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Covance – Non-GLP Lead Optimization

US

Bring Forward Your Best Candidate.

Improve your probability of success while minimizing cycle time with our industry-leading lead optimization solutions. Advance your most promising compounds and experience cost effective insights.

► Lead Optimization – Toxicology
► In Vivo Pharmacology
► Immunotoxicology

Covance – Non-GLP Lead Optimization has not listed any services.

In vitro Genotoxicity Testing
Price on request
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Toxicology
Humanized Mouse Models
Price on request

Humanized mouse models (hCD34+ or PBMC engraftment)
Current model list available on request
Specific models and assays can be developed per sponsor request
Immunophenotyping, PK/PD, Pathology and biomarker support

Humanized mouse models (hCD34+ or PBMC engraftment)
Current model list available on request
Specific models and assays can be developed per sponsor request
Immunophenotyping, PK/PD, Pathology and biomarker support

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Humanized mouse
PK/PD
Toxicology
Small Animal CT Scan
Small Animal Computed Tomography Scan
Price on request

CT Imaging
• Tumor assessment with read outs of bone destruction
• Angiogenesis using contrast agent
• Renal tumor measurements using contrast agents

CT Imaging
• Tumor assessment with read outs of bone destruction
• Angiogenesis using contrast agent
• Renal tumor measurements using contrast agents

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Small animals
Syngeneic (Allograft) Tumor Models
Price on request

Syngeneic (murine) tumor models

Syngeneic (murine) tumor models

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Animal Imaging
Price on request

Bioluminescent Imaging (aka IVIS or Xenogen Imaging)

Bioluminescent Imaging (aka IVIS or Xenogen Imaging)

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Xenograft Models
Price on request

Cell line xenograft models (50+ models)
• Efficacy
• MOA
• PK/PD
• Combination therapies
• Immunotherapy

Cell line xenograft models (50+ models)
• Efficacy
• MOA
• PK/PD
• Combination therapies
• Immunotherapy

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Toxicology
Price on request

Lead Optimization Toxicology (Non-GLP)

Reduce timelines up to 40 days with our integrated lead optimization toxicology solution. Get the right study designs working with a cross-functional team of scientific experts. Anticipate and respond to challenges earlier — for better decision making:

Lead Optimization Toxicology (Non-GLP)

Reduce timelines up to 40 days with our integrated lead optimization toxicology solution. Get the right study designs working with a cross-functional team of scientific experts. Anticipate and respond to challenges earlier — for better decision making:

  • Lead optimization toxicology

    • Dose escalation and pilot studies (large animals)
    • Dose range finding studies (large and small animals)
    • Screening and pilot studies (rodent)
    • Toxicokinetic studies (large and small animals)
  • Evaluation of cardiovascular function with telemetry technology (rat, canine, NHP)

    • HR, BP, ECG, left ventricular pressure, body temperature
  • Consultation on regulatory requirements and nonclinical studies

  • Evaluation of endocrine function (rat, canine, NHP)

  • Genetic Toxicology Screening Studies (including micro-well AMES screening assay)

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Rabbit
Rat
Dog
Rodents
Drug Safety and Toxicology
Toxicology
Nonhuman Primate
In vivo Toxicity Testing
Price on request
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Rabbit
Rat
Dog
Rodents
Toxicology
General Toxicology
Nonhuman Primate
In vivo Genotoxicity Testing
Price on request
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Rabbit
Rat
Dog
Rodents
Toxicology
Nonhuman Primate
In vivo Pharmacology Studies
Price on request

Get the efficacy answers you need — early in the process — with our integrated in vivo pharmacology solutions for small and large molecule discovery. Partner with our experts to design, validate, conduct and analyze efficacy studies for your drug candidates.

Wide range of model development and validation, including these top... Show more »

Get the efficacy answers you need — early in the process — with our integrated in vivo pharmacology solutions for small and large molecule discovery. Partner with our experts to design, validate, conduct and analyze efficacy studies for your drug candidates.

Wide range of model development and validation, including these top therapeutic areas:

  • Cardiovascular
  • Inflammatory disease
  • Metabolic disease
  • Oncology

Species: Canine, Rodent, Non-human primate

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Rabbit
Rat
Dog
Rodents
Toxicology
Nonhuman Primate
In vitro Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
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Toxicology
In vivo Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
    -... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
  • Immunohistochemistry
  • Host Resistance Assays
  • Delayed Type Hypersensitivity
  • Rodent Anaphylaxis Models
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Monoclonal Antibody Derivation and Production
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
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Rabbit
Rat
Dog
Rodents
Drug Safety and Toxicology
Drug safety and toxicology
Toxicology
Nonhuman Primate
Immunophenotyping
Price on request
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Immune Function Testing
Price on request
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Tissue Cross Reactivity Studies
Price on request
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Immunohistochemistry (IHC)
Price on request
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Delayed-Type Hypersensitivity (DTH) Animal Models
Delayed Type Hypersensitivity Animal Models
Price on request
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Monoclonal Antibody (mAb) Production
Price on request
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Animal Immunization for Antibody Production
Price on request
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Bioanalysis
Price on request
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Biochemistry & Molecular Biology
Price on request
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Clinical Immunology Tests
Price on request
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In vivo PK/PD Studies
Price on request
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Rabbit
Rat
Dog
Rodents
Nonhuman Primate
Biomarkers
Price on request
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Clinical Research
Price on request
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Pharmacology & Toxicology
Price on request
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Clinical Laboratory Services
Price on request
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Animal Models and Studies
Price on request
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Animal Models of Disease
Price on request
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Biology
Price on request
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Antibody Services
Price on request
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In vitro Toxicity Testing
Price on request
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Protein Services
Price on request
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Immunostaining
Price on request
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Protein Expression Visualization
Price on request
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Immunology Animal Models
Price on request
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Animal Model in vivo Analyses
Price on request

Animal Model in vivo Analyses Services

Animal Model in vivo Analyses Services

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Oncology Animal Models
Price on request

Oncology Animal Models Services

Oncology Animal Models Services

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In vitro Disease Models
Price on request

Oncology - In vitro Assays

• 100+ genotyped and pathogen-tested cancer cell lines
• Target and pathway activity modulation
• Agonist and antagonist reporter assays
• Biochemical assays and immunoassays to evaluate target expression, engagement and modulation
• Cellular toxicity and proliferation assays
• Cell death... Show more »

Oncology - In vitro Assays

• 100+ genotyped and pathogen-tested cancer cell lines
• Target and pathway activity modulation
• Agonist and antagonist reporter assays
• Biochemical assays and immunoassays to evaluate target expression, engagement and modulation
• Cellular toxicity and proliferation assays
• Cell death assays including apoptosis assays
• Angiogenesis and cell migration assays
• ADCC and CDC activity assays
• Phenotypic and functional characterization of various cell types using flow cytometry
• Cell-based biomarker discovery and qualification
• Immunological assessment of therapeutic article/ vaccine efficacy

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Oncology
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request

ADME/DMPK Studies Services

ADME/DMPK Studies Services

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Rabbit
Rat
Dog
Rodents
Nonhuman Primate
Cells and Tissues
Price on request

Cells and Tissues Services

Cells and Tissues Services

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Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology
Price on request

Pharmacology Services

Pharmacology Services

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2018-08-08 18:45:03 -0400

Net Promoter Score of 9 received for Scientific Sourcing.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 8.

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