Corning Life Sciences
About Corning Life Sciences
Corning is one of the world's leading innovators in materials science, with more than 165 years of life-changing inventions. Corning applies its unparalleled expertise in glass science, ceramics science, and optical physics, along with its deep manufacturing and engineering capabilities, to develop products... Show more »
Corning is one of the world's leading innovators in materials science, with more than 165 years of life-changing inventions. Corning applies its unparalleled expertise in glass science, ceramics science, and optical physics, along with its deep manufacturing and engineering capabilities, to develop products that transform industries and enhance lives. Offering biological research products and services, Corning® Gentest™ has contributed to hundreds of pharmaceutical discovery and development programs for many of the world's leading pharmaceutical and biotech companies for more than 25 years.
The Gentest offerings, including Contract Research studies and a full range of ADME/Tox services, continue to grow, helping you stay on the leading edge of drug discovery and development.
The Corning® Gentest™ lab offers:
- Full range of ADME/Tox services
- Proven track record of success
- Skilled scientists
- Alignment with regulatory guidance
- Superior quality
- Assay customization
Our Services (14)
Reaction Phenotyping
Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated pathways of elimination for your compound. Available enzymes for evaluation: CYP, UGT, CES, SULT, and AO.
Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated pathways of elimination for your compound. Available enzymes for evaluation: CYP, UGT, CES, SULT, and AO.
CYP Induction Assay
Testing options include enzyme activity and mRNA endpoints for CYP1A2, CYP2B6, CYP3A4, CYP2C8, CYP2C9, CYP2C19, UGTs, and more. Data may include EC50, Emax or relative induction scores (RIS). Rapid and conventional assay protocols are available which can be modified to your needs.
Testing options include enzyme activity and mRNA endpoints for CYP1A2, CYP2B6, CYP3A4, CYP2C8, CYP2C9, CYP2C19, UGTs, and more. Data may include EC50, Emax or relative induction scores (RIS). Rapid and conventional assay protocols are available which can be modified to your needs.
CYP Inhibition Assay
Conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact.... Show more »
Conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact. Assays are available using hepatocytes or recombinant enzyme study models.
Plasma Protein Binding
Rapid equilibrium dialysis (RED)
Rapid equilibrium dialysis (RED)
Blood to Plasma Ratio
Drug Transporter Assays
We offer diverse study models for ABC efflux and SLC uptake transporter assays which comply with FDA/EMA recommended approaches to determine cell permeability and evaluate your compounds as substrates and/or inhibitors of P-gp, BCRP, BSEP, MRPs, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, and more.
We offer diverse study models for ABC efflux and SLC uptake transporter assays which comply with FDA/EMA recommended approaches to determine cell permeability and evaluate your compounds as substrates and/or inhibitors of P-gp, BCRP, BSEP, MRPs, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, and more.
Cell Permeability Assay
Caco-2, MDCK, LLC-PK1
Caco-2, MDCK, LLC-PK1
Microsomal Stability Assay
Microsomal Binding
Microsomal Binding
In vitro Metabolic Stability Assays
Hepatocytes, S9, liver microsomes - from human and preclinical species
Hepatocytes, S9, liver microsomes - from human and preclinical species
Custom Cell-Based Assay Development
Specialized Cell-Based Assays
Specialized Cell-Based Assays Services
Specialized Cell-Based Assays Services
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
UDP-Glucuronosyltransferases (UGT) Assays
Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution... Show more »
Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact. Assays are also available using hepatocytes or recombinant enzyme study models.
Transferase Assays
Transferase Assays Services
Transferase Assays Services
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Get info on this provider's capabilities without requesting a quote.George Zhang
Contract Research Services Manager
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