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Charles River - Cardiovascular and Metabolic Diseases

Wilmington, Massachusetts, US

Cardiovascular disease continues to be an ever-growing global health issue and remains the leading cause of death worldwide. And while it is a preventable disease, developing new methods and technologies to investigate and fight this disease remains a top priority.

Endocrine disorders and metabolic diseases are often quite complex and typically involve the regulation of various body functions. Charles River’s expertise in this therapeutic area includes the progression and analysis of compounds and agents targeting a wide range of conditions, including diabetes, obesity, bone disease, thyroid disease, metabolic disorders, cholesterol and lipid disorders, among several others.

Regardless of what stage your research is in, Charles River’s comprehensive portfolio of products and services provides you with the necessary resources to advance your work.

In the last six decades, we have seen technologies advance and... Show more »

Cardiovascular disease continues to be an ever-growing global health issue and remains the leading cause of death worldwide. And while it is a preventable disease, developing new methods and technologies to investigate and fight this disease remains a top priority.

Endocrine disorders and metabolic diseases are often quite complex and typically involve the regulation of various body functions. Charles River’s expertise in this therapeutic area includes the progression and analysis of compounds and agents targeting a wide range of conditions, including diabetes, obesity, bone disease, thyroid disease, metabolic disorders, cholesterol and lipid disorders, among several others.

Regardless of what stage your research is in, Charles River’s comprehensive portfolio of products and services provides you with the necessary resources to advance your work.

In the last six decades, we have seen technologies advance and new diseases emerge. Our one-man laboratory has evolved into a worldwide support network, allowing us to act as a steadfast partner to our sponsors, from discovery to lot release testing. By carefully cultivating our portfolio, our growth has become a continuous strategic effort in anticipating tomorrow’s drug development needs. We can’t predict what the future holds, but at Charles River we continue to kindle the spark that inspired our founding: an urgency to advance human health by supporting our clients’ research every step of the way.

Charles River is AAALAC certified.

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Charles River - Cardiovascular and Metabolic Diseases has not listed any services.

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Animal Surgery
Price on request

Cardiovascular Procedures
Charles River offers cardiovascular surgical procedures in rat models from our AAALAC-accredited production facilities. Our surgical procedures are developed in-house and subject to approval by our ethics committee. The procedures are performed by trained surgical technicians under the supervision of... Show more »

Cardiovascular Procedures
Charles River offers cardiovascular surgical procedures in rat models from our AAALAC-accredited production facilities. Our surgical procedures are developed in-house and subject to approval by our ethics committee. The procedures are performed by trained surgical technicians under the supervision of veterinary staff, with regular quality control checks.

  • Abdominal Banding – Hypertension Model
  • Atherosclerosis – Carotid Artery Embolectomy
  • Left Coronary Artery Ligation
  • Portal circulation redirected to the vena cava, bypassing the liver
  • Thoracic Aortic Banding – Transverse Aorta
  • Thoracic Aortic Banding – Ascending Aorta
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Cardiac Channel Assays
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Charles River offers preclinical cardiac risk assessment services together with industry-leading expertise. Offerings range from GLP hERG and action potential duration (ADP) assays, which are recommended for candidate selection and IND submissions, to a comprehensive survey of cardiac ion channels and cardiomyocyte assays. Our... Show more »

Charles River offers preclinical cardiac risk assessment services together with industry-leading expertise. Offerings range from GLP hERG and action potential duration (ADP) assays, which are recommended for candidate selection and IND submissions, to a comprehensive survey of cardiac ion channels and cardiomyocyte assays. Our services provide insight into potential cardiac risk and aid in effective decision-making in early preclinical development.

  • GLP Ion Channel Assays & Dose Formulation Analysis
  • ChanTest Cardiac Channel Panel & SaVety™ Assessment
  • Cardiac Action Potential Assays
  • hERG Serum Shift Assay
  • Comprehensive In Vitro Proarrhythmia Assay (CiPA)
  • Integrative Human Cardiomyocyte Assays
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Cardiac Safety Assays
Price on request

Charles River offers preclinical cardiac risk assessment services together with industry-leading expertise. Offerings range from GLP hERG and action potential duration (ADP) assays, which are recommended for candidate selection and IND submissions, to a comprehensive survey of cardiac ion channels and cardiomyocyte assays. Our... Show more »

Charles River offers preclinical cardiac risk assessment services together with industry-leading expertise. Offerings range from GLP hERG and action potential duration (ADP) assays, which are recommended for candidate selection and IND submissions, to a comprehensive survey of cardiac ion channels and cardiomyocyte assays. Our services provide insight into potential cardiac risk and aid in effective decision-making in early preclinical development.

  • GLP Ion Channel Assays & Dose Formulation Analysis
  • ChanTest Cardiac Channel Panel & SaVety™ Assessment
  • Cardiac Action Potential Assays
  • hERG Serum Shift Assay
  • Comprehensive In Vitro Proarrhythmia Assay (CiPA)
  • Integrative Human Cardiomyocyte Assays
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Animal Glucose and Insulin Tolerance Testing
Price on request

Glucose Tolerance in Rodents
The glucose tolerance test (GTT) is valuable as a primary in vivo screening assay. This test can be used to assess the ability of your compound to enhance glucose handling following acute or chronic administration in rodents. With quick study initiation and rapid turnaround times on data... Show more »

Glucose Tolerance in Rodents
The glucose tolerance test (GTT) is valuable as a primary in vivo screening assay. This test can be used to assess the ability of your compound to enhance glucose handling following acute or chronic administration in rodents. With quick study initiation and rapid turnaround times on data generation, the GTT can collect information on gut hormone responses, changes in hepatic glucose output and whole-body glucose disposal in the postprandial state. A quick go/no-go on an inexpensive platform, it is ideal for investigating multiple routes of compound and glucose administration (PO, IP, IV, SC and IM) to move your discovery program to the next step in short order.

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Rodents
Diabetes Animal Models
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Mouse Models of Diabetes
Genetically altered mice are at the center of much of the drug discovery world, and metabolic disease is no exception. The ob/ob, db/db and NOD mouse models are widely used across the field as they offer a defined and robust whole-body phenotype of diabetes, with the ob/ob and db/db specifically... Show more »

Mouse Models of Diabetes
Genetically altered mice are at the center of much of the drug discovery world, and metabolic disease is no exception. The ob/ob, db/db and NOD mouse models are widely used across the field as they offer a defined and robust whole-body phenotype of diabetes, with the ob/ob and db/db specifically adding an obese phenotype to the profile. The ob/ob and db/db strains have deficiencies in the leptin signaling pathway (lacking leptin and lacking the leptin receptor, respectively), which results in an early phenotype of hyperphagia and an ensuing profile of impaired glucose tolerance, reduced insulin sensitivity, hyperglycemia (transient in the ob/ob mouse) and hyperinsulinemia. The db/db mouse is a more aggressive model of type 2 diabetes that will progress to pancreatic failure and frank diabetes.

The NOD mouse provides an animal model that is similar to the etiology of type 1 diabetes. The severe combined immunodeficiency (SCID) mutation provides a genetic background for insulitis to develop in the pancreatic beta cell by way of leukocyte infiltration, resulting in a type 1 diabetic-specific phenotype of glycosuria and hyperglycemia.

All these mouse models are well suited for assessment of drug candidates in a chronic (2–4 week studies are common among discovery groups) setting paired with oral glucose tolerance tests and drug target-specific biomarkers, as well as advanced histological endpoints. Whether your group is looking to screen compounds to identify a lead candidate or dive deeper into mechanism-of-action studies to prepare for IND submission, these mouse models are useful tools that our scientists have relied on for years to help clients move towards the clinic.

Rat Models of Diabetes
The Zucker Fatty rat (ZFR) and the Zucker Diabetic Fatty (ZDF) rat have been used in metabolic disease research for decades. With related phenotypes of metabolic disease centered around impaired leptin signaling, these strains can be used to provide a rich dataset for investigators looking to assess the efficacy of lead candidate therapies for this multifactorial disease.

The ZDF strain initially presents as modestly hyperglycemic, but profoundly hyperinsulinemic, representing a state of considerable insulin resistance. Over time, the pancreas becomes exhausted, insulin secretion decreases (as it does in human diabetics) and plasma glucose increases in the face of insulin resistance.

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Mouse
Rat
In vivo Pharmacology Studies
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In Vivo Pharmacology

  • Atherosclerosis Models
  • Dyslipidemia and Atherosclerosis Models
  • Mouse Models of Diabetes
  • Rat Models of Diabetes
  • Streptozotocin-induced Type 1 Diabetes Model
  • Diabetic Complication Models
  • Diet-Induced Obesity Models
  • Glucose Tolerance in Rodents
  • Nonalcoholic Steatohepatitis (NASH)... Show more »

In Vivo Pharmacology

  • Atherosclerosis Models
  • Dyslipidemia and Atherosclerosis Models
  • Mouse Models of Diabetes
  • Rat Models of Diabetes
  • Streptozotocin-induced Type 1 Diabetes Model
  • Diabetic Complication Models
  • Diet-Induced Obesity Models
  • Glucose Tolerance in Rodents
  • Nonalcoholic Steatohepatitis (NASH) Models
  • Large Animal Models for Efficacy
  • Clinically Relevant Endpoints
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Obesity Animal Models
Price on request

Rodent models chronically fed high-fat diets provide a unique opportunity to assess a compound’s ability to treat obesity and related outcomes in a wide range of manners. Through the use of specific diets, appropriate positive controls and a robust suite of analytical endpoints, researchers can hone in on certain aspects of... Show more »

Rodent models chronically fed high-fat diets provide a unique opportunity to assess a compound’s ability to treat obesity and related outcomes in a wide range of manners. Through the use of specific diets, appropriate positive controls and a robust suite of analytical endpoints, researchers can hone in on certain aspects of obesity and related metabolic syndrome endpoints. Be it as simple as a change in body weight gain or as complicated as whole-body calorimetry, body composition, accurate acute food intake and a range of histological markers, our Discovery Services group can accommodate your study design.

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Mouse
Rat
Rodents
Medicinal Chemistry
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Our medicinal chemistry team is world-class, with many of our scientists bringing a wealth of experience from previous employment in the pharmaceutical and biotechnology industries. With our exposure to a wide range of therapeutic areas and collaborative working styles, we are well equipped to drive your program forward. We have... Show more »

Our medicinal chemistry team is world-class, with many of our scientists bringing a wealth of experience from previous employment in the pharmaceutical and biotechnology industries. With our exposure to a wide range of therapeutic areas and collaborative working styles, we are well equipped to drive your program forward. We have an enviable record of delivering 64 preclinical candidates to our partners, and the strength and consistency of our innovation is exemplified by inventorship on more than 290 patent applications filed by clients.

We provide integrated drug discovery services spanning hit identification, hit-to-lead and lead optimization, all complemented by synthetic, process and scale-up chemistry, computer-aided drug design, structural biology, assay development and screening, and comprehensive ADME and PK profiling.

Key Skills and Experience
Delivery of high-quality preclinical candidates
Broad therapeutic disease area expertise (e.g., respiratory, CNS, oncology, inflammation)
Significant experience working across all druggable gene family target classes
Problem-solving expertise and creativity
Interpretation of biological data
Understanding of physicochemical properties
Application of compound quality metrics
Development of structure-activity relationships
Removal of unwanted off-target activities
Optimization of ADME, PK and PK/PD profiles
Ability to execute patenting strategies

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Animal Models and Studies
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Animal Model in vivo Analyses
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Animal Models of Disease
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Biology
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Metabolic Animal Models
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Cardiovascular Toxicology
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Animal Physiology Analyses
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Drug Discovery & Development
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Drug Discovery
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