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Codex Biosolutions

Gaithersburg, Maryland, US

Codex Biosolutions, Inc. is an advanced biotechnology company headquartered in the state of Maryland. We offer simple and high throughput solutions to aid scientists in solving complex problems. One of our primary focuses is on drug discovery. We are a leader in providing live cell based assays for novel compound screening. Our patented ACTOne based phosphodiesterase (PDE) and G-protein coupled receptor (GPCR) cell lines offer clients the ability to conduct efficient screenings of new compounds in a physiologically accurate, live cell based environment. We are the first in the world to produce commercially available cell lines to screen for compounds that target PDEs. We also provide a number of unique biochemical assay kits and specialty dyes. We strive to deliver high quality products that help our fellow scientists in the discovery process.

In the past five years, Codex participated Tox21, a federal Collaboration... Show more »

Codex Biosolutions, Inc. is an advanced biotechnology company headquartered in the state of Maryland. We offer simple and high throughput solutions to aid scientists in solving complex problems. One of our primary focuses is on drug discovery. We are a leader in providing live cell based assays for novel compound screening. Our patented ACTOne based phosphodiesterase (PDE) and G-protein coupled receptor (GPCR) cell lines offer clients the ability to conduct efficient screenings of new compounds in a physiologically accurate, live cell based environment. We are the first in the world to produce commercially available cell lines to screen for compounds that target PDEs. We also provide a number of unique biochemical assay kits and specialty dyes. We strive to deliver high quality products that help our fellow scientists in the discovery process.

In the past five years, Codex participated Tox21, a federal Collaboration involving the NIH, EPA and FDA. We have developed assays for nuclear hormone receptors, dye based mitochondria toxicity assays. Now we are developing the assays to evaluate the toxicities on TSHR and TRHR.

Selected Publications

  • Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y. Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013 Nov;19(11):1505-12. doi: 10.1038/nm.3314.
  • Jonsson MKB, Wang Q, Becker B. Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-Derived Cardiomyocytes. Assay Drug Dev Technol. 2011 Dec; 9(6): 589–599. doi: 10.1089/adt.2011.0396.
  • Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. J Biomol Screen. 2008 Aug;13(7):609-18. doi: 10.1177/1087057108319977.
  • Chen J, Kovacs JM, Peng H, Rits-Volloch S, Lu J, Park D, Zablowsky E, Seaman MS, Chen B. HIV-1 ENVELOPE. Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein. Science. 2015 Jul 10;349(6244):191-5. doi: 10.1126/science.aaa9804.
  • Lachno DR, Evert BA, Vanderstichele H, Robertson M, Demattos RB, Konrad RJ, Talbot JA, Racke MM, Dean RA. Validation of assays for measurement of amyloid-β peptides in cerebrospinal fluid and plasma specimens from patients with Alzheimer's disease treated with solanezumab. J Alzheimers Dis. 2013;34(4):897-910. doi: 10.3233/JAD-122317.
  • Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect. 2015 Jan;123(1):49-56. doi: 10.1289/ehp.1408642.
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Drug Target Identification
Price on request

Mainly on GPCRs and PDEs. Codex uses its proprietary GPCR and PDE cells lines to provide profiling services

Gs-coupled receptor cell lines
Cat: CB-80200-209 Vasoactive Intestinal Peptide Receptor 2 (VIPR2)
Cat: CB-80200-211 Melanocortin 4 Receptor (MC4R)
Cat: CB-80200-215 ... Show more »

Mainly on GPCRs and PDEs. Codex uses its proprietary GPCR and PDE cells lines to provide profiling services

Gs-coupled receptor cell lines
Cat: CB-80200-209 Vasoactive Intestinal Peptide Receptor 2 (VIPR2)
Cat: CB-80200-211 Melanocortin 4 Receptor (MC4R)
Cat: CB-80200-215 Melanocortin 5 Receptor (MC5R)
Cat: CB-80200-216 Parathyroid Hormone Receptor 1 (PTHR1)
Cat: CB-80200-217 Glucagon Receptor (GCGR)
Cat: CB-80200-218 Dopamine Receptor 1 (DRD1)
Cat: CB-80200-219 Prostaglandin E Receptor 4 (PTGER4)
Cat: CB-80200-220 Vasoactive Intestinal Peptide Receptor 1 (VIPR1)
Cat: CB-80200-221 Gastric Inhibitor Peptide Receptor (GIPR)
Cat: CB-80200-222 Dopamine Receptor 5 (DRD5)
Cat: CB-80200-228 Parathyroid Hormone Receptor 2 (PTHR2)
Cat: CB-80200-231 Serotonin Receptor 4 (HTR4)
Cat: CB-80200-233 Corticotropin Releasing Hormone Receptor 2 (CRHR2)
Cat: CB-80200-234 Adenylate Cyclase Activating Polypeptide 1Receptor (ADCYAP1R1)
Cat: CB-80200-235 Secretin Receptor (SCTR)
Cat: CB-80200-236 Follicle Stimulating Hormone Receptor (FSHR)
Cat: CB-80200-237 Serotonin Receptor 6 (HTR6)
Cat: CB-80200-240 Serotonin Receptor Receptor 7 (HTR7)
Cat: CB-80200-241 Glucagon-like Receptor 2 (GLP2R)
Cat: CB-80200-242 Thyroid Stimulating Hormone Receptor (TSHR)
Cat: CB-80200-243 Melanocortin 3 Receptor (MC3R)
Cat: CB-80200-246 Arginine Vasopressin 2 Receptor (AVPR2)
Cat: CB-80200-247 Prostaglandin I2 Receptor (PTGIR)
Cat: CB-80200-248 Glucagon-like Receptor 1 (GLP1R)
Cat: CB-80200-249 Corticotropin Releasing Hormone Receptor 1 (CRHR1)
Cat: CB-80200-251 Calcitonin-like Receptor (CALCRL)
Cat: CB-80200-253 Beta-2 Adrenergic Receptor
Cat: CB-80200-255 Prostaglandin D Receptor 2 (PTGDR2)
Cat: CB-80200-256 PTGER2 (EP2)
Cat: CB-80200-257 Melanocortin 1 Receptor (MC1R)
Cat: CB-80200-258 Calcitonin Receptor (CALCR)
Cat: CB-80200-260 Adenosine A2b Receptor
Cat: CB-80200-261 Adenosine A2a Receptor
Cat: CB-80200-271 Amylin 3 Receptor
Cat: CB-80200-272 Adrenergic receptor beta 1 (ADRB1)
Cat: CB-80200-274 GPR119
Cat: CB-80200-275 TGR5
Cat: CB-80200-287 Luteinizing hormone/Choriogonadotropin receptor (LHCGR)

Gi-coupled receptor cell lines
Cat: CB-80300-205 Cannabinoid Receptor 1
Cat: CB-80300-206 Dopamine Receptor 2 (DRD2)
Dopamine Receptor 3 (DRD3)
Cat: CB-80300-207 Somatostatin Receptor 5 (SSTR5)
Cat: CB-80300-212 Adenosine A1 Receptor
Cat: CB-80300-213 Chemokine (C-C motif) Receptor 5
Cat: CB-80300-214 Melanin Concentrating Hormone Receptor 1 (MCHR1)
Cat: CB-80300-225 Cannabinoid Receptor 2
Cat: CB-80300-230 Opioid receptor, kappa 1
Cat: CB-80300-232 Adenosine A3 Receptor
Cat: CB-80300-239 Glutamate Receptor, Metabotropic 8
Cat: CB-80300-244 Neuropeptide Y Receptor Y1 (NPY1R)
Cat: CB-80300-245 Neuropeptide Y Receptor Y2 (NPY2R)
Cat: CB-80300-254 Sphingolipid G-protein-coupled receptor 1 (S1PR1)
Cat: CB-80300-259 Glutamate Receptor, Metabotropic 7
Cat: CB-80300-262 Glutamate Receptor, Metabotropic 2
Cat: CB-80300-265 Chemokine (C-X-C motif) Receptor 4
Cat: CB-80300-266 Opiate Receptor-like 1 (ORL1)
Cat: CB-80300-267 Angiotensin Receptor-like 1
Cat: CB-80300-268 Opioid receptor, Mu
Cat: CB-80300-269 Glutamate Receptor, Metabotropic 4
Cat: CB-80300-270 Neuropeptide Y Receptor Y4 (NPY4R)
Cat: CB-80300-276 Serotonin Receptor 1F (HTR1F)
Cat: CB-80300-277 Serotonin Receptor 1A (HTR1A)
Serotonin Receptor 1B--Rat (HTR1B)
Cat: CB-80300-279 Opioid receptor, delta 1
Cat: CB-80300-280 Neuropeptide Y Receptor Y5 (NPY5R)
Cat: CB-80300-285 Cholinergic receptor, muscarinic 4 (CHRM4)
Cat: CB-80300-288 Sphingolipid G-protein-coupled receptor 3 (S1PR3)
Cat: CB-80300-290 Sphingolipid G-protein-coupled receptor 5 (S1PR5)
Cat: CB-80300-291 Sphingolipid G-protein-coupled receptor 2 (S1PR2)
Cat: CB-80300-293 Cholinergic receptor, muscarinic 2 (CHRM2)

PDE cell lines
Cat: CB-81200-100 PDE4 (cAMP)
Cat: CB-81200-101 PDE2A (cAMP)
Cat: CB-81200-102 PDE10A (cAMP)
Cat: CB-81200-103 PDE1B (cAMP)
Cat: CB-81200-104 PDE1C (cAMP)
Cat: CB-81200-105 PDE4A (cAMP)
Cat: CB-81200-106 PDE4B (cAMP)
Cat: CB-81200-107 PDE4D (cAMP)
Cat: CB-81200-110 PDE1A (cAMP)
Cat: CB-81300-101 PDE9 (cGMP)
Cat: CB-81300-102 PDE1B (cGMP)
Cat: CB-81300-103 PDE5A (cGMP)
Cat: CB-81300-104 PDE1C (cGMP)
Cat: CB-81300-106 PDE1A (cGMP)

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Cell-Based Compound Screening
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e.g., GPCRs, PDEs, cancer cell proliferation, toxicology

e.g., GPCRs, PDEs, cancer cell proliferation, toxicology

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Stable Cell Line Generation
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Assay Development
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Luminescence, fluorescence, ELISA….

Luminescence, fluorescence, ELISA….

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Protein Purification
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CNG Channel Assay
Cyclic Nucleotide Gated Channel Assay
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Biochemical Reagents
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Experimental Design
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Project Management, Consulting, & Support Services
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Cell-Based Assays
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Biochemical Assays
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Biochemical Assays Services

Biochemical Assays Services

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Protein Services
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Biology
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Cells and Tissues
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Protein Purification and Quantification
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Mammalian Cell Culture
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Lead Identification and Validation
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Cellular Ion Channel Assays
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Cell Culture Media and Reagents
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Hit Identification
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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