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Cyclotron Facility

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St Louis, Missouri, US

About Cyclotron Facility

The Mallinckrodt Institute of Radiology (MIR) Cyclotron Facility provides positron emission tomography (PET) isotopes, radiochemicals, radio-tracers and radiopharmaceuticals to the research and medical communities. Used for research and clinical practice, these agents meet or exceed user requirements, while safely and reliably insuring the highest level of quality that is achieveable with federal regulations and guidelines.

Selected publications by Cyclotron Facility's users:

  • Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, Sutphen CL, Benzinger TLS, Mintun MA, Holtzman DM, Morris JC. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology. 2013;80(19):1784-91. Epub 2013/04/12. doi: 10.1212/WNL.0b013e3182918ca6. PubMed PMID: 23576620; PubMed Central PMCID: PMC3719431
  • Guo Y, Parry JJ, Laforest R, Rogers BE, Anderson CJ. The role of p53 in combination radioimmunotherapy with 64Cu-DOTA-cetuximab and cisplatin in a mouse model of colorectal cancer. J Nucl Med. 2013 Sep;54(9):1621-9. doi: 10.2967/jnumed.112.118539. Epub 2013 Jul 19. PMID:23873478
  • Grubb RL Jr, Clarke WR, Adams H, Videen TO, Derdeyn CP, Powers WJ for the COSS investigators. Surgical Results of the Carotid Occlusion Surgery Study. Journal of Neurosurgery 2013 118:25-33.
  • Dhar R, Scalfani MT, Blackburn S, Zazulia AR, Videen T, Diringer M. Relationship between angiographic vasospasm and regional hypoperfusion in aneurysmal subarachnoid hemorrhage. Stroke 2012; 43: 1788-94.
  • Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T. A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[11 C]methyl)benperidol. Synapse 2013 67(11): 748-56. PMCID: PMC3778147
  • Kotagiri N, Niedzwiedzki DM, Ohara K, Achilefu S. Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation. Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7756-60.
  • Chang, A.J., DeSilva, R, Lapi, S.E. Development and Characterization of 89Zr-labeled Panitumumab for ImmunoPET Imaging of the EGF Receptor, Molecular Imaging 2013 12(1), 17-27
  • Eric Pressly, Rich Pierce, Luke A Connal, Craig J. Hawker, Yongjian Liu. Nanoparticle PET/CT Imaging of Natriuretic Peptide Clearance Receptor in Prostate Cancer. Bioconjugate Chemistry, 2013, 24, 196-204. PMCID: PMC3578065.
  • Fowler KJ, McConathy J, Narra VR. Whole-body simultaneous positron emission tomography (PET)-MR: optimization and adaptation of MRI sequences. J Magn Reson Imaging. 2014;39:259-268. 10.1002/jmri.24308.
  • Bagchi D, Yu L, Perlmutter JS, Xu J, Mach R, Tu Z, Kotzbauer P, “Binding of the Radioligand SIL234 to alpha-synuclein fribrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.” PLoS One 8(2), e55031, 2013. PMCID: PMC3566091.
  • Lyons MR, Peterson LR, McGill JB, Herrero P, Coggan A, Saeed IM, Recklein C, Schechtman KB, Gropler RJ. Impact of sex on the heart’s metabolic and functional responses to diabetic therapies. Am J Physiol 2013, 305(11):H1584-91.
  • Lamb J, Robinson C, Bradley J, Laforest R, Dehdashti F, White B, Wuenschel S, Low D. “Generating Internal Target Volumes for Lung Tumors from 4D-PET Maximum Intensity Projections” Med Phys 2011 38(10):5732-5737.
  • Jiang, M.; Ferdani, R.; Shokeen, M. and Anderson, C.J. “Comparison of two cross-bridged macrocyclic chelators for the evaluation of 64Cu-labeled-LLP2A, a peptidomimetic ligand targeting VLA-4-positive tumors” Nucl Med Biol 2013, 40(2): 245-51. PMID: 23265977
  • Creach KM, Nussenbaum B, Siegel BA, Grigsby PW. Thyroid carcinoma uptake of 18F-fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative 131I scintigraphy. Am J Otolaryngol 2013; 34:51-56.
  • Synthesis, [(18)F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem. 2014 Mar 1;22(5):1700-7. doi: 10.1016/j.bmc.2014.01.019. Epub 2014 Jan 24

Our Services (4)


Radiotracers and Radiopharmaceuticals

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Radioisotope Production

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Mallinckrodt Institute of Radiology is a resource for longer-lived PET radionuclides used in the United States and Canada. They include:

  • Cu-64,
  • Zr-89,
  • Y-86
  • Br-76,77


Chemistry and Materials

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