3h8kr4szsmavlcwd97ww wbu1xmxmrusibzefgdf8 screen shot 2017 01 19 at 12.44.20 pm

Covance – Non-GLP Lead Optimization

US

Bring Forward Your Best Candidate.

Improve your probability of success while minimizing cycle time with our industry-leading lead optimization solutions. Advance your most promising compounds and experience cost effective insights.

► Lead Optimization – Toxicology
► In Vivo Pharmacology
► Immunotoxicology

Covance – Non-GLP Lead Optimization has not listed any services.

Ask A Question Find what you're looking for? If not, you can ask this lab a question:
Humanized Mouse Models
Price on request

Humanized mouse models (hCD34+ or PBMC engraftment)
Current model list available on request
Specific models and assays can be developed per sponsor request
Immunophenotyping, PK/PD, Pathology and biomarker support

Humanized mouse models (hCD34+ or PBMC engraftment)
Current model list available on request
Specific models and assays can be developed per sponsor request
Immunophenotyping, PK/PD, Pathology and biomarker support

« Show less
Small Animal CT Scan
Small Animal Computed Tomography Scan
Price on request

CT Imaging
• Tumor assessment with read outs of bone destruction
• Angiogenesis using contrast agent
• Renal tumor measurements using contrast agents

CT Imaging
• Tumor assessment with read outs of bone destruction
• Angiogenesis using contrast agent
• Renal tumor measurements using contrast agents

« Show less
Syngeneic (Allograft) Tumor Models
Price on request

Syngeneic (murine) tumor models

Syngeneic (murine) tumor models

« Show less
Animal Imaging
Price on request

Bioluminescent Imaging (aka IVIS or Xenogen Imaging)

Bioluminescent Imaging (aka IVIS or Xenogen Imaging)

« Show less
Xenograft Models
Price on request

Cell line xenograft models (50+ models)
• Efficacy
• MOA
• PK/PD
• Combination therapies
• Immunotherapy

Cell line xenograft models (50+ models)
• Efficacy
• MOA
• PK/PD
• Combination therapies
• Immunotherapy

« Show less
Toxicology
Price on request

Lead Optimization Toxicology (Non-GLP)

Reduce timelines up to 40 days with our integrated lead optimization toxicology solution. Get the right study designs working with a cross-functional team of scientific experts. Anticipate and respond to challenges earlier — for better decision making:

Lead Optimization Toxicology (Non-GLP)

Reduce timelines up to 40 days with our integrated lead optimization toxicology solution. Get the right study designs working with a cross-functional team of scientific experts. Anticipate and respond to challenges earlier — for better decision making:

  • Lead optimization toxicology

    • Dose escalation and pilot studies (large animals)
    • Dose range finding studies (large and small animals)
    • Screening and pilot studies (rodent)
    • Toxicokinetic studies (large and small animals)
  • Evaluation of cardiovascular function with telemetry technology (rat, canine, NHP)

    • HR, BP, ECG, left ventricular pressure, body temperature
  • Consultation on regulatory requirements and nonclinical studies

  • Evaluation of endocrine function (rat, canine, NHP)

  • Genetic Toxicology Screening Studies (including micro-well AMES screening assay)

« Show less
In vivo Toxicity Testing
Price on request
Request a quote for more information about this service.
Genotoxicity Testing
Price on request
Request a quote for more information about this service.
In vivo Pharmacology Studies
Price on request

Get the efficacy answers you need — early in the process — with our integrated in vivo pharmacology solutions for small and large molecule discovery. Partner with our experts to design, validate, conduct and analyze efficacy studies for your drug candidates.

Wide range of model development and validation, including these top... Show more »

Get the efficacy answers you need — early in the process — with our integrated in vivo pharmacology solutions for small and large molecule discovery. Partner with our experts to design, validate, conduct and analyze efficacy studies for your drug candidates.

Wide range of model development and validation, including these top therapeutic areas:

  • Cardiovascular
  • Inflammatory disease
  • Metabolic disease
  • Oncology

Species: Canine, Rodent, Non-human primate

« Show less
In vitro Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
« Show less
In vivo Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
    -... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
  • Immunohistochemistry
  • Host Resistance Assays
  • Delayed Type Hypersensitivity
  • Rodent Anaphylaxis Models
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Monoclonal Antibody Derivation and Production
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
« Show less
Immunophenotyping
Price on request
Request a quote for more information about this service.
Immune Function Testing
Price on request
Request a quote for more information about this service.
Tissue Cross Reactivity Studies
Price on request
Request a quote for more information about this service.
Immunohistochemistry (IHC)
Price on request
Request a quote for more information about this service.
Delayed-Type Hypersensitivity (DTH) Animal Models
Delayed Type Hypersensitivity Animal Models
Price on request
Request a quote for more information about this service.
Monoclonal Antibody (mAb) Production
Price on request
Request a quote for more information about this service.
Animal Immunization for Antibody Production
Price on request
Request a quote for more information about this service.
Bioanalysis
Price on request
Request a quote for more information about this service.
Biochemistry & Molecular Biology
Price on request
Request a quote for more information about this service.
Clinical Immunology Tests
Price on request
Request a quote for more information about this service.
In vivo PK/PD Studies
Price on request
Request a quote for more information about this service.
Biomarkers
Price on request
Request a quote for more information about this service.
Clinical Research
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Clinical Laboratory Services
Price on request
Request a quote for more information about this service.
Animal Models and Studies
Price on request
Request a quote for more information about this service.
Animal Models of Disease
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
Antibody Services
Price on request
Request a quote for more information about this service.
In vitro Toxicity Testing
Price on request
Request a quote for more information about this service.
Protein Services
Price on request
Request a quote for more information about this service.
Immunostaining
Price on request
Request a quote for more information about this service.
Protein Expression Visualization
Price on request
Request a quote for more information about this service.
Immunology Animal Models
Price on request
Request a quote for more information about this service.
Animal Model in vivo Analyses
Price on request

Animal Model in vivo Analyses Services

Animal Model in vivo Analyses Services

« Show less
Oncology Animal Models
Price on request

Oncology Animal Models Services

Oncology Animal Models Services

« Show less
In vitro Disease Models
Price on request

Oncology - In vitro Assays

• 100+ genotyped and pathogen-tested cancer cell lines
• Target and pathway activity modulation
• Agonist and antagonist reporter assays
• Biochemical assays and immunoassays to evaluate target expression, engagement and modulation
• Cellular toxicity and proliferation assays
• Cell death... Show more »

Oncology - In vitro Assays

• 100+ genotyped and pathogen-tested cancer cell lines
• Target and pathway activity modulation
• Agonist and antagonist reporter assays
• Biochemical assays and immunoassays to evaluate target expression, engagement and modulation
• Cellular toxicity and proliferation assays
• Cell death assays including apoptosis assays
• Angiogenesis and cell migration assays
• ADCC and CDC activity assays
• Phenotypic and functional characterization of various cell types using flow cytometry
• Cell-based biomarker discovery and qualification
• Immunological assessment of therapeutic article/ vaccine efficacy

« Show less
Oncology
Cells and Tissues
Price on request

Cells and Tissues Services

Cells and Tissues Services

« Show less

Covance – Non-GLP Lead Optimization has not received any ratings.

Be the first to endorse Covance – Non-GLP Lead Optimization

Endorse this lab