Gs3jeujq0qf25wifc1wa corning logo 301blue 6in

Corning Life Sciences

5 Orders Completed
Corning, New York, US

About Corning Life Sciences

Founded: 1851 Type: Public Company Size: 10,000+ employees

Corning is one of the world's leading innovators in materials science, with more than 165 years of life-changing inventions. Corning applies its unparalleled expertise in glass science, ceramics science, and optical physics, along with its deep manufacturing and engineering capabilities, to develop products... Show more »

Corning is one of the world's leading innovators in materials science, with more than 165 years of life-changing inventions. Corning applies its unparalleled expertise in glass science, ceramics science, and optical physics, along with its deep manufacturing and engineering capabilities, to develop products that transform industries and enhance lives. Offering biological research products and services, Corning® Gentest™ has contributed to hundreds of pharmaceutical discovery and development programs for many of the world's leading pharmaceutical and biotech companies for more than 25 years.

The Gentest offerings, including Contract Research studies and a full range of ADME/Tox services, continue to grow, helping you stay on the leading edge of drug discovery and development.

The Corning® Gentest™ lab offers:

  • Full range of ADME/Tox services
  • Proven track record of success
  • Skilled scientists
  • Alignment with regulatory guidance
  • Superior quality
  • Assay customization
Show less

Our Services (14)


ic

Reaction Phenotyping

Price on request

Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated pathways of elimination for your compound. Available enzymes for evaluation: CYP, UGT, CES, SULT, and AO.

Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated pathways of elimination for your compound. Available enzymes for evaluation: CYP, UGT, CES, SULT, and AO.

Show less

ic

CYP Induction Assay

Price on request

Testing options include enzyme activity and mRNA endpoints for CYP1A2, CYP2B6, CYP3A4, CYP2C8, CYP2C9, CYP2C19, UGTs, and more. Data may include EC50, Emax or relative induction scores (RIS). Rapid and conventional assay protocols are available which can be modified to your needs.

Testing options include enzyme activity and mRNA endpoints for CYP1A2, CYP2B6, CYP3A4, CYP2C8, CYP2C9, CYP2C19, UGTs, and more. Data may include EC50, Emax or relative induction scores (RIS). Rapid and conventional assay protocols are available which can be modified to your needs.

Show less

ic

CYP Inhibition Assay

Price on request

Conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact.... Show more »

Conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact. Assays are available using hepatocytes or recombinant enzyme study models.

Show less

ic

Plasma Protein Binding

Price on request

Rapid equilibrium dialysis (RED)

Rapid equilibrium dialysis (RED)

Show less

ic

Drug Transporter Assays

Price on request

We offer diverse study models for ABC efflux and SLC uptake transporter assays which comply with FDA/EMA recommended approaches to determine cell permeability and evaluate your compounds as substrates and/or inhibitors of P-gp, BCRP, BSEP, MRPs, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, and more.

We offer diverse study models for ABC efflux and SLC uptake transporter assays which comply with FDA/EMA recommended approaches to determine cell permeability and evaluate your compounds as substrates and/or inhibitors of P-gp, BCRP, BSEP, MRPs, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, and more.

Show less

ic

Blood to Plasma Ratio

Price on request
Request a quote for more information about this service.

ic

Cell Permeability Assay

Price on request

Caco-2, MDCK, LLC-PK1

Caco-2, MDCK, LLC-PK1

Show less

ic

Microsomal Stability Assay

Price on request

Microsomal Binding

Microsomal Binding

Show less

ic

In vitro Metabolic Stability Assays

Price on request

Hepatocytes, S9, liver microsomes - from human and preclinical species

Hepatocytes, S9, liver microsomes - from human and preclinical species

Show less

ic

Custom Cell-Based Assay Development

Price on request
Request a quote for more information about this service.

ic

Specialized Cell-Based Assays

Price on request

Specialized Cell-Based Assays Services

Specialized Cell-Based Assays Services

Show less

ic

ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.

ic

UDP-Glucuronosyltransferases (UGT) Assays

Price on request

Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution... Show more »

Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact. Assays are also available using hepatocytes or recombinant enzyme study models.

Show less

ic

Transferase Assays

Price on request

Transferase Assays Services

Transferase Assays Services

Show less

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
Missing Avatar

George Zhang

Contract Research Services Manager

Corning Life Sciences has not received any reviews.

Corning Life Sciences has not received any endorsements.