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CVPath Institute Incorporated

1 Order Completed
Gaithersburg, Maryland, US

About CVPath Institute Incorporated

CVPath Institute is a leading medical research and education organization dedicated to improving patient health management for those suffering from cardiac and vascular diseases. Established in 2005 as a not-for-profit organization under section 501(c)(3) of the Internal Revenue Code, our mission is to conduct... Show more »

CVPath Institute is a leading medical research and education organization dedicated to improving patient health management for those suffering from cardiac and vascular diseases. Established in 2005 as a not-for-profit organization under section 501(c)(3) of the Internal Revenue Code, our mission is to conduct basic and translational “bench to bedside” research. We provide consultation, histology, and diagnostic services to promote discoveries that advance diagnosis and treatment of cardiovascular diseases. Additionally, the institution codifies one of the largest and most comprehensive repositories of diseased human tissue and makes it available for investigative studies and teaching.

The Institute’s research team consists of pathologists, basic scientists, and highly skilled technical staff who have a deep understanding of cardiovascular pathology as well as expertise in all other anatomical systems. Our strengths and capabilities are enriched by an unmatched biorepository. This repository allows for a unique environment where expert pathologists can guide clinicians, cardiologists, forensic pathologists, and basic and translational researchers on investigative studies. The institute offers advanced technical expertise in the area of cardiovascular pathology derived from decades of preclinical investigation. This acquired knowledge allows us to provide clinically relevant consultative support to medical constituencies as well as regulatory bodies for improving the safety profile of cardiac and vascular therapies, including an array of interventional devices, before they reach the patient.

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Our Services (43)


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qPCR

Quantitative PCR
Price on request

Real-time PCR, or qPCR, remains one of the most sensitive and quantitative tools for gene expression used today. We routinely perform both custom and pre-optimized qPCR assays for specific applications. We manage all aspects of the project from assay design to nucleic acid isolation to data analysis.

Real-time PCR, or qPCR, remains one of the most sensitive and quantitative tools for gene expression used today. We routinely perform both custom and pre-optimized qPCR assays for specific applications. We manage all aspects of the project from assay design to nucleic acid isolation to data analysis.

  • Specific applications are offered such as microarray validation, biomarker discovery, RNAi validation, miRNA expression, etc.
  • Nucleic acid is isolated from tissue, cells, blood, etc. The quantity and quality are determined by using a NanoDrop® ND-1000 and an Agilent BioAnalyzer.
  • qPCR is performed by utilizing ABI 7500 Fast Real-Time PCR System.
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Immunohistochemistry (IHC)

Price on request

Our scientists perform routine immunohistochemistry (IHC) and immunofluorescence (IF) staining utilizing known controls on fresh frozen, paraffin and resin embedded tissue sections. To identify two proteins on the same section at the same time, we can also perform double labeling immunohistochemistry using a similar approach.... Show more »

Our scientists perform routine immunohistochemistry (IHC) and immunofluorescence (IF) staining utilizing known controls on fresh frozen, paraffin and resin embedded tissue sections. To identify two proteins on the same section at the same time, we can also perform double labeling immunohistochemistry using a similar approach. Immunohistochemistry services are also provided for MMA embedded sections.

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Enzymatic Spectrophotometric Assays

Price on request

For evaluation of polymer degradation in explanted devices by analytical or visual methods involving scanning electron microscopy, the preparation must contain minimal amounts of tissue. We have established enzymatic tissue digestion methods, particularly for the examination of polymer-coated stents or fully erodible scaffolds, but can also be applied to other devices as well.

For evaluation of polymer degradation in explanted devices by analytical or visual methods involving scanning electron microscopy, the preparation must contain minimal amounts of tissue. We have established enzymatic tissue digestion methods, particularly for the examination of polymer-coated stents or fully erodible scaffolds, but can also be applied to other devices as well.

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Resin Embedding

Price on request

Routine microtomy in paraffin is oftentimes not sufficient to produce the desired results of a sample for microscopic examination as the samples may be too hard or too fragile to section properly. Resin embedding is the main alternative for sectioning if paraffin is not suitable.

Our routine embedding process involves methyl... Show more »

Routine microtomy in paraffin is oftentimes not sufficient to produce the desired results of a sample for microscopic examination as the samples may be too hard or too fragile to section properly. Resin embedding is the main alternative for sectioning if paraffin is not suitable.

Our routine embedding process involves methyl methacrylate (MMA) resin, which is compatible with immunohistochemistry. We also process in glycolmethacrylate (GMA) resins such as Technovit [7100 AND 9100] or JB-4. Histologic sections are generally prepared at 4 to 6 µm, which are stained routine with hematoxylin and eosin (H&E) or connective tissue stains such as Elastic Van Geison, or Movat Pentachrome.

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Tissue Decalcification

Price on request

We use a slow decalcification process with formic acid to decalcify our samples in order to preserve the histological detail as much as possible. We also perform decalcification with EDTA for those samples, which require antigenic preservation.

We use a slow decalcification process with formic acid to decalcify our samples in order to preserve the histological detail as much as possible. We also perform decalcification with EDTA for those samples, which require antigenic preservation.

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H&E Staining

Hematoxylin and eosin staining
Price on request
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Paraffin Embedding

Price on request
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Paraffin Sectioning

Price on request
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Tissue Sectioning

Price on request
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Special Slide Staining

Price on request

We offer the following special stains:

  • Alcian Blue
  • Alizarin Red
  • Congo Red
  • Gram
  • Elastic van Geison
  • Luxol Fast Blue
  • Masson Trichrome
  • Movat Pentachrome
  • Miller’s trichrome
  • Oil Red O
  • Periodic Acid Schiff (PAS)
  • Perl’s Prussian Blue
  • Safranin O
  • Sirius Red
  • Sulphated Alcian Blue
  • Toluidine Blue
  • Von Kossa
  • X-Gal

We offer the following special stains:

  • Alcian Blue
  • Alizarin Red
  • Congo Red
  • Gram
  • Elastic van Geison
  • Luxol Fast Blue
  • Masson Trichrome
  • Movat Pentachrome
  • Miller’s trichrome
  • Oil Red O
  • Periodic Acid Schiff (PAS)
  • Perl’s Prussian Blue
  • Safranin O
  • Sirius Red
  • Sulphated Alcian Blue
  • Toluidine Blue
  • Von Kossa
  • X-Gal
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Histopathology Consulting

Price on request

Digital image analysis services [morphometry, color threshold] are offered using standard computerized software. Board Certified Pathologists are available to score, read, analyze, and report histopathological results.

Digital image analysis services [morphometry, color threshold] are offered using standard computerized software. Board Certified Pathologists are available to score, read, analyze, and report histopathological results.

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Medical Imaging Services

Price on request

The CVPath Insitute offers an established resource for ex-vivo and in-vivo intravascular imaging tools including intravascular ultrasound, optical coherence tomography, angioscopy, near-infrared spectroscopy, etc. and helps develop new or improve existing modalities by offering a wide range of coregistration services between histology and invasive/non-invasive imaging modalities.

The CVPath Insitute offers an established resource for ex-vivo and in-vivo intravascular imaging tools including intravascular ultrasound, optical coherence tomography, angioscopy, near-infrared spectroscopy, etc. and helps develop new or improve existing modalities by offering a wide range of coregistration services between histology and invasive/non-invasive imaging modalities.

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Scanning Electron Microscopy (SEM)

Scanning Electron Microscopy services
Price on request

Scanning Electron Microscope (SEM) is a widely used surface analytical technique, which is especially useful for the evaluation of endothelium, inflammation, and thrombus in stented surfaces. It also provides high magnification images of surface topography, (up to x20,0000) at a high resolution up to 2nm. SEM, accompanied by X-ray... Show more »

Scanning Electron Microscope (SEM) is a widely used surface analytical technique, which is especially useful for the evaluation of endothelium, inflammation, and thrombus in stented surfaces. It also provides high magnification images of surface topography, (up to x20,0000) at a high resolution up to 2nm. SEM, accompanied by X-ray analysis (EDX), is considered a relatively rapid, inexpensive, and non-destructive approach to surface analysis. It is useful for evaluation of surface corrosion and/or elemental analysis.

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Transmission Electron Microscopy (TEM)

Transmission Electron Microscopy services
Price on request

Digital image analysis services [morphometry, color threshold] are offered using standard computerized software. Board Certified Pathologists are available to score, read, analyze, and report histopathological results.

Digital image analysis services [morphometry, color threshold] are offered using standard computerized software. Board Certified Pathologists are available to score, read, analyze, and report histopathological results.

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Confocal Microscopy

Price on request

Confocal Laser Scanning Microscopy (CLSM) is part of our microscopy imaging services. The CLSM is a sophisticated instrument with the ability to penetrate beneath the surface of a tissue and to acquire much higher resolution images than is possible with a conventional fluorescence microscope. The CLSM has advanced optics, which... Show more »

Confocal Laser Scanning Microscopy (CLSM) is part of our microscopy imaging services. The CLSM is a sophisticated instrument with the ability to penetrate beneath the surface of a tissue and to acquire much higher resolution images than is possible with a conventional fluorescence microscope. The CLSM has advanced optics, which eliminates all the information outside of a narrow plane of focus while, simultaneously, the activation of the molecules only takes place in the plane of focus, yielding a well-defined image. Any bleaching of the surrounding tissue or sample is minimized. The Confocal Microscopy Unit provides basic methods for capturing and analyzing microscopic images. It is also equipped for the processing of image data files. CLSM can be used on paraffin, frozen, or for whole mount “en face” tissue examination.

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microCT

X-ray microtomography
Price on request
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Histology and Pathology Services

Price on request

Our CAP-accredited and CLIA-approved laboratory can help you meet the pathology requirements of your clinical trials. We offer diagnostic services for autopsy and surgical specimens associated with the cardiovasculature as well as other related organ systems. Our extensive experience with the interaction and impact of emerging... Show more »

Our CAP-accredited and CLIA-approved laboratory can help you meet the pathology requirements of your clinical trials. We offer diagnostic services for autopsy and surgical specimens associated with the cardiovasculature as well as other related organ systems. Our extensive experience with the interaction and impact of emerging interventional technologies on human tissues will ensure that your clinical research trial pathology needs are well supported.

CVPath provides pathology support for clinical trials involving:

  • Cardiovascular toxicity
  • Medical devices
    • Stents: coronary, peripheral, carotid
    • Grafts
    • Valves: TAVI
    • Heart failure
  • Tissue examination and analysis
    • Whole heart grossing
    • Excised atherosclerotic plaque
      • SilverHawk
      • Carotid endarterectomy
    • Thrombectomy material
  • Distal filter material [embolic protection]
    • Surgically resected aneurysms
    • Endomyocardial biopsies
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Clinical and Anatomic Pathology

Price on request

Our CAP-accredited and CLIA-approved laboratory can help you meet the pathology requirements of your clinical trials. We offer diagnostic services for autopsy and surgical specimens associated with the cardiovasculature as well as other related organ systems. Our extensive experience with the interaction and impact of emerging... Show more »

Our CAP-accredited and CLIA-approved laboratory can help you meet the pathology requirements of your clinical trials. We offer diagnostic services for autopsy and surgical specimens associated with the cardiovasculature as well as other related organ systems. Our extensive experience with the interaction and impact of emerging interventional technologies on human tissues will ensure that your clinical research trial pathology needs are well supported.

CVPath provides pathology support for clinical trials involving:

  • Cardiovascular toxicity
  • Medical devices
    • Stents: coronary, peripheral, carotid
    • Grafts
    • Valves: TAVI
    • Heart failure
  • Tissue examination and analysis
    • Whole heart grossing
    • Excised atherosclerotic plaque
      • SilverHawk
      • Carotid endarterectomy
    • Thrombectomy material
  • Distal filter material [embolic protection]
    • Surgically resected aneurysms
    • Endomyocardial biopsies
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Radiography

Price on request

We radiograph specimens to assess calcification and assist in specimen orientation for trimming and aligning the regions of interest in a correct position.

We radiograph specimens to assess calcification and assist in specimen orientation for trimming and aligning the regions of interest in a correct position.

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Clinical Research

Price on request

Clinical Research Services

Clinical Research Services

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Electron Microscopy

Price on request

Electron Microscopy Services

Electron Microscopy Services

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Fluorescence-Based Microscopy

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Fluorescence-Based Microscopy Services

Fluorescence-Based Microscopy Services

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Optical Microscopy

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Optical Microscopy Services

Optical Microscopy Services

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Microscopy

Price on request

Microscopy Services

Microscopy Services

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Tomography Services

Computed tomography services
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Tomography Services

Tomography Services

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Imaging & Spectroscopy

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Imaging & Spectroscopy Services

Imaging & Spectroscopy Services

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Clinical Laboratory Services

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Clinical Laboratory Services

Clinical Laboratory Services

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Common Histochemical Stains

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Common Histochemical Stains Services

Common Histochemical Stains Services

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Tissue Embedding

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Tissue Embedding Services

Tissue Embedding Services

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Tissue Processing

Price on request

Tissue Processing Services

Tissue Processing Services

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Biospecimens

Price on request

Biospecimens Services

Biospecimens Services

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Cells and Tissues

Price on request

Cells and Tissues Services

Cells and Tissues Services

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Biology

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Biology Services

Biology Services

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Histological Staining

Price on request

Histological Staining Services

Histological Staining Services

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Spectrophotometry

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Spectrophotometry Services

Spectrophotometry Services

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Spectroscopy

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Spectroscopy Services

Spectroscopy Services

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Biochemistry & Molecular Biology

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Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Protein Services

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Protein Services

Protein Services

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Protein Expression Visualization

Price on request

Protein Expression Visualization Services

Protein Expression Visualization Services

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Immunostaining

Price on request

Immunostaining Services

Immunostaining Services

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Nucleic Acid Services

Price on request

Nucleic Acid Services

Nucleic Acid Services

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DNA Services

Price on request

DNA Services

DNA Services

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PCR

Price on request

PCR Services

PCR Services

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Aloke Finn

Physician Scientist

CVPath Institute Incorporated has not received any reviews.

CVPath Institute Incorporated has not received any endorsements.