Vmqxun7lsvo65jky8i7j wbu1xmxmrusibzefgdf8 screen shot 2017 01 19 at 12.44.20 pm

Covance – Drug Metabolism and Pharmacokinetics (DMPK) Solutions

US

Characterize Your Drug Candidate’s ADME Properties

Get a complete range of ADME services to streamline your candidate optimization, early and late development program. With 1,000s of studies conducted annually, you have access to the broadest, deepest and most experienced group of dedicated DMPK scientists in the CRO industry to help you to meet the latest regulatory expectations and avoid delays in your development program.

  • In Vitro ADME Studies
  • Preclinical PK/PD Studies (including Fast PK)
  • Metabolite Profiling
  • In vivo ADME Studies
  • PK/PD Modeling

Covance – Drug Metabolism and Pharmacokinetics (DMPK) Solutions has not listed any services.

Ask A Question Find what you're looking for? If not, you can ask this lab a question:
In vivo Percutaneous Absorption Studies
Price on request
Request a quote for more information about this service.
Toxicology
In vitro Percutaneous Absorption Studies
Price on request
Request a quote for more information about this service.
In vitro ADME/PK Studies
Price on request
  • Enzyme inhibition (e.g. CYP & UGT); determination of IC50, IC50 shift, and Ki, KI, Kinact, etc.
  • In vitro CYP induction assessment using human hepatocytes; enzyme activity and mRNA analysis; determine EC50, Emax
  • Ex vivo enzyme induction (rodent, canine, nonhuman primate)
  • Identification of enzymes involved in... Show more »
  • Enzyme inhibition (e.g. CYP & UGT); determination of IC50, IC50 shift, and Ki, KI, Kinact, etc.
  • In vitro CYP induction assessment using human hepatocytes; enzyme activity and mRNA analysis; determine EC50, Emax
  • Ex vivo enzyme induction (rodent, canine, nonhuman primate)
  • Identification of enzymes involved in metabolism (e.g. CYP, UGT, AO MAO etc.) using selective inhibitors and recombinant enzymes
  • In vitro Met ID and metabolic stability; species comparison; microsomes, hepatocytes, or other matrices
  • In vitro and ex vivo plasma protein binding species comparison (equilibrium dialysis, ultrafiltration etc.)
  • In vitro and ex vivo blood cell partitioning
  • In vitro Caco-2 permeability, P-gp and BCRP assessment
  • In vitro drug-transporter interactions involving key human drug transporters as required by regulatory agencies
  • In vitro dermal absorption in human and animal skin
  • In vitro covalent binding and reactive intermediate assessment
  • Custom in vitro investigational experiments as requested
« Show less
in vitro
Drug safety and toxicology
Toxicology
ADME
Preclinical PK/PD Studies
in vivo Pharmacokinetics/Pharmacodynamics
Price on request
  • Global capacity with harmonized processes to meet individual client needs
  • Large and small molecule experience
  • Definitive and HT screening pharmacokinetics and formulation testing in animal models (rodent, canine, nonhuman primate, rabbit, minipig, other species)
  • Fast PK – from powder (formulation) to PK report in 5 days... Show more »
  • Global capacity with harmonized processes to meet individual client needs
  • Large and small molecule experience
  • Definitive and HT screening pharmacokinetics and formulation testing in animal models (rodent, canine, nonhuman primate, rabbit, minipig, other species)
  • Fast PK – from powder (formulation) to PK report in 5 days or less
  • Quick start NHP PK using naïve or biologic-naïve/non-naïve animals (if available)
  • Colonies of non-naïve canines and NHP; client owned colonies also available
  • Calculation of PK parameters using Phoenix® WinNonlin®
  • Specialty surgical models available including, but not limited to:
    • Cannulation: jugular vein, portal vein, intestinal (multiple), pulmonary artery/vein
    • Bile duct cannulation
      • NHP: acute
      • Canine: acute and recirculating
      • Minipig: acute and recirculating
    • Serial survival (laparoscopic) liver biopsy: canine and NHP
    • Survival biopsy procedures: muscle, colon, skin
    • Serial survival CSF collection
    • Cisterna magna and lumbar catheterization for serial CSF collection in NHP
    • R&D services available for new model development
« Show less
PK/PD
Toxicology
Metabolite Identification
Price on request
  • High resolution accurate mass determination – via Q Exactive™, OrbiTrap®, Ion mobility & QToF instrumentation
  • Radiolabeled and non-radiolabeled
  • NMR (access through partner)
  • Simultaneous collection of radio and MS profiles
  • Sciex 5500 QTRAP platform available if required
  • Dedicated team of Met ID scientists (PhD level) with extensive experience
  • High resolution accurate mass determination – via Q Exactive™, OrbiTrap®, Ion mobility & QToF instrumentation
  • Radiolabeled and non-radiolabeled
  • NMR (access through partner)
  • Simultaneous collection of radio and MS profiles
  • Sciex 5500 QTRAP platform available if required
  • Dedicated team of Met ID scientists (PhD level) with extensive experience
« Show less
In vivo PK/PD Studies
Price on request
  • Excretion and mass balance
  • Placental and lacteal transfer (mouse, rat)
  • Distribution by quantitative whole-body autoradiography (QWBA) and excision (mouse, rat, rabbit, nonhuman primate)
  • Expired CO2 collections (mouse, rat, hamster)
  • Microautoradiography
  • Biliary excretion and enterohepatic cycling (mouse, rat,... Show more »
  • Excretion and mass balance
  • Placental and lacteal transfer (mouse, rat)
  • Distribution by quantitative whole-body autoradiography (QWBA) and excision (mouse, rat, rabbit, nonhuman primate)
  • Expired CO2 collections (mouse, rat, hamster)
  • Microautoradiography
  • Biliary excretion and enterohepatic cycling (mouse, rat, canine, minipig, rabbit, nonhuman primate)
  • Portal vein cannulation (rat, canine, nonhuman primate)
  • Dosimetry calculations for human radiolabeled studies meeting US and European regulations
  • Human metabolism and excretion (Phase I clinical study)
  • Studies with different isotopes (14C, 3H, 125I, 131I, 32P, 33P, 35S, others as requested)
  • Studies in many animal species [mouse, rat, hamster, guinea pig, ferret, rabbit, canine, nonhuman primate (cynomolgus and rhesus macaque), mini-pig]
  • Specialized routes of administration such as: intravenous infusion, dermal, ocular, intravitreal, sub-Tenon, inhalation, intravesicular
  • Ocular pharmacology, ADME and PK
  • Transgenic and tumor animal models available
  • ADME in livestock and avian species to support agrochemical and animal health product development
« Show less
PK/PD
in vivo
PK/PD Modeling
Pharmacokinetics/Pharmacodynamics Modeling
Price on request
  • Large and small molecule compartmental/noncompartmental analysis (Phoenix® WinNonlin®)
  • Bioavailability/bioequivalence/biosimilars
  • PK/PD modeling and simulation
  • Population pharmacokinetics (NONMEM®)
  • Prediction of human PK using allometric scaling and in vitro scale up
  • Physiologically Based PK Modelling (DDI... Show more »
  • Large and small molecule compartmental/noncompartmental analysis (Phoenix® WinNonlin®)
  • Bioavailability/bioequivalence/biosimilars
  • PK/PD modeling and simulation
  • Population pharmacokinetics (NONMEM®)
  • Prediction of human PK using allometric scaling and in vitro scale up
  • Physiologically Based PK Modelling (DDI prediction, mechanistic PK/PD, formulation optimization, FIH dose prediction)
  • Phase I and II clinical PK
  • Consulting services
« Show less
PK/PD
Toxicokinetic (TK) Modeling
Price on request
Request a quote for more information about this service.
PK/PD Data Analysis
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Omics
Price on request
Request a quote for more information about this service.
Metabolomics
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.
In vitro Disease Models
Price on request

In vitro Disease Models Services

In vitro Disease Models Services

« Show less
Cells and Tissues
Price on request

Cells and Tissues Services

Cells and Tissues Services

« Show less
Animal Models and Studies
Price on request

Animal Models and Studies Services

Animal Models and Studies Services

« Show less
Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

« Show less
Pharmacology
Price on request

Pharmacology Services

Pharmacology Services

« Show less

Covance – Drug Metabolism and Pharmacokinetics (DMPK) Solutions has not received any ratings.

Be the first to endorse Covance – Drug Metabolism and Pharmacokinetics (DMPK) Solutions

Endorse this lab