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Charter Preclinical Services

Hudson, Massachusetts, US

Charter Preclinical Services is a GLP-compliant research and development organization offering veterinary pathology services to industry and academic institutions in need of pathology study support. Veterinary pathology can add significant value to your studies and increase the likelihood of publication in high quality journals. We're here to help and offer a variety of pathology services to meet your needs.

We specialize in analysis of histological samples from preclinical safety and efficacy studies. CPS has 2 full-time board-certified veterinary pathologists on staff. We have experience with a variety of animal species including mice, rats, zebrafish, nonhuman primates, sheep, pigs, cows, dogs, cats, reptiles, and amphibians. Our areas of specialty include, but are not limited to:

  • Orthopedic Diseases
  • Cardiovascular Diseases
  • Cancer and Cancer-Related Diseases
  • Neurologic and Neuromuscular... Show more »

Charter Preclinical Services is a GLP-compliant research and development organization offering veterinary pathology services to industry and academic institutions in need of pathology study support. Veterinary pathology can add significant value to your studies and increase the likelihood of publication in high quality journals. We're here to help and offer a variety of pathology services to meet your needs.

We specialize in analysis of histological samples from preclinical safety and efficacy studies. CPS has 2 full-time board-certified veterinary pathologists on staff. We have experience with a variety of animal species including mice, rats, zebrafish, nonhuman primates, sheep, pigs, cows, dogs, cats, reptiles, and amphibians. Our areas of specialty include, but are not limited to:

  • Orthopedic Diseases
  • Cardiovascular Diseases
  • Cancer and Cancer-Related Diseases
  • Neurologic and Neuromuscular Diseases
  • Pulmonary Diseases
  • Immune-Mediated Diseases
  • Renal Disease
  • Gastro-Intestinal Disease
  • Infectious diseases
  • Vaccines
  • Phenotyping

If you do not have a veterinary pathologist on staff or require someone with veterinary pathology training and certification to meet expanded needs, we would be glad to help. We offer quick turn-around times on your projects and generate high-quality, concise, easy-to-understand, customizable reports for your study.

Select Publications:

  • DeMuth PC, Li AV, Abbink P, Liu J, Li H, Stanley KA, Smith KM, Lavine CL, Seaman MS, Kramer JA, Miller AD, Abraham W, Suh H, Elkhader J, Hammond PT, Barouch DH, and Irvine DJ. 'Immunogenic delivery of adenoviral vectors in non-human primates from microneedle skin-patches'. Nature Biotechnology. (In press).
  • Wang H, Yang B, Qiu L, Yang C, Kramer J, Su Q, Guo Y, Brown R, Gao G, and Xu Z. 'Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis'. Human Molecular Genetics. (In Press).
  • Handsley S, Thackray LB, Zhao G, Presti R, Miller D, Droit L, Abbink P, Maxfield LF, Kambal A, Duan E, Stanley K, Kramer J, Macri SC, Permar SR, Schmitz JE, Mansfield K, Brenchley J, Veazey RS, Stappenbeck TS, Wang D, Barouch DH, and Virgin HW. 'Pathogenic simian immunodeficiency virus infection is associated with significant expansion of the enteric virome'. Cell. 2012. PMCID: PMC3490196
  • Li P, Raitcheva D, Hawes M, Moran N, Yu X, Wang F, Matthews GL. 'Hylan G-F 20 maintains cartilage integrity and decreases osteophyte formation in osteoarthritis through both anabolic and anti-catabolic mechanisms'. Osteoarthritis Cartilage. 2012 Jul 15. [Epub ahead of print]
  • Ngo MD, Aberman HM, Hawes ML, Choi B, Gertzman AA. 'Evaluation of human acellular dermis versus porcine acellular dermis in an in vivo model for incisional hernia repair'. Cell Tissue Bank. 2011 May;12(2):135-45. Epub 2011 Mar 6.
  • Stanwix MG, Nam AJ, Hui-Chou HG, Ferrari JP, Aberman HM, Hawes ML, Keledjian KM, Jones LS, Rodriguez ED. 'Abdominal ventral hernia repair with current biological prostheses: an experimental large animal model'. Ann Plast Surg. 2011 Apr;66(4):403-9.'
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Immunohistochemistry (IHC)
Price on request

Our 3 ACVP board-certified veterinary pathologists can analyze your IHC slides. We have experience with dozens of different antibodies and can offer semi-quantitative scoring with cellular localization, and types of cells expressing your antigen, or whole tissue image analysis via VisioPharm Software. Turnaround time is 3 weeks... Show more »

Our 3 ACVP board-certified veterinary pathologists can analyze your IHC slides. We have experience with dozens of different antibodies and can offer semi-quantitative scoring with cellular localization, and types of cells expressing your antigen, or whole tissue image analysis via VisioPharm Software. Turnaround time is 3 weeks from receipt of slides. We can send you data and a report with annotated photomicrographs.

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Whole Slide Imaging
Starting at $10.00 per sample

Digitized, scanned whole slides allow for more advanced image analysis

Whole slides are scanned at high resolution and viewed on a high resolution screen where they can be assessed visually by our pathologists. Because of the extremely high resolution of the scans, advanced computer programs can perform detailed image analysis across an entire study or group of slides with little variability.

Digitized, scanned whole slides allow for more advanced image analysis

Whole slides are scanned at high resolution and viewed on a high resolution screen where they can be assessed visually by our pathologists. Because of the extremely high resolution of the scans, advanced computer programs can perform detailed image analysis across an entire study or group of slides with little variability.

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Fluorescence-Based Microscopy
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Use of fluorescent labels and antibodies to recognize specific cell types

Use of fluorescent markers can allow for detailed examination of drug uptake, antibody co-localization, or use of antibodies not well suited for brightfield microscopy. We can view fluorescently stained slides and analyze them in the same way as... Show more »

Use of fluorescent labels and antibodies to recognize specific cell types

Use of fluorescent markers can allow for detailed examination of drug uptake, antibody co-localization, or use of antibodies not well suited for brightfield microscopy. We can view fluorescently stained slides and analyze them in the same way as brightfield images, as described above. Our veterinary pathologists have extensive experience with fluorescent microscopy.

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Image Analysis
Price on request

More advanced image analysis using computer programs to quantify information on the slide.

Quantitative image analysis utilizes software to generate measurements from a tissue section. This process is guided by a veterinary pathologist. The process involves several steps but in its most basic form involves acquiring an image... Show more »

More advanced image analysis using computer programs to quantify information on the slide.

Quantitative image analysis utilizes software to generate measurements from a tissue section. This process is guided by a veterinary pathologist. The process involves several steps but in its most basic form involves acquiring an image from a microscope, importing that image into a software program, and utilizing tools in that program to process the image and generate data. Whole tissue slide scans can also be analyzed in this way. Some examples include: 1) length or area of specific lesions or features; 2) number of cells stained with a particular marker; 3) amount of one type of tissue identified with a special stain; or 4) cytoplasmic, membrane or nuclear staining of immunohistochemical targets.

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Histopathological Examination
Price on request

Qualitative and semi-quantitative assessment of histologic specimens using light or fluorescence microscopy

Semi-quantitative image analysis relies on the pathologist’s judgment to apply scores to tissue specimens. Years of training in residency programs, board-certification and familiarity with the disease model in question... Show more »

Qualitative and semi-quantitative assessment of histologic specimens using light or fluorescence microscopy

Semi-quantitative image analysis relies on the pathologist’s judgment to apply scores to tissue specimens. Years of training in residency programs, board-certification and familiarity with the disease model in question are the basis of such judgments. A variety of pathologic changes can be scored depending on the aims of the particular experiment being evaluated. Some examples include: inflammation, fibrosis, hyperplasia, necrosis, or edema. We find that this method is reproducible between animals and between experiments and that it often correlates well with other, more quantitative measurements. Using this method, we are able to perform non-parametric statistical analysis to compare different groups within a study. We can generate data and a report with results, conclusions, and annotated photomicrographs in 3 weeks from receipt of slides.

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Clinical Research
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Clinical Laboratory Services
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Clinical and Anatomic Pathology
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Biology
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Biochemistry & Molecular Biology
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Protein Services
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Protein Expression Visualization
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Immunostaining
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Imaging & Spectroscopy
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Microscopy
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Optical Microscopy
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Computational Modeling
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Data Services
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