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Covance - Safety Assessment Solutions

US

Assess the Safety of your Compound — Affordably.

Discover how 30+ years of experience can help you quickly assess the safety profile of your compounds to move your drug development research forward. With on time reporting and world renowned quality, you can now put the world’s largest, most experienced team of GLP toxicology specialists to work on your program.

  • General Toxicology
  • Genetic Toxicology
  • Immunotoxicology
  • Safety Pharmacology
  • Developmental and Reproductive Toxicology (DART)

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Dermal Toxicology
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In vivo Pharmacology Studies
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Toxicology
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Why Covance for toxicology:

  • The largest and most comprehensive toxicology capabilities in the industry, with 5,500+ studies initiated in the last four years
  • > 60% of Study Directors have 10 or more years of experience
  • Best-in-class study timelines with 99% on-time reporting

Species:

Why Covance for toxicology:

  • The largest and most comprehensive toxicology capabilities in the industry, with 5,500+ studies initiated in the last four years
  • > 60% of Study Directors have 10 or more years of experience
  • Best-in-class study timelines with 99% on-time reporting

Species:

  • Rodent: Rat, Mouse, Rabbit, Hamster
  • Non-rodent: Canine, Nonhuman Primate, Mini-pig

Duration:
Single-dose / special, Range-finding, Sub-chronic, Chronic, Carcinogenicity

Administration:
Dermal, Gavage, Implant, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Rectal, Subcutaneous, Vaginal

Specialty Toxicology services also available, including:

  • Cardiovascular studies
  • Ocular toxicology
  • Neurotoxicology
  • Bone toxicology
  • Routine toxicology studies in marmosets
  • Uroflow test
  • Muscle circumference (anabolic effects)
  • Body composition
  • Reproechocardiography
  • Continuous infusion
  • Geriatric models
  • Specialized NHP imaging – including: MRI, CT, Ultrasound
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Genotoxicity Testing
Price on request

Successfully assess the potential for genetic damage or identify genotoxic impurities in your compounds:

  • Regulatory Assays
  • Screening Studies (including micro-well AMES screening assay)
  • Multi-Endpoint Assays

Consider some of our standard battery of tests that meet ICH or OECD requirements:

In vitro... Show more »

Successfully assess the potential for genetic damage or identify genotoxic impurities in your compounds:

  • Regulatory Assays
  • Screening Studies (including micro-well AMES screening assay)
  • Multi-Endpoint Assays

Consider some of our standard battery of tests that meet ICH or OECD requirements:

In vitro assays

  • Ames, mammalian gene mutation (mouse lymphoma assay)
  • Chromosome aberration (human lymphocytes and CHO cells)
  • Micronucleus (human lymphocytes and cell lines)

In vivo assays

  • Rodent bone marrow micronucleus and chromosome aberrations
  • Comet and combination (micronucleus and Comet)

Non-standard assays
Investigative assays give you a quick way to address and resolve issues with lead candidates as you move through the development journey. Tap into unique solutions such as centromere probing of micronuclei, 3D skin models, as well as in vivo comet and transgenic Muta™Mouse assays. These unique solutions enable you to gain genetic insights about your molecule – solutions that most other CROs can’t help you obtain.

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In vivo Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
    -... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
  • Immunohistochemistry
  • Host Resistance Assays
  • Delayed Type Hypersensitivity
  • Rodent Anaphylaxis Models
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Monoclonal Antibody Derivation and Production
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
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In vitro Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
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Safety Pharmacology
Price on request

Follow an integrated approach to non-GLP and GLP safety assessment with a multi-disciplinary approach and obtain your endpoints to meet regulatory requirements, uncover future issues and advance the best molecules.

  • Cardiovascular Assessment
    • Digital multi-lead ECGs
    • Jacketed External Telemetry (JET™)
    • Jacketed... Show more »

Follow an integrated approach to non-GLP and GLP safety assessment with a multi-disciplinary approach and obtain your endpoints to meet regulatory requirements, uncover future issues and advance the best molecules.

  • Cardiovascular Assessment
    • Digital multi-lead ECGs
    • Jacketed External Telemetry (JET™)
    • Jacketed External Telemetry with Blood Pressure (JET-BP)
    • High Definition Oscillometry (HDO)
    • High-quality ECG Analysis and Interpretation
  • ICH Core Battery Tests
  • ICH Supplemental Tests
  • Discovery Support
  • Infusion Services
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DART Studies
Developmental and Reproductive Toxicology Studies
Price on request

Access comprehensive, state-of-the-art DART and Nonhuman DART services:

  • Extensive NHP DART experience with 120+ studies in pregnant NHPs and 25+ (e)PPND studies
  • Social housing is standard for NHP DART studies
  • DART experience and capacity with 70+ studies conducted in small models per year

Get specialized reproductive... Show more »

Access comprehensive, state-of-the-art DART and Nonhuman DART services:

  • Extensive NHP DART experience with 120+ studies in pregnant NHPs and 25+ (e)PPND studies
  • Social housing is standard for NHP DART studies
  • DART experience and capacity with 70+ studies conducted in small models per year

Get specialized reproductive and developmental toxicology experience to design and perform your studies effectively; innovative techniques and the capacity to enable you to meet your timelines efficiently; and regulatory know-how to ensure you meet all requirements compliantly.

  • Seg I — Fertility and Early Embryonic Development
  • Seg II — Embryo Fetal Development
  • Seg III — Prenatal and Postnatal Development
  • ePPND — Enhanced Pre- and Post-natal Development
  • Juvenile Toxicity Studies
  • Special Developmental and Reproductive Toxicology Studies
  • Infusion Services
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In vivo Toxicity Testing
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In vitro Toxicity Testing
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Pharmacology & Toxicology
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Safety Pharmacology & Efficacy Testing
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In vivo PK/PD Studies
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