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Comparative Pathology and Mouse Phenotyping Shared Resource

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Columbus, Ohio, US

About Comparative Pathology and Mouse Phenotyping Shared Resource

The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) provides expert, affordable, experimental pathology support to The Ohio State University Comprehensive Cancer Center members who utilize animal models to study human disease.

The CPMPSR comparative pathologists are experts in normal... Show more »

The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) provides expert, affordable, experimental pathology support to The Ohio State University Comprehensive Cancer Center members who utilize animal models to study human disease.

The CPMPSR comparative pathologists are experts in normal anatomy, physiology and histology as well as background age- and strain-/breed-related lesions, infectious pathogens and husbandry practices for various animal model species. Lesion recognition and interpretation within individual investigations provides a critical component to research that incorporates animal models.

Services include comprehensive macroscopic and microscopic examinations of various laboratory animal species with an emphasis on the phenotype characterization of newly produced lines of genetically engineered mice as well as pre-clinical efficacy and toxicity studies. Additional services include hematology, clinical chemistry, radiography, Aperio whole slide scanning, routine frozen and paraffin slide preparation, tissue microarray preparation, and special histochemical and immunohistochemical staining. The CPMPSR also serves as a referral service to experienced scientists within the OSU research community, providing expertise in animal model development, experimental design, optimal sample collection and data interpretation.

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Our Services (26)


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Cytopathology

Price on request

Clinical Pathology Services
Services include hematology (complete blood counts with white blood cell differentials), serum biochemical panels, analysis of urine and other body fluids, and cytology.

Qualified laboratory professionals trained in veterinary laboratory techniques perform all tests. The laboratory staff is... Show more »

Clinical Pathology Services
Services include hematology (complete blood counts with white blood cell differentials), serum biochemical panels, analysis of urine and other body fluids, and cytology.

Qualified laboratory professionals trained in veterinary laboratory techniques perform all tests. The laboratory staff is committed to research in improved diagnostics, reference range development and state-of-the art assays. New tests are continually added as experimental needs change. A network of reference laboratories is available for tests not performed in-house.

The CPMPSR participates in quarterly quality assurance testing for hematology and chemistry of laboratory animal samples through the Veterinary Laboratories Agency.

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H&E Staining

Hematoxylin and eosin staining
Price on request

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues. Routine stains such as hematoxylin & eosin, and an extensive menu of both special histochemical and immunohistochemical stains optimized specifically for use... Show more »

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues. Routine stains such as hematoxylin & eosin, and an extensive menu of both special histochemical and immunohistochemical stains optimized specifically for use on mouse tissues are available and continuously expanded. Such stains facilitate the identification of infectious agents, apoptotic and proliferating cells, angiogenesis, hematopoietic cell lineages, and more.

Customized tissue microarrays are prepared upon request.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

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Clinical Hematology

Price on request

Clinical Pathology Services
Services include hematology (complete blood counts with white blood cell differentials), serum biochemical panels, analysis of urine and other body fluids, and cytology.

Qualified laboratory professionals trained in veterinary laboratory techniques perform all tests. The laboratory staff is... Show more »

Clinical Pathology Services
Services include hematology (complete blood counts with white blood cell differentials), serum biochemical panels, analysis of urine and other body fluids, and cytology.

Qualified laboratory professionals trained in veterinary laboratory techniques perform all tests. The laboratory staff is committed to research in improved diagnostics, reference range development and state-of-the art assays. New tests are continually added as experimental needs change. A network of reference laboratories is available for tests not performed in-house.

The CPMPSR participates in quarterly quality assurance testing for hematology and chemistry of laboratory animal samples through the Veterinary Laboratories Agency.

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Immunohistochemistry (IHC)

Price on request

Routine stains such as hematoxylin & eosin, and an extensive menu of both special histochemical and immunohistochemical stains optimized specifically for use on mouse tissues are available and continuously expanded. Such stains facilitate the identification of infectious agents, apoptotic and proliferating cells, angiogenesis,... Show more »

Routine stains such as hematoxylin & eosin, and an extensive menu of both special histochemical and immunohistochemical stains optimized specifically for use on mouse tissues are available and continuously expanded. Such stains facilitate the identification of infectious agents, apoptotic and proliferating cells, angiogenesis, hematopoietic cell lineages, and more.

Customized tissue microarrays are prepared upon request.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

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Animal Necropsy Services

Price on request

A complete necropsy is performed. All organs are examined grossly, and the following organs are routinely weighed to the nearest milligram prior to fixation for determining organ-to-body weight ratios (percentage of body weight):

liver with gall bladder
spleen
kidneys (both)
adrenals (both)
heart
lungs
ovaries/uterus... Show more »

A complete necropsy is performed. All organs are examined grossly, and the following organs are routinely weighed to the nearest milligram prior to fixation for determining organ-to-body weight ratios (percentage of body weight):

liver with gall bladder
spleen
kidneys (both)
adrenals (both)
heart
lungs
ovaries/uterus or testes/epididymides
thymus
Other organ(s) can be weighed based on the pathologist's recommendation or investigator's request.

Tissues are trimmed according to a standardized protocol, fixed in 10 percent neutral buffered formalin, processed by routine methods, embedded in paraffin wax, and sectioned at 4 microns for standard H&E.

Unstained and frozen sections can also be made.

All bony tissues are decalcified prior to trimming. Tissues are evaluated histologically by a comparative pathologist board-certified by the American College of Veterinary Pathologists. Final reports include an interpretative summary and recommendations for ancillary analyses offered by the CPMPSR or other Shared Resources.

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Paraffin Embedding

Price on request

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

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Paraffin Sectioning

Price on request

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

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Tissue Preparation

Price on request

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

Experienced histotechnologists provide complete histology services including tissue processing, embedding and sectioning of both paraffin-embedded and frozen animal tissues.

The CPMPSR participates in the quarterly HistoQuip quality assurance program for histochemistry and immunohistochemistry through the College of American Pathologists.

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Urinalysis

Price on request

Clinical Pathology Services
Services include hematology (complete blood counts with white blood cell differentials), serum biochemical panels, analysis of urine and other body fluids, and cytology.

Qualified laboratory professionals trained in veterinary laboratory techniques perform all tests. The laboratory staff is... Show more »

Clinical Pathology Services
Services include hematology (complete blood counts with white blood cell differentials), serum biochemical panels, analysis of urine and other body fluids, and cytology.

Qualified laboratory professionals trained in veterinary laboratory techniques perform all tests. The laboratory staff is committed to research in improved diagnostics, reference range development and state-of-the art assays. New tests are continually added as experimental needs change. A network of reference laboratories is available for tests not performed in-house.

The CPMPSR participates in quarterly quality assurance testing for hematology and chemistry of laboratory animal samples through the Veterinary Laboratories Agency.

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Tissue Sectioning

Price on request
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Clinical and Anatomic Pathology

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Tissue Embedding

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Protein Services

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Immunostaining

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Protein Expression Visualization

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Common Histochemical Stains

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Discovery Pathology

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Biology

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Biochemistry & Molecular Biology

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Histological Staining

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Clinical Chemistry

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Tissue Processing

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Cells and Tissues

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Clinical Research

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Clinical Laboratory Services

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Biospecimens

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