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Charles River - Ion Channel Services

US

Charles River scientists have pioneered ion channel research for nearly 20 years, creating more than 120 functionally validated assays and cell lines. This industry-leading expertise, combined with our wide array of technologies for screening, profiling and safety liability studies, makes us unmatched in our ability to support our partners’ quests for the discovery of novel therapeutics.

Charles River - Ion Channel Services has not listed any services.

In vivo Electrophysiology
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Ion Channel Screening Assays
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Charles River works collaboratively with our partner’s to enable them to translate ion channel discoveries into tomorrow’s therapeutics in a timely and cost effective manner. As your scientific partner, we work to provide innovation through new assays and cell lines, flexibility with our screening services or cell lines for... Show more »

Charles River works collaboratively with our partner’s to enable them to translate ion channel discoveries into tomorrow’s therapeutics in a timely and cost effective manner. As your scientific partner, we work to provide innovation through new assays and cell lines, flexibility with our screening services or cell lines for in-house efforts and efficiency in the drug development process.
Capabilities include:
- Assay development and transfer
- Fluorescence-based screens of up to 700,000 compounds (FLIPR® / Hamamatsu FDSS)
- IonWorks® Quattro and IonWorks® Barracuda™ screens of up to 125,000 compounds per target (voltage-gated and ligand-gated ion channels)
- Conventional as well as PatchXpress® and QPatch HT® automated electrophysiology for detailed pharmacological and biophysical follow-up studies
- Ion channel selectivity profiling
- Computational chemistry for knowledge-based compound deck selection from our 850,000 diverse compound library
- Hit-to-lead and lead optimization support using fluorescence-based, automated and conventional electrophysiology
- GLP hERG and related cardiac safety liability studies

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Drug Discovery
FLIPR® / Hamamatsu FDSS
IonWorks® Quattro
IonWorks® Barracuda™
PatchXpress®
QPatch HT®
Patch Clamp Recording
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High-throughput identification of a compound’s ion channel efficacy, potency, specificity or potential for off-target effects in early drug discovery is available in fluorescence-based, automated patch clamp and conventional (manual patch) electrophysiology assays conducted against ion channels from a large collection (>120)... Show more »

High-throughput identification of a compound’s ion channel efficacy, potency, specificity or potential for off-target effects in early drug discovery is available in fluorescence-based, automated patch clamp and conventional (manual patch) electrophysiology assays conducted against ion channels from a large collection (>120) expressed in mammalian cells. Off-the-shelf or custom assays are available for screening and profiling ion channel targets, including major cardiac, CNS and PNS channels. We also offer GLP hERG and cardiac ion channel assays for IND-enabling cardiac risk evaluation.

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Drug Discovery
Drug Safety and Toxicology
Cardiac Channel Assays
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Automated or conventional (manual patch clamp) screening and concentration-response (IC50) assays in panels of cardiac ion channels provide a rapid, comprehensive evaluation of multiple ion channel effects (MICE) for greater insight into potential cardiac risk and more effective decision-making in early preclinical... Show more »

Automated or conventional (manual patch clamp) screening and concentration-response (IC50) assays in panels of cardiac ion channels provide a rapid, comprehensive evaluation of multiple ion channel effects (MICE) for greater insight into potential cardiac risk and more effective decision-making in early preclinical development.
Assay Benefits:
Complements S7B integrated cardiac risk assessment
Provides mechanistic interpretation
Predicts proarrhythmia potential
Fully validated by expert electrophysiologists
Cardiac Channel Panel includes: Cav1.2 (ICa,L), Cav3.2 (ICa,T), HCN2, HCN4, hERG (IKr), Kir2.1 (IK1), Kir3.1/3.4 (IK,Ach), Kir6.2/SUR2A (IK,ATP), Kv1.5 (IKur), Kv4.3 (ITO), KvLQT1/minK (IKs) and Nav1.5 (INa).

Charles River also offers SaVety™ assessment, which applies a logistic regression model to predict torsadogenic risk from ion channel IC50 data. As a result, the SaVety™ assessment provides more confidence than ever regarding the risk profile of compounds before going into animal and/or human studies and aligns with the recommendations of the comprehensive in vitro proarrhythmia assay (CiPA).

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Cell Line Products - Ion Channels
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The ChanTest Ion Channel Portfolio is the most comprehensive library of ion channel-expressing cell lines for research, drug discovery and preclinical development. Cell lines are validated for structure, function and pharmacology, and performance is characterized on conventional manual patch clamp or on one or more automated... Show more »

The ChanTest Ion Channel Portfolio is the most comprehensive library of ion channel-expressing cell lines for research, drug discovery and preclinical development. Cell lines are validated for structure, function and pharmacology, and performance is characterized on conventional manual patch clamp or on one or more automated electrophysiology platforms.
In addition to stable cell lines, we also offer EZCells™ which are single use, division arrested or transient transfected cells ideal for rapid, cost-effective screening and profiling. We offer detailed methodology and consultation to support and expedite assay set up.
Please send us a message or request a quote for the the latest portfolio and pricing information or to speak with one of our experts.

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cell lines
HEK293
CHO
In vitro Cardiotoxicity Screening
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Charles River offers preclinical cardiac risk assessment services together with industry-leading expertise. Offerings range from GLP hERG and action potential duration (ADP) assays, which are recommended for candidate selection and IND submissions, to a comprehensive survey of cardiac ion channels and cardiomyocyte assays. Our... Show more »

Charles River offers preclinical cardiac risk assessment services together with industry-leading expertise. Offerings range from GLP hERG and action potential duration (ADP) assays, which are recommended for candidate selection and IND submissions, to a comprehensive survey of cardiac ion channels and cardiomyocyte assays. Our services provide insight into potential cardiac risk and aid in effective decision-making in early preclinical development.

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Compound Profiling
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Identification of a compound’s target specificity and potential for off-target effects is a critical step in the drug discovery process and often includes assessments against specific target class families, critical safety targets or by therapeutic area. Charles River offers the largest collection of validated functional assays... Show more »

Identification of a compound’s target specificity and potential for off-target effects is a critical step in the drug discovery process and often includes assessments against specific target class families, critical safety targets or by therapeutic area. Charles River offers the largest collection of validated functional assays for ion channel selectivity profiling. Our ion channel portfolio includes over 120 assays, which have been organized into Channel Panels™ based on current scientific findings. We can provide functional, manual and automated ion channel screening by therapeutic area for profiling and risk assessment.

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Cell Uptake/Transporter Assays
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Epithelial Ion Transport Assays: Ussing Chamber Assay (UCA) for screening CFTR and ENaC ion channels

Epithelial Assay Benefits:
Identify activators or inhibitors channels essential for epithelial ion conductance
Determine concentration-response relationships for CFTR modulators or inhibitors
Evaluate effects on ENaC – an... Show more »

Epithelial Ion Transport Assays: Ussing Chamber Assay (UCA) for screening CFTR and ENaC ion channels

Epithelial Assay Benefits:
Identify activators or inhibitors channels essential for epithelial ion conductance
Determine concentration-response relationships for CFTR modulators or inhibitors
Evaluate effects on ENaC – an important target in hypertension and cystic fibrosis

Ussing Chamber Assays Available:
Screen against the ΔF508-CFTR (associated with Cystic Fibrosis) in CF patient-derived bronchial epithelial (CFhBE) primary cultures
Screen against wild-type CFTR in NhBE cells from normal patients
Epithelial Sodium Channel assay (ENaC) in NhBE.

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Mammalian Cell Culture
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ChanTest offers a variety of Cell & Molecular Biology Services.

ChanTest offers a variety of Cell & Molecular Biology Services.

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Stable Cell Line Generation
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Charles River has extensive experience in generating stable cell lines for high-throughput screening and compound profiling. We offer a customized service, starting with stable expression of single proteins through to stable co-expression of multiple protein subunits.

You can also access a range of validated assays, in addition... Show more »

Charles River has extensive experience in generating stable cell lines for high-throughput screening and compound profiling. We offer a customized service, starting with stable expression of single proteins through to stable co-expression of multiple protein subunits.

You can also access a range of validated assays, in addition to our assay development and validation service, with expression profile selected to suit specific assay formats.

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Lead Identification and Validation
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Cardiovascular Animal Models
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Chloride Channel Assays
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Calcium Channel Assays
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Potassium Channel Assays
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Cell Services
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Hypertension Animal Models
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Coronary Artery Disease Animal Models
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Cardiomyocyte Toxicity Assay
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Arrhythmia Animal Models
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Action Potential Duration Assay
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Drug Target Identification
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hERG Channel Inhibition Assay
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Electrophysiology Animal Models
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Custom Cell-Based Assay Development
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Cell Culture Consulting
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Assay Development Consulting
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Biochemical Assay Kits
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Drug Discovery & Development
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Pharmacology & Toxicology
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CNS/Neurology Animal Models
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In vitro Ion Channel Assays
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Cell Electrophysiology
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Cytotoxicity Assays
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Transporter & Cell Uptake Assays
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Cell-Based Assays
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Cells and Tissues
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Biology
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Process Consulting
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Animal Models and Studies
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Animal Models of Disease
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Biochemistry & Molecular Biology
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Toxicology
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Biochemical Assays
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Cell Lines
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Project and Process Management
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Drug Discovery
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Specialized Cell-Based Assays
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Cell and Tissue Culture
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Electrophysiology
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Electrophysiology Services

Electrophysiology Services

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2017-07-06 00:47:35 +0200

Net Promoter Score of 5 received for Compound Profiling.

Additional Ratings: satisfaction with deliverable: 5, satisfaction with timeliness: 5.

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