactions target screening assays:

  • CDK5:p25/p35, an Alzheimer’s target screening assay
  • Androgen Receptor:Tif2, a prostate cancer target screening assay
  • p53:hDM2, a cancer target screening assay
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Assay Development
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Cyprotex regularly design and develops new assays for our clients. We typically employ a 4 stage process:

Step 1: Our experienced scientists evaluate your needs and discuss the scientific rationale of the project and how your goals can be achieved.

Step 2: We plan and design an assay to match your requirements. We... Show more »

Cyprotex regularly design and develops new assays for our clients. We typically employ a 4 stage process:

Step 1: Our experienced scientists evaluate your needs and discuss the scientific rationale of the project and how your goals can be achieved.

Step 2: We plan and design an assay to match your requirements. We jointly establish the development process and validation criteria.

Step 3: We screen your test articles in the assay using robust QC processes within short turnaround times. We can assist in training, transfer and cross validation of the assay to a client’s site with ongoing support if required.

Step 4: Our reporting options are flexible – ranging from full written reports to customised data formats which can feed directly into your databases. We can assist you in interpreting the data and highlighting potential next steps.

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Toxicology
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Drug toxicity, often manifested as liver toxicity and cardiotoxicity, is a key reason for drug attrition. Identifying potential toxicity at an early stage in drug discovery can save both time and developmental costs, and most importantly reduce the likelihood of late stage failure.

Cyprotex is the ideal partner to assist you in... Show more »

Drug toxicity, often manifested as liver toxicity and cardiotoxicity, is a key reason for drug attrition. Identifying potential toxicity at an early stage in drug discovery can save both time and developmental costs, and most importantly reduce the likelihood of late stage failure.

Cyprotex is the ideal partner to assist you in understanding the toxic liability of your compounds using a panel of different techniques. We can help identify which compounds have the optimal ADME and safety profile to advance into the clinic. Our focus on state of the art technology and automation allow for high quality data to be generated rapidly and cost-effectively.

To that end, Cyprotex have invested in several high content screening (HCS) platforms that use automated fluorescence imaging to simultaneously analyse multi-parametric indicators of cytotoxicity. This improves the prediction of toxicological events and allows for a better understanding of the mechanisms of drug toxicity.

Our CellCiphr® technology was acquired from Cellumen in 2010. The technology provides a thorough assessment of potential mechanisms of toxicity using a HCS platform and links to exposure (Cmax) levels to understand the clinical relevance of the data. In 2013, we launched a new assay (eCiphr®Cardio) to evaluate cardiotoxicity in human iPS cell-derived cells using microelectrode array. This service has the advantage that it determines whole cell electrophysiology for all major ion channels in synchronously beating cardiomyocytes. Using the same microelectrode assay platform, we have also developed a new assay (eCiphr®Neuro) to evaluate neuronal activity using primary cortical neurons.

Cyprotex offer a number of other services including reactive metabolite detection using trapping agents, drug-induced phospholipidosis and steatosis, lysosomal trapping, hemolysis, mitochondrial toxicity using the Glu/Gal assay or using the Seahorse analyser, respiratory irritation, hERG inhibition using automated patch clamp, single end point cell viability endpoints (e.g., MTT, neutral red and LDH), toxicological gene regulation using qRT-PCR and a range of drug-drug interaction screens (available via Cyprotex ADME services). Cyprotex can also assess the potential genotoxicity of your compound using non-GLP screening protocols or GLP and OECD compliant protocols. These include the Ames Test (screening or OECD 471 compliant), in vitro (screening or OECD 487 compliant) micronucleus test, the GreenScreen HC™ assay, or the in vitro Comet assay.

Cyprotex now offer services to analyse 3D microtissue or spheroid models using multi-parametric high content imaging or by assessing ATP content.

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In vitro ADME
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Our in vitro ADME and DMPK services include in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK and bioanalysis

  • Highly reproducible, accurate data - validated and used by over 1500 clients from the pharmaceutical, biotechnology, agrochemical,... Show more »

Our in vitro ADME and DMPK services include in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK and bioanalysis

  • Highly reproducible, accurate data - validated and used by over 1500 clients from the pharmaceutical, biotechnology, agrochemical, tobacco, cosmetics, health care companies and academic and government organisations.
  • Delivery of data for core in vitro ADME screening and physicochemical assays is within 10 working days to fit in with the make-test timelines in drug discovery. A number of different reporting options are available.
  • Highly cost effective due to our emphasis on high throughput engineering for key in vitro screening assays.
  • Attention to good quality customer care, with highly trained Principal Scientists on hand to explain results and suggest the most appropriate experimental strategy.
  • Flexibility - studies can be tailored to our customers’ specific requirements.
  • Regulations - our ADME services maintain and comply with regulatory guidelines providing constant confidence in the data.

Our facility has passed evaluations by a range of different organisations and companies from a variety of differing industries, including government agencies: All now routinely use our services to provide support to their programs.

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Cellular Health & Metabolism Assays
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Nucleic Acid Services
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Cell-Based Assays
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DNA
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Analytical Chemistry Services
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Biology
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Pharmacology & Toxicology
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PCR
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Biochemistry & Molecular Biology
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Experimental Design
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Cell-Based Screening Methods
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Project Management, Consulting, & Support Services
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Bioanalysis
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In vitro Toxicity Testing
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Chemistry and Materials
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Biomarkers
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Chemical Stability Testing
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