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Cyclolab

Budapest, HU

CycloLab is a world-wide recognized and all-round cyclodextrin research and development company, having the longest tradition and broadest circle of customers. Since 1972, a staff of internationally acknowledged experts have been working on the fields of pharmaceutical, cosmetic and food industry, agrochemical, environmental and analytical applications of cyclodextrins.

CycloLab has four main activities:

  • We produce sulfobutylether beta-cyclodextrin (SBECD, Dexolve™) in multiple ton scale annually under cGMP conditions based on an FDA-approved Drug Master File.

  • CycloLab operates as a CRO for cyclodextrin related services including:

Development of products (pharma, cosmetic, food, agricultural industries), formulation development, early phase studies, bioequivalence studies, IP assessment, formulation optimization, etc

Offering custom synthesis of cyclodextrins, fine-tailored for certain guest... Show more »

CycloLab is a world-wide recognized and all-round cyclodextrin research and development company, having the longest tradition and broadest circle of customers. Since 1972, a staff of internationally acknowledged experts have been working on the fields of pharmaceutical, cosmetic and food industry, agrochemical, environmental and analytical applications of cyclodextrins.

CycloLab has four main activities:

  • We produce sulfobutylether beta-cyclodextrin (SBECD, Dexolve™) in multiple ton scale annually under cGMP conditions based on an FDA-approved Drug Master File.

  • CycloLab operates as a CRO for cyclodextrin related services including:

Development of products (pharma, cosmetic, food, agricultural industries), formulation development, early phase studies, bioequivalence studies, IP assessment, formulation optimization, etc

Offering custom synthesis of cyclodextrins, fine-tailored for certain guest molecules (like Sugammadex) or other purposes,

Performing pilot-scale cGMP compliant manufacturing of cyclodextrins to be used as APIs or excipients in clinical studies or cyclodextrin enabled formulations for the same purpose, and

All analytical tasks related to the above, under GMP (method development, validation, stability studies for formulation ingredients (APIs, cyclodextrins) and final products as well).

  • CycloLab offers the widest variety of cyclodextrins in various grades (pharma, standard, fine chemical) in a web shop system for various purposes (research, analytics, cell cultures, formulation studies, etc). Besides “regular” derivatives, we always develop something new and special, like maltooligomers, polymers or fluorescent-tagged products.

  • As an R&D company, we develop next generation proprietary cyclodextrins and explore potential applications as well.

CycloLab is also pioneer in supporting studies for the novel application of cyclodextrins. The company has been present from the early stage as a consultant in the realization of an application to treat the symptoms of a rare fatal disease, Niemann-Pick type C, a lysosomal storage disorder that strikes people generally before 10 years of age and is incurable. Hydroxypropyl Betadex, applied in the therapy could fundamentally change the standard of living and expand the expected lifespan of patients. This cyclodextrin has recently received an Orphan Drug designation by US FDA and EMA.

Cyclolab can also boast with over 120 patents filed so far in this field, more than 450 publications from its staff over the years with cumulative citations exceeding 7000. Cyclolab publishes its own monthly journal on the advances in the field of cyclodextrins and several tutorial lectures on the applications of cyclodextrins.

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Pharmaceutical Formulation
Price on request

Customization of CD enabled formulations, life-cycle management

During the lab experiments with an API/cosmetic ingredient/nutrient the need for improving certain characteristics may arise. Stability, water solubility, pharmacokinetics, bioavailability, etc. can be improved by cyclodextrins. Furthermore cyclodextrins are... Show more »

Customization of CD enabled formulations, life-cycle management

During the lab experiments with an API/cosmetic ingredient/nutrient the need for improving certain characteristics may arise. Stability, water solubility, pharmacokinetics, bioavailability, etc. can be improved by cyclodextrins. Furthermore cyclodextrins are increasingly proving to be clinically appealing molecules by themselves. CycloLab offers conducting interaction studies to select the most effective cyclodextrin for your active, proof of concept studies and development of a new formulation with the selected cyclodextrin. The developed formulation is optimized and preliminary stability studies are performed. CycloLab also supports its customers with all analytical aspects related to the formulation, reporting to authorities, IP issues and relevant documentation.

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Acetyl-cyclodextrin
Cyclodextrin
Cyclodextrin phosphate sodium salt
Cyclodextrin polymer
Cyclodextrin sulfate
Carboxymethyl-cyclodextrin sodium salt
Methyl-cyclodextrin
Succinyl-cyclodextrin
Malvern Mastersizer 2000
NMR
HPLC
Cancer
Health & Inflammation
gram
kilogram
Biology
Drug discovery
Agilent 7820 GC
Antibiotic Development
Antibiotics
Inflammation
Cancer
Central Nervous System
Infectious Disease
Infectious Disease
inflammation
Custom Manufacturing
Price on request

CycloLab with its more than 40-year experience in cyclodextrin synthesis offers more than 150 different cyclodextrin (CD) derivatives! Upon customer's special request, our synthetic unit offers:

Custom synthesis of derivatives which are not on our standard product lists
Taylor-made cyclodextrin derivatives with... Show more »

CycloLab with its more than 40-year experience in cyclodextrin synthesis offers more than 150 different cyclodextrin (CD) derivatives! Upon customer's special request, our synthetic unit offers:

Custom synthesis of derivatives which are not on our standard product lists
Taylor-made cyclodextrin derivatives with special substituents or substitution pattern
Development and optimization of purification and isolation methods
Preparation of cyclodextrin derivatives optimized for a particular target guest molecule
Derivatized maltooligomers and special glucose derivatives derived from cyclodextrins
Cyclodextrin-assisted organic syntheses
Reproduction and evaluation of syntheses reported in the literature
Standardized preparation methods
Scaling-up synthetic procedures for the preparation of selected CD derivatives.

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(2-Carboxyethyl)-cyclodextrin sodium salt
Acetyl-cyclodextrin
Cyclodextrin
Cyclodextrin phosphate sodium salt
Cyclodextrin polymer
Cyclodextrin sulfate
Butyl-cyclodextrin
Carboxymethyl-cyclodextrin sodium salt
Heptakis(2,3,6-tri-O-methyl)-cyclodextrin
Methyl-cyclodextrin
Succinyl-cyclodextrin
Malvern
NMR
HPLC
gram
kilogram
Drug discovery
Agilent 7820 GC
LC-MS/MS
Specialty and Fine Chemicals
Price on request

Cyclolab is a provider of a wide range of cyclodextrins and cyclodextrin derivatives. We have over 100 derivatives in out portfolio in several product categories:
Pharma Grade Cyclodextrins
Standard Grade Cyclodextrins
Nonionic Cyclodextrins
Anionic Cyclodextrins
Cationic Cyclodextrins
... Show more »

Cyclolab is a provider of a wide range of cyclodextrins and cyclodextrin derivatives. We have over 100 derivatives in out portfolio in several product categories:
Pharma Grade Cyclodextrins
Standard Grade Cyclodextrins
Nonionic Cyclodextrins
Anionic Cyclodextrins
Cationic Cyclodextrins
Maltooligomers
Single Isomer Cyclodextrins
Fluorescent Cyclodextrins
Fluorescent Polymers
Cyclodextrin Polymers
Complexes
HPLC Columns

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(2-Carboxyethyl)-cyclodextrin sodium salt
6-O-Maltosyl-cyclodextrin hydrate
Cyclodextrin
Cyclodextrin sulfate
Butyl-cyclodextrin
Cyclodextrin polymer, soluble
Heptakis(2,3,6-tri-O-ethyl)-cyclodextrin
Hexakis (2,3,6-tri-O-acetyl)-cyclodextrin
Octakis (2,3,6-tri-O-methyl)-cyclodextrin
Succinyl-(2-hydroxypropyl)-cyclodextrin
Malvern
UV Detection
NMR
Analytical HPLC
gram
kilogram
Drug discovery
Agilent 7820 GC
LC-MS/MS
Lot Release Testing
Price on request

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its... Show more »

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its vast experience in the field of cyclodextrins: to characterize cyclodextrins, cyclodextrin complexes, to perform related analysis (API assay, formulation specific characterization).
Our experience also includes analysis of cyclodextrins in such complex biological matrices like blood plasma or liquor samples.
The applied techniques include traditional analytical techniques, HPLC, GC, MS and hyphenated-MS, NMR, IR, CE, Dynamic and Static Light Scattering, Bioburden and Bacterial Endotoxin Content and so on.
Complete or partial analysis of the following cyclodextrin derivatives according to the current pharmacopeial monographs: Alphadex, Betadex, Gammadex, Hydroxypropylbetadex and Betadex Sulfobutyl Ether Sodium.

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Malvern
UV Detection
NMR
HPLC
Drug discovery
Agilent 7820 GC
LC-MS/MS
Product Stability Testing
Price on request

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its... Show more »

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its vast experience in the field of cyclodextrins: to characterize cyclodextrins, cyclodextrin complexes, to perform related analysis (API assay, formulation specific characterization).
Our experience also includes analysis of cyclodextrins in such complex biological matrices like blood plasma or liquor samples.
The applied techniques include traditional analytical techniques, HPLC, GC, MS and hyphenated-MS, NMR, IR, CE, Dynamic and Static Light Scattering, Bioburden and Bacterial Endotoxin Content and so on.
Complete or partial analysis of the following cyclodextrin derivatives according to the current pharmacopeial monographs: Alphadex, Betadex, Gammadex, Hydroxypropylbetadex and Betadex Sulfobutyl Ether Sodium.

« Show less
Malvern
UV Detection
NMR
HPLC
Agilent 7820 GC
LC-MS/MS
Product Development, Testing, and Packaging
Price on request

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its... Show more »

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its vast experience in the field of cyclodextrins: to characterize cyclodextrins, cyclodextrin complexes, to perform related analysis (API assay, formulation specific characterization).
Our experience also includes analysis of cyclodextrins in such complex biological matrices like blood plasma or liquor samples.
The applied techniques include traditional analytical techniques, HPLC, GC, MS and hyphenated-MS, NMR, IR, CE, Dynamic and Static Light Scattering, Bioburden and Bacterial Endotoxin Content and so on.
Complete or partial analysis of the following cyclodextrin derivatives according to the current pharmacopeial monographs: Alphadex, Betadex, Gammadex, Hydroxypropylbetadex and Betadex Sulfobutyl Ether Sodium.

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Malvern
UV Detection
NMR
HPLC
Agilent 7820 GC
LC-MS/MS
Intellectual Property Consulting
Price on request

Currently cyclodextrins are applied in more than thirty drug formulations and this number keeps increasing. Most of these products are heavily patented.
CycloLab can provide alternative solutions for circumventing the patent claims as well as strategies for life cycle management.
In case you are developing a new product, we can... Show more »

Currently cyclodextrins are applied in more than thirty drug formulations and this number keeps increasing. Most of these products are heavily patented.
CycloLab can provide alternative solutions for circumventing the patent claims as well as strategies for life cycle management.
In case you are developing a new product, we can help you find the novel, non-infringing possibilities using a comprehensive search in our over 50.000 item large paper and patent database, saving our customers cost, time and effort.
After an extensive data mining we can provide you with an information package report targeted to your individual purposes or help you with the compilation of a patent application. Being the applicant of over 130 patents so far, Cyclolab can surely be of your help in this field.
Besides pharmaceutical applications we provide literature services in the fields of CD synthesis, complex formation, CD application in cell biology, food and cosmetic industry, agriculture, etc.

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Drug Development
Price on request

Customization of CD enabled formulations, life-cycle management

During the lab experiments with an API/cosmetic ingredient/nutrient the need for improving certain characteristics may arise. Stability, water solubility, pharmacokinetics, bioavailability, etc. can be improved by cyclodextrins. Furthermore cyclodextrins are... Show more »

Customization of CD enabled formulations, life-cycle management

During the lab experiments with an API/cosmetic ingredient/nutrient the need for improving certain characteristics may arise. Stability, water solubility, pharmacokinetics, bioavailability, etc. can be improved by cyclodextrins. Furthermore cyclodextrins are increasingly proving to be clinically appealing molecules by themselves. CycloLab offers conducting interaction studies to select the most effective cyclodextrin for your active, proof of concept studies and development of a new formulation with the selected cyclodextrin. The developed formulation is optimized and preliminary stability studies are performed. CycloLab also supports its customers with all analytical aspects related to the formulation, reporting to authorities, IP issues and relevant documentation.

« Show less
Cyclodextrin
Cyclodextrin polymer
Agilent Gas Chromatograph 7890A
NMR
HPLC
Cancer
gram
kilogram
Biology
Drug discovery
Antibiotic Development
Antibiotics
Inflammation
LC-MS/MS
Cancer
Central Nervous System
Infectious Disease
Infectious Disease
inflammation
Compound Synthesis
Price on request

CycloLab with its more than 40-year experience in cyclodextrin synthesis offers more than 150 different cyclodextrin (CD) derivatives! Upon customer's special request, our synthetic unit offers:

  • Custom synthesis of derivatives which are not on our standard product lists
  • Taylor-made cyclodextrin derivatives with special... Show more »

CycloLab with its more than 40-year experience in cyclodextrin synthesis offers more than 150 different cyclodextrin (CD) derivatives! Upon customer's special request, our synthetic unit offers:

  • Custom synthesis of derivatives which are not on our standard product lists
  • Taylor-made cyclodextrin derivatives with special substituents or substitution pattern
  • Development and optimization of purification and isolation methods
  • Preparation of cyclodextrin derivatives optimized for a particular target guest molecule
  • Derivatized maltooligomers and special glucose derivatives derived from cyclodextrins
  • Cyclodextrin-assisted organic syntheses
  • Reproduction and evaluation of syntheses reported in the literature
  • Standardized preparation methods
  • Scaling-up synthetic procedures for the preparation of selected CD derivatives

Sugammadex and related compounds

Sugammadex is one of the greatest success in the history of cyclodextrins. There is an increasing interest for this product and for the development of generic Bridion since the recent approval by the FDA is estimated to have a 3-4-fold increase in the global sales of the product.
CycloLab has vast experience in the production of perhalogenated-γ-CD intermediates and of Sugammadex, supported by readily available sensitive analytical tools to characterize the products. Our current focus is on the isolation and declaration of primary reference standard materials including the API and its intermediates as well as a great number of custom synthesized potential process impurities.

The cyclodextrin component of a cyclodextrin-enabled medical diagnostic tool needs to be of consistent quality for reproducibility reasons. This criterion can only be met via GMP manufacturing. Likewise, cyclodextrins used in clinical trials are also essential to be manufactured under GMP conditions.
CycloLab offers manufacturing cyclodextrins and certain cyclodextrin-enabled formulations under cGMP conditions in its in-house clean area, which has been authorized for manufacturing pharmaceutical ingredients.
This offer is also ideal for cyclodextrin-based clinical investigational products where a simplified preclinical safety study is adequate.Our offer includes the compilation of the product specification and related analytical services as well as stability studies.
Once a comprehensive data package is compiled we can support our customers with every necessary information for filing DMF/CTD/IMPD dossier.The production output of our site reaches several kilograms, a capacity ideal for medical diagnostic tools and clinical investigational products.

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(2,6-Di-O-)ethyl-cyclodextrin
(2-Carboxyethyl)-cyclodextrin sodium salt
Acetyl-cyclodextrin
Cyclodextrin
Heptakis(2,3,6-tri-O-benzoyl)-cyclodextrin
Methyl-cyclodextrin
Octakis (6-O-t-butyldimethylsilyl)-cyclodextrin
Succinyl-cyclodextrin
Malvern
UV Detection
NMR
HPLC
gram
kilogram
Agilent 7820 GC
LC-MS/MS
Analytical Chemistry Services
Price on request

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its... Show more »

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its vast experience in the field of cyclodextrins: to characterize cyclodextrins, cyclodextrin complexes, to perform related analysis (API assay, formulation specific characterization).
Our experience also includes analysis of cyclodextrins in such complex biological matrices like blood plasma or liquor samples.
The applied techniques include traditional analytical techniques, HPLC, GC, MS and hyphenated-MS, NMR, IR, CE, Dynamic and Static Light Scattering, Bioburden and Bacterial Endotoxin Content and so on.
Complete or partial analysis of the following cyclodextrin derivatives according to the current pharmacopeial monographs: Alphadex, Betadex, Gammadex, Hydroxypropylbetadex and Betadex Sulfobutyl Ether Sodium.

« Show less
Perkin Elmer UV/Vis Spectrometer Lambda 25
Malvern Mastersizer 2000
Capillary HPLC
NMR
HPLC
Agilent 7820 GC
LC-MS/MS
Bioavailability and Bioequivalence Studies
Price on request

Design and performance of in vitro studies to support bioequivalence of a CD enabled formulation

The ever spreading applications of cyclodextrins in generic pharmaceutical formulations draw the need to support the hypothesis that the generic formulation is bioequivalent to the originator one. Cyclolab has tremendous experience... Show more »

Design and performance of in vitro studies to support bioequivalence of a CD enabled formulation

The ever spreading applications of cyclodextrins in generic pharmaceutical formulations draw the need to support the hypothesis that the generic formulation is bioequivalent to the originator one. Cyclolab has tremendous experience in the field of in vitro bioequivalence studies that can support this claim and save the huge costs and efforts of preclinical and clinical studies.

Our bioequivalence services include:

  • Regular consultancy
  • Compilation of literature data
  • Membrane penetration studies
  • Protein binding studies
  • Evaluation of binding affinity between cyclodextrin and guest
  • Physical and chemical stability studies
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Cyclodextrin
UV Detection
HPLC
Cancer
Antibiotic Development
Antibiotics
Cancer
Analytical Method Development
Price on request

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its... Show more »

During the development of a new cyclodextrin derivative, a formulation with cyclodextrins or even during in vivo experiments, the efficient analysis of the cyclodextrin component can be challenging especially without proper experience.
CycloLab can assist you with finding the ideal analytical method for your needs owing to its vast experience in the field of cyclodextrins: to characterize cyclodextrins, cyclodextrin complexes, to perform related analysis (API assay, formulation specific characterization).
Our experience also includes analysis of cyclodextrins in such complex biological matrices like blood plasma or liquor samples.
The applied techniques include traditional analytical techniques, HPLC, GC, MS and hyphenated-MS, NMR, IR, CE, Dynamic and Static Light Scattering, Bioburden and Bacterial Endotoxin Content and so on.
Complete or partial analysis of the following cyclodextrin derivatives according to the current pharmacopeial monographs: Alphadex, Betadex, Gammadex, Hydroxypropylbetadex and Betadex Sulfobutyl Ether Sodium.
http://cyclolab.hu/services/40

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Malvern
UV Detection
NMR
HPLC
Agilent 7820 GC
LC-MS/MS
Drug Discovery & Development
Price on request
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Manufacturing Services
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Pharmacology & Toxicology
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Business Development Consulting
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Recombinant Proteins
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Biochemistry & Molecular Biology
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Project Management, Consulting, & Support Services
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Formulation Services
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Protein Expression
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Experimental Design
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Chemistry and Materials
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Protein Services
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Synthetic Chemistry
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Biology
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