Chelatec is an independent Contract Research Organization established in 2000 and based in metropolitan area of Nantes, France.
We provide customized services in the specific fields of radiolabeling and preclinical research.
Our mission is to assist the pharmaceutical and biotechnology industry along the drug development process by using the radioactive tracer for Bioanalyses, PharmacoKinetics and ADME studies.
The broad expertise of our multidisciplinary team and the quality of our technical resources guarantee you optimum support for subcontracted projects. We offer a unique environment of laboratories accredited in both the handling of radionuclides and animal experimentation conducted on rodents.
Chelatec provides you with a rapid quotation detailing all the radiolabeling specifications of either your in house developed compounds (antibodies, proteins, peptides...) or commercially available compounds. Within a 24 hours delay, you will be contacted by a project manager that will set with you details of the radiolabeling process in order to meet your needs.
Chelatec’s scientist have already been involved in various therapeutic areas (drug delivery, oncology, inflammation, vaccines & immunization...) and can work with healthy animals as well as with models to help you make your go/no go decision faster.
On demand Chelatec performs in vivo preclinical studies using radiolabeled compounds (125I, 111In, 3H,14C....) following experiments:
► Various routes of administration (IP, IV, PO, SC, IM, intra Nasal, Intra synovial...) ► Single/multiple dosing, Infusion ► Pharmacokinetics (blood and plasma) ► Tissue distribution ► Elimination (urines and feces) ► Blood-Brain-Barrier permeability ► Specific fluids withdrawal on demand (like CSF) ► Metabolite HPLC profile (plasma and urine) ► SDS-PAGE analysis on tissue extracts, plasma and urine
To optimize the management of your analyses requiring radiolabeled products (125I, 14C, 3H) Chelatec also performs in vitro assays.
► Binding affinity (Kd) ► Competitive binding studies (Ki, IC50) ► Immunoreactivity ► Plasma proteins binding assay ► Customized assay on demand
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