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Chimera Biotec

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Dortmund, DE

About Chimera Biotec

Founded: 2000 Type: Privately Held Size: 11-50 employees

Chimera Biotec is your bioanalytical CRO specialized in ultra sensitive and technically demanding immunoassays.
We provide GLP/GCP bioanalytical support for all phases of drug discovery and development - from antibody qualification, assay development, method validation to bioanalysis.
We provide solutions for the quantification of large molecule targets in virtually any biological matrix, all on your preferred in-house platform, on your matrix and under the strict quality regime of your choice.

Our award-winning Immuno-PCR platform Imperacer® combines sensitivity (detecting in sub pg/ml) and broad assay range (3-6 log units), as well as performing multiple immunoassays in parallel requiring minimal sample volume. Standard platforms like Simoa®, MSD™ and highly sensitive ELISA are available as well.
 
Our team of dedicated scientists is committed to deliver immunoassay performances, which exceede your highest expectations.

Our Services (22)


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Immunoassay Development

Price on request

CUSTOMIZED IMMUNOASSAY SOLUTIONS
Aiming for non-regulated discovery phase support, GCP clinical phase support or IND-enabling TOX under full GLP-regime?
Chimera Biotec is highly experienced at providing ultra sensitive biomarker sample testing for all phases of drug development - from discovery to preclinical and clinical studies.

    ♦ Method Evaluation
    ♦ Reagent qualification
    ♦ Method Development
    ♦ Method Transfer
    ♦ Method Validation
    ♦ Bioanalysis

We have a long track record of supporting trials targetting a wide range of disease areas including:

    ♦ Oncology and Neurology (CNS)
    ♦ Autoimmune diseases
    ♦ Inflammatory diseases
    ♦ Infectious diseases
    ♦ Metabolic diseases
    ♦ Rare diseases
    ♦ Vaccines      and more

Due to our proprietary AnySource® technology, virtually any matrix can be explored.

Our highly experienced project management and scientific team will ensure that your needs for ultra sensitive immunoassay sample testing support and regulatory guidance will make the perfect match.

Multiplex immunoassays Immunoassays Imperacer® Simoa® Meso Scale Discovery (MSD®) ELISA all all Show 8 more tags Show less

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Bioanalytical Assays

Price on request

Chimera Biotec is well aware of the critical role ultra sensitive bioanalysis plays in modern drug development of biologics, biosimilars and biobetters.
It is our goal to ensure your success in all phases of drug development providing highly sensitive, accurate and reliable bioanalysis data on-time.

Your study samples will be stored, handled, analyzed, reported and archived with greatest care and swift turn around:

    ♦ Immunoassay sample testing
    ♦ Kit-based services
    ♦ Platforms: Imperacer® (Immuno-PCR), Simoa®, MSD™ and ELISA
    ♦ Sample storage in monitored environment
    ♦ GLP/GCP regime according to validated SOPs
    ♦ Compliance with FDA and EMA
    ♦ Sample logistics and data reconciliation services to support multi center clinical trials

Immunoassays Multiplex immunoassays microsampling Imperacer® Simoa® Meso Scale Discovery (MSD®) ELISA all all Show 9 more tags Show less

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Assay Development

Price on request

Chimera Biotec is the worlds leading provider of Immuno-PCR-based assay development services for novel biologics and biosimilars and biomarkers; basically any kind of macromolecule analyte. Further technologies like Simoa, MSD and ELISA can be offered.

Immunoassay development at Chimera Biotec begins with in-depth consultation with your dedicated project manager, to develop the optimal workplan for your project:


    ♦ Method Evaluatioin:
        Not sure which platform serves your needs best? Don´t want to switch from your
        preferred in-house platform? We advise and find the best solution.


    ♦ Reagent Qualification:
       Provide us your proprietary critical reagents or support our search of suitable
       commercial material with your guidance

    ♦ Antibody-DNA conjugation (if required):
        We make sure that the coupling of marker DNA to the detection reagent supports it´s
        functionality and binding epitopes

    ♦ Assay development and optimization:
        We aim for highest sensitivity, suitable sample consumption and adaptation to your
        intended study matrix. Direct communication between you and our dedicated project
        managers will support us to develop the method according to your expectations.


    ♦ Assay parameter characterization and validation:
        Fine-tune the method for upcoming studies in preclinics and clinics.   
        Our dedicated project managers develp a validation protocol together with you
        according to your study requirements and regulatory guidelines.


    ♦ Bioanalysis:
        Once your assay is completed, we measure your samples in our GLP-certified lab


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Biomarker Assay Development

Price on request

Chimera Biotec is highly experienced at providing ultra sensitive biomarker sample testing
for all phases of drug development - from discovery to preclinical and clinical studies.


    ♦ Method Evaluation

    ♦ Reagent qualification
    ♦ Method Development
    ♦ Method Transfer
    ♦ Method Validation
    ♦ Bioanalysis


We have a long track record of supporting trials targetting a wide range of disease areas including:

    ♦ Oncology and Neurology (CNS)
    ♦ Autoimmune diseases
    ♦ Inflammatory diseases
    ♦ Infectious diseases
    ♦ Metabolic diseases
    ♦ Rare diseases
    ♦ Vaccines      and more


Due to our proprietary AnySource® technology, virtually any matrix can be explored.

Immuno-Oncology CNS/Neurology Autoimmune Diseases Neurodegenerative diseases Metabolic Disease Biology Drug Discovery Toxicology Good Laboratory Practice Ab labeling ADA Immunoassays ELISA MSD Simoa Imperacer Immuno-PCR Imperacer Simoa Meso Scale Discovery (MSD®) ELISA All Matrices CNS/Neurology Autoimmunity Gastroenterology Immuno-Oncology Immunology Inflammation Metabolic Disease Neurodegeneration Neurology Oncology Ophthalmology Rare Disease Respiratory Show 35 more tags Show less

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IND-Enabling Studies

Price on request
Request a quote for more information about this service.

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Ultra-Sensitive Simoa Assays

Price on request

The Simoa Analyzer combines single molecule analysis with digital ELISA readout. Analytes are captured in solution by antibody loaded beads instead of target-antibody interaction on an antibody immobilized solid surface. Beads -loaded with target or not- are trapped in femtoliter sized microcavities and return digital signal (on/off) for analysis.


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Biomarkers

Price on request

Make use of our bioanalytical sample testing support and check out our Biomarker Menu:

http://www.chimera-biotec.com/applications/biomarker-menu/


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Pharmacology & Toxicology

Price on request

Combining broad quantitative range with excellent sensitivities, Chimera Biotec is able to support biologics PK using single assay formats. From high dosing TOX through extreme low dosing in dose-escalation to later clinical stage, we provide regulated PK sample testing using validated methods, based on the same assay.
Eliminate the need to run several assays to pair sensitivity and range.


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Bioanalysis

Price on request

Chimera Biotec offers state-of-the-art bioanalysis for the development of safe and effective biotherapeutics.
At Chimera, your study samples will be stored, handeled, analyzed, reported and archived with greatest care and swift turn around.
We offer ultra sensitive ligand-binding assay sample testing, exploratory sample testing or GLP/GCP regulated bioanalytical support. We support sample logistics and data reconciliation services in multi-center clinical trials and offer sample storage in a 24-7 monitored environment.


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Project Management

Price on request
Request a quote for more information about this service.

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Pharmacology

Price on request

Pharmacology Services


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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Biomarker Analysis

Price on request
Request a quote for more information about this service.

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ELISA

Enzyme-linked immunosorbent assay
Price on request
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Protein Quantification

Price on request

Protein Quantification Services


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Protein Purification

Price on request

Protein Purification and Quantification Services


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Protein Services

Price on request

Protein Services


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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services


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Biology

Price on request

Biology Services


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Immunoassays

Price on request

Immunoassays Services


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Immunoglobulin Quantification

Price on request
Request a quote for more information about this service.

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Clinical Research

Price on request
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Mark Spengler

Director Project Management

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