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Concept Life Sciences

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High Peak, GB

About Concept Life Sciences

Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors. We also work closely with academic... Show more »

Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors. We also work closely with academic groups.

Formed in 2014, our business has expanded through a mix of organic growth and targeted acquisition. Today, we are home to more than 700 employees, working from ten sites across the UK, sharing a common focus on problem solving, quality, collaboration, communication and flexibility.

By bringing together teams of highly trained scientists, excellent laboratory facilities and an in-depth understanding of our core markets, we have created a business that is greater than the sum of its parts. This synergy means we have the in-house resources to offer a range of integrated services to our clients.

Our operations are structured around two divisions. Our Integrated Discovery and Development Services division supports discovery and development in the pharmaceutical, biotechnology, agrochemical, chemical and consumer industries. Our Analytical Services division provides an extensive range of integrated services to clients in the life sciences, food, industrial and environmental sectors.

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Our Services (27)


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Medicinal Chemistry

Price on request

Concept Life Sciences’ expertise in medicinal chemistry spans numerous therapeutic areas, taking the drug discovery process all the way from hit generation to Phase I clinical studies. Examples include cardiovascular (hypertension, CHF, angina, myocardial infarction, atherosclerosis), metabolic (obesity, diabetes), respiratory... Show more »

Concept Life Sciences’ expertise in medicinal chemistry spans numerous therapeutic areas, taking the drug discovery process all the way from hit generation to Phase I clinical studies. Examples include cardiovascular (hypertension, CHF, angina, myocardial infarction, atherosclerosis), metabolic (obesity, diabetes), respiratory (asthma, COPD, cough), CNS pain, urology and oncology.

We have a proven track record in producing robust candidates suitable for ‘proof-of-concept’ testing in vivo. Our medicinal chemists have made key contributions to drugs undergoing clinical development and many of our scientists are listed as inventors on a variety of patents.

Our highly-experienced teams deliver on project goals while ensuring complete client confidentiality and protection of Intellectual Property (IP).

As we progress from hit generation to scaffold-hopping, hit-to-lead and lead optimisation, our talented medicinal chemists work closely with our computational chemistry services. This ensures timely, practical hypothesis testing is delivered in line with the project’s goals.

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Synthetic Chemistry

Price on request

Concept Life Sciences is a leading provider of synthetic chemistry services. Our expertise extends to chiral synthesis, controlled substances, natural product synthesis and nucleoside, nucleotide and carbohydrate chemistry.

We offer milligram to kilogram chemistry synthesis for new compounds, APIs, intermediates, reference... Show more »

Concept Life Sciences is a leading provider of synthetic chemistry services. Our expertise extends to chiral synthesis, controlled substances, natural product synthesis and nucleoside, nucleotide and carbohydrate chemistry.

We offer milligram to kilogram chemistry synthesis for new compounds, APIs, intermediates, reference compounds, focused libraries, stable labelled compounds, competitor compounds, scaffolds, building blocks, analogues, drug metabolites and impurities. We also specialise in developing custom chemical synthesis solutions designed to overcome specific challenges.

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Process and Scale-Up Chemistry

Price on request

We have a long-established history of scaling up complex chemistry, from milligram to multi kilogram, while delivering yield, cost, safety and process improvements to our clients.

Our service is provided with complete confidentiality with clear and regular communication from a dedicated team of scale-up experts.

Typical... Show more »

We have a long-established history of scaling up complex chemistry, from milligram to multi kilogram, while delivering yield, cost, safety and process improvements to our clients.

Our service is provided with complete confidentiality with clear and regular communication from a dedicated team of scale-up experts.

Typical types of chemistry covered include chlorinations, oxidations, malodorous, low temperature reactions, coupling reactions, exothermic chemistry, pyrophoric reactions and boronic ester formation.

For an overview of our vessels and equipment get in touch with our team using the contact form on the left hand side.

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Chemical Crosslinking/Bioconjugation

Price on request

We collaborate with a number of global pharmaceutical and biotechnology companies, as well as academic groups, on their biotherapeutics programmes. With our experience and state-of-the-art facilities we can be an effective partner in bioconjugation chemistry. We have a clean dedicated laboratory that operates under negative... Show more »

We collaborate with a number of global pharmaceutical and biotechnology companies, as well as academic groups, on their biotherapeutics programmes. With our experience and state-of-the-art facilities we can be an effective partner in bioconjugation chemistry. We have a clean dedicated laboratory that operates under negative pressures for handling high potency compounds. All the necessary risk assessments and SOP are in place to carry out cytotoxic work.

OUR SPECIFIC CAPABILITIES INCLUDE:
Synthesis and characterisation of toxophores/warheads, large macrocycles
Synthesis of payloads and linker fragments (see examples)
Bioconjugation chemistry
Purification and analysis
Drug Antibody Ratio (DAR) by MS or UV
Intact analysis HIC/UV and SEC- LC/MS
Positional isomer determination
Determination of Extinction Coefficient of drug and antibody
Aggregation by SDS-PAGE or by SEC-UV
Centrifugation, ultrafiltration, sample dilution
Toxophores
Auristatins Cleavable/non cleavable
Pyrrolobenzodiazepines (PBD) PEGs
Maitansines Fmoc-Val-Cit-PAB
Topisomerase inhibitors Maleimido
Disulfide
Hydroxysuccinamide
Glucoronidase substrates

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request

in vitro ADMET
Our range of in vitro ADMET models deliver high quality, accurate and reproducible data. With efficient turnaround times, we can help accelerate a drug discovery programme.

In addition to our core assays, we offer clients the option of customised assay design within a completely confidential service. We have the... Show more »

in vitro ADMET
Our range of in vitro ADMET models deliver high quality, accurate and reproducible data. With efficient turnaround times, we can help accelerate a drug discovery programme.

In addition to our core assays, we offer clients the option of customised assay design within a completely confidential service. We have the technology to carry out parallel reactions, either in solution-phase or solid-phase. Complementing our in vitro service, we also offer in silico ADMET screening to aid compound design.

OUR IN VITRO ADMET SERVICES INCLUDE:
PHYSCHEM PROPERTIES
Solubility
Log D (shake flask method at pH7.4)
In vitro non-specific binding
Chemical stability
ABSORPTION PERMEABILITY
Caco permeability (plus BCRP and/or BCRP substrate identification)
MDCK-MDR1 (Pgp substrate identification)
MDCK-BCRP (BCRP substrate identification)
PAMPA
DISTRIBUTION
Plasma protein binding
Whole blood binding
Blood to plasma ratio
Brain tissue binding
Microsome binding
Intestinal tissue binding
Simulated gastric fluid
METABOLISM
Microsome stability
Hepatocyte stability
Plasma stability
S9 stability
Identification of CYP450s involved in metabolism
Metabolite profiling and identification
DRUG-DRUG INTERACTIONS
CYP inhibition
Time-dependant inhibition (single concentration)
PXR, AhR, CAR Nuclear Hormone Receptor Activation
CYP induction in rat and human hepatocytes
CYTOTOXICITY
Various end-points
LDH
Neutral red
MTS
Mitochondrial toxicity
CARDIAC SAFETY PANEL
hERG
CiPA screening strategy
CUSTOMISED ASSAY DESIGN
Time-points
Test concentrations
Customer-specific controls
Validation
BIOASSAYS
COMPUTATIONAL

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Pharmacology

Price on request

Our expertise in drug discovery spans multiple target classes including GPCR, ion channels, nuclear hormones, kinases and other enzymes. Our pharmacologists have many years’ experience working in cardiovascular, respiratory, CNS, urogenital and immune inflammation therapeutic areas. We can set up integrated screening cascades to... Show more »

Our expertise in drug discovery spans multiple target classes including GPCR, ion channels, nuclear hormones, kinases and other enzymes. Our pharmacologists have many years’ experience working in cardiovascular, respiratory, CNS, urogenital and immune inflammation therapeutic areas. We can set up integrated screening cascades to expedite lead discovery and optimisation. We can also validate cell- based and non cell-based assays for primary pharmacology screening and mechanism of action.

Our teams have a strong background in assay development and optimisation of target based and phenotypic screens on electrophysiology platforms. We can access human derived IPSc stem cells for the development of translationally relevant assays.

We believe it is this integration of pharmacology, ADMET and DMPK that is so important for the development of PK/PD relationships.

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Immuno-oncology Assays

Price on request

Aquila (A subsidiary of CLS) can help you understand the immunomodulatory effects of your drug candidates within the tumour microenvironment and/or in combination with other immune modulators, efficiently progressing your route to clinic.

We have extensive in vitro immunology, pre-clinical immuno-oncology and specialist... Show more »

Aquila (A subsidiary of CLS) can help you understand the immunomodulatory effects of your drug candidates within the tumour microenvironment and/or in combination with other immune modulators, efficiently progressing your route to clinic.

We have extensive in vitro immunology, pre-clinical immuno-oncology and specialist multiplex histology experience. Our suite of available immuno-oncology services and assays can be specifically tailored to your project:

Exhausted CD4+ T Cell assay
Human PBMC & T Cell Activation assays
Human Mixed Lymphocyte Reactions
Human DC, Macrophage and Co-culture assays
T Cell Killing assay

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Immunoassays

Price on request

We can help you understand your target’s and/or compound’s mechanism of action to progress your drug discovery pipeline. We offer collaborative experimental design and can advise on the most suitable cell types, mono- or co-culture assays. By tailoring, customising and developing assays to suit your requirements, we can build a... Show more »

We can help you understand your target’s and/or compound’s mechanism of action to progress your drug discovery pipeline. We offer collaborative experimental design and can advise on the most suitable cell types, mono- or co-culture assays. By tailoring, customising and developing assays to suit your requirements, we can build a data package that is right for you.

We offer a tailored program of work and data you can trust, giving you greater confidence in your lead compound selection and accelerating your best route to clinic.

We offer assays and screening for:
DCs
Myeloid Cells
PBMCs
T-cells

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Histopathology Consulting

Price on request

Our team has the experience, expertise and specialist equipment to deliver technically demanding projects. Our ethos is to work closely with you to understand your histology requirements, and to tailor services specifically to meet your needs for:

Histology
Human tissue samples
Multiplex IF/IHC
RNAscope
Image... Show more »

Our team has the experience, expertise and specialist equipment to deliver technically demanding projects. Our ethos is to work closely with you to understand your histology requirements, and to tailor services specifically to meet your needs for:

Histology
Human tissue samples
Multiplex IF/IHC
RNAscope
Image analysis
Clinical trial support
All our staff are GCP and/or GCLP trained and work to GCP for labs standards. A QA audit programme is in place, which includes study-based, process-based and annual facility inspections.

Located in the Edinburgh BioQuarter, a unique geographical location with easy access to multiple expert institutions, we can source local, ethically approved human tissue for most types of cancer. Each cohort of samples is reviewed by a Senior Academic Clinical Histopathologist who can respond to bespoke tissue requests.

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Cell-Based Assays

Price on request
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Toxicology

Price on request

Concept Life Sciences has an extensive track record in the design, performance and interpretation of pre-clinical investigative, mechanistic and exploratory/discovery toxicology programmes.
These programmes are typically intended to identify the toxicological mode of action (MOA)/adverse outcome pathway (AOP) affected by the... Show more »

Concept Life Sciences has an extensive track record in the design, performance and interpretation of pre-clinical investigative, mechanistic and exploratory/discovery toxicology programmes.
These programmes are typically intended to identify the toxicological mode of action (MOA)/adverse outcome pathway (AOP) affected by the compound in question. We establish custom in vitro and in vivo models to answer specific toxicological questions.

We also offer exploratory and discovery toxicology services to characterise potential (for example on-target) or observed toxicity issues. Through an understanding of mechanistic toxicology at the early research stage, we can generate information that informs molecule design, candidate selection and translational risk assessment.

If required we can build and deploy novel in vitro mechanistic assays for screening of candidate compounds to provide comparative data on toxicological risk. This data can be used to drive further chemistry. Our experience in this area spans the agrochemical, chemical, consumer products and pharmaceutical industries.

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Dermal Toxicity Studies

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In vivo Pharmacology Studies

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Bioanalytical Assays

Price on request

We can help you make technical choices or strategic decisions on test compound characterization, SAR generation or optimising compound design. Where necessary, thorough validation will be exercised prior to running a customised experiment. Our facilities are operated by expert scientists according to a strict SOP management... Show more »

We can help you make technical choices or strategic decisions on test compound characterization, SAR generation or optimising compound design. Where necessary, thorough validation will be exercised prior to running a customised experiment. Our facilities are operated by expert scientists according to a strict SOP management system. We perform individual assay parameter monitoring for every run, including constantly recording and tracking our assays’ reagent batches and control performances to maintain our very high standards.

OUR IN VIVO PK AND BIOANALYTICAL SERVICES INCLUDE:
Analytical method development
Determination of PK parameters, whole blood, plasma
Microsampling PK capabilities
Bile duct cannulated studies
Organ distribution
Brain distribution and CSF sampling
In vivo metabolism (hot and cold)
In vitro and in vivo absorption of even the most challenging compounds and mixtures
We offer tightly controlled matrix-matched analytical calibrations that are cross-validated using independently prepared QC preparations. Strict acceptance criteria ensure confidence in the data.

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Drug Preformulation

Price on request

We can prepare the dose form that is to be used in a pre-clinical trial. Samples are produced under cGMP conditions ready for transfer to the team who are to carry out the study. The formulation will be tested and released to the specifications agreed during the development process.

Often additional pre-formulation sample... Show more »

We can prepare the dose form that is to be used in a pre-clinical trial. Samples are produced under cGMP conditions ready for transfer to the team who are to carry out the study. The formulation will be tested and released to the specifications agreed during the development process.

Often additional pre-formulation sample preparation/optimisation work is required, which could include crystallisation, spray or freeze drying, milling or micronisation services. Our proprietary formulation solubility screen can be used to provide a fast and efficient route to investigate and solve many pre-clinical formulation challenges.

We also offer API processing services such as micronising or blending to prepare samples for further development. We can carry out such work on site with characterisation analysis. Again, we can support with small volume spray and freeze drying and a range of milling/micronisation approaches.

We have invested in a range of equipment to support this process including:

Freeze Drier (SCANVAC 110-U PRO)
Homoginiser (IKA T25D)
Multi inlet vortex mixer (4 port custom design)
Combined impinging jets mixer (custom design)
Turbula Blender T2F

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Analytical Method Development

Price on request

Analytical method development, verification and validation to cGMP

We have wide experience in analytical method development for the the pharmaceutical, medical device and healthcare industry sectors, including working with clients carrying out method validation work to meet regulatory requirements, and for internal cGMP... Show more »

Analytical method development, verification and validation to cGMP

We have wide experience in analytical method development for the the pharmaceutical, medical device and healthcare industry sectors, including working with clients carrying out method validation work to meet regulatory requirements, and for internal cGMP needs.
Analytical Method development
We agree an approach with the client, usually in discrete costed sections to control the overall programme cost. The work can include developing a test method from scratch, or changing/improving existing methods. Our experience includes, small and large molecules, also polymers, plastics, bone substitute and similar medical device products, as well as nicotine-based products.

WE DEVELOP METHODS IN THE FOLLOWING BROAD AREAS:
Liquid and gas chromatography (for example, for stability indicating methods, residual solvents)
Materials characterisation/solid state
Wet chemistry
All projects are documented with a final report, including a final write up of the method, and typically with inclusion into our Controlled Documentation systems.

Method validation
Method validation is a process that usually starts with an in-house single validation exercise which can then progress to validation at multiple sites and then to standardised publication.

We are happy to produce our own Validation Protocols, or work to formats provided by our client. After execution of the protocol results are provided as a final method validation report in line with the protocol, with the method details included or referenced. Typical test method validation parameters are based on ICH guidelines (for example robustness, linearity, limit of detection, limit of quantitation, accuracy, precision, and specificity) or as agreed with the client.

OUR VALIDATION METHODS INCLUDE:
HPLC (assay and impurities methods, cleaning verification methods)
Liquid injection chromatography (solvent identification and release test methods)
Headspace gas chromatography (residual solvent analysis)
Physical methods such as Malvern sympatec particle sizing, specific surface area by BET and XRPD
Trace and major elemental determination by ICP-OES and X-ray fluorescence and total organic carbon analysis
API raw material and chemical intermediate methods (Karl Fischer, titration, loss on drying, residue on evaporation)
Method verification
Method verification is used to demonstrate that a standardised published method can be run effectively in each laboratory.

The requirements for method verification are less stringent than for validation but the principle approach is the same. A formal Verification Protocol with defined acceptance criteria is produced and agreed with the client (the client always agrees and signs the protocol). The verification is then executed and reported in a Verification Report, with the method details included or referenced.

The extent of the verification will depend on the procedural and sample complexity but as a minimum the verification will require demonstration that the performance parameters (for example system suitability tests) specified in the method have been met with the matrices to which the method is being applied (typically analyte recovery assessment). For HPLC assay methods it is sometimes necessary to carry out a limited linearity assessment due to flow cell differences.

OUR VERIFICATION METHODS INCLUDE:
HPLC (assay and impurities methods, cleaning verification methods)
Liquid injection chromatography (solvent identification and release test methods)
Headspace gas chromatography (residual solvent analysis)
Physical methods such as Malvern sympatec particle sizing, specific surface area by BET and XRPD
Trace and major elemental determination by ICP-OES and X-ray fluorescence and total organic carbon analysis
API raw material and chemical intermediate methods (Karl Fischer, titration, loss on drying, residue on evaporation)

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Polymorphism Screening

Price on request

Our primary goal in polymorph screening is typically to identify the most thermodynamically stable polymorph under expected ambient and processing conditions. Getting to that point often requires a structured screen, but tailored to the specific goals of the development team.

The solubility of the compound in each target... Show more »

Our primary goal in polymorph screening is typically to identify the most thermodynamically stable polymorph under expected ambient and processing conditions. Getting to that point often requires a structured screen, but tailored to the specific goals of the development team.

The solubility of the compound in each target solvent utilised in the stable polymorph screen is also assessed during this programme. This protocol is supported by the wide range of analytical equipment on site able to quickly characterise the differences between the identified forms (XRPD, FTIR, DSC, TGA, polarised light microscopy, DVS, Raman spectroscopy, Headspace GC and Karl Fischer). Further analytical techniques are then available to determine the solubility/bioavailability of the found forms like low volume dissolution.

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Solubility and Dissolution Testing

Price on request

Our primary goal in polymorph screening is typically to identify the most thermodynamically stable polymorph under expected ambient and processing conditions. Getting to that point often requires a structured screen, but tailored to the specific goals of the development team.

The solubility of the compound in each target... Show more »

Our primary goal in polymorph screening is typically to identify the most thermodynamically stable polymorph under expected ambient and processing conditions. Getting to that point often requires a structured screen, but tailored to the specific goals of the development team.

The solubility of the compound in each target solvent utilised in the stable polymorph screen is also assessed during this programme. This protocol is supported by the wide range of analytical equipment on site able to quickly characterise the differences between the identified forms (XRPD, FTIR, DSC, TGA, polarised light microscopy, DVS, Raman spectroscopy, Headspace GC and Karl Fischer). Further analytical techniques are then available to determine the solubility/bioavailability of the found forms like low volume dissolution.

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Biochemical Assays

Price on request

Biochemical Assays Services

Biochemical Assays Services

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Biology

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Biology Services

Biology Services

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Bioanalysis

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Bioanalysis Services

Bioanalysis Services

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Drug Discovery

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Drug Discovery Services

Drug Discovery Services

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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Analytical Chemistry Services

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Chemistry and Materials

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Chemistry and Materials Services

Chemistry and Materials Services

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Functional & Cell Type Specific Assays

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Functional & Cell Type Specific Assays Services

Functional & Cell Type Specific Assays Services

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