Clyde Biosciences Ltd.
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Newhouse, GB
Clyde Biosciences is a leading global cardiac safety service provider. Our speciality is in the assessment of cardiotoxicity potential for the global pharmaceutical industry. We work with:
Our technology was developed in... Show more »
Clyde Biosciences is a leading global cardiac safety service provider. Our speciality is in the assessment of cardiotoxicity potential for the global pharmaceutical industry. We work with:
Our technology was developed in the laboratory of Professor Godfrey Smith (Chief Scientific Officer, Clyde Biosciences) a world-leading cardiac scientist with 25+ years experience in cardiac electrophysiology research. Clyde’s CellOPTIQ® platform delivers reliable, high resolution functional output from a range of cardiac cell types including iPS-derived heart cells. High bandwidth membrane voltage signals from CellOPTIQ® provides new insights into electrophysiological effects of drugs. Rapid data capture and analysis is made possible by our bespoke software which allows accelerated assay throughput in a 96 well format.
In vitro cardiotox using iPS cardiomyocytes on a voltage sensitive dye platform. Voltage, calcium contraction studies.
In vitro cardiotox using iPS cardiomyocytes on a voltage sensitive dye platform. Voltage, calcium contraction studies.
Clyde Biosciences is an official member of the CiPA consortium, and a Core Group member contributing towards the development of the next generation of assays.
We run drug screening studies on our CellOPTIQ® system using the accepted CiPA Protocol. Only Clyde can provide you with a rapid-turnaround VSD screening study on your... Show more »
Clyde Biosciences is an official member of the CiPA consortium, and a Core Group member contributing towards the development of the next generation of assays.
We run drug screening studies on our CellOPTIQ® system using the accepted CiPA Protocol. Only Clyde can provide you with a rapid-turnaround VSD screening study on your compounds.
Clyde works with virtually all of the major suppliers of iPS-CMs to characterise their cells on using the standard CiPA protocol. These data provide an invaluable reference point for the performance of cells. CellOPTIQ® works with 2D and 3D structures.
Major benefits include:
Clyde Biosciences works with the leading manufacturers of iPS-CMs to provide a broad dataset of parameters, enabling companies to understand the performance of their cells in the context of drug testing.
These data are essential for iPS-CM suppliers to communicate accurately the characteristics of their cells to biopharma... Show more »
Clyde Biosciences works with the leading manufacturers of iPS-CMs to provide a broad dataset of parameters, enabling companies to understand the performance of their cells in the context of drug testing.
These data are essential for iPS-CM suppliers to communicate accurately the characteristics of their cells to biopharma companies.
Clyde’s Approach:
Clyde is able to provide our clients with access to the highest quality ion channel screening technology
Clyde’s Ion Channel Service:
The Rational Approach
Clyde is able to provide our clients with access to the highest quality ion channel screening technology
Clyde’s Ion Channel Service:
The Rational Approach
hiPSC-CM - Human induced pluripotent stem cell-derived cardiomyocytes
hiPSC-CM - Human induced pluripotent stem cell-derived cardiomyocytes
Drug Discovery & Development Services
Drug Discovery & Development Services
Toxicology Services
Toxicology Services
In vitro Toxicity Testing Services
In vitro Toxicity Testing Services
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