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COBO Technologies Aps

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Maaloev, DK

About COBO Technologies Aps

COBO Technologies is a fast-growing start-up company located in Copenhagen, Denmark, that develop tools and services based around the CRISPR/Cas9 technology. The powerful INDEL Profiling Platform, CIPP™, was launched in December 2017 and in October 2018 they launched the Protein Expression... Show more »

COBO Technologies is a fast-growing start-up company located in Copenhagen, Denmark, that develop tools and services based around the CRISPR/Cas9 technology. The powerful INDEL Profiling Platform, CIPP™, was launched in December 2017 and in October 2018 they launched the Protein Expression analysis Platform, PIPPR™. Both platforms are today used to do Quality Control of cells modified with CRISPR, ZFNs or TALENs.

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Our Services (4)


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INDEL Profiling

Insertion/Deletion Profiling
Starting at $15.00 per sample

Use our powerful INDEL Profiling Platform (CIPP) and receive a detailed INDEL Profiling report of your gene editing events within only 3 days.

Simple Procedure:

  1. Do your gene targeting in your cell line of interest using CRISPR (or ZFN, TALEN).
  2. Ship the cell pellets directly to us or extract DNA (recommend to use the proven... Show more »

Use our powerful INDEL Profiling Platform (CIPP) and receive a detailed INDEL Profiling report of your gene editing events within only 3 days.

Simple Procedure:

  1. Do your gene targeting in your cell line of interest using CRISPR (or ZFN, TALEN).
  2. Ship the cell pellets directly to us or extract DNA (recommend to use the proven CoboXtract™) from the pellets, do tri-primer PCR around the target region and then ship the PCR samples to us.
  3. We do INDEL Profile analysis on the received samples and send a detailed INDEL Profiling report to you using our INDEL analysis software: ProfileIt™ (includes overview stats, total INDELs %, total out-of-frame INDELs, Top5 INDELs %, profile image)
  4. You will have your results within 3 days (PCR samples).

Details:
• Identification of down to single base insertions/deletions (INDELs) in pools and clones.
• Detection of down to 0.1% INDEL events.
• Detect large deletions up to 1000bs.
• Detect small insertions up to 150bs.
• Fast INDEL profiling in high-throughput format in pools and clones.
• 96 samples can be analysed in 2 hours.
• Easy detection of bi-allelic targeting events in single cell clones.
• Easy analysis of profiles using the INDEL analysis software: ProfileIt™
• Work with any nuclease system (CRISPR, ZFN, TALEN).

Applications:
• gRNA validation.
• Selection of pools or/and clones with out-of-frame INDELs.
• Tag confirmation (up to 150bs).
• Cas9 kinetics.
• Cas9 delivery methods.
• NHEJ inhibitor screening/validation.
• HDR inhibitor screening/validation.
• Drug-resistance allele generation (in-frame insertions/deletions)

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ABI3500XL ProfileIt PCR IDAA Method ProfileIt gDNA CIPP Show 7 more tags Show less

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CRISPR Bioinformatics

Price on request

ProfileIt™ is the first CRISPR/Cas9 INDEL Analysis Software that will give you what you need in just one-click.

Developed to analyse samples from the IDAA™ method.

-Easy One-Click INDEL profiling of your sample.
-Total % of INDELs in your sample.
-Total % of out-of frame INDELs in your sample.
-Top5 % INDELs visualised per... Show more »

ProfileIt™ is the first CRISPR/Cas9 INDEL Analysis Software that will give you what you need in just one-click.

Developed to analyse samples from the IDAA™ method.

-Easy One-Click INDEL profiling of your sample.
-Total % of INDELs in your sample.
-Total % of out-of frame INDELs in your sample.
-Top5 % INDELs visualised per profile.
-Individual peak analysis of all peaks over threshold.
-One-Click download (excel) statistics of % INDELs of all samples analysed.
-One-Click download (PNG) of individual INDEL profile images (publication quality-see example below)
-Work with ABI3500/ABI3500XL .fsa files.

Applications where ProfileIt™ are used today:
-gRNA validation
-INDEL profiling of pools and clones
-NHEJ inhibitor validation
-Cas9 kinetics
-Large deletions
-Tag confirmation (up to 150bs)
-Optimisation of delivery methods

ProfileIt™ is part of the COBO INDEL Profiling Platform (CIPP).

ProfileIt™ is a trademark of COBO Technologies™

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Mass Spectrometry-Based Proteomics

Price on request

"Antibody-free validation of knockout cells"

PIPPR™ is the first platform that offer the gene editing scientist an extensive and detailed protein expression analysis solution for any cells modified with CRISPR, ZFN or TALENs.

PIPPR™ is powered by SWATH LC-MS, which gives you label-free proteome scale identification and... Show more »

"Antibody-free validation of knockout cells"

PIPPR™ is the first platform that offer the gene editing scientist an extensive and detailed protein expression analysis solution for any cells modified with CRISPR, ZFN or TALENs.

PIPPR™ is powered by SWATH LC-MS, which gives you label-free proteome scale identification and quantification of any the protein in your cell.

Easy Setup - Just ship your proteins from your cells and receive protein expression report within 4-6 weeks.

Applications:

-Confirm knockouts of target protein
-Compare protein expression between wildtype cells with modified cells
-Full proteome expression analysis
-Detailed pathway and gene family expression analysis
-Quality control of modified cells
-Protein expression analysis of potential off-target sites
-Treated versus non-treated cells
...

Services available:

PIPPR™ - Simple:
PIPPR-Simple is for the scientist who just need to validate knockout in a cell-line.

PIPPR™ - Advanced:
PIPPR-Advanced is for the scientist interested in a more detailed proteome expression analysis of wildtype and modified cells including changes in selected pathways and gene families expression profiles.

PIPPR™ is a trademark of COBO Technologies™. SWATH is a trademark of SCIEX.

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Sciex TripleTOF MS SWATH-MS Proteins

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Proteomics

Price on request

"Antibody-free validation of knockout cells"

PIPPR™ is the first platform that offer the gene editing scientist an extensive and detailed protein expression analysis solution for any cells modified with CRISPR, ZFN or TALENs.

PIPPR™ is powered by SWATH LC-MS, which gives you label-free proteome scale identification and... Show more »

"Antibody-free validation of knockout cells"

PIPPR™ is the first platform that offer the gene editing scientist an extensive and detailed protein expression analysis solution for any cells modified with CRISPR, ZFN or TALENs.

PIPPR™ is powered by SWATH LC-MS, which gives you label-free proteome scale identification and quantification of any the protein in your cell.

Easy Setup - Just ship your proteins from your cells and receive protein expression report within 4-6 weeks.

Applications:

-Confirm knockouts of target protein
-Compare protein expression between wildtype cells with modified cells
-Full proteome expression analysis
-Detailed pathway and gene family expression analysis
-Quality control of modified cells
-Protein expression analysis of potential off-target sites
-Treated versus non-treated cells
...

Services available:

PIPPR™ - Simple:
PIPPR-Simple is for the scientist who just need to validate knockout in a cell-line.

PIPPR™ - Advanced:
PIPPR-Advanced is for the scientist interested in a more detailed proteome expression analysis of wildtype and modified cells including changes in selected pathways and gene families expression profiles.

PIPPR™ is a trademark of COBO Technologies™. SWATH is a trademark of SCIEX.

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