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Covance – Non-GLP Lead Optimization

US

Bring Forward Your Best Candidate.

Improve your probability of success while minimizing cycle time with our industry-leading lead optimization solutions. Advance your most promising compounds and experience cost effective insights.

► Lead Optimization – Toxicology
► In Vivo Pharmacology
► Immunotoxicology

Covance – Non-GLP Lead Optimization has not listed any services.

Toxicology
Price on request

Lead Optimization Toxicology (Non-GLP)

Reduce timelines up to 40 days with our integrated lead optimization toxicology solution. Get the right study designs working with a cross-functional team of scientific experts. Anticipate and respond to challenges earlier — for better decision making:

Lead Optimization Toxicology (Non-GLP)

Reduce timelines up to 40 days with our integrated lead optimization toxicology solution. Get the right study designs working with a cross-functional team of scientific experts. Anticipate and respond to challenges earlier — for better decision making:

  • Lead optimization toxicology

    • Dose escalation and pilot studies (large animals)
    • Dose range finding studies (large and small animals)
    • Screening and pilot studies (rodent)
    • Toxicokinetic studies (large and small animals)
  • Evaluation of cardiovascular function with telemetry technology (rat, canine, NHP)

    • HR, BP, ECG, left ventricular pressure, body temperature
  • Consultation on regulatory requirements and nonclinical studies

  • Evaluation of endocrine function (rat, canine, NHP)

  • Genetic Toxicology Screening Studies (including micro-well AMES screening assay)

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In vivo Toxicity Testing
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Genotoxicity Testing
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In vivo Pharmacology Studies
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Get the efficacy answers you need — early in the process — with our integrated in vivo pharmacology solutions for small and large molecule discovery. Partner with our experts to design, validate, conduct and analyze efficacy studies for your drug candidates.

Wide range of model development and validation, including these top... Show more »

Get the efficacy answers you need — early in the process — with our integrated in vivo pharmacology solutions for small and large molecule discovery. Partner with our experts to design, validate, conduct and analyze efficacy studies for your drug candidates.

Wide range of model development and validation, including these top therapeutic areas:

  • Cardiovascular
  • Inflammatory disease
  • Metabolic disease
  • Oncology

Species: Canine, Rodent, Non-human primate

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In vitro Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Tissue Cross-Reactivity
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
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In vivo Immunotoxicity Testing
Price on request

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
    -... Show more »

Characterize adverse effects on the immune system utilizing a variety of cell-based assays and technology platforms, such as:

  • Immuophenotyping Assays
  • T-Cell Dependent Antibody Response Assays
  • Natural Killer Cell Cytotoxicity Assays
  • Lymphocyte Proliferation Assays
  • Cytokine Analysis
  • Local Lymph Node Assays
  • Immunohistochemistry
  • Host Resistance Assays
  • Delayed Type Hypersensitivity
  • Rodent Anaphylaxis Models
  • ELISA and other Immunochemistry Models
  • ELISPOT assay
  • Toxicology Assessment of Vaccines
  • Monoclonal Antibody Derivation and Production
  • Neutrophil and Monocyte Function
  • Platelet Function
  • Flow Cytometry
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Immunophenotyping
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Immune Function Testing
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Tissue Cross Reactivity Studies
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Immunohistochemistry (IHC)
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Delayed-Type Hypersensitivity (DTH) Animal Models
Delayed Type Hypersensitivity Animal Models
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Monoclonal Antibody (mAb) Production
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Animal Models and Studies
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Clinical Immunology Tests
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Protein Expression Visualization
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Clinical Research
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Animal Models of Disease
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Protein Services
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Biology
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Immunostaining
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In vitro Toxicity Testing
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Clinical Laboratory Services
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Immunology Animal Models
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Pharmacology & Toxicology
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Bioanalysis
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Antibody Services
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Biomarkers
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In vivo PK/PD Studies
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Biochemistry & Molecular Biology
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