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Cofactor Genomics

St. Louis, Missouri, US

Cofactor Genomics is a Contract Research Organization (CRO) formed in 2008 with a vision to fill the gap of beginning-to-end sequencing - now focused specifically on RNA-seq.

Our team of experts boasts decades of collective experience working in the Technology Development Group at the Genome Center at Washington University in St. Louis, Missouri. We currently work with some of the largest life-science, pharmaceutical, agriculture, and biofuels companies in the world.

Cofactor is not a sequencing company. Cofactor is a client-focused CRO that uses its multiple sequencing platforms and in-house bioinformaticians to execute experimental design. Our clients are professionals that demand results as opposed to requiring data.

Cofactor has completed more than 3,000 projects to date and has provided unparalleled products, services, and solutions. All of our clients' projects benefit from the constant feedback... Show more »

Cofactor Genomics is a Contract Research Organization (CRO) formed in 2008 with a vision to fill the gap of beginning-to-end sequencing - now focused specifically on RNA-seq.

Our team of experts boasts decades of collective experience working in the Technology Development Group at the Genome Center at Washington University in St. Louis, Missouri. We currently work with some of the largest life-science, pharmaceutical, agriculture, and biofuels companies in the world.

Cofactor is not a sequencing company. Cofactor is a client-focused CRO that uses its multiple sequencing platforms and in-house bioinformaticians to execute experimental design. Our clients are professionals that demand results as opposed to requiring data.

Cofactor has completed more than 3,000 projects to date and has provided unparalleled products, services, and solutions. All of our clients' projects benefit from the constant feedback process of “build, measure, learn” that is ingrained at Cofactor in our beginning-to-end service. This feedback optimization process has created our service and products, and is simply not possible in non-CRO firms that are exposed to only a small aspect of the entire process (just sample prep, just sequencing, just analysis... or even design without industry experience).

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Cofactor Genomics has not listed any services.

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RNA-Based Immune Profiling Assay
Price on request

Paragon Assay

Paragon Assay

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Tumor Profiling
Price on request

Comprehensive, Quantitative Immune Profiling from only 2 sections of solid tumor FFPE tissue

Cofactor Paragon delivers:
-Fully-analyzed and easy-to-interpret report including immune cell types and immune escape genes from only two sections of FFPE
-Comprehensive, quantitative characterization of solid tumor immune profiles... Show more »

Comprehensive, Quantitative Immune Profiling from only 2 sections of solid tumor FFPE tissue

Cofactor Paragon delivers:
-Fully-analyzed and easy-to-interpret report including immune cell types and immune escape genes from only two sections of FFPE
-Comprehensive, quantitative characterization of solid tumor immune profiles in challenging clinical samples previously inaccessible by IHC or flow cytometry
-Improved biological insights for immune-oncology from RNA - built on robust molecular and informatics

Cofactor Genomics introduces Paragon, an RNA-based immune profiling assay which enables a unique look into an oncology patient’s immune profile - far beyond traditional “hot” or “cold” classification.

Clinical archives and samples such as FFPE, FNAs, CNBs, and LCM solid tumors have previously been difficult to characterize. Paragon accommodates these valuable and degraded materials with very low inputs and provides extensive immune characterization beyond current technologies - including differentiating cells such as M1 and M2 macrophages and Tregs - with high confidence. Find new biomarkers or improve patient selection as you transition from translational to clinical research applications.

Submit your samples to Cofactor and we’ll deliver a fully-analyzed data set highlighting immune escape genes and immune cell profiles, in one easy-to-interpret report. Don’t settle for qualitative, generic characterization from disparate assays such as IHC, flow cytometry, or expression arrays. Gain novel immune insights quickly and confidently.

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Human
Immunotherapy
immunology
FFPE tissue
Human tumor
Illumina
Immune Profiling
Immunooncology
Immunooncology
Immunooncology
RNA
Illumina
tumor
Machine learning
Fresh Tissue
Fresh Tumors
Fresh Frozen
FFPE
Solid tumor
Solid Tissue
pre-treatment samples
post-treatment samples
Clinical Biomarkers
Starting at $1,500.00 per sample

RNAseqDx - CAP/CLIA Validated Assay

Cofactor's RNAseqDx enables the identification of important cancer associated features, not detectable by DNA sequencing alone. We are one of the only CAP/CLIA accredited RNA-seq labs providing sequencing data with clinical signout.

Contact us to learn more about sample requirements.

RNAseqDx - CAP/CLIA Validated Assay

Cofactor's RNAseqDx enables the identification of important cancer associated features, not detectable by DNA sequencing alone. We are one of the only CAP/CLIA accredited RNA-seq labs providing sequencing data with clinical signout.

Contact us to learn more about sample requirements.

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mRNA Sequencing
Starting at $485.00 per sample

mRNAble
poly(A) enrichment of mRNA species in your samples.

Can you confidently extract 1 μg of RNA with a RIN score of 7 or greater? Then our standard RNA-seq approach is the right choice for you.

Focus your sequencing reads on coding regions of the transcriptome.
Make the most of your analysis with transcript... Show more »

mRNAble
poly(A) enrichment of mRNA species in your samples.

Can you confidently extract 1 μg of RNA with a RIN score of 7 or greater? Then our standard RNA-seq approach is the right choice for you.

Focus your sequencing reads on coding regions of the transcriptome.
Make the most of your analysis with transcript annotation.
Excellent approach for non-model organisms.
https://cofactorgenomics.com/discovery-services/

All projects include Cofactor’s molecular quality control checkpoints at each stage in the molecular workflow, and full comparative expression analysis delivered via the ActiveSite interface.

Library construction:
Illumina Poly-A RNA library construction
Strand specific RNA kit
ERCC spike-ins

Sequencing:
Illumina
Guaranteed: 30 million reads per sample*
Single-end reads, 75 bp read length

Analysis:
Provide FASTQ raw sequence files
Alignments to client-supplied reference transcriptome
Alignments to client-supplied reference genome
Clustering of reads to loci and calculation of expression levels
Coverage statistics for each sample
Comparative expression across all samples or replicates groups
RNA-seQC-Transcript Associated reads
RNA-seQC-Mean Coverage Across Transcripts
Replicate Correlation Analysis: Pearson Correlation Matrix**
Saturation curve analysis***
Web-based ActiveSite Comparative Expression Viewer
Analysis consultation
Publication-ready Materials & Methods

Number of reads pre samples can be customized
**requires a minimum of 3 biological replicates
*
*Proprietary QC metric that allows insight into, sensitive, budgeting, biology, trouble shooting.

Turn-around time: 3 weeks

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RNA
Illumina NextSeq 500
RNA Sequencing
Starting at $625.00 per sample

Total RNAble
Cofactor's Total RNAble protocol utilizes the depletion of ribosomal species, which allows for analysis of non-coding species.

Allows for the analysis of lncRNA and non-polyadenylated species
More forgiving molecular approach able to accommodate some sample degradation
Access the breadth of your sample’s... Show more »

Total RNAble
Cofactor's Total RNAble protocol utilizes the depletion of ribosomal species, which allows for analysis of non-coding species.

Allows for the analysis of lncRNA and non-polyadenylated species
More forgiving molecular approach able to accommodate some sample degradation
Access the breadth of your sample’s transcriptome
Ideal for model organisms (human, mouse, and rat)

All projects include Cofactor’s molecular quality control checkpoints at each stage in the molecular workflow, and full comparative expression analysis delivered via the ActiveSite interface.
https://cofactorgenomics.com/discovery-services/

Library construction:
Ribo-depleted RNA library construction
Strand-specific RNA kit
ERCC spike-ins

Sequencing:
Illumina sequencing
Guaranteed: 40 million reads per sample
Single-end reads, 75 bp read length

Analysis:
Provide FASTQ raw sequence files
Alignments to client-supplied reference transcriptome
Alignments to client-supplied reference genome
Clustering of reads to loci and calculation of expression levels
Coverage statistics for each sample
Comparative expression across all samples or replicates groups
RNA-seQC-Transcript Associated reads
RNA-seQC-Mean Coverage Across Transcripts
Replicate Correlation Analysis: Pearson Correlation Matrix
Saturation curve analysis
Web-based ActiveSite Comparative Expression Viewer
Analysis consultation

How we are different than other providers for RNA-seq?
**statistical power in analysis of 3 or more biological replicates
**Proprietary QC metrics from sample QC, library QC, data QC and analysis

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Low Input/Single Cell RNA Sequencing
Starting at $670.00 per sample

picoRNA
Low-input RNA Expression Characterization

Precious biological samples resulting from Laser capture microdissection (LCM), Low numbers of sorted cells, Fine needle aspirate biopsies (FNAs), Other small snap-frozen tissue biopsies often yield very minimal, yet high-quality RNA (< 250 ng).

Cofactor has developed... Show more »

picoRNA
Low-input RNA Expression Characterization

Precious biological samples resulting from Laser capture microdissection (LCM), Low numbers of sorted cells, Fine needle aspirate biopsies (FNAs), Other small snap-frozen tissue biopsies often yield very minimal, yet high-quality RNA (< 250 ng).

Cofactor has developed this robust amplification protocol to allow unbiased interpretation of transcriptome data from as low as 10-20 cells (100 pg of RNA).

Our picoRNA offering ensures:
Minimized amplification bias
Focused analysis of mRNA/poly-adenylated species
Accurate representation of the transcriptome, even at low input

With this approach you can avoid pooling biological replicates, interrogate previously inaccessible low-input samples, and trust the picoRNA results from your samples.

Library construction:
picoRNA (low input) library construction
Strand specific RNA kit
ERCC spike-ins

Sequencing:
Illumina
Guaranteed: 30 million reads per sample*
Single-end reads, 75 bp read length

Analysis:
Provide FASTQ raw sequence files
Alignments to client-supplied reference transcriptome
Alignments to client-supplied reference genome
Clustering of reads to loci and calculation of expression levels
Coverage statistics for each sample
Comparative expression across all samples or replicates groups
RNA-seQC-Transcript Associated reads
RNA-seQC-Mean Coverage Across Transcripts
Replicate Correlation Analysis: Pearson Correlation Matrix**
Saturation curve analysis***
Web-based ActiveSite Comparative Expression Viewer
Analysis consultation
Publication-ready Materials & Methods

Number or reads per samples can be customized
**requires a minimum of 3 biological replicates
*
*Proprietary QC metric that allows insight into, sensitive, budgeting, biology, trouble shooting.

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MicroRNA (miRNA) Sequencing
Starting at $410.00 per sample

miRNAble
Small RNA Expression Characterization from total RNA

Standard RNA-seq experiments use size selection steps which do not retain small RNA molecules. In order to ensure this information is accessed, fragment size monitoring and size selection is required. Cofactor’s small RNA characterization is optimized for total RNA... Show more »

miRNAble
Small RNA Expression Characterization from total RNA

Standard RNA-seq experiments use size selection steps which do not retain small RNA molecules. In order to ensure this information is accessed, fragment size monitoring and size selection is required. Cofactor’s small RNA characterization is optimized for total RNA samples*, which streamlines sample delivery for you.

Cofactor’s miRNAble ensures:
Enrichment of small RNA molecules including miRNA, snoRNA, and more.
Economical read depth (10 million reads) ensures high coverage of desired molecules.
Annotation using comprehensive database and comparative expression analysis.

*Note: Total RNA must be extracted using an approach that retains small RNA. Please contact us to discuss appropriate extraction methods.

Library construction:
miRNA library construction
Strand specific RNA kit

Sequencing:
Illumina
Guaranteed: 10 million reads per sample
Single-end reads, 75 bp read length

Analysis:
Provide FASTQ raw sequence files
Alignments to client-supplied reference transcriptome
Alignments to client-supplied reference genome
Clustering of reads to loci and calculation of expression levels
Coverage statistics for each sample
Comparative expression across all samples or replicates groups
RNA-seQC-Transcript Associated reads
RNA-seQC-Mean Coverage Across Transcripts
Replicate Correlation Analysis: Pearson Correlation Matrix**
Saturation curve analysis***
Web-based ActiveSite Comparative Expression Viewer
Analysis consultation

How we are different than other providers for RNA-seq?
**statistical power in analysis of 3 or more biological replicates
**Proprietary QC metrics from sample QC, library QC, data QC and analysis

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RNA
Illumina NextSeq 500
FFPE RNA Extraction
Starting at $725.00 per sample

FFPExact
Low-quality RNA Expression Characterization from FFPE and Fresh/Frozen HMR

With the vast majority of patient samples and clinical archives stored as formalin-fixed and paraffin embedded (FFPE) tissue blocks, a reliable solution for chemically-modified and fragmented RNA from FFPE is required.
For samples with >250... Show more »

FFPExact
Low-quality RNA Expression Characterization from FFPE and Fresh/Frozen HMR

With the vast majority of patient samples and clinical archives stored as formalin-fixed and paraffin embedded (FFPE) tissue blocks, a reliable solution for chemically-modified and fragmented RNA from FFPE is required.
For samples with >250 ng of RNA, our FFPExact pipeline first evaluates RNA fragmentation via DV200 analysis, then applies standardized library prepara­tion protocols to guarantee reproducible, interpreta­ble results from these valuable samples.

FFPExact delivers:
Non-biased analysis of fragmented RNA
Minimization of reads lost to ribosomal content
Access to valuable clinical archives and patient samples

Think your samples won’t yield >250 ng of total RNA? Afraid your low-input samples may be fragmented? Request our RNAccess protocol. Also, check out our standard mRNA sequencing and total RNA sequencing services for high quality and quantity RNA.

Library construction:
FFPE RNA library construction
Strand specific RNA kit
ERCC spike-ins

Sequencing:
Illumina
Guaranteed: 40 million reads per sample
Single-end reads, 75 bp read length

Analysis:
Provide FASTQ raw sequence files
Alignments to client-supplied reference transcriptome
Alignments to client-supplied reference genome
Clustering of reads to loci and calculation of expression levels
Coverage statistics for each sample
Comparative expression across all samples or replicates groups
RNA-seQC-Transcript Associated reads
RNA-seQC-Mean Coverage Across Transcripts
Replicate Correlation Analysis: Pearson Correlation Matrix**
Saturation curve analysis***
Web-based ActiveSite Comparative Expression Viewer
Analysis consultation

How we are different than other providers for RNA-seq
**requires a minimum of 3 biological replicates
**Proprietary QC metric that allows insight into, sensitive, budgeting, biology, trouble shooting.

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FFPE tissue
RNA-Seq
RNA
Illumina NextSeq
Illumina NextSeq 500
RNA Services
Price on request
Request a quote for more information about this service.
Clinical Chemistry
Price on request
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Biochemistry & Molecular Biology
Price on request
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Biology
Price on request
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Nucleic Acid Services
Price on request
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Clinical Research
Price on request
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Clinical Laboratory Services
Price on request
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Tumor Marker Testing
Price on request

Tumor Marker Testing Services

Tumor Marker Testing Services

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Clinical Molecular Diagnostics
Price on request

Clinical Molecular Diagnostics Services

Clinical Molecular Diagnostics Services

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