Corning Life Sciences
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Corning, New York, US
Corning is one of the world's leading innovators in materials science, with more than 165 years of life-changing inventions. Corning applies its unparalleled expertise in glass science, ceramics science, and optical physics, along with its deep manufacturing and engineering capabilities, to develop products that transform industries and enhance lives. Offering biological research products and services, Corning® Gentest™ has contributed to hundreds of pharmaceutical discovery and development programs for many of the world's leading pharmaceutical and biotech companies for more than 25 years.
The Gentest offerings, including Contract Research studies and a full range of ADME/Tox services, continue to grow, helping you stay on the leading edge of drug discovery and development.
The Corning® Gentest™ lab offers:
Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated pathways of elimination for your compound. Available enzymes for evaluation: CYP, UGT, CES, SULT, and AO.
Testing options include enzyme activity and mRNA endpoints for CYP1A2, CYP2B6, CYP3A4, CYP2C8, CYP2C9, CYP2C19, UGTs, and more. Data may include EC50, Emax or relative induction scores (RIS). Rapid and conventional assay protocols are available which can be modified to your needs.
Conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact. Assays are available using hepatocytes or recombinant enzyme study models.
Rapid equilibrium dialysis (RED)
We offer diverse study models for ABC efflux and SLC uptake transporter assays which comply with FDA/EMA recommended approaches to determine cell permeability and evaluate your compounds as substrates and/or inhibitors of P-gp, BCRP, BSEP, MRPs, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, and more.
Caco-2, MDCK, LLC-PK1
Microsomal Binding
Hepatocytes, S9, liver microsomes - from human and preclinical species
Specialized Cell-Based Assays Services
Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe substrates and validated LC/MS/MS methods. Options include direct and time-dependent inhibition studies with flexible endpoints. Kinetic results reported include IC50, IC50 shift (dilution and non-dilution methodology), as well as KI and kinact. Assays are also available using hepatocytes or recombinant enzyme study models.
Transferase Assays Services
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