Charter Preclinical Services is a GLP-compliant research and development organization offering veterinary pathology services to industry and academic institutions in need of pathology study support. Veterinary pathology can add significant value to your studies and increase the likelihood of publication in high quality journals. We're here to help and offer a variety of pathology services to meet your needs.
We specialize in analysis of histological samples from preclinical safety and efficacy studies. CPS has 2 full-time board-certified veterinary pathologists on staff. We have experience with a variety of animal species including mice, rats, zebrafish, nonhuman primates, sheep, pigs, cows, dogs, cats, reptiles, and amphibians. Our areas of specialty include, but are not limited to:
If you do not have a veterinary pathologist on staff or require someone with veterinary pathology training and certification to meet expanded needs, we would be glad to help. We offer quick turn-around times on your projects and generate high-quality, concise, easy-to-understand, customizable reports for your study.
Our 3 ACVP board-certified veterinary pathologists can analyze your IHC slides. We have experience with dozens of different antibodies and can offer semi-quantitative scoring with cellular localization, and types of cells expressing your antigen, or whole tissue image analysis via VisioPharm Software. Turnaround time is 3 weeks from receipt of slides. We can send you data and a report with annotated photomicrographs.
Digitized, scanned whole slides allow for more advanced image analysis
Whole slides are scanned at high resolution and viewed on a high resolution screen where they can be assessed visually by our pathologists. Because of the extremely high resolution of the scans, advanced computer programs can perform detailed image analysis across an entire study or group of slides with little variability.
Use of fluorescent labels and antibodies to recognize specific cell types
Use of fluorescent markers can allow for detailed examination of drug uptake, antibody co-localization, or use of antibodies not well suited for brightfield microscopy. We can view fluorescently stained slides and analyze them in the same way as brightfield images, as described above. Our veterinary pathologists have extensive experience with fluorescent microscopy.
More advanced image analysis using computer programs to quantify information on the slide.
Quantitative image analysis utilizes software to generate measurements from a tissue section. This process is guided by a veterinary pathologist. The process involves several steps but in its most basic form involves acquiring an image from a microscope, importing that image into a software program, and utilizing tools in that program to process the image and generate data. Whole tissue slide scans can also be analyzed in this way. Some examples include: 1) length or area of specific lesions or features; 2) number of cells stained with a particular marker; 3) amount of one type of tissue identified with a special stain; or 4) cytoplasmic, membrane or nuclear staining of immunohistochemical targets.
Qualitative and semi-quantitative assessment of histologic specimens using light or fluorescence microscopy
Semi-quantitative image analysis relies on the pathologist’s judgment to apply scores to tissue specimens. Years of training in residency programs, board-certification and familiarity with the disease model in question are the basis of such judgments. A variety of pathologic changes can be scored depending on the aims of the particular experiment being evaluated. Some examples include: inflammation, fibrosis, hyperplasia, necrosis, or edema. We find that this method is reproducible between animals and between experiments and that it often correlates well with other, more quantitative measurements. Using this method, we are able to perform non-parametric statistical analysis to compare different groups within a study. We can generate data and a report with results, conclusions, and annotated photomicrographs in 3 weeks from receipt of slides.
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