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Clyde Biosciences Ltd.

2 Orders Completed
Newhouse, GB

About Clyde Biosciences Ltd.

Clyde Biosciences is a leading global cardiac safety service provider. Our speciality is in the assessment of cardiotoxicity potential for the global pharmaceutical industry. We work with:

  • Safety Pharmacology
  • Cardiovascular Therapeutics
  • Leading Stem Cell Suppliers

Our technology was developed in the laboratory of Professor Godfrey Smith (Chief Scientific Officer, Clyde Biosciences) a world-leading cardiac scientist with 25+ years experience in cardiac electrophysiology research. Clyde’s CellOPTIQ® platform delivers reliable, high resolution functional output from a range of cardiac cell types including iPS-derived heart cells. High bandwidth membrane voltage signals from CellOPTIQ® provides new insights into electrophysiological effects of drugs. Rapid data capture and analysis is made possible by our bespoke software which allows accelerated assay throughput in a 96 well format.

Our Services (15)


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In vitro Cardiotoxicity Screening

Price on request

In vitro cardiotox using iPS cardiomyocytes on a voltage sensitive dye platform. Voltage, calcium contraction studies.


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Comprehensive in vitro Proarrhythmia Assay (CiPA)

Price on request

Clyde Biosciences is an official member of the CiPA consortium, and a Core Group member contributing towards the development of the next generation of assays.

We run drug screening studies on our CellOPTIQ® system using the accepted CiPA Protocol. Only Clyde can provide you with a rapid-turnaround VSD screening study on your compounds.

Clyde works with virtually all of the major suppliers of iPS-CMs to characterise their cells on using the standard CiPA protocol. These data provide an invaluable reference point for the performance of cells. CellOPTIQ® works with 2D and 3D structures.

Major benefits include:

  • Drug screening using a standard CiPA protocol
  • iPS-CM characterisation studies using CiPA 8 (first phase CiPA)
  • iPS-CM characterisation studies using CiPA 28 (second phase CiPA)


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Stem Cell Analysis and Characterization

Price on request

Clyde Biosciences works with the leading manufacturers of iPS-CMs to provide a broad dataset of parameters, enabling companies to understand the performance of their cells in the context of drug testing.

These data are essential for iPS-CM suppliers to communicate accurately the characteristics of their cells to biopharma companies.

Clyde’s Approach:

  • Clyde Biosciences’ CellOPTIQ™ system measures calcium, voltage and contractility in the same cells
  • Using ratiometric dyes, CellOPTIQ™ can make measurements which are unaffected by movement artefact or variations in cell thickness
  • This means data are more accurate, with significantly reduced signal-to-noise


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Ion Channel Screening Assays

Price on request

Clyde is able to provide our clients with access to the highest quality ion channel screening technology

Clyde’s Ion Channel Service:

The Rational Approach

  • Clyde partners with the industry’s leading specialist ion channel providers
  • Provide CiPA-ready data combining outputs from all assay modalities in one project


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Induced Pluripotent Stem Cell Lines

Price on request

hiPSC-CM - Human induced pluripotent stem cell-derived cardiomyocytes


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Mammalian Cell Culture

Price on request
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Cell-Based Assays

Price on request
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Cells and Tissues

Price on request
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Biology

Price on request
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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Toxicology

Price on request

Toxicology Services


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In vitro Toxicity Testing

Price on request

In vitro Toxicity Testing Services


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Pharmacology & Toxicology

Price on request
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In vitro Ion Channel Assays

Price on request
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Cell Lines

Price on request
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