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Charles River - Neuroscience Services

Wilmington, Massachusetts, US

Charles River offers a wide range of neuroscience research products and services supported by our scientific depth, unique technical capabilities and experience in all the major neurodegenerative diseases and neurological indications, such as schizophrenia, Alzheimer’s disease, Parkinson’s disease, chronic pain, epilepsy, multiple sclerosis, stroke and ischemia. From animal models of disease to discovery research and preclinical testing, we have developed tools to assist clients in identifying the most promising candidate and shortening the development cycle of potential therapies with neurological implications.

In the last six decades, we have seen technologies advance and new diseases emerge. Our one-man laboratory has evolved into a worldwide support network, allowing us to act as a steadfast partner to our sponsors, from discovery to lot release testing. By carefully cultivating our portfolio, our growth has... Show more »

Charles River offers a wide range of neuroscience research products and services supported by our scientific depth, unique technical capabilities and experience in all the major neurodegenerative diseases and neurological indications, such as schizophrenia, Alzheimer’s disease, Parkinson’s disease, chronic pain, epilepsy, multiple sclerosis, stroke and ischemia. From animal models of disease to discovery research and preclinical testing, we have developed tools to assist clients in identifying the most promising candidate and shortening the development cycle of potential therapies with neurological implications.

In the last six decades, we have seen technologies advance and new diseases emerge. Our one-man laboratory has evolved into a worldwide support network, allowing us to act as a steadfast partner to our sponsors, from discovery to lot release testing. By carefully cultivating our portfolio, our growth has become a continuous strategic effort in anticipating tomorrow’s drug development needs. We can’t predict what the future holds, but at Charles River we continue to kindle the spark that inspired our founding: an urgency to advance human health by supporting our clients’ research every step of the way.

Charles River is AAALAC certified.

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Ex vivo Electrophysiology
Price on request

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory... Show more »

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory circuits in tissue obtained from living animals.
Multiplexed electrophysiological recordings from brain slices using multi-electrode arrays are a direct way to probe neural function, detect pathological functional abnormalities and explore sensitivity of spontaneous and evoked electrical signal transmissions to drugs. The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and some brain pathologies. Up- or down-regulation of synaptic transmission can shed light on cellular and network mechanisms of numerous CNS diseases, including Alzheimer’s disease, autism and ataxia.

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Cell Electrophysiology
Price on request

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory... Show more »

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory circuits in tissue obtained from living animals.
Multiplexed electrophysiological recordings from brain slices using multi-electrode arrays are a direct way to probe neural function, detect pathological functional abnormalities and explore sensitivity of spontaneous and evoked electrical signal transmissions to drugs. The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and some brain pathologies. Up- or down-regulation of synaptic transmission can shed light on cellular and network mechanisms of numerous CNS diseases, including Alzheimer’s disease, autism and ataxia.

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Patch Clamp Recording
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Biomarkers
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With years of experience in assay design and sample processing, Charles River can support your drug discovery pipeline by providing biomarker analysis in a non-GLP environment. We offer a wide range of study-specific analytical services using platforms such as Meso Scale Discovery (MSD®), Luminex®, ELISA, EIA, Western blotting,... Show more »

With years of experience in assay design and sample processing, Charles River can support your drug discovery pipeline by providing biomarker analysis in a non-GLP environment. We offer a wide range of study-specific analytical services using platforms such as Meso Scale Discovery (MSD®), Luminex®, ELISA, EIA, Western blotting, HPLC etc. using cell lines, primary cells, tissues and in vivo analytes.

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CNS/Neurology
Neuroscience
Electroencephalogram (EEG) Models
Price on request

At Charles River, we use EEG monitoring to assess changes in sleep state and electrical activity associated with neurological disease models of seizure. Using a telemetric approach, EEG patterns indicative of changes in underlying neuronal function are recorded and show specific rhythmic activity that can be used as... Show more »

At Charles River, we use EEG monitoring to assess changes in sleep state and electrical activity associated with neurological disease models of seizure. Using a telemetric approach, EEG patterns indicative of changes in underlying neuronal function are recorded and show specific rhythmic activity that can be used as characteristic translational biomarkers. Understanding the effects of test compounds on the activity and function of the brain are essential in drug development and Charles River can perform continuous EEG following acute or chronic compound treatment in combination with PK/PD studies and behavioral testing.

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CNS/Neurology
Animal Microdialysis
Price on request

Microdialysis is a minimally-invasive sampling technique used to measure unbound analyte concentrations in extracellular fluid and tissues. At Charles River, we offer conventional microdialysis to measure small molecular weight analytes as well as push-pull microdialysis to measure larger molecules. Additionally, the proprietary... Show more »

Microdialysis is a minimally-invasive sampling technique used to measure unbound analyte concentrations in extracellular fluid and tissues. At Charles River, we offer conventional microdialysis to measure small molecular weight analytes as well as push-pull microdialysis to measure larger molecules. Additionally, the proprietary MetaQuant method is used to sample various tissues. We can customize assays by combining microdialysis with other methods such as behavior or EEG measurements.
Accuracy and sensitivity are critical parameters for bioanalysis and Charles River provides a wide range of bioanalytical services. A combination of expert scientists and state of the art equipment allows us to offer novel analytical techniques to analyze low concentrations of multiple neurotransmitters simultaneously in a single run.

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CNS/Neurology
Neuroscience
Animal Movement Analysis
Price on request

Fine Motor Kinematic Analysis - Scientists at Charles River use a novel automated and high-precision system coupled with proprietary data analysis methods to successfully analyze fine motor skills in mouse models of neurological diseases. Fine motor kinematic analysis reveals early changes in muscular or neuronal function in... Show more »

Fine Motor Kinematic Analysis - Scientists at Charles River use a novel automated and high-precision system coupled with proprietary data analysis methods to successfully analyze fine motor skills in mouse models of neurological diseases. Fine motor kinematic analysis reveals early changes in muscular or neuronal function in disease models to support the development of therapeutics that reverse or slow progressive degeneration and to test compounds that can cause fine motor impairment as a side effect.
The experimental output is a high speed film that is analyzed using proprietary algorithms to generate quantitative analysis of over 100 movement associated parameters.

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Mouse
CNS/Neurology
neurodegenerative disorders
In vivo Electrophysiology
Price on request

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory... Show more »

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory circuits in tissue obtained from living animals.
Multiplexed electrophysiological recordings from brain slices using multi-electrode arrays are a direct way to probe neural function, detect pathological functional abnormalities and explore sensitivity of spontaneous and evoked electrical signal transmissions to drugs. The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and some brain pathologies. Up- or down-regulation of synaptic transmission can shed light on cellular and network mechanisms of numerous CNS diseases, including Alzheimer’s disease, autism and ataxia.

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CNS/Neurology
Neuroscience
electrophysiology
single cells
Integrated Drug Discovery
Price on request

Charles River’s integrated drug discovery programs have reduced the drug discovery timeline to as little as 24 months through industry experienced, multi-disciplinary teams focused on resource efficiency, scientific excellence and strategic partnerships. With numerous technologies for hit identification and knowledge-based... Show more »

Charles River’s integrated drug discovery programs have reduced the drug discovery timeline to as little as 24 months through industry experienced, multi-disciplinary teams focused on resource efficiency, scientific excellence and strategic partnerships. With numerous technologies for hit identification and knowledge-based approach to lead optimization along with the development of targeted in vitro and in vivo assays, our integrated research teams consistently convert leads into successful preclinical development candidates.

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CNS/Neurology
Neuroscience
Cognitive, Behavioral, and Psychiatric Animal Models
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Charles River offers several models of psychiatric disease including autism, schizophrenia, anxiety and depression. Charles River scientists recently characterized the BTBR T+tf/J model of autism using behavioral studies and noninvasive imaging to validate its utility for preclinical drug discovery of ASD therapies.... Show more »

Charles River offers several models of psychiatric disease including autism, schizophrenia, anxiety and depression. Charles River scientists recently characterized the BTBR T+tf/J model of autism using behavioral studies and noninvasive imaging to validate its utility for preclinical drug discovery of ASD therapies.
Additionally, our neuroscientists conduct contract studies in mice to assess the efficacy of novel anti-anxiety compounds, such as anxiolytics and selective serotonin reuptake inhibitors (SSRIs).
You can partner with our scientists to run your studies in well-characterized, disease-relevant models, using a comprehensive toolkit of imaging capabilities, behavioral assays and biomarkers including the forced swim test and touchscreen testing.
Charles River has validated a pencyclidine (PCP)-induced deficit model, which recapitulates several behavioral deficits, mimicking the symptoms of schizophrenia. This model displays both positive and negative symptoms, including cognitive deficits, and facilitates the development of drugs for either or both symptom categories.

Charles River offers mouse behavior analysis via touchscreen-based tests. The touchscreen tests possess several advantages over traditional methods of rodent cognitive assessment and are highly translational as they rely on the stimuli and actions similar to those used in human cognitive assessments. Due to their emphasis on sustained performance, touchscreen tests can be used in longitudinal pharmacological studies and this method can be easily combined with other behavioral or functional tests.

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Mouse
Rat
CNS/Neurology
neurodegenerative disorders
neurodegenerative diseases
psychiatric
Traumatic Brain Injury Animal Models
Price on request

Charles River conducts contract studies in established animal models of traumatic brain injury (TBI) to test the efficacy of novel therapeutics. We offer acute or long-term (chronic) histological, functional and behavioral follow-up along with detailed MRI/MRS imaging capabilities.

Charles River conducts contract studies in established animal models of traumatic brain injury (TBI) to test the efficacy of novel therapeutics. We offer acute or long-term (chronic) histological, functional and behavioral follow-up along with detailed MRI/MRS imaging capabilities.

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Rodents
CNS/Neurology
Neuroscience
spinal cord injury
Parkinsons Disease Animal Models
Price on request

Classical rodent models for Parkinson’s disease, such as 6-OHDA or MPTP lesioning, are standard working tools that offer mechanistic support for therapeutic testing. Charles River has maximized the utility of these models by providing a comprehensive and translatable modeling platform of chemically and biologically induced (6-OHDA... Show more »

Classical rodent models for Parkinson’s disease, such as 6-OHDA or MPTP lesioning, are standard working tools that offer mechanistic support for therapeutic testing. Charles River has maximized the utility of these models by providing a comprehensive and translatable modeling platform of chemically and biologically induced (6-OHDA and MPTP) and genetic models (A53T Alpha-Synuclein mouse model and AAV-human A53T transgenic rat model). Translational tools to assess Parkinson’s disease progression and symptoms include fine motor kinematics to assess gait changes, MRI and nuclear imaging and the assessment of biomarkers via immunohistochemistry, ELISA etc.

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Mouse
Rat
CNS/Neurology
Neuroscience
Parkinson's disease
Alzheimer's Disease Animal Models
Price on request

At Charles River, our scientists can guide you in the selection of the appropriate assay or disease model for every stage of the drug discovery process. Our extensive portfolio supports novel study designs and offers end-to-end validated in vitro services and in vivo models of pharmacology and toxicology. Our novel imaging... Show more »

At Charles River, our scientists can guide you in the selection of the appropriate assay or disease model for every stage of the drug discovery process. Our extensive portfolio supports novel study designs and offers end-to-end validated in vitro services and in vivo models of pharmacology and toxicology. Our novel imaging modalities, behavioral tests and biomarker endpoint assays enable you to make effective decisions to help identify new therapies for Alzheimer’s disease.
Alzheimer’s disease models available for studies include the transgenic CVN and Tg2576 mouse models, which display pathologies associated with Alzheimer’s disease. Aged rodents and scopolamine-induced amnesia models are also available. Established and novel AD models are validated using cognitive testing, MRI and nuclear imaging, measurement of the levels of soluble and insoluble beta amyloid, immunohistochemical measurements and relevant biomarkers. Our services provide an extensive platform for pharmaceutical research and development.

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Cell Culture
Rodents
CNS/Neurology
Neuroscience
Alzheimer's disease
Animal Surgery
Price on request

Neurological Procedures
Charles River offers neurological surgical procedures in rat, mouse and guinea pig models at our AAALAC-accredited production facilities in North America. Our experienced animal surgeons can perform cannulations and other surgical alterations to provide you with the exact rodent models you need for... Show more »

Neurological Procedures
Charles River offers neurological surgical procedures in rat, mouse and guinea pig models at our AAALAC-accredited production facilities in North America. Our experienced animal surgeons can perform cannulations and other surgical alterations to provide you with the exact rodent models you need for your research.

  • Bilateral Brain Cannulation
  • Bilateral Superior Ganglion Denervation
  • Chronic Constriction Injury (CCI) of Sciatic Nerve
  • Intracisternal Cannulation
  • Intralateral Ventricular Cannulation
  • Intrathecal Cannulation (for infusion only)
  • Microdialysis Probe Implantation
  • Parkinson’s Model (Chemical 6-OHDA)
  • Schizophrenia/Epilepsy Model
  • Spinal Nerve Ligation (SNL)
  • Superior Cervical Ganglion Denervation
  • Unilateral Brain Cannulation
  • 3rd Ventricular Cannulation
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Guinea pig
Mouse
Rat
Neuropathology
Price on request

Charles River combines experienced pathologists with a highly trained technical staff and well-designed laboratories to offer pathology services in the specialized area of neuropathology. We provide assistance in study design, development strategies and regulatory submissions for a wide variety of compounds affecting the nervous... Show more »

Charles River combines experienced pathologists with a highly trained technical staff and well-designed laboratories to offer pathology services in the specialized area of neuropathology. We provide assistance in study design, development strategies and regulatory submissions for a wide variety of compounds affecting the nervous system. Each year, our scientists conduct over 30 GLP-compliant neuropathology studies in support of FDA and EPA regulatory submissions.

Neuropathology Services:

  • Whole-body perfusion
  • Specialized nerve tissue embedding
  • Specialized staining capabilities
  • Electron microscopy (transmission electron microscopy and scanning electron microscopy)
  • Morphometric analysis
  • Immunohistochemistry
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In vitro Neurotoxicity Testing
Price on request

Neurotoxicology
The neurotoxicology program at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, chemicals and agrochemicals, in both rodent and nonrodent species. With over two decades of experience, we have a valuable historical control database for tests in developmental... Show more »

Neurotoxicology
The neurotoxicology program at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, chemicals and agrochemicals, in both rodent and nonrodent species. With over two decades of experience, we have a valuable historical control database for tests in developmental neurotoxicology. We also have a knowledgeable staff of scientists and technical personnel who routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies and developmental neurotoxicity.

Capabilities include:

  • Neurobehavior, including assays of locomotor activity, rotarod forced activity, water maze learning and memory testing, auditory startle habituation and functional observational batteries
  • Neurochemistry, including cholinesterase assays in red blood cell, plasma and brain samples, as well as quantification of endogenous levels of neurotransmitters
  • Neuropathology, including in situ perfusion, morphometry, stereology and qualitative neuropathological evaluations
  • Drug abuse/dependence liability testing
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Discovery Pathology
Price on request

Adding anatomic and clinical pathology endpoints in discovery studies enhances the understanding, characterization and translational ability of animal models, as well as allows for comparison of developmental candidates and lead optimization and provides, in some cases, early efficacy information.

Charles River combines... Show more »

Adding anatomic and clinical pathology endpoints in discovery studies enhances the understanding, characterization and translational ability of animal models, as well as allows for comparison of developmental candidates and lead optimization and provides, in some cases, early efficacy information.

Charles River combines expertise from our discovery, research models and preclinical services groups with our pathology expertise to provide clients with a comprehensive approach to animal model evaluation for specialized therapeutic areas, including oncology, cardiovascular, respiratory, CNS, ophthalmology, inflammation and metabolic disease.

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Animal Imaging
Price on request

Imaging has the potential to dramatically increase the efficiency of lead candidate selection by providing earlier and more highly predictive data, compared with traditional methods. Imaging is also well suited for facilitating translation between preclinical testing and clinical evaluation of drugs. Furthermore, imaging methods... Show more »

Imaging has the potential to dramatically increase the efficiency of lead candidate selection by providing earlier and more highly predictive data, compared with traditional methods. Imaging is also well suited for facilitating translation between preclinical testing and clinical evaluation of drugs. Furthermore, imaging methods are more easily applied than traditional methods in the newer, more realistic models of human disease that are becoming increasingly prevalent.

Charles River has an in vivo imaging facility with high-field MRI, PET/CT and SPECT/CT scanners for radionuclide-based imaging applications. All platforms are applicable for longitudinal studies with multiple imaging endpoints to study phenotype progression and treatment efficacy, biodistribution or tissue activity changes.

  • Anatomical MRI
  • Diffusion MRI
  • fMRI & phMRI
  • Hemodynamic MRI
  • Localized 1H-MRS
  • Optical Coherence Tomography
  • Positron Emission Tomography (PET)
  • Single Photon Emission Computed Tomography (SPECT)
  • Radiochemistry
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CNS/Neurology
Neuroscience
neurodegenerative diseases
Pain/Neuropathy Animal Models
Price on request

Pain Drug Discovery Services

At Charles River, we have developed validated models for in vitro and in vivo studies along with a comprehensive toolkit, including imaging, translational behavior and fine motor kinematics to accelerate novel therapies to treat acute and chronic pain. We offer comprehensive ion channel panels... Show more »

Pain Drug Discovery Services

At Charles River, we have developed validated models for in vitro and in vivo studies along with a comprehensive toolkit, including imaging, translational behavior and fine motor kinematics to accelerate novel therapies to treat acute and chronic pain. We offer comprehensive ion channel panels focused on pain as well as multiple in vivo readouts, including tactile and thermal hyperalgestia, cold allodynia, nocifensive behavior, fine motor kinematics, dynamic weight bearing and kinetic PET imaging.
We offer a growing portfolio of various pain models targeting chronic joint pain, inflammatory pain, nociception and neuropathic pain. Additionally, our scientists conduct contract studies in trigeminal ganglia electrostimulation and cortical spreading depression (KCl-induced) animal models to assess the efficacy of novel antimigraine drugs.
We also proof-of-principle/proof-of-concept studies for neuroprotection and reduction of infarct, as well as longer-term, more comprehensive studies looking at functional and cognitive outcomes or stroke prevention. Animal models of stroke and brain ischemia available for use in our studies include the tMCAO, MCAO, EMCAO as well as brain ischemia and hind limb peripheral ischemia models.

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Toxicology
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Drug Discovery
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Cells and Tissues
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Animal Models of Disease
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Marketing, Communication & Graphic Design Services
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Animal Models and Studies
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Drug Discovery & Development
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Clinical Research
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Animal Model in vivo Analyses
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Clinical Laboratory Services
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Biology
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In vitro Toxicity Testing
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Project and Process Management
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Animal Physiology Analyses
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Bioanalysis
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Electrophysiology
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Electrophysiology Services

Electrophysiology Services

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