ChiroSolve, Inc. has been offering chiral resolution services in US and Europe since 2006. Its customers include pharmaceutical companies like GlaxoSmithKline, Amgen, Celgene, Johnson & Johnson, Ely Lilly, etc, as well as agrochemical companies, biochemical companies, and federal government agencies. Under the guidance of Dr. Niteen A. Vaidya, an industry expert in chiral resolution, we have a stellar reputation of having 95% success rate for our services. We have successfully handled chiral molecules with 3 chiral centers and 8 enantiomers and the racemates of any type (acid, base, alcohol, amino acid, aldehyde, ketone).
The services include:
Price: Depends on the number chiral centers, number of enantiomers, molecule type, and the amount needed
Duration: 7 to 15 days
EnantioPrep or method development service offers quick delivery of enantiopure compounds for medicinal chemistry needs within matter of days and defines a stable method that can be used for scale-up production of enantiomers to kilo quantities.
How it works: After the best 3 chiral separation conditions are determined using “Chiral Screen” service, we do bench-top scaleup using each of the 3 resolutions conditions to determine which separation condition offers maximum yield and purity using minimum re-crystallization steps.
If needed, first we recover the racemate from screening kits, prepare the diastereomeric salt using selected chiral resolving agent and solvent; and then purify the salt using series of re-crystallization steps until target purity is achieved. Each step involves treating the increasingly purified enantiomer mixture with the selected solvent; heating and cooling the mixture; and extracting the further purified enantiomeric crystals.
If both enantiomers are needed, the second enantiomer is recovered from the initial filtrate and above enrichment steps are performed using the selected resolution condition for that enantiomer.
Note: All our services are considered “research projects” and we cannot guarantee that the enantiomeric purity will be achieved. Work is done under best-effort basis.
Results
Key Benefits
ChiroSolve offers “one stop shop” experience towards outsourced lead discovery and optimization efforts. We can deliver the compounds from milligrams to 50 gm quantity in-house; and can work with our partners to scale-up beyond this quantity. We can deliver:
Note: All our services are considered “research projects” and we cannot guarantee that the enantiomeric purity will be achieved. Work is done under best-effort basis.
Customer Centric Services
Medicinal Chemistry Services
Process Development
R&D Services
Price: $5,000 to $8,000; Duration: 3 to 5 days
Chiral Screen: We screen the given racemate against more than 384 chiral separation conditions to effectively identify all commercially viable conditions for both +ve and -ve enantiomers. Using our high-throughput screening kits with patent-pending technology, we can provide the results within 3 to 5 days.
How it works: Each 96-vial kit contains unique combination of pre-calibrated amount of chiral resolving agent and polar solvent. We use 4 different such kits (comprising of 384 unique conditions). During the experiment racemate is added to each vial of the kit with 1:1 ratio with the resolving agent. The kits are then heated together in water bath to up to 800C and then cooled to ambient temperature for 24 hours. The vials with crystals then show +ve results and need to be analyzed further to check if any enantiomeric enrichment was achieved. Analysis is done using Digital Polarimeter (to read +ve or –ve specific rotation) and / or through chiral HPLC.
Results: Delivery includes:
• Results Charts that show the amount of crystals and the specific rotation for the vials which yielded the +ve results. Based on the amount of yield and specific rotation, we also identify the best 3 resolution conditions.
• Vials with +ve results (both crystals and filtrate) so the customer can validate the results
**Note: All our services are considered “research projects” since the results are dependant on many factors including the type of target racemate. As such we cannot guarantee that target enantiomeric purity will be achieved. Work is done on a best-effort basis.
Key Benefits
• Confidence that you have considered all commercially viable conditions for the chiral resolution of your racemate. This allows you to establish IP foundation fully
• Provides number of possibilities for rapid preparation of enantiomer for early lead identification and preclinical testing
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