Clyde Biosciences Ltd.

In vitro cardiotox using iPS cardiomyocytes on a voltage sensitive dye platform. Voltage, calcium and contraction studies. Capable of running more straight forward CiPA assays through to complex mechanistic tox studies using chronic protocols. Study design and interpretation performed by Prof Smith (CSO) and data presented at a high standard for IND submission.

Clyde Biosciences is an official member of the CiPA consortium, and a Core Group member contributing towards the development of the next generation of assays.

We run drug screening studies on our CellOPTIQ® system using the accepted CiPA Protocol. Only Clyde can provide you with a rapid-turnaround VSD screening study on your compounds.

Clyde works with virtually all of the major suppliers of iPS-CMs to characterise their cells on using the standard CiPA protocol. These data provide an invaluable reference point for the performance of cells. CellOPTIQ® works with 2D and 3D structures.

Major benefits include:

• Drug screening using a standard CiPA protocol
• iPS-CM characterisation studies using CiPA 8 (first phase CiPA)
• iPS-CM characterisation studies using CiPA 28 (second phase CiPA)

Clyde Biosciences works with the leading manufacturers of iPS-CMs to provide a broad dataset of parameters, enabling companies to understand the performance of their cells in the context of drug testing.

These data are essential for iPS-CM suppliers to communicate accurately the characteristics of their cells to biopharma companies.

Clyde’s Approach:

• Clyde Biosciences’ CellOPTIQ™ system measures calcium, voltage and contractility in the same cells
• Using ratiometric dyes, CellOPTIQ™ can make measurements which are unaffected by movement artefact or variations in cell thickness
• This means data are more accurate, with significantly reduced signal-to-noise

Clyde is able to provide our clients with access to the highest quality ion channel screening technology

Clyde’s Ion Channel Service:

The Rational Approach

• Clyde partners with the industry’s leading specialist ion channel providers
• Provide CiPA-ready data combining outputs from all assay modalities in one project

hiPSC-CM - Human induced pluripotent stem cell-derived cardiomyocytes

Drug Discovery & Development Services

Toxicology Services

In vitro Toxicity Testing Services