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Charles River

174 Orders Completed
Wilmington, Massachusetts, US

About Charles River

Founded: 1947 Type: Public Company Size: 5001-10,000 employees

**Special prioritization may be available for COVID-19-related research. Click 'Request More Info' button on this page to ask about offer details.**

Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Recently Charles River acquired Agilux Laboratories, Chantest, WIL, MPI, KWS Biotest, Brains On-Line, CitoxLab, CitoxLab formerly Xenometrics LLC, ATLANBIO and SOLVO Biotechnology, Inc.

Certifications & Qualifications

AAALAC BSL-1 BSL-2 FDA Inspected GCP GLP

Our Services (284)


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Influenza Virus Preparation

Price on request

Charles River’s Avian Vaccine Services offers a variety of ready-to-ship type A and B viruses, prepared as infected allantoic fluid or sucrose-gradient purified reagents. We also offer outsourcing of virus preparations using customer-supplied Biosafety Level 1 and 2 viruses to researchers in many disciplines. Viruses are grown in specific pathogen-free (SPF) embryonated chicken eggs and can be produced to meet your specific quantity. Final virus preparations can be delivered in crude (bulk fluids), concentrated, fractioned, or purified forms depending on your specific requirements.

A virus B Virus Biosafety 1 biosafety 2 specific pathogen free Influenza A/PR/8/34 N1H1 Influenza A X-31 A/Aichi/68 H3N2 Influenza A/Victoria/3/75 Influenza A/HongKong/8/68 Influenza B/Lee/40 HEPES-buffered saline sonified sucrose step gradient EID50 titer Show 17 more tags Show less

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Avian Vaccine Services

Price on request

Charles River Avian Vaccine Services in Eastern Connecticut provide an all-encompassing approach to support vaccine, diagnostic, testing, and research activities, including bulk cells, virus, bacteria, and recombinant protein production and processing, along with 9CFR testing


Mycoplasma and Pullorum Plate Antigens


To reduce the risk of disease transmission to other poultry populations, flocks must be continually monitored for Mycoplasma and Salmonella pullorum. Charles River’s Avian Vaccine Services makes it easier for you to protect your flocks and satisfy regulatory authorities by offering: USDA-licensed plate antigens, a comprehensive portfolio backed by years of dependable production, step-by-step tests that re quick, simple and easy to read, and all reagents for the plate agglutination test including control sera.

avian vaccine services USDA Virus Isolation autogenous stains commercial strains bulk bacterial antigensbaculorvirus Yeast E.Coli chicken embryo fibroblast CEFs chicken embryo kidney cells CEKs checken embryo liver cells CELCs egg yolk antibody UgY 9CRF Show 17 more tags Show less

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Soil Testing

Price on request

Regulatory studies that evaluate the effects of agrochemicals on plants and soil may also apply to biocides, industrial chemicals and veterinary pharmaceutical products when there is a risk of environmental exposure. What impact does your product have on surrounding plants and earthworms? Our soil studies can produce the data you need for a successful registration.

non target plans soil studies seedling emergence OECD 208 vegetative vigo OECD 227 OCSPP 850.4100 phytotoxocity predicted environmental concentration PEC NOEC no observed effect concentration OECD 226 soil predatory mite assay OECD 207 OECD 222 collembola folsomia candida OECD 232 carbon transformation nitrogen transformation earthworms parasitic wasp aphidius rhopalosiphi predatory mite typhlodromus pyri eisenia fetida Show 27 more tags Show less

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Pollinator Testing

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Bumblebee Acute and Contact Studies


A long-time area of focus for regulators, assessing the impact of plant protection products (PPPs) on pollinators has lately become a hot topic for the general public. In the past, acute and oral contact pollinator testing of agrochemical products (other than insecticides) was often only conducted with the honeybee (Apis mellifera). Adding to the honeybee methods adopted by the OECD in 1998, regulators in 2017 introduced equivalent acute testing methods for bumblebees (Bombus spp) to address the important issue of identifying chemicals that may adversely affect pollinators other than the honeybee

agrichemical contact exposure oral exposure OECD 246 OECD 247 GLP EFSA EPA intrinsic toxicity pollinator toxicity OECD 213 OECD 214 OECD 245 Acute Toxocity to the predatory wasp Acute Toxicity to the predatory mite bumblebee honeybee apis mellifera bombus pollinators Show 20 more tags Show less

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Avian Toxicity Testing

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Avian toxicity studies are a standard requirement for plant protection products (PPPs) where there may be a significant exposure to wild birds; typically, this will include slug-bait pellets, seed coatings, and applications to seedlings. Other PPPs, and occasionally some biocides, industrial chemicals, and veterinary or pharmaceutical products with a risk of environmental exposure to wild birds can also require assessments of avian toxicity.

acute toxicology acute toxicity reprotoxicity eggs ecotoxicology studies GLP OECD 223 OCSPP 850.210 OECD 205 OECD 206 OCSPP 850.2300 North American Bobwhite quail colinus virgianus Japanese quail coturnix japonica avian passerines canary zebra finch water fowl mallard duck Chicken turkey pigeons Show 24 more tags Show less

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High Resolution Respirometry

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Obesity Animal Models

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Rodent models chronically fed high-fat diets provide a unique opportunity to assess a compound’s ability to treat obesity and related outcomes in a wide range of manners. Through the use of specific diets, appropriate positive controls and a robust suite of analytical endpoints, researchers can hone in on certain aspects of obesity and related metabolic syndrome endpoints. Be it as simple as a change in body weight gain or as complicated as whole-body calorimetry, body composition, accurate acute food intake and a range of histological markers, our Discovery Services group can accommodate your study design.


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Reaction Phenotyping

Price on request

Characterization of a chemical series or drug candidate's ADME properties and its potential for drug interactions is best when determined early. This helps to de-risk candidate molecules and improve project productivity through more targeted chemical synthesis and progression of the right compounds In Vitro ADME Assays Many of our in vitro ADME assays have multiple formats available to suit the different stages of the drug discovery and development pipeline, providing a flexible approach to ADME screening. Choosing from a range of formats, we can select the assays that best meet your throughput, data resolution, and quality needs and achieve your project specific goals.

 

reaction phenotyping human liver microsomes recombinant enzymes CYP450-selective chemical inhibitors metabolite monitoring

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Protein Binding HPLC

Price on request

With decades of experience running in vitro ADME assays and analyzing the data, we can offer those same in vitro assays and bioanalyses more efficiently to generate ADME data earlier in the drug discovery process. This high-speed process optimization and reproducibility can generate quality ADME data for every compound in your chemical library.

https://www.criver.com/products-services/lab-sciences/dmpk/high-throughput-adme-ht-adme?region=3601

Protein Binding assay HT LC-MS Automated manual

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Microsomal Stability Assay

Price on request

With decades of experience running in vitro ADME assays and analyzing the data, we can offer those same in vitro assays and bioanalyses more efficiently to generate ADME data earlier in the drug discovery process. This high-speed process optimization and reproducibility can generate quality ADME data for every compound in your chemical library. To help streamline the early drug-discovery process, we have successfully validated and deployed automation and IT infrastructure to enable rapid delivery of in vitro ADME results. The workflow enables up to 500 compounds per week to support primary assays.

https://www.criver.com/products-services/lab-sciences/dmpk/high-throughput-adme-ht-adme?region=3601

microsomal stability assay HT LC-MS Automated manual

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In vivo Protein Binding Assays

Price on request

It is more important than ever to assess ADME properties earlier in the drug discovery process to rapidly convert hits and leads to qualified candidates. Without suitable early evaluation, valuable time and resources can be wasted resulting in drug compounds failing downstream due to unacceptable ADME profiles. With the high number of new chemical entities that need to be screened, streamlined high-throughput in vitro ADME and high-speed bioanalysis is essential

https://www.criver.com/products-services/lab-sciences/dmpk/high-throughput-adme-ht-adme?region=3601

in vivo protein binding assays

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In vitro Metabolic Stability Assays

Price on request

Many of our in vitro ADME assays have multiple formats available to suit the different stages of the drug discovery and development pipeline, providing a flexible approach to ADME screening. Choosing from a range of formats, we can select the assays that best meet your throughput, data resolution, and quality needs and achieve your project specific goals.

https://www.criver.com/products-services/lab-sciences/dmpk/in-vitro-adme-screening?region=3601

liver microsomes S9 non-hepatic microsomes range of formats % remaining intrinsic clearance metabolite monitoring options metabolic stability hepatocytes pooled cryopreserved hepatocytes fresh primary hepatocytes Human Rodents non-rodent Show 13 more tags Show less

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In vitro Bioavailability/Bioequivalence Studies

Price on request

Charles River performs ADME, pharmacokinetic, bioequivalence, residue depletion and target animal safety studies in compliance with EU, VICH, US and Japanese regulations. We have experience in formulating doses ranging from aquatic-based solutions to oil-based suspensions. Our modern facilities offers enough housing capacity for over 200 lactating cattle. Charles River also offers an integrated analytical service for clinical pathology, residue analysis, and metabolite profiling and identification.

https://www.criver.com/products-services/safety-assessment/toxicology-services/target-species/tolerance-safety-metabolism-studies?region=3601

topical Dermal Oral Dietary capsules oral gavage intravenous Intraperitoneal intramuscular subcutaneous Bioequivalence Studies bioavailability cattle Sheep Goat Pig poultry marine fish freshwater fish Show 19 more tags Show less

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HT ADME

Price on request

With decades of experience running in vitro ADME assays and analyzing the data, we can offer those same in vitro assays and bioanalyses more efficiently to generate ADME data earlier in the drug discovery process. This high-speed process optimization and reproducibility can generate quality ADME data for every compound in your chemical library.

https://www.criver.com/products-services/lab-sciences/dmpk/high-throughput-adme-ht-adme?region=3601

microsomal stability HT-ADME Permeability Caco-2 MDCK-MDR1 protein binding RBC partitioning blood plasma ration high speed data acquisition Show 10 more tags Show less

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CYP Inhibition Assay

Price on request

Characterization of a chemical series or drug candidate's ADME properties and its potential for drug interactions is best when determined early. This helps to de-risk candidate molecules and improve project productivity through more targeted chemical synthesis and progression of the right compounds In Vitro ADME Assays Many of our in vitro ADME assays have multiple formats available to suit the different stages of the drug discovery and development pipeline, providing a flexible approach to ADME screening. Choosing from a range of formats, we can select the assays that best meet your throughput, data resolution, and quality needs and achieve your project specific goals.

https://www.criver.com/products-services/lab-sciences/dmpk/in-vitro-adme-screening?region=3601

Human Liver Enzymes recombinant enzymes 1A2 2A6 2B6 2B8 2C9 2D6 3A4 2E1 reversible metabolic time dependent IC50 shift initial screening assessment definitive determination Kinact/Ki determination mic covalent binding LC-MS/MS analysis drug-drug interaction experiment Show 21 more tags Show less

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CYP Induction Assay

Price on request

Characterization of a chemical series or drug candidate's ADME properties and its potential for drug interactions is best when determined early. This helps to de-risk candidate molecules and improve project productivity through more targeted chemical synthesis and progression of the right compounds In Vitro ADME Assays Many of our in vitro ADME assays have multiple formats available to suit the different stages of the drug discovery and development pipeline, providing a flexible approach to ADME screening. Choosing from a range of formats, we can select the assays that best meet your throughput, data resolution, and quality needs and achieve your project specific goals.

https://www.criver.com/products-services/lab-sciences/dmpk/in-vitro-adme-screening?region=3601

Multiple human CYP450 enzymes 1A2 2B6 2C9 2C19 3A4 enzyme catalytic activity mRNA levels human cryopreserved hepatocytes catalytic activities LC-MS/MS analysis Show 11 more tags Show less

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Clinical Supply Chain Management and Logistics

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Clinical Research

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The members of our scientific staff have extensive experience in transferring and developing methods efficiently and expeditiously. In many cases, they get involved at the start of the nonclinical program and stay on through testing, collaborating as part of the clinical study team. This approach results in robust and reliable methods for clinical sample analysis, which, when combined with data management and data transfer expertise, enables us to produce high-quality, on-time clinical data to support drug approval, and to help you effectively make sound go/no-go decisions.

https://www.criver.com/products-services/lab-sciences/clinical-laboratory-support?region=3601

clinical sample analysis Clinical Trials

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Clinical Hematology

Price on request

Our complete range of clinical pathology laboratory services supports animal models, discovery, preclinical studies and/or clinical trials with extensive knowledge of animal and human hematology, coagulation, clinical biochemistry and urinalysis. Specialized pathology laboratory services are available for assays/biomarkers for specific research requirements or drug safety studies. Our staff, including pathologists certified by the American College of Veterinary Pathologists and the European College of Veterinary Clinical Pathology, has expertise across the spectrum of major therapeutic areas and routinely assesses and interprets data from regulatory and investigative/research studies. With six state-of-the-art clinical pathology labs, we can support all stages of the human and veterinary drug development process and conduct research in accordance with the current GLP and GCP standards.

https://www.criver.com/research-phase/clinical-development

laboratory support services Assays clinical phase drug development human hematology coagulation clinical biochemistry Urinalysis Biomarkers GLP GCP Show 11 more tags Show less

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Clinical Drug Management

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Clinical Ancillary and Sample Services

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Our complete range of clinical pathology laboratory services supports animal models, discovery, preclinical studies and/or clinical trials with extensive knowledge of animal and human hematology, coagulation, clinical biochemistry and urinalysis. Specialized pathology laboratory services are available for assays/biomarkers for specific research requirements or drug safety studies. Our staff, including pathologists certified by the American College of Veterinary Pathologists and the European College of Veterinary Clinical Pathology, has expertise across the spectrum of major therapeutic areas and routinely assesses and interprets data from regulatory and investigative/research studies. With six state-of-the-art clinical pathology labs, we can support all stages of the human and veterinary drug development process and conduct research in accordance with the current GLP and GCP standards.

https://www.criver.com/research-phase/clinical-development

laboratory support services Assays clinical phase drug development human hematology coagulation clinical biochemistry Urinalysis Biomarkers GLP GCP Show 11 more tags Show less

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Cell Permeability Assay

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Cell Death Assays

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Blood Partitioning

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Blood Banking and Transfusion Medicine

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Animal Model in vivo Analyses

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Molecular Pathology

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In drug discovery and preclinical safety assessment, morphological changes in cells are often accompanied by alterations in DNA, RNA, or protein molecules. A further understanding of these molecular changes can help to understand target distribution and pharmacology as well as the elucidation of mechanism(s) of toxicity and/or efficacy. 

Our team combines a strong history in molecular biology and histopathology to relate gene expression to tissue histomorphology in both normal tissues and therapeutic models of disease, providing you with valuable functional genomics information. This results in the best possible interpretation and troubleshooting of molecular-based tools, such as chromogenic in situ hybridization (CISH), fluorescent in situ hybridization (FISH), and real-time quantitative polymerase chain reaction (qPCR) as applied to toxicological pathology issues.

Our services include:

Procurement, embedding and sectioning of study tissues
Synthesis of DNA and RNA probes (isotopic and non-isotopic)
Optimized hybridization
Histological evaluation by board-certified pathologists
Reporting with representative color photomicrographs

qPCR Molecular Pathology

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Stereology

Price on request

We are ready to help you with a wide range of measurements, including cell counts, cell or tissue volumes, and length and surface area determination for all tissue sizes from any species.

Stereology Capabilities

Analysis directly on scanned slides using Visiopharm®, GLP-validated software
Plastic and frozen sectioning capability
Systematic uniform random sampling and analysis of tissues of any size from all species
Counting objects using physical or optical dissectors
Estimation of volume for tissues, tissue compartments, or cells
Estimation of surface area and length


https://criver.widen.net/s/rpzibdsxzw

stereology visiopharm Pathology services IHC Staining Whole Tissue single tissue single cell type cell organelles ultrastructural Electron microscopy automated microtomes Show 11 more tags Show less

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Image Analysis

Price on request

Our state-of-the-art facilities house image analysis systems that perform all of the standard and user-defined static and dynamic measurements for bone. The dynamic measurements can be completed with or without fluorochrome labels. For stereological analysis, we offer a full range of services for discovery and GLP-compliant studies from conception and design through to data analysis.

Our facilities provide a wide range of image analysis techniques for other tissues. Whole-slide scanning with online slide viewing capabilities is available, as are whole-slide morphometric analysis and stereological analysis on slides scanned using GLP-validated Visiopharm® software.

Each system is operated by highly trained technical staff supervised by pathologists board certified by the American College of Veterinary Pathologists, Royal College of Pathologists and European College of Veterinary Clinical Pathology.                                                                     Image Analysis Expertise

Small intestine villus length, crypt depth, and villus/crypt ratios
Image analysis of immunohistochemically or histochemically stained slides, including number of labeled cells, area of positive staining, and tissue composition analysis
Determination of cell proliferation index (Ki67, BrdU, PCNA) or apoptotic index (caspase-3, TUNEL)
Diameter of stented blood vessels
Extent of infarcts in the heart
Capillary angiogenesis in cutaneous wound defects, including microvascular density quantification
Goblet cell number in the respiratory tract
Adult and juvenile rat cerebellar and cerebral measurements
Axon and nerve fiber changes in peripheral nerves
Skeletal muscle characterization
Pulmonary fibrosis assessment
Thyroid gland epithelial height and colloid area for endocrine disruptor assessment

fluorochrome labels stereological analysis whole-slide scanning morphometric analysis Visiopharm software Ki67 BrdU PCNA caspase-3 TUNEL Show 10 more tags Show less

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Tissue Cross Reactivity Studies

Price on request

Charles River supports monoclonal antibody research with our extensive expertise in the initial stages of safety assessment for therapeutic large molecules targeted for use in humans. We’ve worked with numerous large molecules and nearly every type of therapeutic antibody, including unconjugated antibodies, antibodies conjugated to a variety of substances, and Fab fragments. We hold a full range of tissues from various animal species. As outlined in FDA guidelines, we store an array of human tissues from multiple donors sourced from ethically approved tissue banks with full patient consent. Our commitment to new and improved pathology techniques has led to the generation of highly specific mechanistic drug action/tissue response data critical to worldwide regulatory filings.

For immunohistochemistry-based tissue cross-reactivity (TCR) studies, we provide efficiency of scale in full compliance with Good Laboratory Practice (GLP) regulations and interpretation of findings, and can represent you in presenting to the applicable regulatory agencies.https://www.criver.com/products-services/safety-assessment/pathology-services/specialty-endpoints/tissue-cross-reactivity?region=3601

tissue cross-reactivity in vitro cross-reactivity Immunophenotyping monoclonal preclinical safety immunohistochemistry

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Biochemical Assays

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Chemistry and Materials

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Cellular Health & Metabolism Assays

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Non-Specific Binding Assay

Price on request

Binding of the test article to the plastic ware used in your study will be tested using either liquid scintillation or LC/MS. Binding will be assayed at multiple TA concentrations.

SOLVO

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Cell Uptake/Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, ASBT, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HPT1, NTCP, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, SGLT1, SGLT2, URAT1, rat Ntcp, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Ntcp, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII **FDA/EMA-compliant transporter assays and reports** inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, OATP1B1, OATP1B3, OCT1, OCT2, OAT1, OAT3, MATE1, MATE2K, HEK293, CHO, MDCKII, Sf9

SOLVO drug discovery Toxicology cellular uptake assays inhibition assessment substrate assessment membrane protein transporter Human Mouse Non-human primates (NHP) Rat Rodents Show 13 more tags Show less

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Cell-Based ATP Binding Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, MRP1, MRP2, MRP3, MRP4, MRP5, MATE1, MATE2K, rat Mdr1a, rat Bcrp, mouse Mdr1a, mouse Bcrp1, rat BSEP, cynomolgous monkey Bcrp, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9

drug discovery Toxicology bi-directional efflux assays Cell-based assays inhibition assessment substrate assessment vesicle assays membrane protein transporter SOLVO Human Mouse Non-human primates (NHP) rats Rat Rodents Show 16 more tags Show less

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Biochemical Assay Kits

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Ready-to-use efflux or uptake transporter kits Membrane preparations Monoclonal antibodies

SOLVO drug discovery Toxicology bi-directional efflux assays cellular uptake assays inhibition assessment substrate assessment vesicle assays membrane protein transporter Human Mouse Non-human primates (NHP) Rat Rodents Show 15 more tags Show less

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Protein Quantification

Price on request

SOLVO Biotechnology a Charles River Company is offering Quantification of Transporter Proteins in tissue, cell lines or membrane vesicles by LC/MS-MS. Transporter quantification by LC/MS-MS allows the quantitative determination of the expression of a particular transporter in the sample of interest. This data will allow more accurate determination of kinetic parameters (e.g. KM, Vmax) and can be used in „in vitro in vivo extrapolations” (IVIVE). SOLVO offers transporter quantification services as a stand alone service or as an add-on to other in vitro transporter experiments. Should you be interested in the quantification of a particular transporter • in the assay system used in our in vitro transporter services, • in the membrane vesicles you purchase from us, • or in your in-house samples (Microsomes or plasma membrane fraction, cell lines or cell culture, organs or tissue of interest (liver, kidney, intestine, brain) *List of Transporters* LC/MS-MS Quantification of Transporter Proteins is available for the following set of transporters through our collaborator Bertin Pharma (France). human BCRP, BSEP, MCT2, MDR1/P-gp, MRP2, NTCP, OCT1, OCT2, OAT1, OAT2, OAT3, OATP1B1, OATP1B3, OATP2B1, PEPT1 & ATPase Na+/K+ mouse Abcb4, Abcc4, Bcrp, Bsep, Mdr1a, Mdr1b, Mrp2, Mrp3, Ntcp, Oatp1a1, Oatp1a4, Abcg8 = sterolin 2, Abcg5 = sterolin 1 & ATPase Na+/K+ Learn more about the LC/MS-MS Quantification of Transporter Protein technology. *Benefits* LC/MS-MS Quantification of Transporter Protein Service has many advantages: • Available for a wide range of proteins, • Specific for the selected protein, • High sensitivity (fmol/ug protein), • Measurement of activity up to 37 proteins in the same analysis, • Assays validated according to the state-of-the-art.

SOLVO drug discovery Toxicology LCMS membrane protein transporter Human Mouse Rodents Show 9 more tags Show less

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Solubility and Dissolution Testing

Price on request

The solubility of the test article in each transporter assay buffer applied in your study will be examined by microscopy.

Physiochemical Tests Solubility Studies

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Glucose Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, SGLT1, SGLT2, HEK293

drug discovery Toxicology cellular uptake assays membrane protein transporter Human Show 6 more tags Show less

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Peptide Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, HPT1, PEPT1, PEPT2, CHO, MDCKII

drug discovery Toxicology cellular uptake assays membrane protein transporter SOLVO Human Show 7 more tags Show less

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Nucleoside Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HEK293, MDCKII

drug discovery Toxicology cell uptake assays membrane protein transporter Human Show 6 more tags Show less

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Organic Ion Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII

SOLVO drug discovery Toxicology cellular uptake assays membrane protein transporter Human Mouse Non-human primates (NHP) Rat Rodents Show 11 more tags Show less

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Multidrug Resistance (MDR) Testing

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, rat Mdr1a, mouse Mdr1a, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9, rat BBB / blood brain barrier penetration

drug discovery Toxicology bi-directional efflux assays Endothelial uptake and BBB transport assays inhibition assessment substrate assessment vesicle assays Brain primary cells SOLVO Human Mouse Non-human primates (NHP) Rat Rodents Show 15 more tags Show less

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Drug Transporter Assays

Price on request

Uptake/SLC/Solute carrier transporter assays: inhibition, IC50, Ki, substrate, Km, Vmax, ASBT, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HPT1, NTCP, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, SGLT1, SGLT2, URAT1, rat Ntcp, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Ntcp, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII Efflux/ABC/ATP-binding cassette transporter assays: inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, MRP1, MRP2, MRP3, MRP4, MRP5, MATE1, MATE2K, rat Mdr1a, rat Bcrp, mouse Mdr1a, mouse Bcrp1, rat BSEP, cynomolgous monkey Bcrp, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9

SOLVO drug discovery Toxicology bi-directional efflux assays calorimetric Endothelial uptake and BBB transport assays LCMS Radioassay uptake vesicle assays membrane protein transporter Human Mouse Non-human primates (NHP) Rat Rodents Show 17 more tags Show less

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Membrane Preparations for Transporter Assays

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QSAR Studies

Quantitative Structure-Activity Relationship Studies
Price on request

With today’s computer technology, we can offer predictive modelling for your drug candidates. This cost-effective technique is principally applicable for : Drug candidate assessment : Based on the chemical structure and molecular substructure of tested compounds, each molecule is modelled by the computer-driven QSAR system. - QSAR analysis helps to understand the potential molecular dynamics between compounds under development and other chemical structures. Results are interpreted against available preclinical data and intended clinical application. To make sure you get the best and most competitive solution, you will receive all necessary information in a format that is user-friendly and relevant to regulatory authority submission.

Cobas analyzers (4000, 6000, or 8000) VENTANA Discovery XT

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Vivarium Service

Price on request

CRADL™ - Turnkey Vivarium Service

The Charles River Accelerator and Development Lab (CRADL™) offers turnkey vivarium rental space for emerging and well-established biotech companies. We combine modern vivarium space with industry-leading expertise in animal husbandry and vivarium management to ensure you achieve your research milestones on time and on budget.

CRADL vivarium vivarium space vivarium rental vivarium suite rental vivarium in vivo support in vivo support services staffing support Show 9 more tags Show less

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In silico Cardiac Safety Assessment

Price on request

With today’s computer technology, we can offer predictive modelling for your drug candidates. This cost-effective technique is principally applicable for : Impurity assessment : Pharmaceuticals generally contain low levels of impurities, the genotoxicity of which can be evaluated by *in silico* modelling. - A wide range of genotoxicity endpoints can be assessed in parallel. Results are interpreted against available preclinical data and intended clinical application. To make sure you get the best and most competitive solution, you will receive all necessary information in a format that is user-friendly and relevant to regulatory authority submission.

Cobas analyzers (4000, 6000, or 8000) VENTANA Discovery XT

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Archive Management

Price on request

Our archiving services and facilities provide short- and long-term GxP-compliant data and sample archiving services in support of preclinical and clinical studies for government and private sector businesses, organizations and consortia.

By archiving with Charles River you get:
Expedited retrieval of records for agency/client inspections
Site visits and on-site access to Study Directors
Full service record keeping from inception to destruction

Facilities & Services
Over 500,000 cubic feet of controlled, dedicated space
Several layers of security to limit access as well as safeguard essential study materials under GLP conditions
Storage conditions include room temperature, refrigerated, frozen at -20°C or -70°C and cryostorage at -196°C
Periodic inventory and materials inspections
Hard copy transfer to CD
Microform printing
Pick-up and delivery services for both short-term and long-term storage

 

https://www.criver.com/products-services/operations-and-staffing-support/archiving-services?region=3601

Archiving services Archive GLP paper data storage record storage report storage electronic media storage microform storage pathology sample storage slide storage test article storage medical record storage vaccine storage biological sample storage radioactive material storage plasma storage microform printing short term storage long term storage Show 19 more tags Show less

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Veterinary Molecular Diagnostics

Price on request

Molecular imaging is an established technology combining both functional and structural imaging to allow for evaluation of specific in vivo processes in relation to spatial orientation within the model of interest. The unique characteristics of molecular imaging provide investigators with an early stage solution to evaluate critical principles of new entity development: exposure at the target site, binding to the target of interest, and expression of the desired pharmacology. Incorporation of molecular imaging solutions into new entity development programs allows you to rapidly assess results and make essential decisions earlier in the drug development process. Imaging can be used in many development efforts, such as those targeting insight into disease processes, validity of new therapeutic targets, target/non-target organ interaction, mechanism of action, biodistribution and others.

qPCR real-time PCR in situ hybridization (ISH) microPET positron Emission tomography MicroSPECT single photon emission computed tomography quantitative whole-body antoradiography two dimensional three dimensional kinetic modeling SPECT PET MRI CT DEXA Fluoroscopy x-ray laser doppler ultrasonography in vivo imaging ex vivo biodistribution histology Show 23 more tags Show less

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Syngeneic (Allograft) Tumor Models

Price on request

The use of syngeneic mouse models as one approach in a preclinical study allows testing of immunotherapies in an intact immune system. Our portfolio of models includes characterization of known immune checkpoint inhibitors, genetic (WES) and immunologic profiling.

BD fatscantoll/LSRII IVIS Atture NXT IVIS Spectrum CT Bruker in vivo MS FX Pro immunology Acute Myloid Leukemia (AML) acute lymphocytic leukemia Chronic myelegenous Leukemia chronic lymphocytic leukemia hodgkin lymphoma non-hodgkin lyphoma colorectal cancer Oncology immunooncology prostate cancer breast cancer lung cancer ovarian cancer gastric cancer melanoma skin cancer Flow cytometry in vitro in vivo tumor cells tumor biology drug discovery genomics drug safety and toxicology syngeneic mouse models Mouse Humanized Mouse Show 33 more tags Show less

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Sterility Testing

Price on request

Sterility testing is designed to demonstrate the presence or absence of extraneous viable contaminating microorganisms in biological parenterals designed for human use.Charles River provides sterility testing that is compliant with both USP and EP regulations. Sterility testing is conducted on bulk or final products by direct inoculation or membrane filtration methods and can be performed in an isolator or cleanroom environment. A bacteriostasis/fungistasis test is also performed to assess whether or not the test article inhibits the growth of microorganisms. The performance of bacteriostasis and fungistasis testing is necessary in order to validate the sterility result and confirm that there are no antimicrobial properties within the test article that would inhibit the detection of microbial organisms during the sterility assay.

GMP Membrane Filtration direct innoculation Sterility Validation Bioburden Test Method Validation Bioburden Testing Show 6 more tags Show less

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Protein Characterization

Price on request

To help clients generate the data needed to gain the level of product characterization required for regulatory submission, Charles River offers protein analysis as part of an integrated package of expert analytical services. We have extensive experience in developing and establishing protein characterization methods, including product-specific in vitro potency assays. These characterization services are also a part of our stability and product release support services, where we offer key identity, purity and potency assays

Immunoassays Potency Assay western blot SDS-PAGE Biocore GMP N-terminal Sequencing DLS (Dynamic Light Scattering) Amino Acid Analysis Circular Dichroism Peptide Map IEF chromotography testing Osmolarity Residuals Biosimilarity analysis Analytical Ultracentrifugation Amino acid sequencing Spectrophotometric assays Biophysical Characterization product-related impurities intact molecule weight disulfide bridge mapping Differential Scanning Calorimetry (DSC) capillary zone electrophoresis Show 25 more tags Show less

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Electroencephalogram (EEG) Models

Price on request

The telemetry electroencephalograph (EEG) model is a benefit to preclinical or research studies by recording unbiased physiological responses that transmit wirelessly, providing better data n the body's reactions to drugs/compounds. The body of the transmitter is placed subcutaneously in the dorsal flank. A set of EEG leads are tunneled subcutaneously to the cranium, then placed into pre-drilled holes and secured with bone graft powder and liquid. Thebody of the transmitter can be slipped into the abdominal cavity per request. Charles River IACUC governs the entire surgical process

CNS/Neurology Rat rats Mice Mouse Guinea pig Show 6 more tags Show less

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Disinfectant Testing

Price on request

Offered in compliance with the Biocidal Products Directive (BPD)-98/8/EC to verify the efficacy of disinfectant programs for cleanrooms or other controlled areas.

Disinfectant Efficacy Determination

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Bone Safety Studies

Price on request

Charles River offers a fully integrated service with a multidisciplinary team of scientists, pathologists, veterinarians, and surgeons to assess the safety and efficacy of drugs and devices that have an intentional or unintentional effect on the musculoskeletal system in both short- and long-term studies. This approach allows for the comprehensive evaluation of bone, muscle, and cartilage drug efficacy and safety as well as orthobiologic applications

Mouse Rat osteoporosis Osteoarthritis (OA) rhumatoid arthritis bone toxicology juvenile bone toxicology gonadectomy induced bone loss OVX ORX TPTx Thyroparathyroidectomy schenk anti-catabolic anti-catabolic agent screen schenk bone defect spinal fusion fracture healing bone formation markers osteocalcin bone-specific alkaline phosphatase PINP bone resorption markers C-Telopeptide CTcl N-telopeptidem Deosypyrindoline TRAP5b Advanced imaging DXA pQCT micro-CT XtremeCT II HR-pQCT digital radiography biochemical strength testing histomorphometry Show 37 more tags Show less

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Animal Movement Analysis

Price on request

Fine motor kinematic analysis is an automated and high-precision system to quantitatively measure changes in gait and balance that are clinical endpoints in movement disorders. This system can be used to study walking, climbing and wading movements in animal models of neurological diseases.

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/neuroscience-translational-tools/fine-motor-kinematic-analysis?region=3601

CNS/Neurology Animal Movement Analysis Mouse rotarod Kinetic analysis MotoRater Show 6 more tags Show less

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Animal Glucose and Insulin Tolerance Testing

Price on request

The glucose tolerance test (GTT) can be used to assess the ability of your compound to enhance glucose handling following acute or chronic administration in rodents. With quick study initiation and rapid turnaround times on data generation, the GTT can collect information on gut hormone responses, changes in hepatic glucose output and whole-body glucose disposal in the postprandial state. A quick go/no-go on an inexpensive platform, it is ideal for investigating multiple routes of compound and glucose administration (PO, IP, IV, SC and IM) to move your discovery program to the next step in short order.

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/cardiovascularmetabolic-disease-pharmacology-models/glucose-tolerance-rodents?region=3601

in vivo Glucose Tolerance Test drug discovery Rodents Streptozotocin (STZ) Target pancreatic beta cells Mice Mouse Rat rats Minipig Show 11 more tags Show less

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Animal Antiserum Production

Price on request

Charles River offers monoclonal and polyconal antisera production in multiple species, such as mice, rats, rabbits, guinea pigs, chickens, sheep, and goats.  cGMP and non-cGMP production is available. Options include production of antisera by Charles River or preparation of animals for production and shipment to client.

Production of monoclonal antibodies in performed by production of hybridomas. Charles River also offers polyclonal antibody production services including antigen synthesis, purification, and analysis.

https://p.widencdn.net/v0tjz1/BI-PS-antibody-production

Antibody Production GMP Rabbit Goat Chicken antisera production immunization Monoclonal Antibody Polyclonal Antibody Production polyclonal antibody Show 10 more tags Show less

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Adventitious Agent Testing

Price on request

Charles River offers a fully integrated service with a multidisciplinary team of scientists, pathologists, veterinarians, and surgeons to assess the safety and efficacy of drugs and devices that have an intentional or unintentional effect on the musculoskeletal system in both short- and long-term studies. This approach allows for the comprehensive evaluation of bone, muscle, and cartilage drug efficacy and safety as well as orthobiologic applications.

 

https://www.criver.com/sites/default/files/resources/InVivoBiosafetyTestingDatasheet.pdf

PCR qPCR Cell-based assays GMP In vivo assays in vitro assay murine antibody production bovine antibody production MAP HAP Adventitous Agent Testing PAA BAA XC plaque S+L co-cultivation retovirus detection assay porcine adventitious agents bovine adventitious agents Guinea pig pigs Minipig swine Mice Mouse eggs Show 26 more tags Show less

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In vivo Drug Efficacy Testing

Price on request

In vivo pharmacology is the study of the biological effects of a drug in a complex living organism and is used to observe the complex physiological effects of a drug. Charles River offers early research and proof-of-principle pharmacology studies in relevant animal models of human diseases to assist your efficacy evaluations. Our scientific team has extensive experience helping clients with the selection of appropriate models and assays, as well as collaborating to design new models to meet the specific needs of a particular compound or discovery program. Capabilities include: Animal models of invection, Cardiovascular/Metabolic Disease pharmacology models, Inflammation and autoimmune disease models, musculoskeletal disease pharmacology models, neuroscience pharmacology models, ocular disease pharmacology models, oncology pharmacology models, rare disease pharmacology models, respiratory disease pharmacology models.

 

https://www.criver.com/products-services/discovery-services/vivo-pharmacology?region=3601

In vivo pharmacology disease models in vivo pharmacology models

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Oncology Animal Models

Price on request

Charles River’s experience with oncology drug discovery spans all phases, from target identification to IND studies. Utilizing the most effective combination of tools available to identify promising compounds, we work with our partners to design studies by selecting from amongst a broad range of well-characterized xenograft, patient-derived xenograft (PDX), and syngeneic tumor models. Combining those models with appropriate biomarkers, including flow cytometry and imaging, allows our partners to choose the most appropriate study design and screening method to identify promising compounds and optimize lead candidates. Please find the following resource. Discovery: Oncology

PDX Patient-derived xenograft cell-line derived xenograft CDX human tumor xenograft

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Toxicology

Price on request

Charles River designs and performs in vitro and in vivo safety programs to best characterize potential human drug toxicity and move your product from discovery to market in a rapid and efficient manner. Please find the following resource. Safety:Toxicology Services

Toxicology preclinical toxicology studies Toxicology studies Toxicology testing toxicity testing Tox Toxicology Services Non-GLP Acute Toxicology Guinea pig Mouse Rat Rabbit Minipig Non-human primates (NHP) Dog Dermal Toxicity studies in vitro cardiotoxicity drug safety drug safety and toxicology in vitro in vivo acute Toxicity studies infusion toxicology inhalation Toxicology respiratory diseases in vivo maximum tolerated dose MTD Dose range finder DRF acute subchronic chronic DART testing Fertility Embryo-fetal development Pre-Post Natal development Sperm Analysis FOB WinNonlin® feline ocular toxicology Show 41 more tags Show less

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Cancer Cell Line Panels

Price on request
Request a quote for more information about this service.

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Microbial Identification and Strain Typing

Price on request

Axcess® System for Microbial Identification

The Axcess® system pairs the precision of the MALDI Biotyper instrument with the industry-leading Accugenix® proprietary microbial library through a secure online network. Based on MALDI-TOF mass spectrometry, the MALDI Biotyper is a paradigm shift which has become widely accepted across industry segments as the next generation of microbial identification. While conventional identification methods are time-consuming and often require ancillary tests, the Axcess® system allows for nearly instantaneous identification of isolated colonies from a plate.

AccuBLAST®
Analysis & Interpretation of 16S Raw Data Sequence Files (*.ab1)

Exclusively designed for customers who have purchased the MicroSEQ® identification system, this service is provided for users who are not confident in the identifications made by the automated system. The AccuBLAST® service employs our own unrivaled sequence libraries and expert data analysis to generate meaningful reports, allowing us to deliver IDs more quickly and accurately.

AccuPRO-ID®
Proteotypic Identification of Bacteria and Yeast (MALDI-TOF Backed by 16S/ITS Sequencing)

AccuPRO-ID®, MALDI-TOF identification, is supported by AccuGENX-ID® rDNA sequencing. We have been offering this technology under cGMP for industrial applications since 2010, longer than any other contract laboratory in the industry. Our MALDI-TOF library is specific to industrial manufacturing environments; this maintains higher confidence in species-level identifications and yields accurate and effective ability to track and trend data that is pertinent to your environmental monitoring program.

AccuGENX-ID®
Genotypic Identification of Bacteria and Fungi (rDNA Sequencing)

The most accurate and reproducible method for identifying unknown microorganisms, AccuGENX-ID® utilizes comparative DNA sequencing of the 16S rRNA gene in bacteria and the ITS2 rRNA region in fungi through our BacSeq and FunITS identifications. This sequencing method is independent of the health or growth conditions of the isolate; samples can be viable or nonviable cultures, or simply genomic DNA from your microbe. For each sample submitted for identification, the resulting DNA sequence is compared against our validated libraries for bacteria and fungi. Our sequencing services are the most accurate method for identification of unknown microorganisms. This is important for contamination investigations.

AccuGENX-ST®
Sequence-Based Strain Typing - (M/SLST)

In production facilities, it is often necessary to determine the source of a contamination, the root cause, by
differentiating organisms to the subspecies (strain level). Strain typing allows you to ascertain how closely related an organism is to the same species observed in past events, or to verify if a certain production strain is the correct one. Our sequence-based strain typing method targets genes specific to the characterization of the species.

QC Custom Solutions

Identification and characterization, preservation and secure storage, and custom manufacturing in ready-to-use kit formats for your compendial testing.

PCR ITS2 rDNA sequencing MALDI-TOF Mass Spec MLST SLST Multi-Locus Sequence Typing Bacteria Yeast Fungi Bacteria Yeast isolate storage isolate preservation Yeast mold filamentous fungi mycoplsama 165 rDNA Sequencing Show 18 more tags Show less

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Bioanalytical Analysis LC/MS/MS

Price on request

Charles River provides small and large molecule bioanalysis by chromatography and mass spectrometry for pharmaceutical, industrial, and chemical programs.

We have validated the quantitation of NCE drugs, metabolites and biomarkers from a wide variety of biological matrices. Rapid sample analysis delivers reliable results on time for any project, ranging from nonclinical studies through Phase I-IV clinical programs. In addition to traditional pharmaceutical bioanalysis, our laboratories are equipped to handle industrial and agrochemical applications.

The scientists in our 7 laboratories located throughout North America, the United Kingdom and mainland Europe analyze over 250,000 samples per year. With decades of experience, our scientists collaborate directly with you, providing solutions tailored to your molecule and program.https://www.criver.com/products-services/lab-sciences/bioanalysis/glp-chromatographic-and-mass-spectrometric-bioanalysis?region=3601

Sciex API 6500, 5500, 5000, 4000 MS liquid chromatography-tandem mass spectrometry liquid chromatography-high resolution mass spectrometry LC-MS,HRMS

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Radiotracers and Radiopharmaceuticals

Price on request

Molecular imaging is an established technology combining both functional and structural imaging to allow for evaluation of specific in vivo processes in relation to spatial orientation within the model of interest. The unique characteristics of molecular imaging provide investigators with an early stage solution to evaluate critical principles of new entity development: exposure at the target site, binding to the target of interest, and expression of the desired pharmacology. Incorporation of molecular imaging solutions into new entity development programs allows you to rapidly assess results and make essential decisions earlier in the drug development process. Imaging can be used in many development efforts, such as those targeting insight into disease processes, validity of new therapeutic targets, target/non-target organ interaction, mechanism of action, biodistribution and others.

microPET MicroSPECT computed tomography large animal small animal quantitative whole-body antoradiography QWBA GLP Two-Dimensional Three-Dimensional Radiolabeling cell therapies antibodies peptides oligonucleotides Nanoparticles small molecule SPECT Large molecule PET tracer organic radiochemical MRI CT DEXA Fluoroscopy x-ray laser doppler ultrasonography in vivo imaging ex vivo biodistribution animal model development histology radioisotopes Show 34 more tags Show less

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High Throughput Screening (HTS)

Price on request

Get protection from the unpredictability of science and make the most of your high-throughput screening investment by working with a flexible, collaborative partner who lets you know the minute the unexpected occurs and makes the necessary adjustments to optimize your program and keep you on track.

Please find the following resource. Discovery- Hit finding eguide 

hit finding Hit Identification Phenotypic screening Hts assay services hit discovery assay validation idbs titian dotmatics hts assay htms high throughput mass spectrometry Show 13 more tags Show less

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Laboratory Animal Genetic Quality Control

Price on request

Genotyping that is conducted routinely can help keep colony sizes manageable, aid in selecting animals for study cohorts, and set aside animals for future breeding. Our high-throughput, multi-platform genotyping laboratory delivers results from sample receipt to facilitating more efficient lab animal colony management.
Assay development and genetic quality control (GQC) work in conjunction to help identify contamination early and keep your lines in check. Assays are custom designed based on the information you provide to ensure specificity of allele detection and accurate genotype determinations. Each protocol is reviewed by our expert team of scientists. Our scientists will work with you to help resolve any issues and deploy new breeding strategies to overcome any challenges that may arise.
Genetic background characterization alerts you to genetic variation, which may eventually arise even in closed breeding programs, as well as via the introduction of contaminating genetic backgrounds through misbreeding. Charles River has microsatellite and SNP panels appropriate for the genetic monitoring of any inbred strain of mouse or rat, from detecting a genetic contamination to fine-mapping a transgene insertion point.
Marker-assisted accelerated backcrossing (MAX-BAX®) could save a year and a half or more of breeding by screening the background strain genetics of your research animals and selecting those with the highest percentage of the desired background. Our MAX-BAX® service is a custom microarray platform that utilizes robust fluorescence-based assays. The 384 SNP marker screens are strategically spaced across the genome to analyze common polymorphisms found between inbred strains.
Expression profiling data has proven useful in safety lead optimization and dose-limited toxicity studies, yielding insights sometimes not gleaned from traditional methods. Charles River offers low- and mid-density mouse and rat gene expression testing using pre-validated TaqMan® gene expression assays from Life Technologies.
PCR-based screening services for CRISPR/Cas9-generated models quickly and accurately identifies which founders or cell lines carry mutations with small INDELS at the intended targeting site. Our PCR analysis platform based on microfluidic, laser-induced fluorescence technology allows sensitive detection of heteroduplex formation when small INDELs are present, which is the basis for T7 endonuclease digestion, the most commonly used screening method for CRISPR/Cas9 generated mutations. This PCR platform combined with our proprietary assays produce cleaner data compared to T7 digestion, which often produces background noise, making mutation detection ambiguous.

Genotyping Assay Development and Genetic Quality Control Background Strain Characterization MAX-BAX Cogenic Strain Production strategies Expression testing strain-specific genetic variation CRISPR Cas9 zygosity testing mutations gene targeting ES cells transgenic carriers transgene segregation instability gene targeted screening assay development assay validation colony management genentic quality control GQC SNP Analysis SNP Genotyping services genentic background speed congenics phenotype congenic strain production MAX-BAX congenic strain marker-assisted accelerated backcrossing espression testing expression profiling Gene expression profiling gene expression testing TaqMan gene expression CRISPR/Cas9 CRISPR-Cas9 INDELS PCR analysis heteroduplex formation PCR-based screening PCR based screening Show 44 more tags Show less

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Animal Model Housing and Maintenance

Price on request

Due to the challenges inherent in researching and developing anticancer therapeutics, it is important that you have the right tools and resources available to you. Furthermore, selecting the most appropriate animal model is a critical step when designing an oncology study.Preconditioning services can help alleviate the space, time, and labor costs involved with refining a model to meet your unique research requirements. Whether you are looking for animals fed a special diet, altered through surgery, or reared to a certain age, Charles River has the state-of-the-art animal facilities, professional animal care, and robust model selection to deliver study-ready animals right to your door.With more than 20 breeding facilities around the world, Charles River is the leading global supplier of standard rat models for biomedical research. Charles River stocks and strains are managed under the International Genetic Standardization (IGS) program, a unique program designed to manage the health and genetics of outbred and inbred strains on a global basis, ensuring that researchers worldwide have access to standardized models, regardless of the production location.Because most diseases cause a wide range of complications, their study is complex and often requires research programs to take a multidisciplinary approach. Therefore, aside from mouse and rat models, we also provide other species of research models in order to support your program requirements.

Rat Model Mouse Model Immunodeficient Models Guinea pig, hamster, Gerbil, and Rabbit Models Preconditioning services rats inbred rats outbred rats hybrid rats immunodeficient rats nude rats mice inbred mice outbred mice hybrid mice germ-free mice immunodeficient mice nude mice SCID mice congenic mice Coisogenic mice oncology mice humanized mice microbiome mice hartley guinea pigs hairless guinea pigs LVG Golden Syrian Hamsters Mongolian gerbils NZW Rabbits NZW Research models and services surgical services vascular catheterizations catheterizations catheter soft tissue procedures neurological procedures cardiovasular procedures device implants surgical support Pre-ID Pre-Screening Pre-Dosing Pre-Injection Custom Diets aging study phenotypic evaluations biospecimens blood products serum whole blood organs tissues Rat Mouse Guinea pig Hamster Gerbil Rabbit Show 59 more tags Show less

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Flow Cytometry

Price on request

Flow cytometry is a method that is easily added to in vitro and in vivo studies to comprehensively profile changes in immune cell populations in response to therapeutics. With a streamlined process for tissue dissociation, cell isolation, staining and acquisition, hundreds of systemic and tumor-infiltrating immune cells can be processed per day to give clients the benefit of reviewing data and making decisions about compounds and studies in near-real time.

Oncology immuno-oncology immunology syngeneic mouse models multiplex flow cytometry

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In vivo Pharmacology Studies

Price on request

In vivo pharmacology is the study of the biological effects of a drug in a complex living organism and is used to observe the complex physiological effects of a drug. Charles River offers early research and proof-of-principle pharmacology studies in relevant animal models of human diseases to assist your efficacy evaluations. Our scientific team has extensive experience helping clients with the selection of appropriate models and assays, as well as collaborating to design new models to meet the specific needs of a particular compound or discovery program. Capabilities include: Animal models of invection, Cardiovascular/Metabolic Disease pharmacology models, Inflammation and autoimmune disease models, musculoskeletal disease pharmacology models, neuroscience pharmacology models, ocular disease pharmacology models, oncology pharmacology models, rare disease pharmacology models, respiratory disease pharmacology models

Diabetes Atherosclerosis Dyslipidemia Mouse Rat large animal Guinea pig in vivo pharmacology studies services Show 8 more tags Show less

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request

With decades of experience running in vitro ADME assays and analyzing the data, we can offer those same in vitro assays and bioanalyses more efficiently to generate ADME data earlier in the drug discovery process. This high-speed process optimization and reproducibility can generate quality ADME data for every compound in your chemical library. Please find the following resource. Discovery: Safety Assessment Services and Facilities

ADME DMPK LC-MS/MS in vitro assays In vivo assays Guinea pig Mouse Rat rats Mice in vivo ADME/DMPK Studies acute WinNonlin® Rabbit Minipig feline Dog pharmacokinetic screening cerebral spinal fluid collection bile duct cannulation BDC Show 21 more tags Show less

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Animal Models and Studies

Price on request

Preconditioning services can help alleviate the space, time, and labor costs involved with refining a model to meet your unique research requirements. Whether you are looking for animals fed a special diet, altered through surgery, or reared to a certain age, Charles River has the state-of-the-art animal facilities, professional animal care, and robust model selection to deliver study-ready animals right to your door. Please find the following resources. RMS:Surgical Services and RMS:Labstamp animal identification

Rabbit Sheep Goat Mouse Pig Rat Cow Minipig Diabetes animal models diabetes drug discovery drug safety and toxicology BD fatscantoll/LSRII IVIS Atture NXT IVIS Spectrum CT Bruker in vivo MS FX Pro immunology Acute Myloid Leukemia (AML) acute lymphocytic leukemia Chronic myelegenous Leukemia chronic lymphocytic leukemia hodgkin lymphoma non-hodgkin lyphoma colorectal cancer Oncology immunooncology prostate cancer breast cancer lung cancer ovarian cancer gastric cancer melanoma skin cancer Flow cytometry immunoassay Cell culture Biomarker discovery Immune Profiling biomarker cells Cell Lines tumor biology genomics biomarker drug-gene regulation kinases antibody oncotest PDX collection Humanized Mouse Obesity Animal Models obesity Rodents custom pain animal models Show 53 more tags Show less

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In vitro Immunotoxicity Testing

Price on request

Immunology is an increasingly challenging field of study. The immune system itself is not only a complex, interdependent system of various cell types, but also the actions of those cells are influenced by an array of genetic and environmental factors. Therefore, a wide range of single or multi-cellular assays are required for determining MOA, screening compounds, validating biomarkers, and providing predictive immunotoxicology. Our expertise in cell biology, including primary human, large animal, and rodent cell cultures, provides a platform for the immunological and pharmacological investigations that will help you to understand your drug better.

Toxicology Rat Mouse Rodents drug safety and toxicology predicitve immunotoxicology immunology immunology assay B-Cell CD4 cell CD8 cell macrophage NK cell Neutrophil Neutrophil platelets platelets neurons neurons microglia astrocyte Epithelial Cells fibroblast tumour cells MDSC dendritic cell immune system fibroblast-like synoviocyte activation assay chemotaxis asay:monocyte chemotaxis assay: Neutrophils conventional dendritic cell activation asay Flow cytometry Show 33 more tags Show less

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Biochemical Compound Screening

Price on request

The Charles River assay development and screening department offers a unique combination of target class and cell biology expertise together with state-of-the-art instrumentation to provide services tailored to your requirements.

We provide a collaborative environment and work closely with our teams in medicinal chemistry, ADME, structural biology and fragment-based drug discovery to deliver within challenging timelines.

Charles River has a range of orthogonal approaches that can deliver high-quality, validated hit compounds for your drug discovery project. These approaches can be applied in parallel or individually, depending on the nature of the project and the resources available. Our highly experienced teams regularly evaluate early-stage programs and will advise you concerning the best strategy for successful progression to hit-to-lead studies.

Hit Identification Approaches
High-throughput screening
Fragment screening
Virtual screening
Medicinal chemistry knowledge-based design

Biology Drug Discovery

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Immunobiology Services

Price on request

We understand and have validated models for every cell in the immune system, and those cells which interact with it. This level of expertise is what enables our dedicated analytical and cell biology teams to run assays using primary cells that closely mimic human biology and are suitable for immunology drug screening programs.
Please find the following resources. Discovery:• Infectious Disease Drug Discovery: Pharmacology Models and In Vitro Capabilities, Discovery:Osteoarthritis Rat Model, Discovery:• Predictive Immunotoxicology Services, Discovery:• Pharmacodynamic Efficacy Biomarker Services, Discovery:Respiratory Disease Pharmacology Models, Discovery:Immunology Pharmacology Portfolio, Discovery:•End-to-end Capabilities to Assess Neuroinflammation, Discovery:Cell-based Assays for the Tumor Microenvironment, and Discovery:•End-to-end capabilities for Infectious Disease

immunology

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Alzheimer's Disease Animal Models

Price on request

At Charles River, our scientists can guide you in the selection of the appropriate assay or disease model for every stage of the drug discovery process. Our extensive portfolio supports novel study designs and offers end-to-end validated in vitro services and in vivo models of pharmacology and toxicology. Our novel imaging modalities, behavioral tests and biomarker endpoint assays enable you to make effective decisions to help identify new therapies for Alzheimer’s disease.
Alzheimer’s disease models available for studies include the transgenic CVN and Tg2576 mouse models, which display pathologies associated with Alzheimer’s disease. Aged rodents and scopolamine-induced amnesia models are also available. Established and novel AD models are validated using cognitive testing, MRI and nuclear imaging, measurement of the levels of soluble and insoluble beta amyloid, immunohistochemical measurements and relevant biomarkers. Our services provide an extensive platform for pharmaceutical research and development.
Please find the following resource. Discovery:Neuroscience

Alzheimers Disease Rodents CNS/Neurology cognitive decline aged rats aged mice aged rat aged mouse Show 8 more tags Show less

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Biology

Price on request

The Charles River Ion Channel Portfolio is the most comprehensive library of ion channel-expressing cell lines for research, drug discovery and preclinical development. Cell lines are validated for structure, function and pharmacology, and performance is characterized on conventional manual patch clamp or on one or more automated electrophysiology platforms.   In addition to stable cell lines, we also offer EZCells,  which are single use, division arrested or transient transfected cells ideal for rapid, cost-effective screening and profiling.  We offer detailed methodology and consultation to support and expedite assay set up.   Charles River scientists have pioneered ion channel research for nearly 20 years, creating more than 120 functionally validated assays and cell lines. This industry-leading expertise, combined with our wide array of technologies for screening, profiling and mechanism of action (MOA) studies, makes us unmatched in our ability to support our partners’ quests for the discovery of novel ion channel therapeutics. Please find the following resources. Discovery: Ion Channel Portfolio

Cell Lines CHO HEK293

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Cell-Based Compound Screening

Price on request

Charles River in vitro assay development services offers bespoke in vitro assay testing from target discovery through expression to provide insights that improve translation in vivo and ultimately the clinic. With over 100 validated in vitro human primary cell-based assays and access to patient-derived cell lines and gene editing tools we have proven efficacy testing in oncology, neurology, immunology and rare diseases. Capabilities include human and rodent primary cell-based assays; oncology, immuno-oncology and immunology assays; antiviral and antimicrobial testing; rare disease assays, neuroscience assays, ion channel screening, mechanism of action studies, genome engineering techniques including RNAi and CRISPR.

Biology Drug Discovery Hit Identification Approaches Fragment screening human primary cell based assay in vitro assay in vitro studies High Throughput Screening medicinal chemistry Show 9 more tags Show less

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CNS/Neurology Animal Models

Price on request

Charles River offers a broad selection of neurological disease models that are validated for preclinical in vivo pharmacology and safety studies. Models are available for multiple areas of interest, including chronic and acute neurology, pain, neuromuscular and muscular atrophy, and psychiactry.

Please find the following resource. [Discovery: Neuroscience](https://p.widencdn.net/bdiyym/DS-OS-neuroscience-drug-discovery)

Parkinson's disease (PD) Alzheimers Disease cognition Dogs canine Rat rats Rhesus/Cynomolgus Monkey CVN mouse Tg2576 mouse Thy-1-SNCA 301L and S aged rat aged rats aged mouse aged mice AAV-A53T mouse 6-OHDA lesion model in rats Show 18 more tags Show less

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Drug Discovery & Development

Price on request

Discovering and characterizing novel drug candidates for preclinical development depends on innovative and reliable science. Our unique combination of integrated, multidisciplinary drug discovery expertise and unparalleled scope of capabilities in targets, platforms, and therapeutic areas allow us to deliver depth and breadth in science with data and insight you can trust to progress your drug discovery programs

Action Potential Duration Assay Bioanalytical Assay Development and Optimization Biopharmaceutical Characterization Computational Drug Discovery Drug Absorption studies Drug Mechanisms of Action Studies Drug Targt Identification hERG Channel Inhibition Assay Hit Identification Lead Identification and Validation Inflammation and Immunology Pharmacology models Amino Acid Analysis Biophysical Characterization Biosimilarity analysis ELISA glycan charaterization Glycosylation GMP liposomal product characterization Mass Spectrometry N-terminal Sequencing Potency Assay hERG Ion Channel Screening Cardiac Safety Assessment Dermatitis Scleroderma Psoriasis DTH IBD Immune function RA Rheumatoid Arthritis SLE nephritis Anutoimmune uveitis chromotography testing glycoportein characterization Show 38 more tags Show less

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Imaging & Spectroscopy

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Spectroscopy NMR Spectroscopy Nuclear Magnetic Resonance MRS Magnetic Resonance Spectroscopy Fluorescence UV/VIS Absorbance Fourier Transform Infrared Spectroscopy (FTIR) Circular Dichroism UV-VIS Spectroscopy analytical chemistry CNS/Neurology neurodegenerative disease Show 13 more tags Show less

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Mycoplasma Testing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

Mycoplama detection Mycoplasma Testing Spiroplasma spiroplasma testing Spiroplasma Detection PCR QF-PCR GMP mycoplasma clearance studies mollicute contamination Show 10 more tags Show less

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Veterinary Laboratory Services

Price on request

With over 40 years’ experience in the field, Charles River offers a complete veterinary pharmaceutical development service, including regulatory trial approval (e.g., ATC), protocol and case report form (CRF) design, investigator selection and training, external laboratory facilities selection and monitoring, project management, study monitoring, adverse event responses, drug supply and management, quality assurance, statistics, and production of the final study report.

https://www.criver.com/industry/veterinary-medicine

Veterinary laboratory sevices

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Free Amino Acid Analysis

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please see the following resources Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

AAA Amino Acid Analysis hydrolyzed Amino Acid Analysis Protein Chemistry analytical testing extinction coefficient determination Extinction Coefficient Show 7 more tags Show less

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Assay Development

Price on request

Charles River scientists have more than 20 years of experience in the design and performance of viral and transmissible spongiform encephalopathy (TSE) clearance studies. With laboratories in Europe and the US, we have the technical and regulatory expertise to ensure studies comply with the relevant guidelines in a client’s target market (e.g., EU, US, Japan, and WHO, including ICH Q5A). Intelligent, tailored study designs and robust, timely reporting create successful, cost-effective programs that meet the unique needs of each biopharmaceutical product. We have worked with a range of products, including monoclonal antibodies (mAbs), recombinant proteins, transgenic products, tissue- and blood-derived products, vaccines and medical devices. In addition, our team offers virus cleaning validation.

assay development assay method development Assay Method validation Assay Method feasibility

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Cell Line Authentication

Price on request

Cell lines must be tested for the presence of general and specific contaminants to ensure the safety of the associated biological product. Our team collaborates with clients to develop scientifically sound and cost-effective cell bank programs. We manufacture cell banks for mammalian, microbial, insect, yeast and stem cells and can provide the appropriate cell storage services, all under Good Manufacturing Practice (GMP) guidelines. Our capabilities include purity, sterility, identity, genetic stability testing and an array of other characterization assays from our expansive testing portfolio. Our experienced technical staff can customize a project to create and characterize master cell banks, working cell banks, research cell banks, end-of-production cells and cells at the limit of in vitro cell age, according to client specifications.

Genetic Stability 165 rDNA Sequencing Adventitious Agent testing bacteriophage testing Barcode analysis Cell Line Identification Copy Number DNA fingerprinting DNA sequencing GMP Microbial Contamination Mycoplasma Detection Purity Assay Restriction Endonuclease Analysis retention of recombinant construct retention of selectable markers RNA sequencing Sterility STR analysis viability testing virology Virology Contamination Show 22 more tags Show less

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Cell-Based Assays

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Cell-based assays Cell-Based Screening Methods Custom Cell-Based Assay Development Specialized Cell-Based Assays

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Chemical Synthesis

Price on request

Charles River synthetic chemistry capabilities are multi-stage syntheses (>10 steps) of milligram quantities; larger amounts can be prepared by our scale-up team, validation of synthetic routes to previously unknown scaffold, parallel chemistry including the synthesis of small arrays, chiral synthesis and resolution, flow chemistry, automated mass-directed purification, analytical and semi-prep supercritical fluid chromatography

Please find the following resource. Discovery:Synthetic Chemistry 

 

milligram gram multi-stage synthesis validation of synthetic routes parallel chemistry synthesis of small arrays chiral synthesis Chiral Resolution flow chemistry automated mass-directed purification analytical and semi-prep supercritical fluid chromatography synthetic route designs Show 12 more tags Show less

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GEM Colony Care

Genetically Engineered Mouse Colony Care
Price on request

Charles River provides off-site space for holding, breeding, and developing genetically engineered mouse and rat colonies. All colonies are assigned a dedicated project manager and clients are granted access to Charles River’s innovative Internet Colony Management (ICM™) system. Whether you want to simply maintain a line, produce regular animal shipments for your studies, or backcross your strain to a different genetic background, each breeding colony is scalable to your specific research needs. Our Isolator-based animal quarantine facilities allow for the direct acceptance of animals from any institution worldwide, regardless of their known or unknown health status. This flexibility provides options to screen animals that would otherwise not be allowed into many animal facilities and speed up the process of acquiring valuable research animals. At the completion of the quarantine period, animals that are proven negative of excluded agents are allowed directly into most barrier facilities without the need to rederive. Charles River works with global customers on unique transgenic models to deliver study-ready cohorts to meet research needs. Our dedicated project management team, scientists, and animal care staff are always available to offer guidance, develop work plans, and help overcome any challenges. Through partnerships with genomics industry leaders, our combined expertise provides an optimum environment for generating, characterizing, preserving, and distributing your transgenic lines.

Charles River provides a wide range of genetically engineered models and services. Please see the following resources. GEMS:rederivation services , GEMS:Rapid Quarantine , GEMS:Line rescue services , GEMS:Transgenic models creation through colony expansion , GEMS:Model Creation , GEMS:Transgenic Model and Service


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Histology and Pathology Services

Price on request

Charles River employs the largest assembly of pathologists in the contract research industry, offering multidisciplinary expertise for all types of drugs, biologics, chemicals, and devices and performing a wide array of routine and specialized pathology services either in support of in vivo studies performed at our sites or as a standalone service. We have also added comprehensive digital pathology. We have deployed a suite of digital slide scanners and an integrated slide managment system to connect our team of nearly 150 pathologist with each other and their clients. These scanners produce whole slide images (WSI) of microscopic slides at a range of magnifications.


https://p.widencdn.net/hnjw75/SA-OS-anatomic-and-clinical-pathology-services

https://www.criver.com/sites/default/files/resource-files/SA-Digital-Pathology-Service-Sheet.pdf;https://criver.widen.net/s/pf9x6pmxzf

Pathology services pathology laboratory pathology lab pathology associates histopathological examination clinical and Anatomic pathology Digital Pathology WSI Patholytix Preclinical specialized pathology Artificial Intelligence AI-Powered pathology telepathology eslide manager Show 14 more tags Show less

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ICP-MS

Inductively Coupled Plasma Mass Spectrometry
Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please see the following resources Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

ICP-MS ICP Inductively coupled plasma mass spectrometry Elemental Impurities

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Immunohistochemistry (IHC)

Price on request
  • Safety assessments for approximately 70 humanized, chimeric or murine monoclonal antibodies annually
  • Protocol development for over 80 different antibodies in a variety of species
  • Experience with unconjugated antibodies, antibodies conjugated to a variety of substances and Fab fragments
  • Techniques to reduce or eliminate the binding of secondary reagents to endogenous immunoglobulin, even when the tissue is of the same species as the immunoglobulin
  • Reproducibility of immunohistochemical techniques in conjunction with morphometric and stereological analyses
  • QIHC-certified staff using state-of-the-art automated staining instruments
  • Double IHC staining

immunostaining immunohistochemistry in situ hybridization proteins RNA Transcript gene expressions mRNA humanized chimeric murine monoclonal antibodies antibodies unconjagated antibodies conjagated antibodies immunoglobin QIHC QIHC certified double IHC staining Show 17 more tags Show less

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In vitro ADME/DMPK Studies

Price on request

Charles River helps clients identify the metabolic pathways, potential interactions and routes of elimination of their compound at an early stage. We can characterize your drug candidate's ADME properties through in vitro and in vivo studies providing expert study design and data interpretation. Please find the following resource. Safety:Drug Metabolism

Cobas analyzers (4000, 6000, or 8000) VENTANA Discovery XT

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In vitro Toxicity Testing

Price on request

Charles River has been leading the way in the development, validation, and acceptance of various animal-free models through rapid, reproducible, and reliable in vitro toxicology assays to examine the toxic properties of compounds of interest. Please find the following resource. Safety: Advanced in vitro Models

in vitro studies metabolic toxicokinetic hERG Cyp cell proliferation enzyme drug-drug interactions protein binding drug transporters MiST reactive drug motabolites in vitro testing metabolism cytochrome p450 caco-2 cells Cytotoxicity mic Show 19 more tags Show less

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In vivo PK/PD Studies

Price on request

ADME is the evaluation of absorption, distribution, metabolism and excretion properties of compounds and their metabolites. We can help you develop ADME testing strategies spanning early stage development, preclinical toxicity and through your clinical trials. The synergy within our group gives you a head start for competitive time-lines and efficient advice. You gain easy assess to our experts and we can evaluate your precise requirements and ensure you get the best ADME package at the best price.

Dog Rabbit Rat Non-human primates (NHP) Mouse

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Mass Spectrometry

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Mass Spectrometry Mass Spec MS LC-MS LC-MS/MS ICP-MS MALDI-TOF GMP Reference Standard Biosimilarity analysis Show 10 more tags Show less

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Monoclonal Antibody (mAb) Production

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers

mAB Monoclonal antibodies Monoclonal antisera Monoclonal Anbtibody (mAB) Production monoclonal antisera production Animal Immunization for anitbody production Rabbit Goat Chicken Show 9 more tags Show less

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Plasmid DNA Preparation

Price on request

Charles River can detect and quantify minute amounts of residual host cell DNA by using three highly sensitive, validated methods. These methods encompass the entire range of residual DNA from nonspecific detection of total DNA to highly specific detection of single target sequences.

GMP Hybridization Assay qPCR Assay Threshold Assay

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Process Consulting

Price on request
Request a quote for more information about this service.

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Project Management

Price on request

Every project, regardless of scope or complexity, is assigned a client portfolio manager to gain a deeper understanding of the goals and challenges of each project. Your client portfolio manager will be an integral part of your study team, an extension of your internal efforts, and a valuable partner in your research.

https://www.criver.com/products-services/research-models-services/genetically-engineered-model-services/project-management-program?region=3601

Genetically engineered animal colony project management client portfolio manager internet colony management system

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Protein Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Discovery- ccms technical sheet 

protein quantification Protein Characterization Protein Services GMP Analytical Ultracentrifugation Biocore Biosimilarity analysis Circular Dichroism differential scanning calorimetry DLS (Dynamic Light Scattering) extrinsic fluorescence Fourier Transform Infrared Spectroscopy (FTIR) HPLC-SEC intrinsic tryptophan fluorescence Surface plasmon resonance (SPR) Protein Biophysical Characterization Amino Acid Analysis Amino acid sequencing capillary zone electrophoresis disulfide bridge mapping IEF Immunoassays intact molecular weight N-terminal Sequencing Osmolarity Peptide mapping Potency Assay product-related impurities Residuals SDS-PAGE Spectrophotometric assays western blot Protein Structure Determination Biophysical Characterization protein Expression Visualization 18S CCMS Proteomics protein mass spectrometry discovery proteomics protein phosphorylation chemo proteomics quantitative proteomics Protein Expression stem cell proteomics proteome informatics Show 46 more tags Show less

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qPCR

Quantitative PCR
Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources Biologics: Drug Product Release and Biologics: Comprehensive Services for Biologics Developers and Manufacturers

qPCR PCR Quantitative Polymerase Chain Reaction Polymerase chain reaction qPCR Assay

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RNA Sequencing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers

RNA sequencing DNA sequencing Sanger Sequencing

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Sanger Sequencing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers

RNA sequencing DNA sequencing Sanger Sequencing

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Surface Plasmon Resonance (SPR)

Price on request

Surface Plasmon Resonance - Biacore 4000 for high-throughput hit identification - Biacore T200 with added sensitivity for kinetic profiling, mechanistic analysis and backup screening. Please find the following resource [Biologics: Comprehensive Services for Biologics Developers and Manufacturers](http://embed.widencdn.net/pdf/plus/criver/obksob4lyh/BI-OS-comprehensive-services-for-biologics-developers-and-manufacturers.pdf?u=wfwdux)

Biacore Biacore 4000 Biacore T-200 Surface plasmon resonance (SPR) SPR potency Biacore Show 7 more tags Show less

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Whole Genome Sequencing

Price on request

Cell lines must be tested for the presence of general and specific contaminants to ensure the safety of the associated biological product. Our team collaborates with clients to develop scientifically sound and cost-effective cell bank programs. We manufacture cell banks for mammalian, microbial, insect, yeast and stem cells and can provide the appropriate cell storage services, all under Good Manufacturing Practice (GMP) guidelines. Our capabilities include purity, sterility, identity, genetic stability testing and an array of other characterization assays from our expansive testing portfolio. Our experienced technical staff can customize a project to create and characterize master cell banks, working cell banks, research cell banks, end-of-production cells and cells at the limit of in vitro cell age, according to client specifications.

Genetic Stability 165 rDNA Sequencing Adventitious Agent testing bacteriophage testing Barcode analysis Cell Line Identification Copy Number DNA fingerprinting DNA sequencing GMP Microbial Contamination Mycoplasma Detection Purity Assay Restriction Endonuclease Analysis retention of recombinant construct retention of selectable markers RNA sequencing Sterility STR analysis viability testing Virology Contamination Show 21 more tags Show less

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Cell Line Generation

Price on request

Charles River has extensive experience in generating stable cell lines for high-throughput screening and compound profiling. We offer a customized service, starting with stable expression of single proteins through to stable co-expression of multiple protein subunits.    You can also access a range of validated assays, in addition to our assay development and validation service, with expression profile selected to suit specific assay formats.

In vitro biology Cell Lines Maxcyte GPCR cell lines High Throughput Screening compound profiling drug discovery Show 7 more tags Show less

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Hydrolyzed Amino Acid Analysis

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers

AAA Amino Acid Analysis hydrolyzed Amino Acid Analysis Protein Chemistry analytical testing extinction coefficient determination Extinction Coefficient Show 7 more tags Show less

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16S rRNA Sequencing

Price on request

Cell lines must be tested for the presence of general and specific contaminants to ensure the safety of the associated biological product. Our team collaborates with clients to develop scientifically sound and cost-effective cell bank programs. We manufacture cell banks for mammalian, microbial, insect, yeast and stem cells and can provide the appropriate cell storage services, all under Good Manufacturing Practice (GMP) guidelines. Our capabilities include purity, sterility, identity, genetic stability testing and an array of other characterization assays from our expansive testing portfolio. Our experienced technical staff can customize a project to create and characterize master cell banks, working cell banks, research cell banks, end-of-production cells and cells at the limit of in vitro cell age, according to client specifications.

Genetic Stability 165 rDNA Sequencing Adventitious Agent testing bacteriophage testing Barcode analysis Cell Line Identification Copy Number DNA fingerprinting DNA sequencing GMP Microbial Contamination Mycoplasma Detection Purity Assay Restriction Endonuclease Analysis retention of recombinant construct retention of selectable markers RNA sequencing Sterility STR analysis viability testing Virology Contamination Show 21 more tags Show less

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HPLC

High Performance Liquid Chromatography
Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Chromatography HPLC LC UPLC Analytical GMP GC Liquid Chromatography High Performance Liquid Chromatography Show 9 more tags Show less

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Synthetic Chemistry

Price on request

High-quality synthetic chemistry creating novel compounds to progress your drug discovery programs. Capabilites include: Multi-stage syntheses (>10 steps) of milligram quantities (larger amounts can be prepared by our scale-up team); Validation of synthetic routes to previously unknown scaffolds; Parallel chemistry including the synthesis of small arrays; Chiral synthesis and resolution; Flow chemistry; Automated mass-directed purification; Analytical and semi-prep supercritical fluid chromatography

Hit ID Hit Identification Hit to lead campaigns kilogram-scale API mass-directed high performance liquid chromatography facilities MDAP semi-prep supercritical fluid chromatography SFC GMP Large scale synthesis non-GLP SoftFocus Show 13 more tags Show less

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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers

LC-MS Liquid Chromatography Mass Spectrometry Mass Spec

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DNA Sequencing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers

RNA sequencing DNA sequencing Sanger Sequencing

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Analytical Chemistry Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.Formulation development services range from preformulation investigations to analytical method development and validation. Charles River prepares formulations based on our extensive knowledge of vehicle suitability in animal models for most formulation types to support GLP preclinical studies. Please fine the following resource. [Safety: Formulation Development/AnChem](https://p.widencdn.net/f7dy67/SA-PS-formulation-dev-anchem)

https://p.widencdn.net/p4ge8b/BI-PS-protein-formulation

GMP analytical chemistry QC testing Quality Control Analytical Development Release Testing formulation development Preformulation Formulation assay development assay validation concentration homogeneity stability bioavailability HPLC UPLC Method Development Method Validation Waters Acquity UPC2 Waters Thar SFC-MS WatersThar SFC Prep 100 Gilson chiral HPLC system Micromass Quattro Micro UPLC-MS Agilent 7820 GC Agilent 5975 MSD SCIEX API5000 Waters XEVO QTO Bruker Avance III HD 400 Bruker Avance DPX300 Bruker avance AV400 Bruker avance AVII400 Bruker Fourier 300 Agilent 1200 Show 34 more tags Show less

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Protein Production

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Cell Banking and Storage and Biologics: Cell Line Characterization

mAB Monoclonal antibodies Monoclonal antisera Monoclonal Anbtibody (mAB) Production monoclonal antisera production

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ELISA

Enzyme-linked immunosorbent assay
Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource. Biologics: Comprehensive Services for Biologics Developers and Manufacturers

ELISA Residual Testing Impurities testing Enzyme-linked immunosorbent assay

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Patch Clamp Recording

Price on request

Whatever your therapeutic area – cognitive decline, schizophrenia, neuropathic pain, or epilepsy – chances are you are interested in the precise action of your compounds on neurotransmission. Manual patch-clamp electrophysiology allows for high resolution recordings from a single neuron. Detailed physiological and pharmacological inquiries can be addressed with this technique.

drug discovery drug safety and toxicology Manual patch clamp Automated patch clamp ion channel Dog Rabbit Rhesus/Cynomolgus Monkey Show 8 more tags Show less

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Patient-Derived Xenograft (PDX)

Price on request

We currently have more than 400 fully characterized proprietary patient-derived xenografts in our portfolio, which represent all major histotypes and tumors, and provide extensive background and characterization. Our PDX Model portfolio includes:
Subcutaneous, orthotopic, and disseminated models of cancer, extensive molecular and pharmacological characterization, and complete records on patients‘ pretreatment, integrated approach using the same PDX models and/or the corresponding cell line, 2D/3D screening assays and subsequent PDX in vivo efficacy studies, identification of biomarkers, which predicts tumor sensitivity of compounds and a PDX Model platform using humanized mice in standard or single mouse trial format (SMT).

Oncology drug discovery in vivo efficacy PDX IVIS Attune NXT IVIS Spectrum CT Bruker in vivo MS FX Pro immunology cancer hematologic milignancy acute myeloid leukemia acute lymphocytic leukemia chronic myelogenous leukemia chronic lymphocytic leukemia hodgekin lymphoma non-hodgkin lyphoma colorectal cancer prostate cancer breast cancer hematology lung cancer ovarian cancer gastric cancer melanoma skin cancer tumor metabolism Flow cytometry scaffold-free 3D culture Biomarker discovery Biomarker analysis FACS Cell line engineering 3D culture cell imaging multiplex flow cytometry in vitro in vivo bioinfomratics human tumor tumor cells cell ine tumor biology genomics drug discovery and toxicology oncotest PDX collection Mouse Humanized Mouse Show 48 more tags Show less

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Animal Models of Disease

Price on request

Charles River offers early research and proof-of-principal pharmacology studies in relevant animal models of human diseases to assist efficacy evaluations. We have animal models of various disease areas ranging from cardiovascular, inflammation, autoimmune, musculoskeletal, neuroscience, ocular, oncology, rare and respiratory disease.

Please find the following resource Discovery:CNS Models 

Animal models of infection cardiovascular disease Neurodegenerative diseases Neuroinflammation musculoskeletal disease Autoimmune Diseases Inflammation Pain psychiatric disorders Metabolic Disease Rare Disease ocular disease oncology animal models respiratory disease models Show 14 more tags Show less

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Cell Lines

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers, Biologics: Cell Banking and Storage and Biologics: Cell Line Characterization

Cell Line testing Genetic Stability 165 rDNA Sequencing Adventitious Agent testing bacteriophage testing Barcode analysis Cell Line Identification Copy Number DNA fingerprinting DNA sequencing GMP Microbial Contamination Mycoplasma Detection Purity Assay Restriction Endonuclease Analysis retention of recombinant construct retention of selectable markers RNA sequencing Sterility STR analysis viability testing Virology Contamination Show 22 more tags Show less

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Virology Testing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

Virology testing In vitro adventitious virus testing retrovirus detection assays adenovirus assay

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In vitro Disease Models

Price on request

Charles River in vitro assay development services offers bespoke in vitro assay testing from target discovery through expression to provide insights that improve translation in vivo and ultimately the clinic. With over 100 validated in vitro human primary cell-based assays and access to patient-derived cell lines and gene editing tools we have proven efficacy testing in oncology, neurology, immunology and rare diseases. Capabilities include human and rodent primary cell-based assays; oncology, immuno-oncology and immunology assays; antiviral and antimicrobial testing; rare disease assays, neuroscience assays, ion channel screening, mechanism of action studies, genome engineering techniques including RNAi and CRISPR

human primary cell based assays in vitro assays in vitro studies

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Pharmaceutical Formulation

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource. Biologics: Comprehensive Services for Biologics Developers and Manufacturers

Formulation Preformulation drug development manufacturing services Protein Formulation

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Biomarkers

Price on request

Choosing the right translational biomarker is based on whether it is detectable, measurable and, in the end, able to be qualified or validated. Charles River advises on selecting the appropriate biomarker, analytical methodology and pull through from nonclinical to clinical use. Please see the following resource. Safety:Biomarker Assays

Biomarker discovery drug development drug discovery Biomarker Assay Development Biomarker Identification Biomarkers ELISA Enzyme immunoassay (EIA) HPLC Luminex Meso Scale Discovery predictive biomarkers western blot Show 13 more tags Show less

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Rodent Breeding

Price on request

Charles River provides off-site space for holding, breeding, and developing genetically engineered mouse and rat colonies. All colonies are assigned a dedicated project manager and clients are granted access to Charles River’s innovative Internet Colony Management (ICM™) system. Whether you want to simply maintain a line, produce regular animal shipments for your studies, or backcross your strain to a different genetic background, each breeding colony is scalable to your specific research needs.

Rat Rodents Mouse Mice rats

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Clinical Sample Analysis

Price on request

The members of our scientific staff have extensive experience in transferring and developing methods efficiently and expeditiously. In many cases, they get involved at the start of the nonclinical program and stay on through testing, collaborating as part of the clinical study team. This approach results in robust and reliable methods for clinical sample analysis, which, when combined with data management and data transfer expertise, enables us to produce high-quality, on-time clinical data to support drug approval, and to help you effectively make sound go/no-go decisions.

clinical sample kits LIMS immunogenicity Biomarkers Immunotoxicology immunomodulation molecular biology Show 7 more tags Show less

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Cognitive, Behavioral, and Psychiatric Animal Models

Price on request

Charles River offers several models of psychiatric disease including autism, schizophrenia, anxiety and depression. Charles River scientists recently characterized the BTBR T+tf/J model of autism using behavioral studies and noninvasive imaging to validate its utility for preclinical drug discovery of ASD therapies.
Additionally, our neuroscientists conduct contract studies in mice to assess the efficacy of novel anti-anxiety compounds, such as anxiolytics and selective serotonin reuptake inhibitors (SSRIs).
You can partner with our scientists to run your studies in well-characterized, disease-relevant models, using a comprehensive toolkit of imaging capabilities, behavioral assays and biomarkers including the forced swim test and touchscreen testing.
Charles River has validated a pencyclidine (PCP)-induced deficit model, which recapitulates several behavioral deficits, mimicking the symptoms of schizophrenia. This model displays both positive and negative symptoms, including cognitive deficits, and facilitates the development of drugs for either or both symptom categories.

Charles River offers mouse behavior analysis via touchscreen-based tests. The touchscreen tests possess several advantages over traditional methods of rodent cognitive assessment and are highly translational as they rely on the stimuli and actions similar to those used in human cognitive assessments. Due to their emphasis on sustained performance, touchscreen tests can be used in longitudinal pharmacological studies and this method can be easily combined with other behavioral or functional tests.

Mouse Rat Neurodegenerative diseases Psychiatry/Mental Health CNS/Neurology

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Compound Identification and Characterization

Price on request

Charles River has a full suite of capabilities to provide chemical purity (including chiral purity) and structural elucidation on compounds, impurities and degradants. We have access both internally and externally to state-of-the-art technologies, including high-field and solid-state NMR, high-resolution MS-MS and X-ray diffraction.    If required, compounds can also be characterized by IR or Raman spectroscopy and their optical rotation/circular dichroism determined. Elemental analysis and small molecule crystallography are also available via third parties.  The reports produced by Charles River are suitable for inclusion in an IMPD (Investigational Medicinal Product Dossier).    In house:    - Two 400 MHz and two 300 MHz NMR instruments  - 14 mass spectrometers  - Agilent mass-directed autopurification system.

NMR Infrared Spectroscopy Raman Spectroscopy

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Computational Drug Discovery

Price on request

Collaborating with Charles River’s Computer-Aided Drug Design (CADD) group puts leading informatics, virtual screening and molecular modeling expertise at your fingertips. Our highly experienced team works closely with our colleagues in medicinal chemistry, screening and structural biology to support projects and also plays a leading role in the design of our fragment and SoftFocus® libraries. Our CADD capabilities are available as part of integrated hit identification, hit expansion, hit-to-lead and lead optimization programs or as a stand-alone offering. - Structure-based drug design - Ligand-based drug design - Virtual screening - Protein modeling - QSAR modeling - Screening library design and subset selection - Design of fragment and SoftFocus® libraries - HTS data triage - Chemo- and bio-informatics


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Pain/Neuropathy Animal Models

Price on request

Charles River conducts several hundred disease model studies on candidates targeting various types of pain including acute pain, inflammatory pain and neuropathic pain. We have developed a variety of clinically relevant pain models that have been validated using existing and novel methods to effectively test new therapeutic candidates. Capabilites include: neuropathic pain model, chronic joint pain model, inflammatory pain model, spinal nerve ligation model, peripheral neuroinflammation model, nociceptive pain model.
Please find the following resource. Discovery:Neuroscience

Pain neuropathic pain chronic joint pain inflammatory pain Spinal Nerve Ligation (SNL) peripheral neuroinflammation nociceptive pain Show 7 more tags Show less

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Xenograft Models

Price on request

Cell-line derived or patient-derived tumor xenografts are used to conduct in vivo efficacy evaluation of potential cancer therapies. Our broad range of well-characterized CDX and PDX tumor lines ensures a wide variety of testing alternatives for your molecule; complete profiling can be carried out in a variety of tumor types or in combination with the desired clinical compound. Efficacy evaluation can be combined with: Hematology (CBC/Diff) analysis; Pharmacokinetic or bioavailability sampling and analysis; Histopathology or tissue sampling; Biomarker screening, sampling or evaluation

PDX Patient-derived xenograft cell-line derived xenograft CDX human tumor xenograft

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Animal Microdialysis

Price on request

Microdialysis is a minimally-invasive sampling technique used to measure unbound analyte concentrations in extracellular fluid and tissues. At Charles River, we offer conventional microdialysis to measure small molecular weight analytes as well as push-pull microdialysis to measure larger molecules. Additionally, the proprietary MetaQuant method is used to sample various tissues. We can customize assays by combining microdialysis with other methods such as behavior or EEG measurements.
Accuracy and sensitivity are critical parameters for bioanalysis and Charles River provides a wide range of bioanalytical services. A combination of expert scientists and state of the art equipment allows us to offer novel analytical techniques to analyze low concentrations of multiple neurotransmitters simultaneously in a single run.
Please find the following resource. Discovery:Translational tool for neuroscience

CNS/Neurology Conventional Microdialysis push-pull microdialysis

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DART Studies

Developmental and Reproductive Toxicology Studies
Price on request

Developmental and reproductive toxicology (DART) services for the progression of pharmaceuticals and biopharmaceuticals include male and female fertility, developmental toxicity and pre/postnatal development (PPND) studies to assess the potential effects of a test article on the full spectrum of reproduction. Please find the following resources. Safety: Reproductive Toxicology

Mouse Rat Rabbit Minipig Cow Goat Pig Sheep developmental and reproductive toxicology Reproductive Toxicology developmental toxicology juvenile toxicology juvenile toxicity testing DART testing endocrine disruptor screening drug discovery Embryo-fetal development Fertility and early embryonic development Maternal toxicity Pre/post-natal development, inc. maternal function Show 20 more tags Show less

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Drug Mechanism of Action Studies

Mechanism of Action Studies
Price on request

Charles River uses its adenoviral technology to elucidate the mechanism of action of small molecules. By combining the compound of interest with knockdown or overexpression of candidate gene in the same phenotypic assay, we can start to elucidate the mechanism of action of the compound(s). In addition, we are able to access our other technologies to perform mode-of-action studies: - Use of our in-house chemogenomics database to predict candidate targets - Cross-screening of compounds of interest through panels of biochemical and cell-based assays linked by candidate pathways or candidate gene families - Biophysical assays to look for compound binding to candidate target proteins – SPR, size exclusion chromatography, X-ray crystallography

In vivo pharmacology in vitro assays Hit Identification medicinal chemistry Hts High Throughput Screening Show 6 more tags Show less

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Pharmacology & Toxicology

Price on request

In the design and execution of safety pharmacology and toxicology studies, vast experience in stand-aline and integrated repeat dose designs is necessary.

Rat Mouse safety pharmacology studies in vitro assays for safety pharmacology in vivo pharmacology models in vivo studies of safety pharmacology Show 6 more tags Show less

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PK/PD Data Analysis

Price on request

Charles River provides bioanalytical support for samples generated in toxicology studies, and the resultant test article/item concentration data can be interpreted by our pharmacokinetics staff utilizing industry-standard WinNonlin® software using noncompartmental and compartmental approaches. We offer this as an integrated service, where all aspects of the study are managed within our laboratories, or as a stand-alone service, which enables analysis of concentration data generated elsewhere by the sponsor.
Toxicokinetic parameter estimation output includes a comprehensive interpretation of the data, as required. In addition, we can address preclinical-to-clinical considerations (e.g., allometric scaling) when planning first-in-human studies.

WinNonlin®

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Electron Microscopy

Price on request

Recognized for our experience in this field, Charles River offers full-service GLP ultrastructural microscopy evaluations with both transmission (TEM) and scanning (SEM) electron microscopic capabilities. Ultrastructural morphology procedures enable the visualization of unique details of the structure and the quantification of cellular organelles. This imaging technique gives investigators precise data on mitochondria, peroxisomes, smooth and rough endoplasmic reticulum, Golgi cytoskeletal components, cytoplasmic granules, and inclusion bodies, which assist in determining a compound’s mode of action and understanding the pathogenesis of toxicologically-related lesions. SEM enables the investigator to examine the surface topography and morphology of cells, tissues or medical devices by scanning a beam of electrons across a sample. This imaging technique may also be employed in studies in which exterior damage or integrity is of concern.


https://www.criver.com/sites/default/files/resource-files/SA-PS-electron-microscopy-supporting-discovery-safety-and-manufacturing.pdf


https://www.criver.com/sites/default/files/resource-files/SA-SEM-Tech-Sheet.pdf

ultrastructural microscopy transmission electron microscopy Scanning electron microscopy TEM SEM Electron microscopy ultrastructural Pathology Quantiification of peroxisomes viral particle identification evaluation of tissue interface evaluation of medical device interface characterization of red blood cell morphology Tranmission electron microscopy Light microscopy Dual-energy X-ray absorptiometry DXA Quantitative computed tomography QCT Micro-computed tomography digital radiography Show 20 more tags Show less

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Electrophysiology

Price on request

Charles River offers a comprehensive portfolio of electrophysiology assays to monitor neuron-to-neuron communication and study the effects of physiological or pharmacological stimuli. Assays include single cell recordings, brain slice electrophysiology, and In vitro / ex vivo patch clamp studies to get a comprehensive understanding of the effect of a therapeutic on neuronal activity, synaptic changes and firing rates. The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and some brain pathologies. Up- or down-regulation of synaptic transmission can shed light on cellular and network mechanisms of numerous CNS diseases, including Alzheimer's disease, autism and ataxia. Please find the following resource. Discovery:Neuroscience Translational Tool

CNS/Neurology Neuroscience Synaptic firing electrical signals LTP brain slice ephys multi-electrode arrays Show 7 more tags Show less

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Protein Crystallization Screening and Optimization

Price on request

The structural biology team at Charles River carries out high-resolution structure determination by X-ray crystallography to support both stand-alone and integrated drug discovery projects. We have access to both in-house and synchrotron data collection facilities to provide fast turnaround and high-throughput structure determination (including fragment screening campaigns). Integration of protein production, crystallization and structure solution allows for efficient streamlining of the structure determination process. The resulting structures, combined with the significant industrial design experience of our crystallographers and integrated with results from advanced biophysical assays, allow us to detail protein-ligand interactions at a structural, kinetic and thermodynamic level and provide insight to drug design projects. - Robotic nanoliter-scale screening and imaging - Screening with known ligands - Automated optimization of conditions for crystal growth - Co-crystallization or soaking of ligands

X-ray crystallography

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Ligand Binding Assays

Price on request

Charles River scientists are global leaders in this rapidly growing and evolving field of ligand binding assays including peptides, monoclonal antibodies (mAb), multi-domain antibodies, antibody-drug conjugates (ADC), biosimilars, and traditional and next-generation oligonucleotides. Ligand binding assay bioanalysis is not an independent discipline, our scientists work closely with our immunogenicity, pharmacokinetic and statistical specialists to deliver the pertinent solutions and interpretations applicable to your molecule and your study. Platforms: - Ligand binding assays (ELISA and MSD) - Automated ELISA systems - Ligand binding with LC-MS detection (Hybrid assays) - LC-MS/MS - Oligonucleotides - High-resolution mass spectrometry - Luminex technologies - Radioimmunoassay (RIA) - Enzyme immunoassay (EIA) - Fluorescence immunoassay (FIA) - Immunoradiometric assay (IRMA) - Dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) - Scintillation proximity assay (SPA)

Immunoassays Automated ELISA Mass Spectrometry Radioimmunoassay (RIA) Enzyme immunoassay (EIA) Fluorescence immunoassay (FIA) Immunoradiometric assay (IRMA) Dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) Scintillation proximity assay (SPA) ligand binding assays (ELISA and MSD) Ligan Binding with LC-MS Detection Luminex-AE Show 12 more tags Show less

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Cell and Tissue Culture

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.


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Material Testing Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

GMP analytical chemistry QC testing Quality Control Analytical Development Release Testing Show 6 more tags Show less

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Medicinal Chemistry

Price on request

Our medicinal chemistry team is world-class, with many of our scientists bringing a wealth of experience from previous employment in the pharmaceutical and biotechnology industries. With our exposure to a wide range of therapeutic areas and collaborative working styles, we are well equipped to drive your program forward. We have an enviable record of delivering 64 preclinical candidates to our partners, and the strength and consistency of our innovation is exemplified by inventorship on more than 290 patent applications filed by clients.    We provide integrated drug discovery services spanning hit identification, hit-to-lead and lead optimization, all complemented by synthetic, process and scale-up chemistry, computer-aided drug design, structural biology, assay development and screening, and comprehensive ADME and PK profiling.    Key Skills and Experience  Delivery of high-quality preclinical candidates  Broad therapeutic disease area expertise (e.g., respiratory, CNS, oncology, inflammation)  Significant experience working across all druggable gene family target classes  Problem-solving expertise and creativity  Interpretation of biological data  Understanding of physicochemical properties  Application of compound quality metrics  Development of structure-activity relationships  Removal of unwanted off-target activities  Optimization of ADME, PK and PK/PD profiles  Ability to execute patenting strategies. Please find the following resource. Discovery:Medicinal Chemistry Handbook

Drug Discovery PK/PD PK ADME

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hERG Channel Inhibition Assay

Price on request

In vitro hERG patch clamp assays have become standard components in cardiac safety evaluation during nonclinical drug development. Conventional manual patch clamp evaluation of hERG potency in the presence of 100% fetal bovine serum (FBS, dialyzed) evaluates the effect of drug-protein binding on hERG inhibition.

hERG hERG Channel Inhibition Assay Ion Channel Screening Cardiac Safety Assessment

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Transdermal/Transmucosal Drug Delivery Systems

Price on request
Request a quote for more information about this service.
medical devices Toxicology testing Pathology

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Transgenic Animal Model Development

Price on request

Charles River works with global customers on unique transgenic models to deliver study-ready cohorts to meet research needs. Our dedicated project management team, scientists, and animal care staff are always available to offer guidance, develop work plans, and help overcome any challenges. Through partnerships with genomics industry leaders, our combined expertise provides an optimum environment for generating, characterizing, preserving, and distributing your transgenic lines.

Transgenic model creation Model Creation genomics CRISPR/Cas9 genome editing RNAi ES Cell mutagenesis Knockin Mice Knockout Mice microinjection services DNA Transgenesis transgenes SNP modification ES Cell Injection CRISPR Injection plasmid BAC DNA Mouse Mice Show 19 more tags Show less

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Transporter & Cell Uptake Assays

Price on request

The cellular uptake mechanism of transporters plays a key role in the pharmacokinetic profile of many structurally unrelated drugs. Present at all important pharmacological barrier tissues, these proteins enable the translocation of medium to low permeability drug substances across plasma membranes, and thereby determine absorption, distribution and elimination routing. Testing for interactions with uptake transporters has the potential to predict the main factors in the system level movement of drugs. Assessing the inhibitory potential of test articles on uptake transporters may indicate drug-drug interaction implications

In Vitro ADME ADME ADME Assays Physiochemical screening CYP450 inhibition CYP450 Reaction Phenotyping CYP450 Induction protein binding Rapid Equilibrium Dialysis RED Ultrafiltration Analytical Ultracentrifugation UC Melanin Binding Metabolic Stability microsomes S9 hepatocytes Metabolic ID Metabolic profiling Matrix stability Red Blood Cells RBC Permeability Effux Caco-2 MDCK MDCK-MDRI MDCK-BCRP influx transporters hERG hERG Inhibition cell proliferation Cytotoxicity Show 34 more tags Show less

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Mouse Models

Price on request

With more than 20 breeding facilities around the world, Charles River is the leading global supplier of standard mouse models for biomedical research. Charles River stocks and strains are managed under the International Genetic Standardization (IGS) program, a unique program designed to manage the health and genetics of outbred and inbred strains on a global basis, ensuring that researchers worldwide have access to standardized models, regardless of the production location. Please find the following resource. RMS: Germ-Free Mice

Mouse Models inbred mice outbred mice hybrid mice germ-free mice immunodeficient mice nude mice SCID mice congenic mice Coisogenic mice oncology mice humanized mice microbiome mice Mice Show 14 more tags Show less

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3D Cell Culture Models

Price on request

In conjunction with our drug sensitivity and molecular characterization data, our 3D assays, done by using our proprietary patient-derived xenograft (PDX) explants, enable you to evaluate the potency of your compound compared to standard-of-care drugs. This allows you to identify the most promising drug candidates, tumor histotypes and molecular subtypes for further testing.

Data collected in these assays can then be used to select PDX models for subsequent in vivo efficacy tests. The data can also be used to run systematic two-drug combination therapy studies over a range of concentrations and to correlate the tumor response with molecular data (biomarker identification).

PDX Patient-derived xenograft 3D Tissue Culture spheriod assays

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Hit to Lead and Lead Optimization

Price on request

Hit to lead: Charles River conducts hit-to-lead projects in an efficient cycle of rational design, synthesis and biological evaluation. Typically, multiple hit series are evaluated in parallel, with a view to establishing the scope for further optimization. One or two series are then selected for progression into lead optimization studies.
Lead optimization projects: We are able to consistently deliver high-quality development candidates (over 75 since 2001) within industry standard timelines, including the data required to support progression into investigational new drug studies. A significant percentage of the 75+ candidates identified have progressed to clinical proof-of-concept, illustrating their high quality.

Hit to lead Lead optimization

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Traumatic Brain Injury Animal Models

Price on request

Charles River conducts contract studies in established animal models of traumatic brain injury (TBI) to test the efficacy of novel therapeutics. We offer acute or long-term (chronic) histological, functional and behavioral follow-up along with detailed MRI/MRS imaging capabilities.

Spinal cord injury Rodents CNS/Neurology TBI Traumatic Brain injury

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Vaccine Production

Price on request

Charles River Laboratories can help expedite our clients’ vaccine development programs, from manufacturing for early-phase clinical trials through to lot release (potency assays) for commercial products. We have more than 20 years of experience manufacturing vaccines and viruses in cell culture, including dengue, influenza, and respiratory syncytial viruses.
Services:

  • cGMP virus and cell banking
  • Vaccine manufacturing via cell culture and SPF eggs
  • Vaccines for clinical trials (manufacturing scale – up to 7,500 vials per batch)
  • Pilot-scale virus manufacturing
  • Adaptation of production using animal component free reagents
  • Ability to work with clients to optimize processes and raise titers

Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers, Biologics: Cell Banking and Storage and Biologics: Cell Line Characterization

Vaccine Production manufacturing GMP Virus Production Cell Banking

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Ocular Toxicology

Price on request

Charles River performs safety and efficacy assessments for all ocular indications and tests for ocular effects of compounds administered by other routes. Ocular toxicity is characterized by one or more adverse changes that affect the structure or function of the eye following application of a substance, drug, or device. Please find the following resource. Safety: Ocular Toxicology

Mouse Rat Minipig Rabbit Ocular Research Ocular Image Ocular Study Macular Degeneration AMD Diabetic Retinopathy glaucoma cytomegalovirus intravitreal subretinal eye irritation test cnv opthalmology veterinary opthalmology MPI Research Show 18 more tags Show less

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Analytical Method Development

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following source. Biologics: Comprehensive Services for Biologics Developers and Manufacturers

Analytical Method Development Method Development QC testing Quality Control Method Validation Method Transfer Release Testing Show 7 more tags Show less

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Immunoassays

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource. Biologics: Comprehensive Services for Biologics Developers and Manufacturers Assay types include ADA screening, confirmatory, titration and isotyping, and neutralizing antibody (nAb). Please find the following resource. Safety:Investigational new drug development

Immunoassays Host cell proteins HCP

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Compound Profiling

Price on request

Identification of a compound’s target specificity and potential for off-target effects is a critical step in the drug discovery process and often includes assessments against specific target class families, critical safety targets or by therapeutic area. Charles River offers the largest collection of validated functional assays for ion channel selectivity profiling. Our ion channel portfolio includes over 120 assays, which have been organized into Channel Panels™ based on current scientific findings. We can provide functional, manual and automated ion channel screening by therapeutic area for profiling and risk assessment. Molecular target identification, or target deconvolution, is essential for understanding compound mechanism and further optimizing compounds of interest in the drug discovery pathway. Leverage CCMS, our proprietary technology for phenotypic screening target deconvolution.

CCMS Ion Channel Selectivity Ion channel profiling

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Analytical Method Validation

Price on request

Production, supply and analysis of quality dose formulations are essential to the integrity of any preclinical program and key to a successful study. Whether we are following a client-derived formulation procedure or a procedure developed by one of our experienced formulation development scientists, we ensure that pharmaceutical formulations are prepared and analyzed appropriately.

https://www.criver.com/products-services/lab-sciences/formulation-product-chemistry/formulation-development-analytical-chemistry?region=3601

High performance liquid chromatography (HPLC)  Ultra-high performance liquid chromatography (UPLC)  Gas chromatography (GC) Gas chromatography–mass spectrometry (GC-MS) Liquid chromatography/mass spectrometry  (LC-MS and LC-MS/MS) Atomic absorption spectroscopy (AAS)  UV/Vis spectroscopy Fourier transform infrared (FTIR) spectroscopy  Capillary electrophoresis (CE)  Karl Fischer titration Inductively coupled plasma (ICP-OES, ICP-MS)  Nuclear Magnetic Resonance Differential Scanning Calorimetry (DSC) Thermogravimetric analysis Show 14 more tags Show less

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X-ray Crystallography

Price on request

The structural biology team at Charles River carries out high-resolution structure determination by X-ray crystallography to support both stand-alone and integrated drug discovery projects. We have access to both in-house and synchrotron data collection facilities to provide fast turnaround and high-throughput structure determination (including fragment screening campaigns).
Integration of protein production, crystallization and structure solution allows for efficient streamlining of the structure determination process. The resulting structures, combined with the significant industrial design experience of our crystallographers and integrated with results from advanced biophysical assays, allow us to detail protein-ligand interactions at a structural, kinetic and thermodynamic level and provide insight to drug design projects.

  • In-house X-ray facility with synchrotron access
  • Crystal bank of structures
  • Electron density maps
  • Scaled and merged diffraction data
  • Complete atomic coordinates
  • Structure interpretation
  • Ligand binding analysis (where appropriate)
  • Advice on medicinal chemistry design (where appropriate)

X-ray crystallography

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Orthotopic Tumor Animal Models

Price on request

Orthotopic cancer models by Charles River were developed for use in the efficacy evaluation of novel anticancer compounds. Charles River offers the following orthotopic tumor models: Renal Sub-Capsule Orthotopic Model of Cancer; Intracranial Orthotopic Model; Intrasplenic Hepatic Colonization Model; Orthotopic Breast Tumor Model; Systemic Leukemia/Lymphoma Model

Syngeneic tumor model xenograft tumor model

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Animal Behavior Studies

Price on request

Anxiety/Depression
Forced Swim Test
Tail Suspension Test
Light/Dark Box
Cognition
-Novel Object Recognition (Natural Forgetting, Scopolamine -Induced Deficits, Phencyclidine Induced Deficits)
-Contextual Fear Conditioning
Motor Activity/Coordination
-Home Cage Locomotor Activity
-Open Field Test
-Rotorod
-Grip Strength
Psychosis/Mania
-Apomorphine Rearing/Climbing
-Psychostimulant Induced Locomotion
All behavior studies are carried out in mice or rats in our state of the art U.S. facility under review of an Institutional Animal Care and Use Committee. In addition to the array of pharmacologically validated assays, we strive to develop of new tests (in house or in collaboration with the sponsor). Given our expertise in microdialysis, all of our behavioral studies can be coupled to in vivo neurotransmitter monitoring via traditional microdialysis or with the use of biosensors.


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X-Ray Powder Diffraction

Price on request

Use X-ray crystallography to generate protein-ligand complexes that provide invaluable insights to your drug discovery teams. Charles River carries out high-resolution structure determination by X-ray crystallography to support both stand-alone and integrated drug discovery projects. We have access to both in-house and synchrotron data collection facilities to provide fast turnaround and high-throughput structure determination (including fragment screening campaigns). Protein Crystallization capabilities include: Robotic nanoliter-scale screening and imaging; Screening with known ligands; Automated optimization of conditions for crystal growth; Co-crystallization or soaking of ligands
X-ray crystallography capabilities include: Electron density maps; Scaled and merged diffraction data; Complete atomic coordinates; Structure interpretation; Ligand binding analysis (where appropriate); Advice on medicinal chemistry design (where appropriate)

X-ray crystallography protein crystallization structural biology

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Controlled Release Systems

Price on request
Request a quote for more information about this service.

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Animal Blood Collection

Price on request

Blood sampling is performed using automated Dilab AccuSamplers®
-Higher degree of precision and repeatability
-Sampling over prolonged periods of time
-Robust set-up for overnight operation
-Freely-moving and stress free conditions


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Parkinsons Disease Animal Models

Price on request

Charles River offers a comprehensive and more readily translatable modeling platform of chemically and biologically induced and genetic models to study mechanism of action and efficacy of novel PD therapies. The portfolio of animal models of Parkinson’s disease includes established chemically induced models (6-OHDA and MPTP) and genetic models (alpha-synuclein).
Please find the following resource. Discovery:Neuroscience

Parkinson's disease (PD) PD 6-OHDA MPTP-induced Parkinson's disease model AAV-A53T Mice unilateral 6-OHDA lesion MPTP Lesion model AAV-A53T Mice CNS/Neurology Mouse Rat Show 11 more tags Show less

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Particle Analysis and Characterization

Price on request

Our global capabilities can support the development of small and large molecule pharmaceuticals, as well as chemicals, agrochemicals, biocides and veterinary medicines. By continually investing in highly trained chemists, as well as state-of-the-art facilities and instrumentation, not only do we remain at the forefront of laboratory technology, we can be certain of delivering data that is consistent, rapid and reliable.

https://www.criver.com/products-services/lab-sciences/formulation-product-chemistry?region=3601

residue analysis Physiochemical Testing substance identity testing

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Animal Microsensor Studies

Price on request

Microsensoring has a higher spatial (10-25 μm diameter) and temporal resolution (second-scale recording of neurotransmitters) than microdialysis. Therefore, it can provide more spatial-temporal resolution measurements and capture the fast change neurotransmitter levels, glucose or other physiological compounds.

In our lab we routinely monitor brain glutamate and periphery glucose levels in both anesthetized and freely moving animals.

Currently we have sensors available for the monitoring of
-Lactic acid
-Glutamate
-Glucose
-NO
-H2O2
-Acetylcholine
-Choline

Sensors can be applied in
-Brain
-Spinal cord
-Subcutanous


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Dose Range Finding (DRF) Studies

Price on request

Information generated in dose range finding assessments is used to guide the design and selection of dose levels for subsequent subchronic and chronis toxicity studies. Our staff can advise the selection of appropriate in vivo models and routes of administration for optimum study results. The selection of appropriate dose levels for toxicity studies is of great importance in assessing human risk. Our toxicologist can advise clietns and design dose range finding studies that include dose escalation/maximum tolerated dose studies to provide sufficient information to proceed to longer term studies

https://www.criver.com/sites/default/files/resources/GeneralToxicologyDatasheet.pdf

dose range finding Dose range finder DRF Rat rats Mouse Mice canine Dog Dogs Pig swine Minipig Non-human primates (NHP) Rabbit Show 15 more tags Show less

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PCR

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource. Biologics: Comprehensive Services for Biologics Developers and Manufacturers

qPCR PCR Quantitative Polymerase Chain Reaction qPCR Assay

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In vitro Percutaneous Absorption Studies

Price on request
BPA Skin sensitization skin irritation skin corrosion 3D human skin model

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Animal Plasma and Serum

Price on request

Charles River can provide blood products, tissues, and organs collected from VAF/Plus® rats, mice, guinea pigs, hamsters, or gerbils. We also have VAF/Elite® (immunodeficient and immunocompetent) models available for a limited selection of tissues and organs.

 

 

 

https://www.criver.com/products-services/research-models-services/research-model-products/biospecimens/blood-products-tissues-organs?region=3611

https://www.criver.com/products-services/research-models-services/research-model-products/biospecimens?region=3601

biospecimens blood products VAF/ELITE VAF/Plus Mice Mouse CD-1 mouse Sprague Dawley rat Guinea pig Hamster gerbils Show 11 more tags Show less

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In Vitro Skin Corrosion Test

Price on request

Many acute toxicity tests have been or are being effectively replaced by in vitro human, animal and 3D tissue alternatives. This shift is particularly evident in skin irritation, skin corrosion and skin sensitization models, all of which are fully supported at Charles River.

Skin Corrosion Assays:
SkinEthic EpiSkin® skin corrosion (OECD 431)
Corrositex® skin corrosion (OECD 435)
Acute dermal rodent

SkinEthic Spiskin skin corrosion OECD 431 Corrositex skin corrosion OECD 435 acute dermal rodent Rodents Show 6 more tags Show less

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Animal Surgery

Price on request
  • Vascular Catherterizations
  • Non-Vascular Catheterizations
  • Soft Tissue Procedures
  • Neurological Procedures
  • Cardiovascular Procedures
  • Device Implants

Preconditioning services can help alleviate the space, time, and labor costs involved with refining a model to meet your unique research requirements. Whether you are looking for animals fed a special diet, altered through surgery, or reared to a certain age, Charles River has the state-of-the-art animal facilities, professional animal care, and robust model selection to deliver study-ready animals right to your door. Please find the following resources. RMS:Surgical Services and RMS:Labstamp animal identification

Charles River is AALAC certified.

atherosclerosis Mouse Rat Guinea pig

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In vitro Skin Irritation/Sensitization Testing

Price on request

Many acute toxicity tests have been or are being effectively replaced by in vitro human, animal and 3D tissue alternatives. This shift is particularly evident in skin irritation, skin corrosion and skin sensitization models, all of which are fully supported at Charles River. Skin Sensitization Assays: * DPRA (direct peptide reactivity assay) * KeratinoSens and LuSens * MUSST * hCLAT * In silico (QSAR) * LLNA (local lymph node assay) * GPMT (guinea pig maximization test) * Buehler assay (contact sensitization) * DTH (delayed-type hypersensitization) Irritation Assays: * SkinEthic EpiSkin® skin irritation (OECD 439) * MatTek EpiOcular® eye irritation (OECD 492) * Bovine cornea and opacity permeability (BCOP – OECD 437) * Hen’s Egg Test (HET)-CAM ocular irritation * Ocular and dermal acute non-rodent * Acute dermal rodent

Toxicology Minipig DPRA direct peptide reactivity assay KeratinoSens LuSens MUSST in silico QSAR LLNA Local Lymph node assay GPMT Guinea pig maximization test Buehler assay contact sensitization DTH delayed-type hypersensitization GARDskin genome test SkinEthic Episkin skin irritation OECD 439 Dermal acute nonrodent acute dermal rodent Rodents Guinea pig Rat rats Show 27 more tags Show less

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Drug Preformulation

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resource. Biologics: Comprehensive Services for Biologics Developers and Manufacturers

Preformulation Drug Preformulation Formulation formulation development process development GMP Manufacturing Show 6 more tags Show less

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Bioanalysis

Price on request

With 12 laboratories around the world, we offer comprehensive bioanalytical services at every state of product development from discovery to post marketing studies. Our experienced scientists develop, validate and apply quantitative bioanalytical methods to measure drug and metabolite concentrations for both small and large molecules in all biological matrices. Please find the following resource. Safety:Bioanalysis

bioanalysis Bioanalytical bioanalytical methods bioanalytical support metabolite concentrations LIMS LC-MS/MS Mass Spectrometry capillary microsampling dry blood spot bioanalytical chemistry bioanalytical services Immunochemistry DBS Bioanalytical assays drug development drug discovery Show 17 more tags Show less

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In vivo Biosafety Testing

Price on request

To help with safety evaluation, we provide in vivo biosafety (IVB) testing in our AAALAC-accredited laboratories according to GMP guidelines. IVB testing services include mouse/rat/hamster antibody production (MAP/RAP/HAP), inapparent virus assays, tumorigenicity testing and abnormal toxicity/general safety testing. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

Antibody Production Tumorigenicity GMP inapparent virus general safety Mouse Rat Hamster in vivo Biosafety testing MAP RAP HAP abnormal toxicity Adventitious Agent testing Guinea pig in vitro biologic potency testing Potency Assay Stability Indicating Methods drug protection release Biosimilarity analysis In vivo bioassays In vitro bioassays Show 22 more tags Show less

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Product Quality Control

Price on request

Analytical QC Testing and Product Release

https://p.widencdn.net/ehuoxw/BI-PS-drug-product-release


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Endocrine Disruptor Screening

Price on request

A complete package of 11 endocrine disruptor assays for the EPA and OECD guidelines to screen pesticides, chemicals, and other environmental contaminants for potential impact to human endocrine system.

endocrine disruptor assay endocrine disruptor screening estrogen receptor binding assay Androgen receptor binding assay Estrogen receptor transcriptional activation assay androgen receptor transcriptional activation assay steroidogenesis aromatase assay Show 8 more tags Show less

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Biochemistry & Molecular Biology

Price on request

Charles River performs a comprehensive array of genomics-based assays to support all phases of drug development, from discovery and preclinical studies through clinical trials, in either singleplex or multiplex formats. Please find the following resource. Safety: Laboratory Science

drug development drug discovery

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Endotoxin Testing

Price on request

The endotoxin testing performed by Charles River uses customer-requested methods for submitted samples. Our optimized formulations provide increased sensitivity, greater linearity, and superior interference resistance. Formulations are offered with a comprehensive range of buffers and accessories, providing numerous options for resolving interferences with difficuit to test products. Please find the following resource.
Microbial: Endotoxin Testing

LAL Product Validation Routine Endotoxin Determination-Gel-clot Routine Endotoxin Determination-Turbidimetric Routine Endoctoxin Determination-Chromogenic Kinetic Stability Testing Product Release Testing Depyrogenation Validation On-Site Training SOP and Protocol Writing raw material in-process samples medical devices dialysis fluids chromogenic Kinetic cartridge technology stability gel-clot Kinetic Turbidimetric Chromogenic PTS Product Release final product Limit Tests semi-quantitative test dry heat dry-heat Depyrogenation Gel-clot limit-test Gel-clot semi-quantitative test Turbidimetric Kinetic Chromogenic Endpoint GMP in vitro in vivo Monocyte activation testing Endosafe LAL cartridge technology Kinetic chromogenic reagent Show 40 more tags Show less

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Protein Purification

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers, Biologics: Cell Banking and Storage and Biologics: Cell Line Characterization

GMP Manufacturing Protein Purification Biopharmaceutical manufacturing

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Radiochemistry

Price on request

Charles River uses molecular imaging techniques to examine animal models of disease such as positron emission tomography, PET, a non-destructive imaging procedure.

microPET positron Emission tomography PET MicroSPECT single photon emission computed tomography molecular imaging animal model imaging Show 7 more tags Show less

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IND/NDA/BLA Submission

Investigational New Drug/New Drug Application Submission
Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers, Biologics: Bioassay Services, Biologics: Cell Line Characterization, Biologics: Viral Clearance and TSE Clearance Studies, Biologics: Cell Banking and Storage and Biologics: Drug Product Release

IND NDA BLA IND Submission NDA submission BLA submission regulatory submission Regulatory filing Show 8 more tags Show less

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Environmental Impact Assessment

Price on request

Charles River conducts a range of environmental risk studies to meet the needs of the regulatory bodies worldwide. Studies are available for chemicals, biocides, pharmaceuticals and veterinary products.

environmental risk assessment ectotoxicology bioaccumulation biodegradation REACH

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Integrated Drug Discovery

Price on request

Shorten times to IND with an integrated approach to drug discovery. Eliminate complicated logistics, increased administrative costs, and cycle time slippage by contracting with an organization that manages your project every step of the way.The industry standard from hit identification to development candidate nomination is on average 33-36 months. Charles River’s truly integrated drug discovery programs have reduced this timeline to as little as 24 months through industry experienced, multi-disciplinary teams focused on resource efficiency, scientific excellence and strategic partnerships with clients through all aspects of drug discovery. With numerous technologies for hit identification, coupled with a knowledge-based approach to advance compounds from hit-to-lead into lead optimization, our scientific advisory services team consistently convert leads into successful preclinical development candidates.

CNS/Neurology integrated drug discovery target discovery Hit Identification hit-to-lead Lead optimization Show 6 more tags Show less

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Ex vivo Electrophysiology

Price on request

At Charles River, a variety of in vivo single-cell recording studies and brain slice electrophysiology are performed. In vitro / ex vivo patch clamp recording allows the direct measurement of neuronal activity of a single cell or channel (receptor) and is also used to quantify synaptic inputs from excitatory and inhibitory circuits in tissue obtained from living animals.
Multiplexed electrophysiological recordings from brain slices using multi-electrode arrays are a direct way to probe neural function, detect pathological functional abnormalities and explore sensitivity of spontaneous and evoked electrical signal transmissions to drugs. The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and some brain pathologies. Up- or down-regulation of synaptic transmission can shed light on cellular and network mechanisms of numerous CNS diseases, including Alzheimer’s disease, autism and ataxia.

Safety Pharmacology hERG CiPA Cardiac assays Neuronal assays ADP in vitro Electrophysiology Show 7 more tags Show less

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Regulatory Affairs Services

Price on request
Request a quote for more information about this service.

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Biomolecular Interaction Analysis

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Biacore biomolecular interaction analysis

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Ion Channel Screening Assays

Price on request

Charles River works collaboratively with our partner to enable them to translate ion channel discoveries into tomorrows therapeutics in a timely and cost effective manner. As your scientific partner, we work to provide innovation through new assays and cell lines,  flexibility with our screening services or cell lines for in-house efforts and efficiency in the drug development process.  Capabilities include:  - Assay development and transfer  - Fluorescence-based screens of up to 700,000 compounds (FLIPR¬Æ / Hamamatsu FDSS)  - IonWorks¬Æ Quattro and IonWorks¬Æ Barracuda‚Ñ¢ screens of up to 125,000 compounds per target (voltage-gated and ligand-gated ion channels)  - Conventional as well as PatchXpress¬Æ and QPatch HT¬Æ automated electrophysiology for detailed pharmacological and biophysical follow-up studies  - Ion channel selectivity profiling  - Computational chemistry for knowledge-based compound deck selection from our 850,000 diverse compound library  - Hit-to-lead and lead optimization support using fluorescence-based, automated and conventional electrophysiology  - GLP hERG and related cardiac safety liability studies. Please find the following resources. Discovery: Ion Channel Screening and Discovery: Ion Channel Portfolio

Drug Discovery Hamamatsu FDSS/μCell IonWorks® Quattro IonWorks® Barracuda™ PatchXpress® QPatch HT® ion channels ion channel screening in vitro biology Drug Discovery FLIPR FDSS Quattro PatchXpress QPatch HEK293 CHO Cell Lines Cardiac Channel Assay Mouse Rat Show 21 more tags Show less

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Biopharmaceutical Manufacturing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers, Biologics: Bioassay Services, Biologics: Cell Line Characterization, Biologics: Viral Clearance and TSE Clearance Studies, Biologics: Cell Banking and Storage and Biologics: Drug Product Release

Biopharmaceutical manufacturing biologics vaccines biosimilars GMP Manufacturing

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Safety Pharmacology

Price on request

Understanding and mitigating the potential risks your program faces are crucial to a successful IND submission. Our comprehensive, global and harmonized safety pharmacology program complies with International Conference on Harmonisation (ICH) Guidelines (S7A, S7B) and provides the expert interpretations needed to advance your program successfully. Please find the following resource. Safety: Safety Pharmacology

MPI Research Safety Pharmacology safety pharmacology studies safety pharmacology models ICH S7A ICH S7B core battery test drug safety in vivo research pharmacology program cardiovascular drugs Pharmacology CiToxLabs-Formerly Xenometrics in vivo Cardiovascular Radiolabel telemetry in vitro hERG Patch Clamp CNS/Neurology Functional Observational Battery FOB motor activity Figure-eight maze cognition and memory auditory startle PTZ metrazole seizure model gastrointestinal secretion GI motility Liquid gastric emptying Plethysmography Dog Rabbit Rat Rhesus/Cynomolgus Monkey feline Minipig Mouse Rodents Show 36 more tags Show less

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Liver Fibrosis Animal Models

Price on request

No single animal model accurately recapitulates the histopathology and metabolic profile of nonalcoholic steatohepatitis (NASH), but several have been identified that simulate the disease. Charles River capabilities include two animal models of NASH: Choline Deficient, Defined Amino Acid (CDAA) Mice; High Fructose, High Fat, Cholesterol Diet in ob/ob Mice

Non-Alcoholic Steatohepatitis (NASH) NASH Nonalcoholic Steatohepatitis Models

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Functional Human Tissue Assays

Price on request

Our immunology groups can evaluate a compound’s potential to be an immunosuppressor or an immunostimulator. We can provide you with fully integrated services to support toxicology and clinical studies that determine the safety of compounds and define immunological endpoints and alterations of cellular function induced by test compounds.

 

https://www.criver.com/products-services/lab-sciences/immunology-testing/immune-functional-assays?region=3601

immunology Immune functional assays Flow cytometry ELISA

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Mammalian Cell Culture

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Mammalian Cell Culture Cell Line Characterization Cell Banking

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Gas Chromatography (GC)

Gas Chromatography
Price on request

All of our facilities have laboratories suitable for the preparation of dosing formulations. Each laboratory is equipped to prepare formulations of any batch size required for preclinical programs and is designed to eliminate cross-contamination. Full accountability of test article usage is maintained at all stages, as required by Good Laboratory Practice (GLP). Formulated products are stored under pre-defined controlled conditions. Analyses of dosing formulations for identity, accuracy, homogeneity (if applicable) and stability are conducted in one of our Analytical Chemistry laboratories.

The Dispense™ software system is used throughout the formulation process to maintain a full record of test item usage, from initial receipt through formulation and dispensing to disposal. Extensive use of bar coding and online electronic data capture from the balance ensures a high level of data integrity and minimizes the potential for error.

https://www.criver.com/products-services/lab-sciences/formulation-product-chemistry/formulation-development-analytical-chemistry?region=3601

GLP GC Gas Chromatography Dispense Batch size analytical chemistry identity accuracy homogeneity bar coding solution suspension emulsions capsules diets parental inhalation radiolabeled topical Show 19 more tags Show less

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Gene Therapy Development

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine,gene and cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

Gene Therapy AAV testing Cell Therapy

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Medical Device Testing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

https://p.widencdn.net/okdzgt/SA-DS-medical-devices-services-and-facilities

GMP

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Genetically Engineered Mice

Price on request

Charles River provides off-site space for holding, breeding, and developing genetically engineered mouse and rat colonies. All colonies are assigned a dedicated project manager and clients are granted access to Charles River’s innovative Internet Colony Management (ICM™) system. Whether you want to simply maintain a line, produce regular animal shipments for your studies, or backcross your strain to a different genetic background, each breeding colony is scalable to your specific research needs.
Our Isolator-based animal quarantine facilities allow for the direct acceptance of animals from any institution worldwide, regardless of their known or unknown health status. This flexibility provides options to screen animals that would otherwise not be allowed into many animal facilities and speed up the process of acquiring valuable research animals. At the completion of the quarantine period, animals that are proven negative of excluded agents are allowed directly into most barrier facilities without the need to rederive.
Charles River works with global customers on unique transgenic models to deliver study-ready cohorts to meet research needs. Our dedicated project management team, scientists, and animal care staff are always available to offer guidance, develop work plans, and help overcome any challenges. Through partnerships with genomics industry leaders, our combined expertise provides an optimum environment for generating, characterizing, preserving, and distributing your transgenic lines.

Please see the following resources. GEMS:rederivation services , GEMS:Rapid Quarantine , GEMS:Line rescue services , GEMS:Transgenic models creation through colony expansion , GEMS:Model Creation , GEMS:Transgenic Model and Service

Breeding services Quarantine Services Trangenic Model Creation Model creation Products and Services Rederivation Services Cryopreservation Services Cryorecovery services Assisted Reproduction Services rat breeding mouse breeding rat and mouse breeding rodent colony management MAX-BAX Quarantine Isolator quarantine Transgenic model creation Model Creation genomics CRISPR/Cas9 genome editing RNAi ES cell mutagenesis Knockin Mice Knockout Mice microinjection services DNA transgeneis transgenes SNP modification ES Cell Injection CRISPR Injection plasmid BAC DNA blastokit embryos sperm rederivation IVF IVF rapid expansion embryo rederivation Cryopreservation embryo cryopreservation sperm sperm cryopreservation germplasm cryostrorage cryostorage cryorecovery reconstitution embryo reconstitution sperm reconstitution reproduction services assisted reproduction mouse rescue mouse embryo assay MEA human sperm assay HAS Mouse Rat Show 58 more tags Show less

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Clinical Laboratory Services

Price on request

Charles River may be mostly known for preclinical services but we offer a wide range of clinical support from Phase I through Phase IV clinical trials. Biomarker development and analysis, bioanalytical chemistry, Immunogenicity, biologics testing and manufacturing as well as customized clinical sample kit assembly and sample management for Phase I to III clinicial trials worldwide.

Clinical chemistry

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Laboratory Animal Monitoring

Price on request

360 Diagnostics

Our diagnostic laboratory is a full-service rodent and rabbit necropsy laboratory with a complete spectrum of specialized services, including infectious disease PCR, serology, microbiology, pathology, and parasitology. We offer testing services on multiple laboratory animal species for both routine surveillance and diagnosis of diseases.Using Multiplexed Fluorometric ImmunoAssay® (MFIA®), Charles River's primary serology testing method, allows our lab to test multiple strains of a single pathogen as well as incorporate system and sample suitability controls for increased sensitivity and accuracy. Available profiles include mouse, rat, hamster, guinea pig, rabbit, gerbil, simian, custom profile, and single agent assay upon request.Our microbiology services incorporates MALDI-TOF mass spectrometry analysis for screening bacterial species that are primary pathogens as well as a select group of bacteria that are considered to be important opportunistic agents. Screening can be completed as part of whole live animal health monitoring or from individual samples collected at your facility and submitted to us. Microbiological analysis is available for mice, rats, hamsters, guinea pigs, gerbils, rabbits, zebrafish, ferrets, and nonhuman primates.Endo- and ectoparasites continue to be a significant concern for laboratory animal facilities. Charles River offers multiple screening methods for the detection of parasites in rodent, rabbit, and large animal colonies. Samples (e.g., feces, swabs, tapes) collected at your facility can be submitted directly to our laboratory for testing. We can also work directly with you to develop a testing regimen that supplements your health monitoring program.Charles River offers you the flexibility of outsourcing any part of your pathology requirements. The laboratory is overseen by ACVP board-certified veterinary pathologists and offers custom protocol design and rapid report turnaround. Our services range from routine diagnostic assessment to pathology support as part of your in-house research studies.We offer comprehensive diagnostic testing services for both pre-export testing and health monitoring of your nonhuman primate (NHP) colonies. Please note that these testing services are available for samples only. Our health monitoring services are fully customizable to meet your specific program requirements. Please find the following resources. RMS:360 Diagnostics , RMS:GE-DS Simian Testing Services , RMS:Zebrafish Testing Services , RMS:Ferret Health Surveillance , RMS: Culture Technical Sheet and RMS:Next generation Sequencing

Animal Health Surveillance Serology Profiles Microbiology Culture Rodent and Rabbit Parasitology Necropsy and Histology Services Simain (Non Human Primate) Health Surveillance Zebrafish Health Surveillance Ferret Health Surveillance Serology Reagents for in-house Animal Health Surveillance Clear-cell line Research Biologics screening Microbiome Diagnostic Services health Monitoring alternative health monitoring health surveillance PRIA EAD PCR FELASA Serology MFIA Multiplexed fluorometric immunoassay IFA Indirect Fluorescent Anitbody ELISA Enzyme-linked immunosorbent assay mouse serology HemaTIP Blood microsampler rat serology hamster serology guinea pig serology rabbit serology gerbil serology rodent serology MALDI-TOF upper respiratory culture gastrointestinal tract culture microbiology services Environmental Monitoring surface testing RODAC rodent parasitology rabbit parasitology rat parasitology mouse parasitology necropsy histology diagnostic pathology clinical pathology simian health surveillance simian health monitoring nonhuman primate health monitoring simian macaque baboon african green Flavivirus serology reagants in-house health surveillance indirect fluorescent antibody Clear PCR Panel CLEAR Rodent infectious agent human infectious agent customized panel Next Generation Sequencing NGS Germ-free microbiome microbial cultures animal monitoring Mouse Rat Guinea pig Rabbit Hamster Gerbil Non-human primates (NHP) Zebrafish Ferret Show 81 more tags Show less

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Microbiology Testing

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Please find the following resources. Biologics: Comprehensive Services for Biologics Developers and Manufacturers and Biologics: Drug Product Release

Microbiology testing GMP microbiology endotoxin Sterility USP EP Cytotoxicity bioburdenmicrobial limits Preservative Effectiveness Testing (PET) Disinfectant Efficacy Determination Environmental Monitoring Microbial Identification Spiroplasma Water analysis Antibiotic testing celsis amplified ATP-based bioiluminescnece Rapid Microbial Methods RMM Microbial Detection Show 20 more tags Show less

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Carcinogenesis Animal Models

Price on request

Charles River offers the transgenic rasH2 mouse model as an alternative to the full 2-year carcinogenicity study design and has commenced more than 60 studies in this model since 2013. Please find the following resources. Safety: Carcinogenicity and Safety:Transgenic Carcinogenicity

Sprague Dawley rat Rat rats Wistar Han rat CD-1 mice tg-rasH2 p53 mouse Tg.AC mouse Show 8 more tags Show less

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Carcinogenicity/Tumorigenicity Testing

Price on request

Regulatory guidelines necessitate carcinogenicity testing in human pharmaceuticals intended for long term therapeutic use or chemicals expected to have prolonged human exposure. Carcinogenicity studies expose animals to the test compound for a major portion of their lifespan to assess the development of non-neoplastic and neoplastic lesions of multiple organs and organ systems. Carcinogenicity studies performed to support pharmaceutical candidates are normally completed before submission of an application for market approval. Given the cost of carcingenicity testing, study duration, and the number of animals involved, it is imperative that sponsors work with a contract reseaqrch organization that can deliver flawless execution and that has experience to appropriately assess the tumorigenic potential of a compound and relevance of risk to humans. Charles River has built a worldwide reputation for excellence in teh conduct of conventional design, transgenic,a nd diet optimized rodent carcinogenicity programs. Our global scientific network offers experience, knowledge, and services that are second to none in the industry.

 

[Safety: Carcinogenicity](https://p.widencdn.net/zdpzgb/SA-OS-carcinogenicity-testing-services)

Rabbit Mouse Rat Minipig

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IND-Enabling Studies

Price on request

Learn through our years of IND research experience, unique range of services and best-in-class expertise how we can help you successfully initiate and complete your IND-enabling program. With our ongoing efforts to improve upon our internal processes and continued focus on scientific excellence and guidance, we are pleased to offer a highly cost-effective IND program for our clients. Please find the following resource. Safety:IND E-Guide

IND-Enabling Studies IND Submission Investigative New drugs Exploratory IND studies

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Scientific Sourcing

Price on request

The Charles River RightSourceTM scientific staffing program is a flexible insourcing/outsourcing option for biologics developers and manufacturers. The RightSourceTM program removes the challenges of externalizing your biologics testing by providing customized options that allow you to maintain as much or as little control over your in-house resources, capital assets and facilities that you consider strategic and cost efficient. We work with you to evaluate your quality control (QC) testing programs by reviewing your current testing structure and selecting the best-suited and most cost-efficient mix of insourcing and outsourcing options. Combining 20 years of experience in facility management, staffing and consulting services with a long-standing history of operating quality control testing laboratories makes Charles River the best choice for your scientific staffing needs.

Insourcing Outsourcing Project management QC management QC services QC testing Staffing Show 7 more tags Show less

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Antibody Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Antibody Production antibody manufacturing Antibodies Proteins Monoclonal antibodies polyclonal Antibodies antibodies Monoclonal antibodies polyclonal antibodies proteins antibody/antigen detection based testing Show 11 more tags Show less

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Antibody-Drug Conjugate (ADC) Analysis

Price on request

Charles River provides a broad array of analytical services designed to deliver a complete set of analytical solutions for antibody-drug conjugate (ADC) development and testing. We have worked on many conjugate projects across multiple biologic drug-conjugate technologies for some of the leading ADC product developers, including: Antibody-Drug Conjugates, Protein-Drug Conjugates, Antibody-Peptide Drug Conjugates, Peptide-Drug Conjugates Services for ADCs, and other conjugated products include: Drug-to-Antibody Ratio (DAR) Determination Site Occupancy via Mass Spectrometry Experience with Key Conjugation (Linker) Technologies Analysis of Free Drug (Payload) and Naked Carrier Protein / Antibody Confirmation of Secondary Structure and Aggregation (HOS) Extensive Method Development and ICH Validation Capabilities Methods for Quantifying Drug-Conjugate Components for PK and PD Studies Mapping of PTMs, Disulfide Bonds and Glycosylation cGMP Lot Release and Stability Testing Reference Standard Characterization Solubility Studies, Pre-formulation and Formulation Development Forced Degradation Degradants, Impurities and Isoform Characterization Bridging Studies and Comparability Programs

ADCs ADC Anti-drug Conjugates Protein-Drug Conjugates Anti-peptide Drug Conjugates Peptide-Drug Conjugates Show 6 more tags Show less

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Assay Development Consulting

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

assay development assay method development Assay Method validation Assay Method feasibility

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CAR-T Cell Therapy Development

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Immuno-Oncology

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Cell Banking

Price on request

Cell lines must be tested for the presence of general and specific contaminants to ensure the safety of the associated biological product. Our team collaborates with clients to develop scientifically sound and cost-effective cell bank programs. We manufacture cell banks for mammalian, microbial, insect, yeast and stem cells and can provide the appropriate cell storage services, all under Good Manufacturing Practice (GMP) guidelines. Our capabilities include purity, sterility, identity, genetic stability testing and an array of other characterization assays from our expansive testing portfolio. Our experienced technical staff can customize a project to create and characterize master cell banks, working cell banks, research cell banks, end-of-production cells and cells at the limit of in vitro cell age, according to client specifications. Please find the following resources.
Biologics: Cell Banking and Storage

GMP insect cells Mammalian cells Microbial cells stem cells Yeast Bacteria Show 7 more tags Show less

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Cell Culture Consulting

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

GMP insect cells Mammalian cells Microbial cells stem cells Yeast Bacteria Show 7 more tags Show less

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Cell Line Characterization

Price on request

Cell lines must be tested for the presence of general and specific contaminants to ensure the safety of the associated biological product. Our team collaborates with clients to develop scientifically sound and cost-effective cell bank programs. We manufacture cell banks for mammalian, microbial, insect, yeast and stem cells and can provide the appropriate cell storage services, all under Good Manufacturing Practice (GMP) guidelines. Our capabilities include purity, sterility, identity, genetic stability testing and an array of other characterization assays from our expansive testing portfolio. Our experienced technical staff can customize a project to create and characterize master cell banks, working cell banks, research cell banks, end-of-production cells and cells at the limit of in vitro cell age, according to client specifications.
Please find the following resources.
Biologics: Cell Line Characterization

Genetic Stability 165 rDNA Sequencing Adventitous Agent Testing bacteriophage testing Barcode analysis Cell Line Identification Copy Number DNA fingerprinting DNA sequencing GMP Microbial Contamination Mycoplasma Detection Purity Assay Restriction Endonuclease Analysis retention of recombinant construct retention of selectable markers Sterility STR analysis viability testing Virology Contamination RNA sequencing Show 21 more tags Show less

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Cell-Based Screening Methods

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Cell-based assays Cell-Based Screening Methods Custom Cell-Based Assay Development

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Nucleic Acid Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development

Bioanalytical Nucleic Acid Services Nucleic Acids RNA

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Glycosylation Analysis

Price on request

Charles River offers an expert panel of services for the characterization of glycosylation. We specialize in comparability programs that may be used for manufacturing/process changes and for comparisons of originator vs. biosimilar products. Glycosylation Site Occupancy and Mapping via Peptide Mapping LC-MS/MS N-Linked Oligosaccharide Profile via LC-MS/MS O-Linked Oligosaccharide Profile via LC-MS/MS Quantitative Monosaccharide Analysis Quantitative Sialic Acid Determination Glycan Structural Characterization / Confirmation via MS Glycan Profile / Isoform via cIEF Exoglycosidase Glycan Sequence / Mapping

Glycosylation Glycosulation site GMP monosaccharide analysis oligosaccharide profile sialic acid determination Show 6 more tags Show less

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Host Cell Protein (HCP) Detection

Price on request

The presence of residual host cell proteins (HCPs) is a potential safety risk in any biopharmaceutical product. With over 30 years of combined experience, our team of host cell protein experts assists clients in the development of a downstream process with the use of effective assays to determine both the concentration of the product and the quantity and concentration of host cell proteins present. The assays used accurately monitor changes in the product concentration and the removal of host cell proteins after purification.

ELISA-based assay GMP HCP assay Mass Spectrometry

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Viral Assays

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Viral Assays virology Cell-based assays

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Liposome Characterization

Price on request

Charles River has extensive experience supporting liposomal product characterization as well as release testing and stability program management for liposomal products. Our liposomal product characterization services include all technologies used to characterize the active biologic or small molecule.
Liposomal product characterization services include:

  • Liposome characterization for analysis for identity, purity and quantitation of the lipid components
  • Analysis for identity, purity and quantitation of the active pharmaceutical ingredients (APIs)
  • Liposomal encapsulation efficiency
  • In vitro release testing
  • Method development for extraction and quantification of API, including peptide drug products

Liposome Characterization Liposome Product Characterization Protein Characterization

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Monocyte Activation Testing

Price on request

Reflecting our strong commitment to the 3Rs, Charles River continuously seeks new methods and technologies to provide clients with viable in vitro alternatives to in vivo tests. In this accord, we offer the monocyte activation test (MAT) according to EP 2.6.30. The MAT works by predicting the human response to pyrogens on the basis of human fever, and may be used as an alternative to the rabbit pyrogen test. This assay can be used to detect Gram-positive and Gram-negative organisms and parasitic, viral and other biological pyrogens (e.g., yeast). It also offers a solution for the testing of products that prove problematic in other in vitro endotoxin tests, such as drugs that affect body temperature regulation (e.g., antipyretic drugs and steroids), drugs that cause immunological reactions (e.g., immunoglobulins), detergents, some blood-derived products (e.g., stem cells) and other products that are turbidimetric, strongly colored or interfere with clotting.

GMP in vitro MAT Monocyte activation testing

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Pyrogen Testing

Price on request

In addition to services in biological testing and quality control, Charles River offers rabbit pyrogen testing according to GMP standards. In this assay, the body temperatures of a sampling of rabbits are measured over a period of time following exposure to a test article. An elevated temperature in the rabbits indicates the presence of pyrogenic compounds within the test article. In vivo pyrogen tests are carried out on specific pathogen-free (SPF) rabbits. Testing is available at multiple facilities and can be performed according to USP<151>, EP 2.6.8 and JP 4.04 for release into the United States, Europe and Japan. With over 30 years of experience, Charles River performs more than 2,500 rabbit pyrogen tests per year and is able to provide results 7-10 days after sample receipt.

GMP in vivo Pyrogen testing Rabbit

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Residual DNA Analysis

Price on request

Charles River can detect and quantify minute amounts of residual host cell DNA by using three highly sensitive, validated methods. These methods encompass the entire range of residual DNA from nonspecific detection of total DNA to highly specific detection of single target sequences.

GMP Hybridization Assay qPCR Assay Threshold Assay

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Viral Clearance Assays

Price on request

All manufacturers of biologics are required to assess the ability of the manufacturing process to generate a product safe for human use. Therefore, a viral clearance study is performed to evaluate key steps of the manufacturing process to ensure that it is effective at removing or inactivating viruses. Our scientists have extensive experience in the design and performance of viral clearance studies, including transmissible spongiform encephalopathy (TSE) clearance, for a wide range of products. We take a customized approach that includes advice and regulatory support in the selection of process steps and model viruses, scaling-down of purification processes and subsequent design of study protocols to ensure a successful program is established and reported to meet timelines.
Please find the following resources.
Biologics: Viral Clearance and TSE Clearance Studies

DNA Enveloped DNA non-Enveloped Infectivity assay qPCR RNA Enveloped RNA Non-Enveloped TSE Clearance viral clearance western blot Show 9 more tags Show less

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Western Blot

Price on request

Blotting of proteins or peptides, commonly named 'Western blotting', is the method of choice whenever information is needed on protein identification and protein quantitation. Western blotting can be used a biochemical quantitation method and a topographical localization technique. Western blotting can be performed both on freshly prepared brain-slices and on homogenized brain-tissue. After tissue sample homogenization and they can be subjected to a number of separation treatments to select, for example membrane bound proteins or cytoplasmic proteins. After poly acrylamide gel electrophoreses and transferal to a membrane antibodies can be used to detect and quantify a protein/receptor of interest.

western blot Protein Identification protein quantification

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Feasibility Studies

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Feasibility Studies Method Feasibility Method Development Method Evaluation

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Impurity Analysis

Price on request

The characterization of the purification process is a key part of the chemistry and manufacturing controls (CMC) section of regulatory filings. In support of quality by design for any process, testing of residual process impurities is an integral step. We support testing of all process stages for impurities such as residual Protein A, DNA, Tween, IPTG, TRIS, PEI, endotoxin and host cell proteins. In addition to generic methods, we offer transfer or method development and validation for customized, product-specific methods.

Analytical Ultracentrifugation ELISA HCP assay HPLC Impurity Analysis Mass Spec N-terminal Sequencing PCR Peptide mapping process-related residuals Residuals Show 11 more tags Show less

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Chromatography

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Chromatography HPLC LC UPLC Analytical GMP GC Liquid Chromatography Gas Chromatography Show 9 more tags Show less

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Separation/Purification Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Separation Purification Services Impurities

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Residual Impurity Analysis

Price on request

In the course of product manufacturing, a number of chemicals are typically added upstream to improve on product expression, recovery, etc. These chemicals are almost entirely removed during the downstream purification process; however, residual levels of these agents may be left within the bulk drug substance and drug product. To ensure that the residual level of these agents is within safe amounts, highly sensitive analytical methods have been developed to detect and quantify such residuals. Charles River offers a full spectrum of ready-to-use analytical methods for the detection and quantification of process- and product-related residuals and impurities.

Analytical SEC Analytical Ultracentrifugation CAD Detector ELISA ELSD GMP HPLC LC-MS LC-MS/MS N-terminal Sequencing Peptide mapping process-related residuals product-related impurities Show 13 more tags Show less

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Biopharmaceutical Development

Price on request

With decades of success in building biologics, Charles River is likewise an ideal partner in the development of biosimilars. We deliver client-focused solutions for the specific testing and manufacturing requirements of biosimilars. Services include cell bank creation, characterization and storage, biosafety testing, process evaluation for viral clearance, originator and biosimilar product characterization, including mass spectrometry, originator and biosimilar unstressed and forced degradation comparability studies, stability studies, equivalence studies, bioassays and product release testing. In addition, as a contract research organization with true end-to-end capabilities, our Safety Assessment team can enhance efficiencies by providing the necessary services with a range of tests to support the development process. These can include toxicology studies to demonstrate biosimilarity, analytical (dose formulation analysis) and bioanalytical assays (toxicokinetics and immunogenicity), immunohistochemistry (e.g., tissue-cross reactivity) and immunology (e.g., flow cytometry and other biomarkers as appropriate).

Biosimilarity analysis Cytokines GMP Hormones mABs Biopharmaceutical Characterization ELISA Potency Assay N-terminal Sequencing Amino Acid Analysis Glycosylation chromotography testing Mass Spectrometry Biophysical Characterization liposomal product characterization glycan charaterization glycoprotein characterization Show 17 more tags Show less

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Cytotoxicity Assays

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Cytotoxicity Assays drug discovery Toxicology drug toxicity effects on cells in vitro cultured Dog Hamster Human Pig Show 8 more tags Show less

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Vaccines

Price on request

As part of the Charles River vaccine program, we draw from our global scientific network to provide vaccine companies with considerable flexibility and convenience in the development of their products. We manufacture both live and attenuated viral vaccines and challenge viruses in cell-based expression systems under GMP requirements for both preclinical studies and early-phase clinical trials. We offer testing from release of cell banks and viral stocks to the release of bulk and final vaccine products.

Vaccine Testing Services biodistribution dose response efficacy testing GLP GMP Immunogenicity Studies Immunotoxicology in vivo Influenza Microbiology Potency Assay Reproductive Toxicology Respiratory Syncytial Virus (RSV) safety assessment Tunorigenicity virology challenge studies Contamination Testing formulation development immunology virus manufacturing Show 22 more tags Show less

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Formulation Services

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development. Charles River has expertise in the development of liquid formulations of proteins, peptides and other biologics products. Our formulation experience includes: Various routes of administration, such as IV, IM depot and ocular, several of which required high-concentration formulations Typically insoluble molecules Stability-indicating assays Forced degradation studies Accelerated stability studies Photostability testing Complex proteins Multi-peptide formulated therapeutics

Formulation services Preformulation Drug Preformulation formulation development product developement Protein Formulation Show 6 more tags Show less

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Manufacturing Services

Price on request

All products entering domestic or global pharmaceutical markets require GMP testing to ensure that they are released in accordance with approved specifications. Release testing packages include a range of studies previously validated to demonstrate compliance of the product. Charles River provides release testing services for bulk drug substances, as well as clinical and marketed products for the EU, US and other regulatory-distinct markets, and can unify global release testing with a single provider. We provide a full range of support, including analysis using suitable in vivo and in vitro potency assays, analytical and microbiology tests, and pyrogen and monocyte activation testing (MAT) to determine purity, identity and other biochemical and biophysical characteristics. We develop and produce monoclonal antibodies by production of hybridomas. We can offer our standard services or customize development and production services based on client needs. We can also offer polyclonal antibody production services such as antigen synthesis, purification, and analysis. In addition, we can design studies in terms of number of immunizations, duration, sample bloods, analysis, etc. to meet each customer's needs.
Please find the following resources.
Biologics: Comprehensive Services for Biologics Developers and Manufacturers
and
Biologics: Drug Product Release

Cell Banking virus manufacturing Vaccine Manufacturing GMP Monoclonal Anbtibody (mAB) Production Lot Release testing Drug Product Release Chemistry Manufacturing and controls (CMC) IND BLA GLP nonGMP Polyclonal Antibody Production Show 14 more tags Show less

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Product Development, Testing, and Packaging

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

GMP Product Development QC testing Accelerated Stability Testing ICH Stability Testing Accelerated Stability Stability Storage ICH Stability Testing stability photostability Product Quality Control Release Testing product stability testing Product Testing Services analytical testing Show 16 more tags Show less

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Spectrophotometry

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

spectrophotometry

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Genotyping by PCR

Price on request

Fast, accurate genotyping conducted on a routine basis can help keep colony sizes manageable, select animals for study cohorts and set aside animals for future breeding. Our high-throughput, multi-platform genotyping laboratory delivers results in as little as 24 hours from sample receipt, facilitating more efficient colony management.

RMS: Genetic Services

PCR/Taqman genotyping Perkin Elmer Lab Chip GX microfluidic electropheresis platform applied biosystem quant studio 12k MAX-BAX SNP Panels

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Zygosity Testing

Price on request

It’s often difficult to discriminate between homozygous and hemizygous transgenic animals using traditional PCR, but the distinction between these zygositities is critical to transgenic breeding strategies, as well as to planning study cohorts. Charles River provides a definitive report on an animal’s zygosity quickly and accurately using our high-throughput, state-of-the-art qPCR technology.

RMS: Genetic Services

DNA Genetic

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SNP Genotyping

Single Nucleotide Polymorphism Genotyping
Price on request

RMS: Genetic Services

Charles River offers an array of off-the-shelf and custom-designed SNP panels designed to do everything from detecting a genetic contamination to fine-mapping a transgene insertion point.

qPCR gene expression analysis real time PCR Luminex-based QuantiGene System Bioluminescent reporter gene assay allelic discrimination assay TaqMan probe chemistry Show 7 more tags Show less

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SNP Genotyping Data Analysis

Single nucelotide polymorphism genotyping data analysis
Price on request

RMS: Genetic Services

Charles River offers an array of off-the-shelf and custom-designed SNP panels designed to do everything from detecting a genetic contamination to fine-mapping a transgene insertion point.

qPCR gene expression analysis real time PCR Luminex-based QuantiGene System Bioluminescent reporter gene assay allelic discrimination assay TaqMan probe chemistry Show 7 more tags Show less

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Animal Isolators

Price on request

Isolators are critical for safeguarding your animals' health and genetic status, ensuring the welfare of your research models, and protecting the integrity of your research data. We offer semi-rigid and flexible isolators in three different sizes. We also can provide custom designs to meet individual client requirements. Upon isolator purchase, we can schedule an on-site setup and training, as well as provide SOPs based on your need. Please find the following resource. IS:Semi Rigid and Flexible Film Isolators

3' semi-rigid isolator 6' semi-rigid isolator 8' semi-rigid isolator 3'flexible film isolator 6' flexible film isolator 3' germ-free rodent isolator 6' germ-free isolator 8' germ-free isolator 4' semi-rigid poultry isolator animal isolator autoclavable cylinder animal quarantine biocontainment bioexclusion Rodents avian poultry Show 17 more tags Show less

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Abuse and Dependence Liability Testing

Price on request

Fully GLP-compliant abuse liability assays are offered in both rats and large animals in accordance with regulatory guidelines worldwide along with nonclinical screening in other standard models, addressing pain and specialized sensory functions, and various psychological and neurological disorders.

Abuse Liability abuse potential addiction addiction models behavioral assay behavioural assay conditioned place drug abuse drug addiction drug dependence dependence liability drug seeking discontunuation syndrome drug discrimination Show 14 more tags Show less

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In vivo Genotoxicity Testing

Price on request

Genetic toxicology studies are conducted to assess the potential for induction of genetic mutations or chromosomal damage and for more than 30 years, Charles River has been helping clients to develop custom testing strategies and conduct appropriate assays to meet the unique requirements of their chemicals and drugs.
The in vivo mammalian alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells that are isolated from target tissues following the necessary daily dose of treatment.
The micronucleus assay conducted by Charles River measures chromosome alterations in treated mammals by detecting chromosome breakage and loss. 
Please find the following resource. Safety: Genetic Toxicology

Comet assay single-cell gel electrophoresis assay SSGE assay OECD 489 mammalian alkaline comet assay rodent erythrocyte micronucleus test micronucleus assay chromosome alteration chromosome breakage rodent micronucleus test Rabbit Mouse Rat Minipig Show 14 more tags Show less

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In vitro Genotoxicity Testing

Price on request

Genetic toxicology studies are conducted to assess the potential for induction of genetic mutations or chromosomal damage and for more than 30 years, Charles River has been helping clients to develop custom testing strategies and conduct appropriate assays to meet the unique requirements of their chemicals and drugs.
The in vitro mammalian chromosomal aberration test (OECD 473) is used to identify substances that cause structural chromosomal aberrations in cultured mammalian cells  and Charles River offers the assay under both GLP and nonGLP conditions.
The Ames test  or Salmonella typhimurium reverse mutation assay offered at Charles River is a bacterial short-term test for identification of carcinogens by measuring mutations in the DNA in bacteria as an endpoint.
The in vitro mammalian cell gene mutation test performed at Charles River is used to detect gene mutations induced by chemical substances in the cell lines that measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT). 
The in vitro mammalian cell gene mutation test performed at Charles River is used to detecta spectra of genetic events denoting gene mutations induced by chemical substances in the cell lines that measure mutation at thymidine kinase (TK).hosphoribosyl transferase (HPRT). 
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. 
Please find the following resource. Safety: Genetic Toxicology

in vitro mammalian chromosomal abberration test OECD 473 assay mammalian chromosomal abberration assay Ames test mutagencity Ames assay Salmonella typhimurium reverse mutation assay reverse mutation assay HPRT gene mutation test HPRT gene in vitro cell gene mutations test OECD 476 thymidine kinase TK gene mutation test OECD test 487 in vitro micronucleus test micronucleus test OECD guidelines for chemicals Show 18 more tags Show less

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Ototoxicity Testing

Price on request

The evaluation and assessment of potential ototoxicity of a compound involves a thorough safety evaluation that includes functional auditory testing, relevant histopathology and evaluation of the cytocochleogram. Please find the following resources. Safety:Auditory Safety Inforgraphic and Safety: Auditory Safety Assessment

MPI Research Mattawan Montreal ototoxicity auditory safety ototox cytochleogram auditory brainstem response drug-induced hearing loss drug-induced vestibular loss hearing loss hair cell ototoxicology auditory tox ear hearing Show 16 more tags Show less

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In vivo Phototoxicity Testing

Price on request

We serve the pharmaceutical, chemical and agrochemical industries with in vivo and in vitro study designs to evaluate phototoxicity that meet standard and specialized requirements for evaluation of any test material. Utilizing a number of different light sources, including visible light, xenon arc solar simulators, and fluorescent ultraviolet radiation sources, our scientists can design specialized exposure conditions and custom light source configurations for any product. Please find the following resource. Safety:phototoxicology

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In vitro Phototoxicity Testing

Price on request

We serve the pharmaceutical, chemical and agrochemical industries with in vivo and in vitro study designs to evaluate phototoxicity that meet standard and specialized requirements for evaluation of any test material. Utilizing a number of different light sources, including visible light, xenon arc solar simulators, and fluorescent ultraviolet radiation sources, our scientists can design specialized exposure conditions and custom light source configurations for any product. Please find the following resource. Safety:phototoxicology

visible light xenon arc solar simulators fluorescent ultraviolet radiation cutaneous phototoxicity ocular phototoxicity visceral phototoxicity spectral distribution evaluation 6500w Xenon arc solar simulator unique light source radiometry spectroradiometry system Show 11 more tags Show less

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SEND Data Conversion

Price on request

Partnering with Charles River will ensure that you will have validated, submission-ready SEND packages that include all necessary accompanying materials (define.xml, nsdrg, and dataset validation reports) for your study. Clients can rely on our regulatory and data standards expertise to provide direction through the sometimes confusing, and often changing, data standardization requirements. Please find the following resource. Safety:SEND

Standard for Exchange of Nonclinical data cdisc SEND PhUSE define.xml nsdrg dataset validation reports Show 6 more tags Show less

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Clinical Biomarkers

Price on request

We support our clients in the preclinical phase of their projects to identify potential biomarkers, and can support projects already entering the clinic to implement appropriate assays. Key to a successful program is the implementation of a validated set of analytical, cellular, and even functional assays, as part of the clinical team in Phase 0-2 studies, confirmation that the drug is engaging with the target and is having the effect predicted. Please find the following resource. Safety:Biomarker Assays

KWS Biotest portishead clinical biomarkers PD biomarkers KWS biomarker testing pharmacodynamic biomarkers clinical sample analysis clinical services biomarker services Show 10 more tags Show less

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In vitro Immunogenicity Assays

Price on request

Immunogenicity refers to the ability of an antigen to induce an immune response. Proteins, peptides, monoclonal antibodies (mAbs), PEGylated proteins, multi-domain biotherapeutics, antibody-drug conjugates (ADCs) and cellular therapeutics are likely to be antigenic, which greatly affects the design of safety evaluation programs for biotechnology products. At Charles River, we have the expertise and resources to develop and validate methods, and perform sample analysis to help you fully study the immunogenicity of your novel compounds in discovery, preclinical and clinical stages. Immunogenicity of peptide and protein therapeutics and biosimilars is one of the primary concerns held by regulatory agencies worldwide. All therapeutic proteins and peptides can potentially trigger some level of immune response. Assays: - ADA screening - Confirmatory - Titration and isotyping - Neutralizing antibody (nAb) Platforms/Assay formats: - ELISA - Electrochemiluminescence (ECL) and Meso Scale Discovery (MSD) - Flow cytometry - SPEAD (solid-phase extraction with acid dissociation)

ADA Screening Confirmatory Titration and isotyping neutralizing antibody assays nAB ELISA electrochemiluminescence ECL Meso Scale Discovery MSD Flow cytometry SPEAD solid-phase extraction with acid dissociation Show 13 more tags Show less

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Predictive Toxicology

Price on request

Charles River specialises in mapping human immune function ex vivo in early development and as part of clinical trials, and can work with you to predict unexpected immunotoxicology and reduce the risks involved. Please find the following resource. Safety:Predictive Immunotoxicology Services

Cobas analyzers (4000, 6000, or 8000) VENTANA Discovery XT

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Immunodeficient Animal Models

Price on request

Due to the challenges inherent in researching and developing anticancer therapeutics, it is important that you have the right tools and resources available to you. Furthermore, selecting the most appropriate animal model is a critical step when designing an oncology study. Please find the following resources. RMS:North America Immunodeficient Models and RMS:ncg mouse

Immunodeficient Models nude mice nude rats immunodeficient mice SCID mice congenic mice Coisogenic mice oncology mice humanized mice microbiome mice Show 10 more tags Show less

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Scientific Consulting

Price on request

Charles River has built a team of talented scientific advisors whose sole purpose is to guide clients, every step of the way. With decades of industry experience and a proven ability to navigate a complex regulatory landscape, our Scientific Advisors design and manage lean yet robust nonclinical programs that reduce risk and accelerate timelines. Their strategic advice includes customized program and study designs, risk mitigation tactics, program management, and regulatory advice. Please find the following resource. Safety: Scientific Advisory Services

drug development Project management IND consulting regulatory Consulting Risk Mitigation Scientific Advisory Services Scientific Consulting Show 7 more tags Show less

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Analytical Ultracentrifugation (AUC)

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

AUC Biophysical Characterization higher order structure HOS

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Intact Mass Analysis

Price on request

Charles River provides tailored global testing and manufacturing services to support clients throughout the biologic development cycle, from discovery through preclinical and clinical studies to marketed product release. We have the capabilities to address the needs of clients based anywhere in the world and have specialized programs for companies that focus on vaccine, cell therapy and biosimilar development.

Mass Spectrometry MS Mass Spec

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Glycan Analysis

Price on request

Charles River offers an expert panel of services for the characterization of glycosylation. We specialize in comparability programs that may be used for manufacturing/process changes and for comparisons of originator vs. biosimilar products. Glycosylation Site Occupancy and Mapping via Peptide Mapping LC-MS/MS N-Linked Oligosaccharide Profile via LC-MS/MS O-Linked Oligosaccharide Profile via LC-MS/MS Quantitative Monosaccharide Analysis Quantitative Sialic Acid Determination Glycan Structural Characterization / Confirmation via MS Glycan Profile / Isoform via cIEF Exoglycosidase Glycan Sequence / Mapping

Glycosylation Analysis Glycosylation glycosylation site occupancy GMP monosaccharide analysis oligosaccharide profile sialic acid determination Show 7 more tags Show less

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N-Terminal Sequencing

Price on request

To help clients generate the data needed to gain the level of product characterization required for regulatory submission, Charles River offers protein analysis as part of an integrated package of expert analytical services. We have extensive experience in developing and establishing protein characterization methods, including product-specific in vitro potency assays. These characterization services are also a part of our stability and product release support services, where we offer key identity, purity and potency assays. Analytical Services: Mass spectrometry Biophysical characterization Glycosylation/Glycan characterization Chromatography & electrophoretic methods N-terminal sequencing and amino acid analysis ELISA and immunoassay development Potency assays

Protein Characterization Edman Degradation Biophysical Characterization

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Flow Cytometry Data Analysis

Price on request

In addition, in-house multiplex flow cytometry enables a comprehensive analysis of the immune system, allowing identification of various cell populations and deep interrogation of an immune response elicited from novel therapeutics. With a streamlined process for tissue dissociation, cell isolation, staining and acquisition, hundreds of systemic and tumor-infiltrating immune cells can be processed per day to give clients the benefit of reviewing data and making decisions about compounds and studies in near-real time. Our expert staff have developed and validated panels of flow assays for identification and profiling of several relevant immune cells, such as CD4+ and CD8+ effector T cells, helper and regulatory T cells, myeloid-derived suppressor cells, macrophages and natural killer cells. Additionally, we routinely develop customized panels to identify specific immune cells critical to a particular program. Any of these panels, standard or custom, measured in combination with traditional biomarkers and other endpoints tailored to the program, build a complete data package to drive decision-making.

 

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/oncology-translational-tools/flow-cytometry?region=3601

Flow cytometry cell populations identification immune cells CD4 cell CD8 cell Effector T cells Helper T-cells Regulatory T cells myeloid deprived suppressor cells macrophages natural killer cells Show 12 more tags Show less

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Fluorescence in situ Hybridization (FISH)

Price on request

Genetic toxicology studies are conducted to assess the potential for induction of genetic mutations or chromosomal damage. Genetic toxicity testing is required for all classes of chemicals and drugs, but its conduct can differ from compound to compound to account for regulatory requirements and choice and design of assays.

For more than 30 years, Charles River has been helping clients to develop custom testing strategies and conduct appropriate assays to meet the unique requirements of their chemicals and drugs. With three sites in North America and Europe, our team includes more than 70 scientists and staff who are dedicated to the field of genetic toxicology, as well as regulatory consultants and program managers who can support our clients’ studies with strategic advice. Our ongoing involvement with regulatory working groups (e.g., OECD Expert Working Groups) and international societies (e.g., Genetic Toxicology Association) ensures that our clients have access to the latest developments in science and its and applications in the regulatory environment. Our team works closely with other Safety Assessment groups to enrich study results and integrity with supplementary services such as formulation and analytical chemistry, pathology and bioanalysis. Additionally, we can support and enhance other studies by evaluating genetic toxicology biomarkers and determining mechanism of action identification using in situ hybridization, flow cytometry and determining apoptosis if needed.

 

https://www.criver.com/products-services/safety-assessment/toxicology-services/genetic-toxicology?region=3601

Genetic Toxicity testing FISH in vitro Genotoxicity assays

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Human Tumor Xenograft Models

Price on request

 

Our cell line-derived xenograft CDX models are run as subcutaneous, disseminated, or orthotopic in both mice and rats. Human tumor cell line-derived xenografts in the immunodeficient nude rat model are used to conduct in vivo efficacy evaluation of potential cancer therapies. The nude rat xenograft model is well suited for tumor studies, as it closely mimics human disease state and has similar physiology and metabolic characteristics to humans. This model can be used to evaluate targeted therapy, cytotoxic drugs, antibody therapies, and viral therapies.

Our broad range of tumor lines gives you a wide variety of testing alternatives. We evaluate our tumor xenograft portfolio on a regular basis for response to standards of care and store data to aid the design of combination studies.

In addition to helping you select the most appropriate model for your agent, our scientific staff can fully profile your agent in a variety of tumor types or in combination with the appropriate clinical agent. When you’re ready to prepare your IND filing, we offer our CDX rat models as a second species, in addition to our mouse CDX models.

 

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/oncology-pharmacology-models/human-tumor-xenografts-rats?region=3601

Humanized Xenograft Models xenograft oncololgy mouse CDX model U87MG MDA-MB-231 HCT116 HT29 A431 MV4-11 RS4:11 THP-1 H460 A2058 A375 A2780 MiaPACa-2 PC3 Brain colon Epifermoid Leukemia Lung Melanoma Ovarian Pancreatic Prostate Humanized Mouse Mouse Mice rats Rat Show 32 more tags Show less

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Genotyping and Gene Expression Assays

Price on request

It’s been known for transgenic animals to lose phenotype from one breeding colony to the next. Can you afford to lose valuable research and time due to loss of phenotype? Ensure the genetic integrity of your transgenic colonies is upheld by using a properly managed genetic testing program that can provide scientific expertise with 99% accuracy. Our expert geneticists can work with you to provide scientific guidance and consultation in colony management and complex breeding strategy.

Charles River maintains genetic testing labs in the US and Europe.

 

https://www.criver.com/products-services/research-models-services/animal-health-surveillance/genetic-testing-services?region=3601

Genotyping services zygosity testing transgenics transgenic breeding homozygous hemizygous CRISPR-Cas9 mutation screening PCR ES cells gene targeting transgenic animal model transgene segregation instability transgenic carriers Mouse Mice Rat rats Show 19 more tags Show less

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Small Animal X-ray

Price on request

Molecular imaging is an established technology combining both functional and structural imaging to allow for evaluation of specific in vivo processes in relation to spatial orientation within the model of interest. The unique characteristics of molecular imaging provide investigators with an early stage solution to evaluate critical principles of new entity development: exposure at the target site, binding to the target of interest, and expression of the desired pharmacology. Incorporation of molecular imaging solutions into new entity development programs allows you to rapidly assess results and make essential decisions earlier in the drug development process. Imaging can be used in many development efforts, such as those targeting insight into disease processes, validity of new therapeutic targets, target/non-target organ interaction, mechanism of action, biodistribution and others.

 

https://www.criver.com/products-services/safety-assessment/molecular-imaging-radiochemistry?region=3601

in vivo x-ray x-ray imaging

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Bioethics Consulting

Price on request

The mix of expertise and experience within the Scientific Advisory Services (SAS) team supports client programs by reducing risk and accelerating timelines to the clinic, ensuring that data is relevant and applicable for your end goal, utilizing a comprehensive portfolio for end-to-end drug discovery and so much more. The mission of the SAS is to guide clients, every step of the way.

Scientific Advisory Services consulting

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Animal Husbandry

Price on request

Due to the dynamic nature of the drug development process, you may often need additional scientific staffing for some projects. We can help streamline your program by delivering operational and cost efficiencies through scientific recruitment programs. Our customized options allow you to maintain as much or as little control over your in-house resources, assets, and facilities that you consider strategic and cost-efficient. Charles River Insourcing Solutions℠ can fill your long-term and temporary absences, such as maternity leaves and long-term personnel vacancies. Our scientific recruitment background checks include a thorough review of animal rights connections. Charles River recognizes that the welfare of animals contributing to research is paramount – both for ethical reasons as well as scientific ones. It leads to the accuracy, reliability, and translatability of research. To maintain our commitment to their wellbeing, all newly hired scientific staffing are trained on the latest programs pertaining to animal welfare and the 3Rs.

https://www.criver.com/products-services/operations-and-staffing-support/scientific-staffing?region=3601

CRADL in sourcing Solutions animal husbandry Animal Welfare 3Rs

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Bioanalytical Assays

Price on request

Our non-regulated bioanalysis research grade assays and regulated bioanalytical services can be performed on small and large molecules, including antibody-drug conjugates, biosimilars, monoclonal antibodies, oligonucleotides, peptides, proteins, and vaccines. Our SOPs confirm compliance with Good Laboratory Practice (GLP), Good Clinical Laboratory Practice (cGLP), and current regulatory bioanalytical guidance documents issued by the relevant regulatory bodies.

https://www.criver.com/products-services/lab-sciences/bioanalysis?region=3601

non regulated regulated non-GLP GLP RGA cGLP Bioanalytical bioanalysis small molecule Large molecule Method Transfer Method Development Chromatographic Mass Spectrometry ligand binding assays LLOD ULOQ ULOG ISR Show 19 more tags Show less

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Cells and Tissues

Price on request
Request a quote for more information about this service.

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Protein-Protein Interaction Analysis

Price on request

Proteomics is widely applicable in biomarker discovery, disease research, drug discovery, and development. Proteomics services and techniques can be applied to the analysis of a single protein or used for the large-scale analysis of a specific proteome including protein abundances, protein modifications, protein-protein interactions, and protein-compound interactions.

Charles River’s proteomics services team offers sample extraction, protein fractionation, peptide fractionation, protein mass spectrometry, protein identification, and protein quantification.

 

https://www.criver.com/products-services/discovery-services/integrated-drug-discovery/proteomics-services-and-quantitative-proteomics

chemist protein-protein interaction proteomics services drug discovery drug development sample extraction protein fractionation peptide fractionation protein mass spectrometry Protein Identification protein qualification Protein Expression thermo scientific proteome dicoverer software MaxQuant Skyline proteomics Q Exactive PLus Mass spectrometer Velos Pro Bottom up method recombinant protein Top down method isotopic labelling protein concentration capture compound mass spectrometry CCMS Show 25 more tags Show less

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Induced Pluripotent Stem Cell (iPSC) Culture

Price on request

Advances in stem cell technologies opens new opportunities in drug discovery and development by providing more sophisticated, physiologically relevant biological systems for use in cell-based in vitro assays. Charles River develops custom cell-based assays using induced pluripotent stem cells (iPS cells) from diseased donors and healthy controls for drug screening, biomarker discovery, and evaluation of disease pathophysiology. Reprogramming patient derived somatic cells into induced pluripotent stem cells can be used to generate large numbers of cells and varied tissue types including human neurons which are relevant to neurological related diseases.

https://www.criver.com/products-services/discovery-services/in-vitro-assays/human-primary-cell-based-assays/stem-cells?region=3601

Huntington's Disease Amyotrophic Lateral Sclerosis (ALS) in vitro assays drug discovery iPS cells Human neurons Striatal neurons cortical neurons Hts cell based assays CNS/Neurology Patient Derived cells compound screening target discovery validation medium throughout assays cell morphology fixed cells real-time electrophysiology Show 20 more tags Show less

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Immunocytochemistry

Price on request

Phenotypic assays using disease-relevant cell models are an efficient approach to discover new disease drivers, perform high-throughput screens of compound or antibody libraries, understand mechanism of action, and identify clinically relevant biomarkers. At Charles River, we have developed assays to support drug discovery for specific rare diseases including ALS and Duchenne muscular dystrophy (DMD). The cell-based assays are complementary to in vivo ALS models and the MDX mouse model that is used extensively in DMD research.

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/rare-disease-pharmacology-models/rare-disease-vitro-assays?region=3601

Amyotrophic Lateral Sclerosis (ALS) Duchenne Muscular Dystrophy DMD in vivo MDX mouse model iPSC patient derived induced pluriptnt stem cells HESCS human embryonic stem cells in vivo disease model cell type specific markers MDX mouse model Show 12 more tags Show less

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Transgenic Genotyping

Price on request

Effective rodent colony management depends on rat or mouse genotyping results, not just data. Genotyping that is conducted routinely can help keep colony sizes manageable, aid in selecting animals for study cohorts, and set aside animals for future breeding.

Our high-throughput, multiplatform rat and mouse genotyping laboratory delivers results from sample receipt to the facilitation of more efficient lab animal colony management. Automation of the overall genotyping process enables us to deliver fast turnaround times and makes us readily available to respond to scale up or expedite genotyping requests

 

https://www.criver.com/products-services/research-models-services/animal-health-surveillance/genetic-testing-services/mouse-rat-genotyping?region=3601

zygosity testing CRISPR Cas9 transgenic breeding homozygous hemizygous PCR ES cells transgenic animal model transgene segregation instability transgenic carriers Laboratory Testing Management LTM LTM ship Transgenic Mouse Transgenic rat Show 16 more tags Show less

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Small Animal MRI

Small Animal Magnetic Resonance Imaging
Price on request

Molecular imaging is an established technology combining both functional and structural imaging to allow for evaluation of specific in vivo processes in relation to spatial orientation within the model of interest. The unique characteristics of molecular imaging provide investigators with an early stage solution to evaluate critical principles of new entity development: exposure at the target site, binding to the target of interest, and expression of the desired pharmacology. Incorporation of molecular imaging solutions into new entity development programs allows you to rapidly assess results and make essential decisions earlier in the drug development process. Imaging can be used in many development efforts, such as those targeting insight into disease processes, validity of new therapeutic targets, target/non-target organ interaction, mechanism of action, biodistribution and others.

 

https://www.criver.com/products-services/safety-assessment/molecular-imaging-radiochemistry?region=3601

Small animal MRI in vivo imaging

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Whole Slide Imaging/Digital Slide Scanning

Price on request

Our state-of-the-art facilities house image analysis systems that perform all of the standard and user-defined static and dynamic measurements for bone. The dynamic measurements can be completed with or without fluorochrome labels. For stereological analysis, we offer a full range of services for discovery and GLP-compliant studies from conception and design through to data analysis.

Our facilities provide a wide range of image analysis techniques for other tissues. Whole-slide scanning with online slide viewing capabilities is available, as are whole-slide morphometric analysis and stereological analysis on slides scanned using GLP-validated Visiopharm® software.

Each system is operated by highly trained technical staff supervised by pathologists board certified by the American College of Veterinary Pathologists, Royal College of Pathologists and European College of Veterinary Clinical Pathology.

 

https://www.criver.com/products-services/safety-assessment/pathology-services/specialty-endpoints/image-analysis-and-morphometry?region=3601

fluorochrome labels non-GLP Discovery GLP Image analysis Whole slide scanning on line slide viewing whole slide morphometric analysis stereological analysis Visiopharm software board certified pathologist Mouse Mice Rat rats Dog Dogs Minipig Guinea pig Non-human primates (NHP) Show 20 more tags Show less

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RT-PCR

Reverse transcription polymerase chain reaction
Price on request

Cell substrates used in the manufacture of biologics must be shown to be free of adventitious agents, including mycoplasma. Testing for mycoplasma contamination must be performed at various phases of product development, including raw materials, cell banks, viral seed stocks, unprocessed bulk harvest materials and final products. Spiroplasma testing is also suggested for biopharmaceutical products that have been in contact with plant or insect materials. This assay includes a growth enrichment step prior to the nucleic acid test in order to delineate viable organisms from non-viable organisms and residual environmental sources. Samples are tested at day 0 and day 7.

RT-PCR qPCR Method Culture growth Nucleic acid test organisms biologics Mycoplasma contamination Product Development raw materials cell banks viral seed stock unprocessed bulk harvest materials final products biopharmaceutical products Show 15 more tags Show less

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Fluorescence Activated Cell Sorting (FACS)

Fluorescence Activated Cell Sorting
Price on request

The identification and use of predictive biomarker assays has become an integral part of the drug discovery and development process. Charles River has broad expertise in biomarker identification and assay development across a range of therapeutic areas, including respiratory disease, oncology, CNS and metabolic diseases.

Our capabilities span the identification and validation of biomarkers and the development of quantitative assays in primary cells and disease tissue, pharmacodynamic and disease models, and as efficacy and translational medicine markers in the clinic. Our experience includes the translation of biomarker assays for use in the clinic for several client projects.

Fluorescence Activated Cell Sorting FACS

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Spectroscopy

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Once compounds have been synthesized, they undergo purification, rigorous characterization, analysis and structural determinations as required using the latest equipment. Charles River has the capability to perform nuclear magnetic resonance spectroscopy, mass spectrometry, infrared spectroscopy and single-crystal X-ray experiments. High-throughput mass measurements are performed alongside high-throughput LC-MS analysis for structural and chemical purity determinations.

https://www.criver.com/products-services/discovery-services/chemistry/analytical-chemistry?region=3601

Waters/Agilent mass-directed autopurification Waters Acquity UPC2 for supercritical fluid chromatography Waters Thar SFC Prep 100 and Investigator systems Waters Thar HT Resolution Analytical SFC-MS Agilent 1200 chiral analytical HPLC Gilson UV directed chiral HPLC purification system High-throughput Acquity UPLC MS systems Micromass Quattro Micro UPLC-MS-MS Agilent 7820 GC plus Agilent 5975 MSD Perkin Elmer SCIEX API5000,Waters XEVO QTOF accurate mass MS-MS system Bruker Avance III HD 400 (x2), Avance DPX300, AV400, AVII 400 Fourier 300 NMR spectrometers analytical chemistry nuclear magnetic resonance spectroscopy Mass Spectrometry Infrared Spectroscopy single crystal X-ray Show 17 more tags Show less

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Liquid Chromatography (LC)

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Selecting the correct solid form for use in formulations ensures consistent stability, hygroscopicity and dissolution behavior across batches. By use of polymorph screening, salt screening and a suite of solid form characterization techniques, Charles River scientists ensure that they understand the physical properties of the APIs they are working with, resulting in the identification of robust formulations.

https://www.criver.com/products-services/lab-sciences/formulation-product-chemistry/formulation-development-analytical-chemistry?region=3601

analytical chemistry GLP LC-MS LC-MS/MS

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Validation, Services

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Bioanalytical analytical chemistry

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Contract Services Directory

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Nonclinical Research

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Drug Discovery

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Discovery from Charles River is the partner of choice with the industry’s most comprehensive drug discovery service portfolio and a multidisciplinary staff of hundreds of scientists. We have the scientific excellence and technological capabilities to support our clients throughout the drug development life cycle, from target identification to IND programs. Our team takes a true collaborative approach working in partnership with clients to find and follow the optimum path to market while moving forward together to bring novel therapies to the patients who need them

https://www.criver.com/research-phase/discovery

target discovery assay development Synthetic Chemistry medicinal chemistry process chemistry In Vitro ADME In vivo pharmacology discovery pharmacokinetics Show 8 more tags Show less

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Contract Research

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Biomarker Analysis

Price on request

Scientific excellence is ensured by a synergy between experts in multiple areas, adding value to the preclinical studies. In addition to our portfolio of GLP-compliant markers, qualified assays can also be rapidly validated for GLP compliance.

https://www.criver.com/products-services/lab-sciences/biomarker-services?region=3601

biomarker drug discovery and development Drug Mechanisms of Action Studies therapeutic efficacy toxicity GLP identification in vitro in vivo Show 9 more tags Show less

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