ChemBio Discovery Solutions is a professional consultancy and contract research platform founded in 2015 to offer computational modeling services and solutions for small-molecule and biologics (antibody) drug discovery research. Our main mission is to help our clients by providing specialised computational chemistry and biology services, to rationally and economically tackle the design and discovery obstacles facing drug discovery scientists.
We promise to be highly flexible with our working business models by offering our services (under confidentiality agreements) on a retainer basis (dedicated time for a fixed monthly rate), per project basis (short- and long-term plans), or as per individual needs of clients and project. Our clients include pharmaceutical & biotech companies (small-to-medium size in general), academic research institutes, universities, government laboratories and regulatory institutes.
Sequence alignment, analysis, and manipulation, secondary structure prediction, homology modeling, and analysis of experimental data (e.g. antibody display).
Proprietary peptide QSAR modeling (CoRIA: Comparative Residue Interaction Analysis).
Automation of redundant tasks – KNIME workflows, scripts writing, etc.
Assistance with drug repurposing, ADME/Tox evaluations.
Feasibility and exploratory studies on specific targets of interest (TOI).
Filtering (PAINS), manipulation (clustering), property analysis & maintenance of molecular libraries
Combinatorial library design– creating focused virtual libraries around leads, or create a library form commercial databases using substructure similarity for binding affinity calculations and ranking.
Multi-parameter optimization and predictive modeling such as QSAR.
Selectivity profiling of lead compounds against related proteins (to pursue interesting polypharmacology or to avoid off-target activities).
Structure-based / ligand-based strategies
Virtual screening of commercial or corporate libraries
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